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The map label for this gene is cysS [H]

Identifier: 108801700

GI number: 108801700

Start: 5015186

End: 5016631

Strand: Reverse

Name: cysS [H]

Synonym: Mmcs_4737

Alternate gene names: 108801700

Gene position: 5016631-5015186 (Counterclockwise)

Preceding gene: 108801701

Following gene: 108801699

Centisome position: 87.93

GC content: 69.57

Gene sequence:

>1446_bases
GTGACCGATCGCGCTGATGCCGACCGGCCGGCGACGTCGCCGACGGGTCTGCGCCTCTACGACACCATGACGGGTGCCGT
GCGTGACTTCGTGCCGCTGCGCGACGGCCATGTGTCCATTTACCTGTGCGGGGCGACCGTTCAGGGGCTGCCGCACATCG
GCCACGTCCGCAGCGGGGTGGCGTTCGACGTGCTGCGCCGCTGGCTGACCGCCAAGGGGCTCGACGTGGCGTTCATCCGC
AACGTCACCGACATCGACGACAAGATCCTCAACAAGGCCGCCGACGCGGGCCGGCCGTGGTGGGAGTGGGCGGCGACCTA
CGAACGCGCCTTCAGCGCGGCCTACGACGCGCTCGGTGTCCTGCCGCCCTCGGCCGAACCGCGCGCCACCGGGCACATCA
CCCAGATGGTCGAGTTGATCGAGCGGCTGATCGACCGCGGCCACGCCTACACCGGCGACGGTGACGTGTATTTCAACGTC
GCCACGCTGCCCGACTACGGCAAGCTCTCCGGACATCGCATCGACGACGTGCACCAGGGCGAGGGCGTCGCGACCGGGAA
ACGCGATCAGCGCGACTTCACGCTCTGGAAGGGCGCCAAACCGGGGGAACCGTCCTGGCCCACCCCGTGGGGCCGGGGAC
GGCCAGGTTGGCACACCGAATGCGTCGCCATGTGCGAGGCGTACCTGGGTGCCGAATTCGACATCCACGCCGGCGGTATG
GATCTGGTGTTCCCGCACCACGAGAACGAGATCGCCCAGGCCGAGGCGGCGGGTGACGGGTTCGCCCGCTTCTGGCTGCA
CAACGGCTGGGTCACCATGGGCGGCGAGAAGATGAGCAAGTCGCTCGGCAACGTGCTCTCGATTCCCGCTGTGCTGCAAC
GTGTTCGGGCCGCCGAGTTGCGGTACTACCTGGGCAGTGCGCACTACCGGTCGATGCTGGAGTTCTCCGAGACCGCGCTG
CAGGATGCGGTCAAGGCCTACGCCGGTGTCGAGGACTTCCTGCACCGCGTCCGCACCCGCGTCGGCACCGTGGTGCCCGG
CGACTGGACGCCGAAGTTCGCCGCCGCCCTCGACGACGACCTGTCGGTGCCGATCGCGCTGGCCGAGGTGCACGCCGCCC
GCGCCGTGGGCAACCGGGCGTTGGACTCCGGCGACCACGAGACGGCGATGACACAGGCCCGCTCGATCCGCGCCATGATG
GGCATCCTCGGGTGCGACCCGCTCGACGAACGGTGGGAGTCGCGCGACGAGACGTCGGCGGCGCTGGCCGCGATCGACGT
GCTGGTCCGGTGGGCGCTCGACAGCCGCGCCGACGCCCGGAACCGTAAGGACTGGGCGACCGCCGATCAGATCCGTGACC
GGCTCAAAGAAGCCGGCATCGAGGTGACCGACACCGCCGACGGTCCGCAGTGGTCGCTGCTCGACGGCGACAGCAAGGAT
GTCTGA

Upstream 100 bases:

>100_bases
GGCTCGGGCTGACCGGCCGTGGTGAGGGGCTGGCCGCGATCGCAACCGCTCTCGTGGTCGATGAGGGATAACGGCATATC
GGCCGGTAAGCTGGCACGTC

Downstream 100 bases:

