Click here to switch to the map view.

The map label for this gene is zraR [H]

Identifier: 108812984

GI number: 108812984

Start: 3179316

End: 3180707

Strand: Reverse

Name: zraR [H]

Synonym: YPN_2824

Alternate gene names: 108812984

Gene position: 3180707-3179316 (Counterclockwise)

Preceding gene: 108812985

Following gene: 108812983

Centisome position: 70.14

GC content: 44.9

Gene sequence:

>1392_bases
ATGGGCAAGAACAAAAGGCGTCGAATAATGACAACACATAAAGCGCATATTTTGGTCGTTGATGATGACCTGAGCCACTG
CACAATTATCCAGGCTTTAATGAAAGGCTGGGGTTATCAAACCACGCCAGCCCACAATGGATTAGAGGCCATCGAACTGG
CTAAAGAGATCCCTTTCGATTTAATTCTGACTGATGTGCGAATGTCTGAAATGGATGGTATTGAGGCATTAAAGGCAATT
AAAGCCTATAACCCGGCAATCCCTATTTTAATTATGACGGCTTATTCCAACGTTGAATCTGCGGTTGAGGCAATTAAAGC
CGGGGCATACGATTATCTTACCAAACCGCTTGATTTCGACATGTTACAACTCACCCTTGAGCGGGCACTGGAACATACGC
ATCTCAAGAATGAGAATAAAACACTTAAACAGCAGATCATCAGTAACCAAAATATTATTGGTCGCAGCCCACAAATGCGC
TATCTGATGGATATGGTTGGCATGATTGCGCCTTCTGAAGCGACGGTGTTGATATGTGGAGAATCGGGTACGGGCAAAGA
AATTATTGCCCGCTCAGTTCATGCTAACAGCGCCCGTAAAGATCAACCGTTGGTGATTGTTAACTGCGCGGCACTCAGTG
AGTCATTGCTGGAGTCCGAGCTATTCGGCCATGAAAAAGGGGCGTTTACTGGCGCAGATAAACGTCGGGAAGGGCGCTTT
ATGGAGGCACATAAGGCAACGTTATTTTTGGATGAGATTGGTGAAATCTCAGGGTTGATGCAGGCAAAACTCCTGCGTGC
TATCCAAGAACGGGAGATCCAGCGCGTTGGCAGTAATCAGACATTAGATATTGATGTCAGGTTGATTGCCGCCACTAACC
GCAATCTTAAAGCCGATGTTGATAGTGGAAAGTTTCGCCAGGATCTCTACTATCGATTAAATGTGGTCACGATAGATACC
CCGGCGTTGAGAGAGCGAAGCGAAGATATTCCGCCGTTGTCGATGCATTTCTTGGAAAAGTTTGCGCTCAAGAACCGTAA
ATCAATCAAAGGATTCACACCGCAAGCGATGAATATGCTGTTGAAATACAACTGGCCTGGTAACGTGCGTGAATTGGAAA
ATACGGTGGAGCGTGCGGTGATTTTACTGACCGGTGATTTCATCAGCGAGAAGGAGTTGCCGTTAAATATTAATCATTAT
ATTCAGGAGAATGCCGGTAGTGAGAATATAGGTTATGAGGATGCAGAAAAACCTATCCAGTCTCTCGAATGGGTCGAAAT
AGACGCTATTTTGACTGCGTTGGAAAAGACGGGAGGCAATAAAACAGAGGCAGCAAAACATTTAGGCATCACGCGCAAAA
CATTGCAGGCAAAATTACAAAAAAGAACTTAG

Upstream 100 bases:

>100_bases
GAAGAGCATCAAGGTAGAATCACCGTTACCAGCCACCCGCAATCTGGAACCCGCTTTGACATGACAATCCCCTTGGTACA
ACGCGGCCAATATCGCCCAG

Downstream 100 bases:

>100_bases
CTATTTTTTTATAAAAATACAGGCATTTTAAAAAGCGGATTGTGTTTAAAATAAAAGTTTAAATATCAATGTGTTGTGTA
TTTACCTGCTTAATCTGACA

Product: helix-turn-helix, Fis-type

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MGKNKRRRIMTTHKAHILVVDDDLSHCTIIQALMKGWGYQTTPAHNGLEAIELAKEIPFDLILTDVRMSEMDGIEALKAI
KAYNPAIPILIMTAYSNVESAVEAIKAGAYDYLTKPLDFDMLQLTLERALEHTHLKNENKTLKQQIISNQNIIGRSPQMR
YLMDMVGMIAPSEATVLICGESGTGKEIIARSVHANSARKDQPLVIVNCAALSESLLESELFGHEKGAFTGADKRREGRF
MEAHKATLFLDEIGEISGLMQAKLLRAIQEREIQRVGSNQTLDIDVRLIAATNRNLKADVDSGKFRQDLYYRLNVVTIDT
PALRERSEDIPPLSMHFLEKFALKNRKSIKGFTPQAMNMLLKYNWPGNVRELENTVERAVILLTGDFISEKELPLNINHY
IQENAGSENIGYEDAEKPIQSLEWVEIDAILTALEKTGGNKTEAAKHLGITRKTLQAKLQKRT

Sequences:

>Translated_463_residues
MGKNKRRRIMTTHKAHILVVDDDLSHCTIIQALMKGWGYQTTPAHNGLEAIELAKEIPFDLILTDVRMSEMDGIEALKAI
KAYNPAIPILIMTAYSNVESAVEAIKAGAYDYLTKPLDFDMLQLTLERALEHTHLKNENKTLKQQIISNQNIIGRSPQMR
YLMDMVGMIAPSEATVLICGESGTGKEIIARSVHANSARKDQPLVIVNCAALSESLLESELFGHEKGAFTGADKRREGRF
MEAHKATLFLDEIGEISGLMQAKLLRAIQEREIQRVGSNQTLDIDVRLIAATNRNLKADVDSGKFRQDLYYRLNVVTIDT
PALRERSEDIPPLSMHFLEKFALKNRKSIKGFTPQAMNMLLKYNWPGNVRELENTVERAVILLTGDFISEKELPLNINHY
IQENAGSENIGYEDAEKPIQSLEWVEIDAILTALEKTGGNKTEAAKHLGITRKTLQAKLQKRT
>Mature_462_residues
GKNKRRRIMTTHKAHILVVDDDLSHCTIIQALMKGWGYQTTPAHNGLEAIELAKEIPFDLILTDVRMSEMDGIEALKAIK
AYNPAIPILIMTAYSNVESAVEAIKAGAYDYLTKPLDFDMLQLTLERALEHTHLKNENKTLKQQIISNQNIIGRSPQMRY
LMDMVGMIAPSEATVLICGESGTGKEIIARSVHANSARKDQPLVIVNCAALSESLLESELFGHEKGAFTGADKRREGRFM
EAHKATLFLDEIGEISGLMQAKLLRAIQEREIQRVGSNQTLDIDVRLIAATNRNLKADVDSGKFRQDLYYRLNVVTIDTP
ALRERSEDIPPLSMHFLEKFALKNRKSIKGFTPQAMNMLLKYNWPGNVRELENTVERAVILLTGDFISEKELPLNINHYI
QENAGSENIGYEDAEKPIQSLEWVEIDAILTALEKTGGNKTEAAKHLGITRKTLQAKLQKRT

