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The map label for this gene is catF [H]

Identifier: 108801653

GI number: 108801653

Start: 4969344

End: 4970504

Strand: Reverse

Name: catF [H]

Synonym: Mmcs_4690

Alternate gene names: 108801653

Gene position: 4970504-4969344 (Counterclockwise)

Preceding gene: 108801654

Following gene: 108801645

Centisome position: 87.12

GC content: 68.04

Gene sequence:

>1161_bases
ATGGCAGTGCCAACCTCGACGGCGTATGTCATCGACGCTGTGCGGACCCCCATCGGCAAGCGCGGCGGCTCGCTGGCCCA
CGTGCACCCGATCGATCTGGGCGTGCACGCGTTCCGCGGCATCTTCGACCGCGTCGACGTCGACCCGGGTGCCGTGGACG
ACGTGATCGTCGGTTGCGTGGACGCACTGGGTGGGCAGGCGGGCAACATCGGCCGCAACGCGTGGCTCGCCGCCGGCTAC
CCCGAAGAGGTGCCGGGGGTGACCGTCGACCGCCAGTGCGGGTCCAGCCAGCAGGCCATCTCGTTCGGCGCGCAGGCCAT
CATGTCGGGCACCGCCGACATCATCCTGGCCGGCGGTATGCAGAACATGAGCCAGATCCCGATCGCGTCGGCGATGGTGG
TGGGCAAGGAGTTCGGCTTCACCTCGCCGACCGGTGAGTCGGAGAACTGGCGGCACCGCTACGGCGACCAGGAGATCTCG
CAGTTCCGCGGCGCGGAGATGATCGCTGAGAAGTGGGACATCTCCCGCGAGGAGATGGAGCAGTTCGCCTACACCAGCCA
CCAGCGGGCGTTCGCCGCCATCCGTGGCGGCCACTTCGACAACGAGATCATCCCGGTGGGCGACTTCGGGGTCGACGAGG
GTCCGCGGGAGTCGACGCTGGAGAAGCTGGCCTCGCTCAAGCCGCTGTCCGAAGGTGGCCGGCTTACCGCCGCTGTCGCC
AGCCAGATCTCGGACGGTGCGAGTGCGGTGCTGCTGGCCTCCGAAGACGCAGTGAAGGCTCATAACCTCAAGCCGCGCGC
CCGCATCCACCACATCAGCGCCCGCGGTGCCGATCCGGTGTTCATGCTGACCGGCCCGATCCCCGCGACCCGCTACGCGC
TGGACAAGACCGGGCTGTCGATCGACGACATCGACGTGGTGGAGATCAACGAGGCGTTCGCGCCGGTGGTGATCGCGTGG
CTCAAGGAGCTCAAGGCCGATCCGGAGAAGGTGAACCCGAACGGTGGGGCGATCGCGCTCGGGCACCCGCTCGGTGCGAC
GGGCGCCAAGCTGTTCGCCACGATGCTCAACGAACTCGAGCGCACGGGTGGCCGCTACGGTCTGCAGACGATGTGCGAGG
GCGGCGGCACCGCCAACGTCACGATCATCGAACGTCTCTGA

Upstream 100 bases:

>100_bases
GGCCGCCAATACCTTTCCATAGTCCTCGGCGGAATCACCGCCGGCGATGAGCGCTTGCTCGAATAGCGTTCACCATCAGC
ATCCGAAGGAGAATGACATC

Downstream 100 bases:

>100_bases
GCACAGACCCCTGCCGAGCAGACGCAAAAGTACCCGAAACACCGCTATTTTAGGGACATTTGCGTCTGCTCGTGGGGAAA
CTCAGTGGTCGTGCAGGATC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: 3-oxoadipyl-CoA thiolase [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MAVPTSTAYVIDAVRTPIGKRGGSLAHVHPIDLGVHAFRGIFDRVDVDPGAVDDVIVGCVDALGGQAGNIGRNAWLAAGY
PEEVPGVTVDRQCGSSQQAISFGAQAIMSGTADIILAGGMQNMSQIPIASAMVVGKEFGFTSPTGESENWRHRYGDQEIS
QFRGAEMIAEKWDISREEMEQFAYTSHQRAFAAIRGGHFDNEIIPVGDFGVDEGPRESTLEKLASLKPLSEGGRLTAAVA
SQISDGASAVLLASEDAVKAHNLKPRARIHHISARGADPVFMLTGPIPATRYALDKTGLSIDDIDVVEINEAFAPVVIAW
LKELKADPEKVNPNGGAIALGHPLGATGAKLFATMLNELERTGGRYGLQTMCEGGGTANVTIIERL

Sequences:

>Translated_386_residues
MAVPTSTAYVIDAVRTPIGKRGGSLAHVHPIDLGVHAFRGIFDRVDVDPGAVDDVIVGCVDALGGQAGNIGRNAWLAAGY
PEEVPGVTVDRQCGSSQQAISFGAQAIMSGTADIILAGGMQNMSQIPIASAMVVGKEFGFTSPTGESENWRHRYGDQEIS
QFRGAEMIAEKWDISREEMEQFAYTSHQRAFAAIRGGHFDNEIIPVGDFGVDEGPRESTLEKLASLKPLSEGGRLTAAVA
SQISDGASAVLLASEDAVKAHNLKPRARIHHISARGADPVFMLTGPIPATRYALDKTGLSIDDIDVVEINEAFAPVVIAW
LKELKADPEKVNPNGGAIALGHPLGATGAKLFATMLNELERTGGRYGLQTMCEGGGTANVTIIERL
>Mature_385_residues
AVPTSTAYVIDAVRTPIGKRGGSLAHVHPIDLGVHAFRGIFDRVDVDPGAVDDVIVGCVDALGGQAGNIGRNAWLAAGYP
EEVPGVTVDRQCGSSQQAISFGAQAIMSGTADIILAGGMQNMSQIPIASAMVVGKEFGFTSPTGESENWRHRYGDQEISQ
FRGAEMIAEKWDISREEMEQFAYTSHQRAFAAIRGGHFDNEIIPVGDFGVDEGPRESTLEKLASLKPLSEGGRLTAAVAS
QISDGASAVLLASEDAVKAHNLKPRARIHHISARGADPVFMLTGPIPATRYALDKTGLSIDDIDVVEINEAFAPVVIAWL
KELKADPEKVNPNGGAIALGHPLGATGAKLFATMLNELERTGGRYGLQTMCEGGGTANVTIIERL

Specific function: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=389, Percent_Identity=40.8740359897172, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=39.8976982097187, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=35.5329949238579, Blast_Score=212, Evalue=4e-55,
Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=38.265306122449, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI4504327, Length=416, Percent_Identity=33.1730769230769, Blast_Score=191, Evalue=7e-49,
Organism=Homo sapiens, GI194353979, Length=378, Percent_Identity=29.8941798941799, Blast_Score=132, Evalue=5e-31,
Organism=Escherichia coli, GI48994986, Length=394, Percent_Identity=41.8781725888325, Blast_Score=271, Evalue=7e-74,
Organism=Escherichia coli, GI1787663, Length=404, Percent_Identity=41.8316831683168, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=40.6091370558376, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI87082165, Length=389, Percent_Identity=36.7609254498715, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1788683, Length=427, Percent_Identity=28.1030444964871, Blast_Score=134, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI133906874, Length=393, Percent_Identity=38.9312977099237, Blast_Score=254, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI17535921, Length=403, Percent_Identity=33.7468982630273, Blast_Score=194, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI25147385, Length=395, Percent_Identity=32.1518987341772, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=30.8235294117647, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17535917, Length=399, Percent_Identity=30.0751879699248, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6325229, Length=399, Percent_Identity=37.593984962406, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6322031, Length=385, Percent_Identity=35.3246753246753, Blast_Score=177, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24655093, Length=395, Percent_Identity=38.9873417721519, Blast_Score=242, Evalue=3e-64,
Organism=Drosophila melanogaster, GI17648125, Length=401, Percent_Identity=38.4039900249377, Blast_Score=232, Evalue=4e-61,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=34.0153452685422, Blast_Score=192, Evalue=5e-49,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=32, Blast_Score=181, Evalue=9e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012793
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.174 [H]

Molecular weight: Translated: 40810; Mature: 40678

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVPTSTAYVIDAVRTPIGKRGGSLAHVHPIDLGVHAFRGIFDRVDVDPGAVDDVIVGCV
CCCCCCHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
DALGGQAGNIGRNAWLAAGYPEEVPGVTVDRQCGSSQQAISFGAQAIMSGTADIILAGGM
HHHCCCCCCCCCCCEEECCCCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCC
QNMSQIPIASAMVVGKEFGFTSPTGESENWRHRYGDQEISQFRGAEMIAEKWDISREEME
CCHHHCCHHHHHHHHHHCCCCCCCCCCCCHHHHCCHHHHHHHCCHHHHHHHHCCCHHHHH
QFAYTSHQRAFAAIRGGHFDNEIIPVGDFGVDEGPRESTLEKLASLKPLSEGGRLTAAVA
HHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHH
SQISDGASAVLLASEDAVKAHNLKPRARIHHISARGADPVFMLTGPIPATRYALDKTGLS
HHHCCCCCEEEEECCCCHHHCCCCCHHHEEEEECCCCCCEEEEECCCCHHHHHHHHCCCC
IDDIDVVEINEAFAPVVIAWLKELKADPEKVNPNGGAIALGHPLGATGAKLFATMLNELE
CCCEEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHH
RTGGRYGLQTMCEGGGTANVTIIERL
HCCCCCCHHHHHCCCCEEEEEEEECC
>Mature Secondary Structure 
AVPTSTAYVIDAVRTPIGKRGGSLAHVHPIDLGVHAFRGIFDRVDVDPGAVDDVIVGCV
CCCCCHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
DALGGQAGNIGRNAWLAAGYPEEVPGVTVDRQCGSSQQAISFGAQAIMSGTADIILAGGM
HHHCCCCCCCCCCCEEECCCCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCC
QNMSQIPIASAMVVGKEFGFTSPTGESENWRHRYGDQEISQFRGAEMIAEKWDISREEME
CCHHHCCHHHHHHHHHHCCCCCCCCCCCCHHHHCCHHHHHHHCCHHHHHHHHCCCHHHHH
QFAYTSHQRAFAAIRGGHFDNEIIPVGDFGVDEGPRESTLEKLASLKPLSEGGRLTAAVA
HHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHH
SQISDGASAVLLASEDAVKAHNLKPRARIHHISARGADPVFMLTGPIPATRYALDKTGLS
HHHCCCCCEEEEECCCCHHHCCCCCHHHEEEEECCCCCCEEEEECCCCHHHHHHHHCCCC
IDDIDVVEINEAFAPVVIAWLKELKADPEKVNPNGGAIALGHPLGATGAKLFATMLNELE
CCCEEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHH
RTGGRYGLQTMCEGGGTANVTIIERL
HCCCCCCHHHHHCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8125318 [H]