>100_bases
CGATGGCGGGTAACTCGAAACGCCGTGGCGCAGTGCGCAAAGCAGGCACCAAGAAGGGGCCGACCGTCGGTTCGGGCGGC
GTGCGCCGTCGCGGGCTCGA

Product: cysteinyl-tRNA synthetase

Products: NA

Alternate protein names: Cysteine--tRNA ligase; CysRS [H]

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MTDRADADRPATSPTGLRLYDTMTGAVRDFVPLRDGHVSIYLCGATVQGLPHIGHVRSGVAFDVLRRWLTAKGLDVAFIR
NVTDIDDKILNKAADAGRPWWEWAATYERAFSAAYDALGVLPPSAEPRATGHITQMVELIERLIDRGHAYTGDGDVYFNV
ATLPDYGKLSGHRIDDVHQGEGVATGKRDQRDFTLWKGAKPGEPSWPTPWGRGRPGWHTECVAMCEAYLGAEFDIHAGGM
DLVFPHHENEIAQAEAAGDGFARFWLHNGWVTMGGEKMSKSLGNVLSIPAVLQRVRAAELRYYLGSAHYRSMLEFSETAL
QDAVKAYAGVEDFLHRVRTRVGTVVPGDWTPKFAAALDDDLSVPIALAEVHAARAVGNRALDSGDHETAMTQARSIRAMM
GILGCDPLDERWESRDETSAALAAIDVLVRWALDSRADARNRKDWATADQIRDRLKEAGIEVTDTADGPQWSLLDGDSKD
V

Sequences:

>Translated_481_residues
MTDRADADRPATSPTGLRLYDTMTGAVRDFVPLRDGHVSIYLCGATVQGLPHIGHVRSGVAFDVLRRWLTAKGLDVAFIR
NVTDIDDKILNKAADAGRPWWEWAATYERAFSAAYDALGVLPPSAEPRATGHITQMVELIERLIDRGHAYTGDGDVYFNV
ATLPDYGKLSGHRIDDVHQGEGVATGKRDQRDFTLWKGAKPGEPSWPTPWGRGRPGWHTECVAMCEAYLGAEFDIHAGGM
DLVFPHHENEIAQAEAAGDGFARFWLHNGWVTMGGEKMSKSLGNVLSIPAVLQRVRAAELRYYLGSAHYRSMLEFSETAL
QDAVKAYAGVEDFLHRVRTRVGTVVPGDWTPKFAAALDDDLSVPIALAEVHAARAVGNRALDSGDHETAMTQARSIRAMM
GILGCDPLDERWESRDETSAALAAIDVLVRWALDSRADARNRKDWATADQIRDRLKEAGIEVTDTADGPQWSLLDGDSKD
V
>Mature_480_residues
TDRADADRPATSPTGLRLYDTMTGAVRDFVPLRDGHVSIYLCGATVQGLPHIGHVRSGVAFDVLRRWLTAKGLDVAFIRN
VTDIDDKILNKAADAGRPWWEWAATYERAFSAAYDALGVLPPSAEPRATGHITQMVELIERLIDRGHAYTGDGDVYFNVA
TLPDYGKLSGHRIDDVHQGEGVATGKRDQRDFTLWKGAKPGEPSWPTPWGRGRPGWHTECVAMCEAYLGAEFDIHAGGMD
LVFPHHENEIAQAEAAGDGFARFWLHNGWVTMGGEKMSKSLGNVLSIPAVLQRVRAAELRYYLGSAHYRSMLEFSETALQ
DAVKAYAGVEDFLHRVRTRVGTVVPGDWTPKFAAALDDDLSVPIALAEVHAARAVGNRALDSGDHETAMTQARSIRAMMG
ILGCDPLDERWESRDETSAALAAIDVLVRWALDSRADARNRKDWATADQIRDRLKEAGIEVTDTADGPQWSLLDGDSKDV