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=453, Percent_Identity=64.0176600441501, Blast_Score=596, Evalue=1e-171,
Organism=Escherichia coli, GI1788550, Length=448, Percent_Identity=46.6517857142857, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1788905, Length=443, Percent_Identity=39.0519187358916, Blast_Score=334, Evalue=7e-93,
Organism=Escherichia coli, GI1790299, Length=462, Percent_Identity=39.8268398268398, Blast_Score=325, Evalue=4e-90,
Organism=Escherichia coli, GI87082117, Length=338, Percent_Identity=44.6745562130178, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI1789087, Length=339, Percent_Identity=44.2477876106195, Blast_Score=254, Evalue=6e-69,
Organism=Escherichia coli, GI1789233, Length=320, Percent_Identity=41.875, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI87082152, Length=238, Percent_Identity=49.5798319327731, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1786524, Length=359, Percent_Identity=38.7186629526462, Blast_Score=235, Evalue=5e-63,
Organism=Escherichia coli, GI87081872, Length=326, Percent_Identity=40.7975460122699, Blast_Score=215, Evalue=5e-57,
Organism=Escherichia coli, GI1787583, Length=318, Percent_Identity=34.2767295597484, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1789828, Length=259, Percent_Identity=37.4517374517375, Blast_Score=152, Evalue=6e-38,
Organism=Escherichia coli, GI87081858, Length=307, Percent_Identity=31.2703583061889, Blast_Score=135, Evalue=8e-33,
Organism=Escherichia coli, GI1789149, Length=114, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1786784, Length=103, Percent_Identity=30.0970873786408, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788191, Length=129, Percent_Identity=30.2325581395349, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51974; Mature: 51842

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKNKRRRIMTTHKAHILVVDDDLSHCTIIQALMKGWGYQTTPAHNGLEAIELAKEIPFD
CCCCCCCCEEEECCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHH
LILTDVRMSEMDGIEALKAIKAYNPAIPILIMTAYSNVESAVEAIKAGAYDYLTKPLDFD
EEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHCCCHHHHCCCCCHH
MLQLTLERALEHTHLKNENKTLKQQIISNQNIIGRSPQMRYLMDMVGMIAPSEATVLICG
HHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEC
ESGTGKEIIARSVHANSARKDQPLVIVNCAALSESLLESELFGHEKGAFTGADKRREGRF
CCCCCHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCH
MEAHKATLFLDEIGEISGLMQAKLLRAIQEREIQRVGSNQTLDIDVRLIAATNRNLKADV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCEECC
DSGKFRQDLYYRLNVVTIDTPALRERSEDIPPLSMHFLEKFALKNRKSIKGFTPQAMNML
CCCHHHHEEEEEEEEEEECCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LKYNWPGNVRELENTVERAVILLTGDFISEKELPLNINHYIQENAGSENIGYEDAEKPIQ
EEECCCCCHHHHHHHHHHEEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHH
SLEWVEIDAILTALEKTGGNKTEAAKHLGITRKTLQAKLQKRT
HCCHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCC
>Mature Secondary Structure 
GKNKRRRIMTTHKAHILVVDDDLSHCTIIQALMKGWGYQTTPAHNGLEAIELAKEIPFD
CCCCCCCEEEECCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHH
LILTDVRMSEMDGIEALKAIKAYNPAIPILIMTAYSNVESAVEAIKAGAYDYLTKPLDFD
EEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHCCCHHHHCCCCCHH
MLQLTLERALEHTHLKNENKTLKQQIISNQNIIGRSPQMRYLMDMVGMIAPSEATVLICG
HHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEC
ESGTGKEIIARSVHANSARKDQPLVIVNCAALSESLLESELFGHEKGAFTGADKRREGRF
CCCCCHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCH
MEAHKATLFLDEIGEISGLMQAKLLRAIQEREIQRVGSNQTLDIDVRLIAATNRNLKADV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCEECC
DSGKFRQDLYYRLNVVTIDTPALRERSEDIPPLSMHFLEKFALKNRKSIKGFTPQAMNML
CCCHHHHEEEEEEEEEEECCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LKYNWPGNVRELENTVERAVILLTGDFISEKELPLNINHYIQENAGSENIGYEDAEKPIQ
EEECCCCCHHHHHHHHHHEEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHH
SLEWVEIDAILTALEKTGGNKTEAAKHLGITRKTLQAKLQKRT
HCCHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]