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The map label for this gene is toxA [H]

Identifier: 108812689

GI number: 108812689

Start: 2841056

End: 2842036

Strand: Reverse

Name: toxA [H]

Synonym: YPN_2528

Alternate gene names: 108812689

Gene position: 2842036-2841056 (Counterclockwise)

Preceding gene: 108812690

Following gene: 108812686

Centisome position: 62.67

GC content: 35.68

Gene sequence:

>981_bases
ATGCTCGAACAGATTGTTAGTGGTGTGGTAGATACTAATTACATAATGTATTCTAATAAAAACATTCGTGAACGTAACGT
ATTTGAATCAATGGCGTTTTCTACCCGAGAAAGAAGCTTTAATGATGGTGATGTAATTATTAAATCAAACGCAGAAGTCC
AGCGAGATTATGCCCTGAATGTTTTACAAACCATTTTATCTTTGAGCCCTATATTTGATATCGTGCTCCCGGAAGTTTCT
ATTCCGATTAGCCTTGGTATAACCGCTTCAAGTGTCGGTATTAGTTTTGATGAGTTAATAAACGGGGATACTTATGAAGA
GCGCCGCTCTGCAATTCCTGGATTGGCAACAAATGCTGTGTTATTGGGTATATCATTCGCAATACCATTTTTAATCAGTA
AGGCAGCAGAAAATAAGTTAATTATCAATAATTTAGTAGGTAGTGACGAAAACATACTTAATAAAAATAATCTTGCTGAT
TTTTTGGAAAAGTACAATATTAGCGAGAGTGATATTCCAGAAAATGGCTCTTTAGTTATTAATTTGAAAAACACTAACGT
ACCTGTTCGTCTTGTTAAACTGAATGATGAAGAGGGCGAAATTGTTGCAATCAAAGGAAGCACATTGAGCGGGATTTACT
ACGAAGTAGATACTGAAACAGGTTATGAGATATTGTCACGCCGGGTATTTCGAACCGAATATAATGAAAAAATTTACTGG
ACAAGGGGGGGAGGACTGAAAGGTGGTCAGCCATTTAACTTCGAGGGGCTTGATATTCCTGTTTATTTTATAGATAAACC
ATATTCTGAACTTGCATCTTCAGTGGAACTTTCATTTGTGAATGATGATAGCCCTTTGTTATTCCCTGAAATGGACTCCA
GATTACCAAAACCGACTCCAGAGTTAGATATAAAATACTACTCTTCTAATTTATCTTCTTTTAAAGAAGATACGGTAATT
CTAATGAGAGGAACGACATAA

Upstream 100 bases:

>100_bases
AAAGGCGTTAATTTCTGATAAAAACACCCGTGAGTTATTTTCTAAGCATTTTTATTTATATTACCGACAAGATGGAAACA
CGTATTTAGGTGTTAATTCA

Downstream 100 bases:

>100_bases
GAAGAAGCGTGGAATATTGCAAACTATAAAACGGCAGGTGGGAGCAACAAAGATCTTGATGAGAACTTTATTGAGGCTGG
ACCACAGTTCAACTTAAGTT

Product: hypothetical protein

Products: NA

Alternate protein names: DNT; Mitogenic toxin; PMT [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MLEQIVSGVVDTNYIMYSNKNIRERNVFESMAFSTRERSFNDGDVIIKSNAEVQRDYALNVLQTILSLSPIFDIVLPEVS
IPISLGITASSVGISFDELINGDTYEERRSAIPGLATNAVLLGISFAIPFLISKAAENKLIINNLVGSDENILNKNNLAD
FLEKYNISESDIPENGSLVINLKNTNVPVRLVKLNDEEGEIVAIKGSTLSGIYYEVDTETGYEILSRRVFRTEYNEKIYW
TRGGGLKGGQPFNFEGLDIPVYFIDKPYSELASSVELSFVNDDSPLLFPEMDSRLPKPTPELDIKYYSSNLSSFKEDTVI
LMRGTT

Sequences:

>Translated_326_residues
MLEQIVSGVVDTNYIMYSNKNIRERNVFESMAFSTRERSFNDGDVIIKSNAEVQRDYALNVLQTILSLSPIFDIVLPEVS
IPISLGITASSVGISFDELINGDTYEERRSAIPGLATNAVLLGISFAIPFLISKAAENKLIINNLVGSDENILNKNNLAD
FLEKYNISESDIPENGSLVINLKNTNVPVRLVKLNDEEGEIVAIKGSTLSGIYYEVDTETGYEILSRRVFRTEYNEKIYW
TRGGGLKGGQPFNFEGLDIPVYFIDKPYSELASSVELSFVNDDSPLLFPEMDSRLPKPTPELDIKYYSSNLSSFKEDTVI
LMRGTT
>Mature_326_residues
MLEQIVSGVVDTNYIMYSNKNIRERNVFESMAFSTRERSFNDGDVIIKSNAEVQRDYALNVLQTILSLSPIFDIVLPEVS
IPISLGITASSVGISFDELINGDTYEERRSAIPGLATNAVLLGISFAIPFLISKAAENKLIINNLVGSDENILNKNNLAD
FLEKYNISESDIPENGSLVINLKNTNVPVRLVKLNDEEGEIVAIKGSTLSGIYYEVDTETGYEILSRRVFRTEYNEKIYW
TRGGGLKGGQPFNFEGLDIPVYFIDKPYSELASSVELSFVNDDSPLLFPEMDSRLPKPTPELDIKYYSSNLSSFKEDTVI
LMRGTT

Specific function: This is a dermonecrotic toxin. This osteolytic toxin, induces bone resorption. Potent mitogen. This toxin is associated with the severe progressive form of the atrophic rhinitis, a major respiratory disease in pigs [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Probable). Secreted (Probable). Host membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020972 [H]

Pfam domain/function: PF11647 PMT_C [H]

EC number: NA

Molecular weight: Translated: 36392; Mature: 36392

Theoretical pI: Translated: 4.24; Mature: 4.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQIVSGVVDTNYIMYSNKNIRERNVFESMAFSTRERSFNDGDVIIKSNAEVQRDYALN
CHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHH
VLQTILSLSPIFDIVLPEVSIPISLGITASSVGISFDELINGDTYEERRSAIPGLATNAV
HHHHHHHHHHHHHHHCCCCCCCEEECEEEHHCCCCHHHHCCCCCHHHHHHCCCCCHHHHH
LLGISFAIPFLISKAAENKLIINNLVGSDENILNKNNLADFLEKYNISESDIPENGSLVI
HHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCEEE
NLKNTNVPVRLVKLNDEEGEIVAIKGSTLSGIYYEVDTETGYEILSRRVFRTEYNEKIYW
EEECCCCCEEEEEECCCCCCEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEE
TRGGGLKGGQPFNFEGLDIPVYFIDKPYSELASSVELSFVNDDSPLLFPEMDSRLPKPTP
ECCCCCCCCCCCCCCCCEEEEEEECCCHHHHHCCEEEEEECCCCCEECCCHHHCCCCCCC
ELDIKYYSSNLSSFKEDTVILMRGTT
CCEEEEECCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MLEQIVSGVVDTNYIMYSNKNIRERNVFESMAFSTRERSFNDGDVIIKSNAEVQRDYALN
CHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHH
VLQTILSLSPIFDIVLPEVSIPISLGITASSVGISFDELINGDTYEERRSAIPGLATNAV
HHHHHHHHHHHHHHHCCCCCCCEEECEEEHHCCCCHHHHCCCCCHHHHHHCCCCCHHHHH
LLGISFAIPFLISKAAENKLIINNLVGSDENILNKNNLADFLEKYNISESDIPENGSLVI
HHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCEEE
NLKNTNVPVRLVKLNDEEGEIVAIKGSTLSGIYYEVDTETGYEILSRRVFRTEYNEKIYW
EEECCCCCEEEEEECCCCCCEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEE
TRGGGLKGGQPFNFEGLDIPVYFIDKPYSELASSVELSFVNDDSPLLFPEMDSRLPKPTP
ECCCCCCCCCCCCCCCCEEEEEEECCCHHHHHCCEEEEEECCCCCEECCCHHHCCCCCCC
ELDIKYYSSNLSSFKEDTVILMRGTT
CCEEEEECCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2201870; 2339066; 2269370 [H]