Specific function: Unknown

COG id: COG0215

COG function: function code J; Cysteinyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI13375695, Length=518, Percent_Identity=33.5907335907336, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI10835051, Length=362, Percent_Identity=33.7016574585635, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI21269877, Length=362, Percent_Identity=33.7016574585635, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI303304987, Length=362, Percent_Identity=33.7016574585635, Blast_Score=199, Evalue=6e-51,
Organism=Homo sapiens, GI62240992, Length=362, Percent_Identity=33.7016574585635, Blast_Score=199, Evalue=6e-51,
Organism=Escherichia coli, GI1786737, Length=464, Percent_Identity=42.6724137931034, Blast_Score=335, Evalue=3e-93,
Organism=Caenorhabditis elegans, GI17509797, Length=263, Percent_Identity=35.7414448669202, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI17509795, Length=263, Percent_Identity=35.7414448669202, Blast_Score=171, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6324082, Length=331, Percent_Identity=33.2326283987915, Blast_Score=199, Evalue=6e-52,
Organism=Drosophila melanogaster, GI19922218, Length=508, Percent_Identity=30.511811023622, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI19922364, Length=320, Percent_Identity=34.0625, Blast_Score=182, Evalue=4e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015803
- InterPro:   IPR015273
- InterPro:   IPR014729
- InterPro:   IPR009080 [H]

Pfam domain/function: PF09190 DALR_2; PF01406 tRNA-synt_1e [H]

EC number: =6.1.1.16 [H]

Molecular weight: Translated: 52843; Mature: 52711

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRADADRPATSPTGLRLYDTMTGAVRDFVPLRDGHVSIYLCGATVQGLPHIGHVRSGV
CCCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCEEEEEECCHHCCCCCHHHHHCCH
AFDVLRRWLTAKGLDVAFIRNVTDIDDKILNKAADAGRPWWEWAATYERAFSAAYDALGV
HHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
LPPSAEPRATGHITQMVELIERLIDRGHAYTGDGDVYFNVATLPDYGKLSGHRIDDVHQG
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCC
EGVATGKRDQRDFTLWKGAKPGEPSWPTPWGRGRPGWHTECVAMCEAYLGAEFDIHAGGM
CCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCE
DLVFPHHENEIAQAEAAGDGFARFWLHNGWVTMGGEKMSKSLGNVLSIPAVLQRVRAAEL
EEECCCCCCHHHHHHHCCCCCEEEEEECCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHH
RYYLGSAHYRSMLEFSETALQDAVKAYAGVEDFLHRVRTRVGTVVPGDWTPKFAAALDDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCC
LSVPIALAEVHAARAVGNRALDSGDHETAMTQARSIRAMMGILGCDPLDERWESRDETSA
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHH
ALAAIDVLVRWALDSRADARNRKDWATADQIRDRLKEAGIEVTDTADGPQWSLLDGDSKD
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCC
V
C
>Mature Secondary Structure 
TDRADADRPATSPTGLRLYDTMTGAVRDFVPLRDGHVSIYLCGATVQGLPHIGHVRSGV
CCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCEEEEEECCHHCCCCCHHHHHCCH
AFDVLRRWLTAKGLDVAFIRNVTDIDDKILNKAADAGRPWWEWAATYERAFSAAYDALGV
HHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
LPPSAEPRATGHITQMVELIERLIDRGHAYTGDGDVYFNVATLPDYGKLSGHRIDDVHQG
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCC
EGVATGKRDQRDFTLWKGAKPGEPSWPTPWGRGRPGWHTECVAMCEAYLGAEFDIHAGGM
CCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCE
DLVFPHHENEIAQAEAAGDGFARFWLHNGWVTMGGEKMSKSLGNVLSIPAVLQRVRAAEL
EEECCCCCCHHHHHHHCCCCCEEEEEECCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHH
RYYLGSAHYRSMLEFSETALQDAVKAYAGVEDFLHRVRTRVGTVVPGDWTPKFAAALDDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCC
LSVPIALAEVHAARAVGNRALDSGDHETAMTQARSIRAMMGILGCDPLDERWESRDETSA
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHH
ALAAIDVLVRWALDSRADARNRKDWATADQIRDRLKEAGIEVTDTADGPQWSLLDGDSKD
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCC
V
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA