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The map label for this gene is holB [H]

Identifier: 108801757

GI number: 108801757

Start: 5075786

End: 5076994

Strand: Reverse

Name: holB [H]

Synonym: Mmcs_4794

Alternate gene names: 108801757

Gene position: 5076994-5075786 (Counterclockwise)

Preceding gene: 108801759

Following gene: 108801748

Centisome position: 88.99

GC content: 71.05

Gene sequence:

>1209_bases
ATGGCCGGAGTTTTTTCCCGTTTGGTGGGTCAACACGCTGTTGAGGCGGAGTTGGTGGGTGCCGCACAGGCGGCCCGTGG
TGACGCCGCTCACAGTGCCTCGGCGACGGGGACCATGACACATGCGTGGCTGATCACGGGCCCGCCCGGGTCCGGGAGGT
CGATCGCGGCGCTGTGTTTCGCCGCCGCGCTGCAGTGCACCTCCGAGGGTGTCCCCGGCTGTGGGGAGTGCCGGGCGTGC
ACCACGACGATGGCCGGTACGCATGCCGATGTTCGCCGGATCATCCCCGAGGGGCTGTCGATCGGTGTCGACGAGATGCG
TTCCATCGTTCAGATCGCCTCGCGGCGACCGGGGACCGGCCGGTGGCAGATCGTGGTCGTCGAGGACGCCGACCGACTCA
CCGAGGGTGCGGCGAACGCGCTGCTGAAGGTGGTCGAGGAGCCGCCGCCGTCGACGGTGTTCCTGCTGTGTGCGCCGTCG
GTGGACCCCGAGGACATCGCGATCACGCTGCGGTCGCGCTGTCGGCACATCGCGTTGGTGACGCCGTCGGTGGATGCGAT
CACCCAGGTGCTCATCGAGGGTGACGGCATGTCGGAGCAGGAGGCCCGCTGGGCTGCGTCGGTGAGCGGCGGGCACGTCG
GCCGGGCGCGCCGGCTGGTGGTCGACGAGCAGGCGCGTGACCGGCGCAAGCGGGCGCTGAGTCTGGCGCGCGACGCGGCC
ACCCCGTCGCGGGCCTACGCCGCGGCCGAGGAGTTGGTGGCCTCGGCGGAGGCCGAGGCCAAGGCGTTGACCGTGGACCG
CAACGAGACCGAGGCCGAGGAACTCCGCACGGCGCTGGGAGCGGGCGGTACCGGGAAGGGCACCGCGGGCACCATGCGTG
GCGCGACCGGGGCGATCAGGGATCTGGAGAAGCGGCAGAAGTCGCGCCAGACCCGTGCGTCGCGCGATGCGCTCGACCGG
GCGCTGATCGATCTGGCAACGTACTTCCGGGACGCGCTTCTGGTGTCGTCGGGGGCGGGGCATGTGCAGGCCAACCATCC
GGACATGGCGGAGAAGGTCGCCGCGTTGGCGGCGCATGCGCCCCCGGAGAAGCTGCTGCGCTGCATCGAGGCGGTGCTGG
AGTGCCGCGAGGCGCTGGCGGTCAACGTCAAGCCGAAGTTCGCGGTCGATGCGATGGTGGCCACCGTCGGACAGGCGTTG
CGGGACTGA

Upstream 100 bases:

>100_bases
GTATCGCCTCCGAAGCCACCCGTTTACCGTATCGGGCGAAGGTGACCTTGAGCGCCGCTGTCAGCCAGTTGTGTCGGTCT
GACCACTACTGTTGGCGGTG

Downstream 100 bases:

>100_bases
CTGTGGGCGTTTTTGGCGACCGGTGGGCGCTGCCGTAGACTCGTGCCGCCCGGTTCGCCGGGCACGCCGCCTTAGCTCAG
TCGGTAGAGCGATTCACTCG

Product: DNA polymerase III subunit delta'

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MAGVFSRLVGQHAVEAELVGAAQAARGDAAHSASATGTMTHAWLITGPPGSGRSIAALCFAAALQCTSEGVPGCGECRAC
TTTMAGTHADVRRIIPEGLSIGVDEMRSIVQIASRRPGTGRWQIVVVEDADRLTEGAANALLKVVEEPPPSTVFLLCAPS
VDPEDIAITLRSRCRHIALVTPSVDAITQVLIEGDGMSEQEARWAASVSGGHVGRARRLVVDEQARDRRKRALSLARDAA
TPSRAYAAAEELVASAEAEAKALTVDRNETEAEELRTALGAGGTGKGTAGTMRGATGAIRDLEKRQKSRQTRASRDALDR
ALIDLATYFRDALLVSSGAGHVQANHPDMAEKVAALAAHAPPEKLLRCIEAVLECREALAVNVKPKFAVDAMVATVGQAL
RD

Sequences:

>Translated_402_residues
MAGVFSRLVGQHAVEAELVGAAQAARGDAAHSASATGTMTHAWLITGPPGSGRSIAALCFAAALQCTSEGVPGCGECRAC
TTTMAGTHADVRRIIPEGLSIGVDEMRSIVQIASRRPGTGRWQIVVVEDADRLTEGAANALLKVVEEPPPSTVFLLCAPS
VDPEDIAITLRSRCRHIALVTPSVDAITQVLIEGDGMSEQEARWAASVSGGHVGRARRLVVDEQARDRRKRALSLARDAA
TPSRAYAAAEELVASAEAEAKALTVDRNETEAEELRTALGAGGTGKGTAGTMRGATGAIRDLEKRQKSRQTRASRDALDR
ALIDLATYFRDALLVSSGAGHVQANHPDMAEKVAALAAHAPPEKLLRCIEAVLECREALAVNVKPKFAVDAMVATVGQAL
RD
>Mature_401_residues
AGVFSRLVGQHAVEAELVGAAQAARGDAAHSASATGTMTHAWLITGPPGSGRSIAALCFAAALQCTSEGVPGCGECRACT
TTMAGTHADVRRIIPEGLSIGVDEMRSIVQIASRRPGTGRWQIVVVEDADRLTEGAANALLKVVEEPPPSTVFLLCAPSV
DPEDIAITLRSRCRHIALVTPSVDAITQVLIEGDGMSEQEARWAASVSGGHVGRARRLVVDEQARDRRKRALSLARDAAT
PSRAYAAAEELVASAEAEAKALTVDRNETEAEELRTALGAGGTGKGTAGTMRGATGAIRDLEKRQKSRQTRASRDALDRA
LIDLATYFRDALLVSSGAGHVQANHPDMAEKVAALAAHAPPEKLLRCIEAVLECREALAVNVKPKFAVDAMVATVGQALR
D

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG0470

COG function: function code L; ATPase involved in DNA replication

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786676, Length=157, Percent_Identity=29.9363057324841, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787341, Length=178, Percent_Identity=37.0786516853933, Blast_Score=75, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004622 [H]

Pfam domain/function: NA

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 42140; Mature: 42009

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGVFSRLVGQHAVEAELVGAAQAARGDAAHSASATGTMTHAWLITGPPGSGRSIAALCF
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHH
AAALQCTSEGVPGCGECRACTTTMAGTHADVRRIIPEGLSIGVDEMRSIVQIASRRPGTG
HHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCC
RWQIVVVEDADRLTEGAANALLKVVEEPPPSTVFLLCAPSVDPEDIAITLRSRCRHIALV
CEEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHCCEEEEE
TPSVDAITQVLIEGDGMSEQEARWAASVSGGHVGRARRLVVDEQARDRRKRALSLARDAA
CCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHEECHHHHHHHHHHHHHHHHCC
TPSRAYAAAEELVASAEAEAKALTVDRNETEAEELRTALGAGGTGKGTAGTMRGATGAIR
CCHHHHHHHHHHHHHHCCCHHEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
DLEKRQKSRQTRASRDALDRALIDLATYFRDALLVSSGAGHVQANHPDMAEKVAALAAHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHCC
PPEKLLRCIEAVLECREALAVNVKPKFAVDAMVATVGQALRD
CHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AGVFSRLVGQHAVEAELVGAAQAARGDAAHSASATGTMTHAWLITGPPGSGRSIAALCF
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHH
AAALQCTSEGVPGCGECRACTTTMAGTHADVRRIIPEGLSIGVDEMRSIVQIASRRPGTG
HHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCC
RWQIVVVEDADRLTEGAANALLKVVEEPPPSTVFLLCAPSVDPEDIAITLRSRCRHIALV
CEEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHCCEEEEE
TPSVDAITQVLIEGDGMSEQEARWAASVSGGHVGRARRLVVDEQARDRRKRALSLARDAA
CCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHEECHHHHHHHHHHHHHHHHCC
TPSRAYAAAEELVASAEAEAKALTVDRNETEAEELRTALGAGGTGKGTAGTMRGATGAIR
CCHHHHHHHHHHHHHHCCCHHEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
DLEKRQKSRQTRASRDALDRALIDLATYFRDALLVSSGAGHVQANHPDMAEKVAALAAHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHCC
PPEKLLRCIEAVLECREALAVNVKPKFAVDAMVATVGQALRD
CHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]