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The map label for this gene is manA [H]

Identifier: 108811897

GI number: 108811897

Start: 1953871

End: 1955142

Strand: Reverse

Name: manA [H]

Synonym: YPN_1735

Alternate gene names: 108811897

Gene position: 1955142-1953871 (Counterclockwise)

Preceding gene: 108811899

Following gene: 108811896

Centisome position: 43.12

GC content: 47.96

Gene sequence:

>1272_bases
ATGGCTTATTTTTTCAGGGTTTGCTATCCAGAACCGGTTAATCACTGGCTAACGCGCAGCCTTATTTTAGTCCTTTGCAA
ACGGCAGATCATAAACATGCTAAAAATGAATAACGCAGTTCAAAACTATGCTTGGGGCAGTACTGATGCCCTGACCCAGC
TTTATGGCATACCTAACCCACAAGGAATGCCAATGGCTGAACTGTGGATGGGTGCGCACCCGAAAAGCAGTTCCCAGGTT
CTTGACGCAAATGGCCAGTGGCATTCATTACGTGATGTGATTGATCAAGATCCAGATAACACGCTGGGGAGTGATATTTT
CAAGCGCTTTGGTGAACTGCCATTCCTGTTCAAAGTACTTTGTGCAGCTCAACCTCTATCGATTCAGGTTCACCCGAGCA
AAGCGGCAGCAGAGGTCGGTTTTGCTAAAGAAAACCAGGCAGGTATCCCACTGGATGCGGCTGAGCGCAATTATAAAGAT
GCGAACCATAAGCCTGAGCTGGTTTATGCCCTCACCCCTTTTCAGGCAATGAATGGTTTTCGCACACTAGAAGATATCCA
GGCGCTGTTACAACCACTAGCAGCGGCACACCCTGATATTGCCGCGTTCTTGCGCCAACCCGATACTGAGCATTTAGCCA
GTTTATTTGCCAGCTTACTCAGTATGAGCGGTGAGACAAAAACGCGGGCACTCGGTATTCTGAAAGCGGCATTGAATAGC
CAACTCGGAGAGCCTTGGGATACGATCCGCAGCATTTCGTGTTTTTATCCCGATGACAGCGGGTTGTTCTCCCCACTACT
GCTTAATGCCGTGACATTGCAACCGGGTGAGGCCATGTTCCTTTATGCCGAAACACCACACGCTTACCTCAATGGGGTTG
CATTAGAGGTCATGGCAAACTCGGATAATGTGTTGAGAGCTGGGCTAACGCCGAAGTTTATTGATATTCCAGAGTTAATG
TCCAATCTGCAATTTATCCCTAAACCGGCTAATGCCCTACTCACAACACCAAAGCAACAGGGTAATGAACTGATATTCCC
TATTCCTGTCGAGGACTTCGCTTTCTCACTGCATACCTTGGTGGTTGAACCACACGTTCTGGCACAACACAGTGCGGCAA
TTATTTTTTGTGTTGAAGGCTGTGCGGTGCTGAAAAAACAAGAGCAAGAAATTACGCTGCACCCTGGTGAGTCTTGCTTC
ATATCGGCTAAGGAATCACCTGTAACCGTGCAAGGGGTGGGTTCAATTGCTCGTGTTTATAACGCGGTGTGA

Upstream 100 bases:

>100_bases
TGCGCTTATGCGATTGATTCGCATTTCTGGAATTTTGTGATGGCTACTTTGGTGATGATCGTATTACCACTTGCAACACC
TTTAGCCTCATTGTCTACTA

Downstream 100 bases:

>100_bases
ACTAACTTAATGAATTTGTTGCCAATAAATAGCTTCTCACCATAAATTGAAGGCTCTGTCGCGATTAAGTCTTTGTTACG
GTCGCAATAATATTTGTGTA

Product: mannose-6-phosphate isomerase

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MAYFFRVCYPEPVNHWLTRSLILVLCKRQIINMLKMNNAVQNYAWGSTDALTQLYGIPNPQGMPMAELWMGAHPKSSSQV
LDANGQWHSLRDVIDQDPDNTLGSDIFKRFGELPFLFKVLCAAQPLSIQVHPSKAAAEVGFAKENQAGIPLDAAERNYKD
ANHKPELVYALTPFQAMNGFRTLEDIQALLQPLAAAHPDIAAFLRQPDTEHLASLFASLLSMSGETKTRALGILKAALNS
QLGEPWDTIRSISCFYPDDSGLFSPLLLNAVTLQPGEAMFLYAETPHAYLNGVALEVMANSDNVLRAGLTPKFIDIPELM
SNLQFIPKPANALLTTPKQQGNELIFPIPVEDFAFSLHTLVVEPHVLAQHSAAIIFCVEGCAVLKKQEQEITLHPGESCF
ISAKESPVTVQGVGSIARVYNAV

Sequences:

