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The map label for this gene is btuC [H]

Identifier: 108812041

GI number: 108812041

Start: 2124204

End: 2125226

Strand: Reverse

Name: btuC [H]

Synonym: YPN_1879

Alternate gene names: 108812041

Gene position: 2125226-2124204 (Counterclockwise)

Preceding gene: 108812042

Following gene: 108812040

Centisome position: 46.87

GC content: 48.58

Gene sequence:

>1023_bases
ATGGCCGAGGGTGTAATGCAGACAAGTCAGTTATTTACCGCACTTCAACAACGGCAGCGGCAGCGCGACTATCGTTATCT
TACTGGGCTGGTTGTCATGCTTTTGTTCGCGCTACTCATCAGTTTATGTGCGGGTGATGTCTGGATTTGGCCAGAGCATT
GGTTCAGTGAAAGTGGCAAATTATTTGTTTGGCAACTACGTTTGCCCCGATCTATGGCTGTAATTATGGTTGGTGCCAGT
CTGGCCGTGTCGGGTGCCGTGATGCAGGCACTGTTTGAAAATCCGTTAGCTGAACCAGGTCTACTTGGCGTGGCAAATGG
CGCAGGTGTTGCATTGGTGACGGCCGTATTATTAGGTCATGGATTATTGCCAATTTGGGTTCTGAGCACGTGTGCTATTA
TTGGCGCATTGTTGATGACATCTATTCTGTTAAGTTTCACCCGTCGCCGTTTATTAACTAATGCCCAGCTATTATTGGTC
GGTGTAGCCTTAGGTATTATTTGCAGTGCAATGATGACTTGGGCCGTCTATTTCAGCACCAGTTTGGATTTACGTCAGCT
CATGTATTGGATGATGGGTGGGTTCAGCGGTGTTGACTGGCGTCAGCAAAGTTTGGTGCTGGCTCTCTTGCCTACCGTCA
TATGGCTTTGCTGCCAAGGCCGTGTCCTGAACTTCATGTCACTCGGTGAGCAGCAGGCCAGGCAATTGGGGGTGTCGCTT
CATTTATGGCGGAATTTATTAGTACTGGCGATCGGATTACTGGTCGGCATTAGTGTTGCACTCGCGGGTGTCATCAGTTT
TATTGGCTTGGTTATTCCTCATATTTTACGGTTAACCGGTTTAACTGATCAGCGCCGGCTATTAGCGGGCTGTGCATTCG
CCGGCGGGGGGGTATTATTATTAGCTGATGTTGTCGCTCGCACGGTATTATCTTCGGCAGAGCTACCGATTGGTGTGGTT
ACCGCAACATTAGGATCGCCATTATTTATCTGGTTACTGATACGGGTGAAAGGAGTAAAGTGA

Upstream 100 bases:

>100_bases
ACAACTTCCCCTTCACGCTCTAACCCCCTAATATCAGTGCCTGAGAATGGGCAGTAGGCCCTTGTATGTTTACCCGACCT
ATTCGGGTAAGTCTTGGGTA

Downstream 100 bases:

>100_bases
TTTGTCTTCTTATAAATGCCGCGGTGATTTTACCGGTTTATTATCATTACTGAATAAGGATCCAACCTGATGAGTCACCC
AATTTACGCCATTTCAGTGC

Product: vtamin B12-transporter permease

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MAEGVMQTSQLFTALQQRQRQRDYRYLTGLVVMLLFALLISLCAGDVWIWPEHWFSESGKLFVWQLRLPRSMAVIMVGAS
LAVSGAVMQALFENPLAEPGLLGVANGAGVALVTAVLLGHGLLPIWVLSTCAIIGALLMTSILLSFTRRRLLTNAQLLLV
GVALGIICSAMMTWAVYFSTSLDLRQLMYWMMGGFSGVDWRQQSLVLALLPTVIWLCCQGRVLNFMSLGEQQARQLGVSL
HLWRNLLVLAIGLLVGISVALAGVISFIGLVIPHILRLTGLTDQRRLLAGCAFAGGGVLLLADVVARTVLSSAELPIGVV
TATLGSPLFIWLLIRVKGVK

Sequences:

>Translated_340_residues
MAEGVMQTSQLFTALQQRQRQRDYRYLTGLVVMLLFALLISLCAGDVWIWPEHWFSESGKLFVWQLRLPRSMAVIMVGAS
LAVSGAVMQALFENPLAEPGLLGVANGAGVALVTAVLLGHGLLPIWVLSTCAIIGALLMTSILLSFTRRRLLTNAQLLLV
GVALGIICSAMMTWAVYFSTSLDLRQLMYWMMGGFSGVDWRQQSLVLALLPTVIWLCCQGRVLNFMSLGEQQARQLGVSL
HLWRNLLVLAIGLLVGISVALAGVISFIGLVIPHILRLTGLTDQRRLLAGCAFAGGGVLLLADVVARTVLSSAELPIGVV
TATLGSPLFIWLLIRVKGVK
>Mature_339_residues
AEGVMQTSQLFTALQQRQRQRDYRYLTGLVVMLLFALLISLCAGDVWIWPEHWFSESGKLFVWQLRLPRSMAVIMVGASL
AVSGAVMQALFENPLAEPGLLGVANGAGVALVTAVLLGHGLLPIWVLSTCAIIGALLMTSILLSFTRRRLLTNAQLLLVG
VALGIICSAMMTWAVYFSTSLDLRQLMYWMMGGFSGVDWRQQSLVLALLPTVIWLCCQGRVLNFMSLGEQQARQLGVSLH
LWRNLLVLAIGLLVGISVALAGVISFIGLVIPHILRLTGLTDQRRLLAGCAFAGGGVLLLADVVARTVLSSAELPIGVVT
ATLGSPLFIWLLIRVKGVK

Specific function: Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane [H]

COG id: COG4139

COG function: function code H; ABC-type cobalamin transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=325, Percent_Identity=68, Blast_Score=383, Evalue=1e-108,
Organism=Escherichia coli, GI1790740, Length=293, Percent_Identity=36.518771331058, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1790741, Length=282, Percent_Identity=33.6879432624113, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1786347, Length=324, Percent_Identity=30.2469135802469, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1786805, Length=282, Percent_Identity=35.4609929078014, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1786804, Length=290, Percent_Identity=32.4137931034483, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36820; Mature: 36689

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEGVMQTSQLFTALQQRQRQRDYRYLTGLVVMLLFALLISLCAGDVWIWPEHWFSESGK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHCCCCC
LFVWQLRLPRSMAVIMVGASLAVSGAVMQALFENPLAEPGLLGVANGAGVALVTAVLLGH
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCHHHHHHHHHHHC
GLLPIWVLSTCAIIGALLMTSILLSFTRRRLLTNAQLLLVGVALGIICSAMMTWAVYFST
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SLDLRQLMYWMMGGFSGVDWRQQSLVLALLPTVIWLCCQGRVLNFMSLGEQQARQLGVSL
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHCHHH
HLWRNLLVLAIGLLVGISVALAGVISFIGLVIPHILRLTGLTDQRRLLAGCAFAGGGVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHH
LADVVARTVLSSAELPIGVVTATLGSPLFIWLLIRVKGVK
HHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
AEGVMQTSQLFTALQQRQRQRDYRYLTGLVVMLLFALLISLCAGDVWIWPEHWFSESGK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHCCCCC
LFVWQLRLPRSMAVIMVGASLAVSGAVMQALFENPLAEPGLLGVANGAGVALVTAVLLGH
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCHHHHHHHHHHHC
GLLPIWVLSTCAIIGALLMTSILLSFTRRRLLTNAQLLLVGVALGIICSAMMTWAVYFST
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SLDLRQLMYWMMGGFSGVDWRQQSLVLALLPTVIWLCCQGRVLNFMSLGEQQARQLGVSL
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHCHHH
HLWRNLLVLAIGLLVGISVALAGVISFIGLVIPHILRLTGLTDQRRLLAGCAFAGGGVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHH
LADVVARTVLSSAELPIGVVTATLGSPLFIWLLIRVKGVK
HHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA