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The map label for this gene is zwf [H]

Identifier: 108801939

GI number: 108801939

Start: 5265091

End: 5266608

Strand: Reverse

Name: zwf [H]

Synonym: Mmcs_4976

Alternate gene names: 108801939

Gene position: 5266608-5265091 (Counterclockwise)

Preceding gene: 108801940

Following gene: 108801937

Centisome position: 92.31

GC content: 66.53

Gene sequence:

>1518_bases
GTGACATCATCGCCAGGGTGGCCCCCGAGACCCCGCAGTCCATCGCCTACCCCGCACCCGGTTCGCATCCGCACCGGATC
GAGGAGGAAAAACTCGATCCCCACGTCATCGTGTTGTTCGGGGCGACCGGCGATCTGGCGAAACGCAAACTCCTGCCCGG
GATGGCCTACCTGGTCCAGTCCGCGCTGGCGCCCAAGATCCGGGTGGTCGGCACGTCACTGGAGGACCTCAGCGGCGACG
AGTTCCGGGCGCTGGCGCGAGGCCGTCGACGCGTTCGGCAGCCACGAACTCAGCGACGAGGAGTGGGAGGGCTTCGCCTG
CCGCATCTCCTACGTGCCGCAGAGCGCGGGACCCGAAGCCCTCGCGGACGCGGTGAAGGCGGCCAAGGCCGAACTCGGGC
CGGACACGCGACGGTTGCACTATCTGTCGGTCCCGCCCAAGGCGGCCAAGGCCGTCATCACCATGCTCAAGGAGTCCGGC
CTCGTCGACCGCTCGCGGGTGGTGATGGAGAAACCGTTCGGCACCGACCTGGCCAGCGCCTGCGAACTCAACGCCTTCGT
CCACGACACTTTTGACGAATCGCAGATCTTCCGCATCGACCACTTCCTCGGCAAGGAGGCGGCGCAGAACATCCTGGCGT
TCCGGTTCGCCAACGGCCTGTTCGAACCGATCTGGAACCGCAACTTCATCGACCACATCCAGATCGACATCCCGGAGAAA
CTCGGCCTCGACGAGCGGGCCGACTTCTACGAGAGCACCGGGGCCTACAAGGACATGGTGGTGACCCACCTGTTCCAGGT
GATGGCCTTCGTCGTGATGGAGCCGCCGACCGCGCTGGAGCCCAGGGCGATCAGCGAGGAGAAGAACAAGGTCTTCCGGT
CGATGCTGCCGGTCGACCCGGCCAAGGTGATCCGCGGGCAGTACGTCGGGTACCGGCGCGAGGACGGGGTCGCACCGGAT
TCGGAGACCGAGACGTTCATCGCGCTGCAGGTCGGCATCGACAACTGGCGCTGGGCCGGTGTGCCGATCTATCTGCGCAC
CGGCAAGAAGATGGCCGAGGGGCAGCGGATCATCTCGATCGCGTTCAGAGAGGCGCCGCGCTCGATGTTCCCGGCCGGTT
CGGGTGTCGGGTCGCAGGGTCCGGACCACCTCACGTTCGACCTGGCCGACAACTCCAAGGTGTCGCTGTCGTTCTACGGC
AAGCGGCCGGGGCCGGGCATGAAGCTGGACAAGCTGTCCATGCAGTTCTCCACTCAGGAGACCGGACGCGTCGGCGATGT
GCTCGAGGCCTACGAACGCCTGATCCTCGACGCGATGCGCGGTGACCACACGCTGTTCACGACGGCCGCGGGTATCGAGT
CGCTGTGGGACCGATCGACCCCGCTGCTCGAGGACCCGCCGCCGGTGAAGGTGTACCAACCCGGGACCTGGGGGCCCAAC
GCCATCCACCAGCTGATCGCCCCGAATGCATGGCGGCTGCCGTTCGAACGGGAGTGGCGCGAGAAGACGCCGGAGTAG

Upstream 100 bases:

>100_bases
TGATCCAGGATGCGTGGTTGTCACGCGCGTCGCGGCGGCGGGCGGAACGCTGGCTGGCCGACCGGCACTGCTGACAAGCC
ACTGCGCGCCGGTGATCATG

Downstream 100 bases:

>100_bases
CTCAGCCGGTCTTCGCCGCGCAGATCAGATCGATGTGCCTGGTGGCCCAATCGCCCAGCGGTGCAAGCGCGTCCAACAGT
TCCCGGCCCACCGGCGTCAT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MTSSPGWPPRPRSPSPTPHPVRIRTGSRRKNSIPTSSCCSGRPAIWRNANSCPGWPTWSSPRWRPRSGWSARHWRTSAAT
SSGRWREAVDAFGSHELSDEEWEGFACRISYVPQSAGPEALADAVKAAKAELGPDTRRLHYLSVPPKAAKAVITMLKESG
LVDRSRVVMEKPFGTDLASACELNAFVHDTFDESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNRNFIDHIQIDIPEK
LGLDERADFYESTGAYKDMVVTHLFQVMAFVVMEPPTALEPRAISEEKNKVFRSMLPVDPAKVIRGQYVGYRREDGVAPD
SETETFIALQVGIDNWRWAGVPIYLRTGKKMAEGQRIISIAFREAPRSMFPAGSGVGSQGPDHLTFDLADNSKVSLSFYG
KRPGPGMKLDKLSMQFSTQETGRVGDVLEAYERLILDAMRGDHTLFTTAAGIESLWDRSTPLLEDPPPVKVYQPGTWGPN
AIHQLIAPNAWRLPFEREWREKTPE

Sequences:

>Translated_505_residues
MTSSPGWPPRPRSPSPTPHPVRIRTGSRRKNSIPTSSCCSGRPAIWRNANSCPGWPTWSSPRWRPRSGWSARHWRTSAAT
SSGRWREAVDAFGSHELSDEEWEGFACRISYVPQSAGPEALADAVKAAKAELGPDTRRLHYLSVPPKAAKAVITMLKESG
LVDRSRVVMEKPFGTDLASACELNAFVHDTFDESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNRNFIDHIQIDIPEK
LGLDERADFYESTGAYKDMVVTHLFQVMAFVVMEPPTALEPRAISEEKNKVFRSMLPVDPAKVIRGQYVGYRREDGVAPD
SETETFIALQVGIDNWRWAGVPIYLRTGKKMAEGQRIISIAFREAPRSMFPAGSGVGSQGPDHLTFDLADNSKVSLSFYG
KRPGPGMKLDKLSMQFSTQETGRVGDVLEAYERLILDAMRGDHTLFTTAAGIESLWDRSTPLLEDPPPVKVYQPGTWGPN
AIHQLIAPNAWRLPFEREWREKTPE
>Mature_504_residues
TSSPGWPPRPRSPSPTPHPVRIRTGSRRKNSIPTSSCCSGRPAIWRNANSCPGWPTWSSPRWRPRSGWSARHWRTSAATS
SGRWREAVDAFGSHELSDEEWEGFACRISYVPQSAGPEALADAVKAAKAELGPDTRRLHYLSVPPKAAKAVITMLKESGL
VDRSRVVMEKPFGTDLASACELNAFVHDTFDESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNRNFIDHIQIDIPEKL
GLDERADFYESTGAYKDMVVTHLFQVMAFVVMEPPTALEPRAISEEKNKVFRSMLPVDPAKVIRGQYVGYRREDGVAPDS
ETETFIALQVGIDNWRWAGVPIYLRTGKKMAEGQRIISIAFREAPRSMFPAGSGVGSQGPDHLTFDLADNSKVSLSFYGK
RPGPGMKLDKLSMQFSTQETGRVGDVLEAYERLILDAMRGDHTLFTTAAGIESLWDRSTPLLEDPPPVKVYQPGTWGPNA
IHQLIAPNAWRLPFEREWREKTPE

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=420, Percent_Identity=31.1904761904762, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI108773793, Length=420, Percent_Identity=31.1904761904762, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI52145310, Length=378, Percent_Identity=29.6296296296296, Blast_Score=135, Evalue=1e-31,
Organism=Escherichia coli, GI1788158, Length=440, Percent_Identity=34.5454545454545, Blast_Score=252, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI17538218, Length=423, Percent_Identity=31.6784869976359, Blast_Score=224, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6324088, Length=427, Percent_Identity=32.3185011709602, Blast_Score=218, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24643350, Length=382, Percent_Identity=29.0575916230367, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24643352, Length=381, Percent_Identity=29.1338582677165, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI221513548, Length=360, Percent_Identity=27.2222222222222, Blast_Score=136, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56549; Mature: 56417

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSPGWPPRPRSPSPTPHPVRIRTGSRRKNSIPTSSCCSGRPAIWRNANSCPGWPTWSS
CCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHCCCCCHHCCCCCCCCCCCCCCC
PRWRPRSGWSARHWRTSAATSSGRWREAVDAFGSHELSDEEWEGFACRISYVPQSAGPEA
CCCCCCCCCCCHHEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHH
LADAVKAAKAELGPDTRRLHYLSVPPKAAKAVITMLKESGLVDRSRVVMEKPFGTDLASA
HHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHEECCCCCCHHHH
CELNAFVHDTFDESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNRNFIDHIQIDIPEK
HHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHH
LGLDERADFYESTGAYKDMVVTHLFQVMAFVVMEPPTALEPRAISEEKNKVFRSMLPVDP
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCH
AKVIRGQYVGYRREDGVAPDSETETFIALQVGIDNWRWAGVPIYLRTGKKMAEGQRIISI
HHHHHHHHCCEECCCCCCCCCCCCEEEEEEECCCCCEECCEEEEEECCCHHHCCCEEEEH
AFREAPRSMFPAGSGVGSQGPDHLTFDLADNSKVSLSFYGKRPGPGMKLDKLSMQFSTQE
HHHHCCHHHCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCEEHHHHEEECCCC
TGRVGDVLEAYERLILDAMRGDHTLFTTAAGIESLWDRSTPLLEDPPPVKVYQPGTWGPN
CCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCCCCCCCCCEEEECCCCCCHH
AIHQLIAPNAWRLPFEREWREKTPE
HHHHHHCCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure 
TSSPGWPPRPRSPSPTPHPVRIRTGSRRKNSIPTSSCCSGRPAIWRNANSCPGWPTWSS
CCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHCCCCCHHCCCCCCCCCCCCCCC
PRWRPRSGWSARHWRTSAATSSGRWREAVDAFGSHELSDEEWEGFACRISYVPQSAGPEA
CCCCCCCCCCCHHEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHH
LADAVKAAKAELGPDTRRLHYLSVPPKAAKAVITMLKESGLVDRSRVVMEKPFGTDLASA
HHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHEECCCCCCHHHH
CELNAFVHDTFDESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNRNFIDHIQIDIPEK
HHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHH
LGLDERADFYESTGAYKDMVVTHLFQVMAFVVMEPPTALEPRAISEEKNKVFRSMLPVDP
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCH
AKVIRGQYVGYRREDGVAPDSETETFIALQVGIDNWRWAGVPIYLRTGKKMAEGQRIISI
HHHHHHHHCCEECCCCCCCCCCCCEEEEEEECCCCCEECCEEEEEECCCHHHCCCEEEEH
AFREAPRSMFPAGSGVGSQGPDHLTFDLADNSKVSLSFYGKRPGPGMKLDKLSMQFSTQE
HHHHCCHHHCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCEEHHHHEEECCCC
TGRVGDVLEAYERLILDAMRGDHTLFTTAAGIESLWDRSTPLLEDPPPVKVYQPGTWGPN
CCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCCCCCCCCCEEEECCCCCCHH
AIHQLIAPNAWRLPFEREWREKTPE
HHHHHHCCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]