>Translated_423_residues
MAYFFRVCYPEPVNHWLTRSLILVLCKRQIINMLKMNNAVQNYAWGSTDALTQLYGIPNPQGMPMAELWMGAHPKSSSQV
LDANGQWHSLRDVIDQDPDNTLGSDIFKRFGELPFLFKVLCAAQPLSIQVHPSKAAAEVGFAKENQAGIPLDAAERNYKD
ANHKPELVYALTPFQAMNGFRTLEDIQALLQPLAAAHPDIAAFLRQPDTEHLASLFASLLSMSGETKTRALGILKAALNS
QLGEPWDTIRSISCFYPDDSGLFSPLLLNAVTLQPGEAMFLYAETPHAYLNGVALEVMANSDNVLRAGLTPKFIDIPELM
SNLQFIPKPANALLTTPKQQGNELIFPIPVEDFAFSLHTLVVEPHVLAQHSAAIIFCVEGCAVLKKQEQEITLHPGESCF
ISAKESPVTVQGVGSIARVYNAV
>Mature_422_residues
AYFFRVCYPEPVNHWLTRSLILVLCKRQIINMLKMNNAVQNYAWGSTDALTQLYGIPNPQGMPMAELWMGAHPKSSSQVL
DANGQWHSLRDVIDQDPDNTLGSDIFKRFGELPFLFKVLCAAQPLSIQVHPSKAAAEVGFAKENQAGIPLDAAERNYKDA
NHKPELVYALTPFQAMNGFRTLEDIQALLQPLAAAHPDIAAFLRQPDTEHLASLFASLLSMSGETKTRALGILKAALNSQ
LGEPWDTIRSISCFYPDDSGLFSPLLLNAVTLQPGEAMFLYAETPHAYLNGVALEVMANSDNVLRAGLTPKFIDIPELMS
NLQFIPKPANALLTTPKQQGNELIFPIPVEDFAFSLHTLVVEPHVLAQHSAAIIFCVEGCAVLKKQEQEITLHPGESCFI
SAKESPVTVQGVGSIARVYNAV

Specific function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide [H]

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI4505235, Length=409, Percent_Identity=36.4303178484108, Blast_Score=206, Evalue=4e-53,
Organism=Escherichia coli, GI1787899, Length=391, Percent_Identity=70.5882352941177, Blast_Score=563, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI71997620, Length=405, Percent_Identity=32.5925925925926, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17557650, Length=408, Percent_Identity=28.4313725490196, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320839, Length=434, Percent_Identity=31.5668202764977, Blast_Score=185, Evalue=1e-47,
Organism=Drosophila melanogaster, GI21356061, Length=401, Percent_Identity=29.925187032419, Blast_Score=147, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR016305
- InterPro:   IPR018050
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 46463; Mature: 46332

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00965 PMI_I_1 ; PS00966 PMI_I_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYFFRVCYPEPVNHWLTRSLILVLCKRQIINMLKMNNAVQNYAWGSTDALTQLYGIPNP
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
QGMPMAELWMGAHPKSSSQVLDANGQWHSLRDVIDQDPDNTLGSDIFKRFGELPFLFKVL
CCCCHHHHHCCCCCCCCCCEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHH
CAAQPLSIQVHPSKAAAEVGFAKENQAGIPLDAAERNYKDANHKPELVYALTPFQAMNGF
HCCCCCEEEECCCHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCEEEEECCHHHHCCC
RTLEDIQALLQPLAAAHPDIAAFLRQPDTEHLASLFASLLSMSGETKTRALGILKAALNS
HHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
QLGEPWDTIRSISCFYPDDSGLFSPLLLNAVTLQPGEAMFLYAETPHAYLNGVALEVMAN
HCCCCHHHHCCEEEECCCCCCCHHHHHHHHEEECCCCEEEEEECCCHHHHCCEEEEEEEC
SDNVLRAGLTPKFIDIPELMSNLQFIPKPANALLTTPKQQGNELIFPIPVEDFAFSLHTL
CCCEEEECCCCCEECHHHHHHCCEECCCCCHHEEECCHHCCCEEEEECCHHHHHHHHHHH
VVEPHVLAQHSAAIIFCVEGCAVLKKQEQEITLHPGESCFISAKESPVTVQGVGSIARVY
EECCHHHHCCCCEEEEEECCHHHHHCCCCEEEECCCCCEEEECCCCCEEEEHHHHHHHHH
NAV
HCC
>Mature Secondary Structure 
AYFFRVCYPEPVNHWLTRSLILVLCKRQIINMLKMNNAVQNYAWGSTDALTQLYGIPNP
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
QGMPMAELWMGAHPKSSSQVLDANGQWHSLRDVIDQDPDNTLGSDIFKRFGELPFLFKVL
CCCCHHHHHCCCCCCCCCCEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHH
CAAQPLSIQVHPSKAAAEVGFAKENQAGIPLDAAERNYKDANHKPELVYALTPFQAMNGF
HCCCCCEEEECCCHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCEEEEECCHHHHCCC
RTLEDIQALLQPLAAAHPDIAAFLRQPDTEHLASLFASLLSMSGETKTRALGILKAALNS
HHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
QLGEPWDTIRSISCFYPDDSGLFSPLLLNAVTLQPGEAMFLYAETPHAYLNGVALEVMAN
HCCCCHHHHCCEEEECCCCCCCHHHHHHHHEEECCCCEEEEEECCCHHHHCCEEEEEEEC
SDNVLRAGLTPKFIDIPELMSNLQFIPKPANALLTTPKQQGNELIFPIPVEDFAFSLHTL
CCCEEEECCCCCEECHHHHHHCCEECCCCCHHEEECCHHCCCEEEEECCHHHHHHHHHHH
VVEPHVLAQHSAAIIFCVEGCAVLKKQEQEITLHPGESCFISAKESPVTVQGVGSIARVY
EECCHHHHCCCCEEEEEECCHHHHHCCCCEEEECCCCCEEEECCCCCEEEEHHHHHHHHH
NAV
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1879695; 11677609 [H]