BacMap

Definition	Mycobacterium sp. MCS chromosome, complete genome.
Accession	NC_008146
Length	5,705,448

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The map label for this gene is fabG [C]

Identifier: 108801644

GI number: 108801644

Start: 4961449

End: 4962354

Strand: Reverse

Name: fabG [C]

Synonym: Mmcs_4681

Alternate gene names: 108801644

Gene position: 4962354-4961449 (Counterclockwise)

Preceding gene: 108801645

Following gene: 108801642

Centisome position: 86.98

GC content: 70.42

Gene sequence:

>906_bases
ATGGGACTGCTCGACGGCCGCGTGGTCATCGTGACGGGTGCGGGCGGCGGCATCGGCCGTGCGCACGCACTGGCATTCGC
CGCCGAAGGCGCGCGCGTGGTGGTCAACGACATCGGTGTCGGCCTGGACGGATCGCCGGCCGGCGGCGGCAGCGCCGCGC
AGAGCGTCGTCGACGAGATCACCGCCGCCGGTGGGGAAGCCGTCACCAGCGGTGCCAACGTCGCGGACTGGGCGCAGGCC
GAGGGACTGATCCAAACGGCGGTCGACTCGTTCGGCGGACTCGACGTCCTGGTCAACAACGCCGGCATCGTGCGGGACCG
GATGTTCGCCAACACCAGCGAAGAGGAGTTCGACGCGGTCATCGCGGTGCACCTCAAGGGGCATTTCGCCACCATGAAGC
ACGCTGCGGCGTACTGGCGCGCACAGTCCAAGGCCGGGAAGACCGTGGACGCCCGCATCGTCAACACCAGTTCCGGTGCC
GGCCTGCAGGGCAGCGTCGGACAGGCCAACTACAGCGCCGCCAAGGCCGGTATCGCCGCCATGACGCTGGTGGCCGCCGC
CGAGATGGGCCGCTACGGCGTCACCGTGAACGCCATTGCGCCGTCGGCGCGGACCCGGATGACCGAAACGGTGTTCGCCG
AGATGATGTCCACCCAGGGCAACGACTTCGACGCCATGGCGCCGGAGAACGTCTCCCCGCTGGTGGTGTGGCTGGGTAGC
ACCGAGTCCCGCGACATCACCGGGCAGGTGTTCGAGGTCGAAGGCGGCAAGATCCGCGTGGCCGAGGGGTGGGCACACGG
CCCGCAGGTCGACAAGGGCGCCCGTTGGGACCCCGCCGAACTCGGACCCGTCGTCGCGGATCTGCTGGCCAAGGCGCGGC
CGCCGGTGCCGGTCTACGGCGCCTGA

Upstream 100 bases:

>100_bases
CATCAGCGGCGCATCGCTCGAGGTGCACGGTGGTGGCGAACCCCCGCACTACCTGTCGACCACCACCGCCGACATCAAAA
AGTAAGAGGAGACAACACAT

Downstream 100 bases:

>100_bases
GGAACTACGGTTCGCAGATGACGATCGGGATCTCCCGGTCGGTCCACGAGCGGTAGTTGTCGAAGTCCGGGTACATCGCG
GTCAGTTTCGGCCAGTAGTG

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MGLLDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGVGLDGSPAGGGSAAQSVVDEITAAGGEAVTSGANVADWAQA
EGLIQTAVDSFGGLDVLVNNAGIVRDRMFANTSEEEFDAVIAVHLKGHFATMKHAAAYWRAQSKAGKTVDARIVNTSSGA
GLQGSVGQANYSAAKAGIAAMTLVAAAEMGRYGVTVNAIAPSARTRMTETVFAEMMSTQGNDFDAMAPENVSPLVVWLGS
TESRDITGQVFEVEGGKIRVAEGWAHGPQVDKGARWDPAELGPVVADLLAKARPPVPVYGA

Sequences:

>Translated_301_residues
MGLLDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGVGLDGSPAGGGSAAQSVVDEITAAGGEAVTSGANVADWAQA
EGLIQTAVDSFGGLDVLVNNAGIVRDRMFANTSEEEFDAVIAVHLKGHFATMKHAAAYWRAQSKAGKTVDARIVNTSSGA
GLQGSVGQANYSAAKAGIAAMTLVAAAEMGRYGVTVNAIAPSARTRMTETVFAEMMSTQGNDFDAMAPENVSPLVVWLGS
TESRDITGQVFEVEGGKIRVAEGWAHGPQVDKGARWDPAELGPVVADLLAKARPPVPVYGA
>Mature_300_residues
GLLDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGVGLDGSPAGGGSAAQSVVDEITAAGGEAVTSGANVADWAQAE
GLIQTAVDSFGGLDVLVNNAGIVRDRMFANTSEEEFDAVIAVHLKGHFATMKHAAAYWRAQSKAGKTVDARIVNTSSGAG
LQGSVGQANYSAAKAGIAAMTLVAAAEMGRYGVTVNAIAPSARTRMTETVFAEMMSTQGNDFDAMAPENVSPLVVWLGST
ESRDITGQVFEVEGGKIRVAEGWAHGPQVDKGARWDPAELGPVVADLLAKARPPVPVYGA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=256, Percent_Identity=47.265625, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI15277342, Length=268, Percent_Identity=34.7014925373134, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI40254992, Length=251, Percent_Identity=31.4741035856574, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI7705925, Length=261, Percent_Identity=30.6513409961686, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI31542939, Length=214, Percent_Identity=31.7757009345794, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI40254986, Length=203, Percent_Identity=30.0492610837438, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI4758504, Length=204, Percent_Identity=31.3725490196078, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI19923817, Length=272, Percent_Identity=27.2058823529412, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI66933014, Length=268, Percent_Identity=29.4776119402985, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI40807363, Length=211, Percent_Identity=29.8578199052133, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI32483357, Length=270, Percent_Identity=27.7777777777778, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI83715985, Length=197, Percent_Identity=30.4568527918782, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI224922801, Length=183, Percent_Identity=31.6939890710383, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=261, Percent_Identity=33.3333333333333, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1789208, Length=265, Percent_Identity=29.0566037735849, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082100, Length=273, Percent_Identity=30.4029304029304, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI2367175, Length=265, Percent_Identity=31.6981132075472, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790717, Length=261, Percent_Identity=27.2030651340996, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1789378, Length=268, Percent_Identity=28.7313432835821, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1787905, Length=267, Percent_Identity=27.3408239700375, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788459, Length=261, Percent_Identity=27.5862068965517, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082160, Length=263, Percent_Identity=26.615969581749, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789057, Length=271, Percent_Identity=26.5682656826568, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1786812, Length=267, Percent_Identity=28.4644194756554, Blast_Score=71, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17568967, Length=249, Percent_Identity=42.1686746987952, Blast_Score=180, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI25147288, Length=260, Percent_Identity=35, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17555706, Length=262, Percent_Identity=32.0610687022901, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71982365, Length=246, Percent_Identity=29.2682926829268, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17564282, Length=201, Percent_Identity=29.3532338308458, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17508895, Length=201, Percent_Identity=30.3482587064677, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI72000259, Length=273, Percent_Identity=28.2051282051282, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560150, Length=286, Percent_Identity=29.3706293706294, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562990, Length=289, Percent_Identity=27.681660899654, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17562910, Length=292, Percent_Identity=26.3698630136986, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=292, Percent_Identity=29.7945205479452, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17559104, Length=206, Percent_Identity=31.5533980582524, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562908, Length=288, Percent_Identity=25.6944444444444, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17563726, Length=204, Percent_Identity=29.9019607843137, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=290, Percent_Identity=26.551724137931, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17558628, Length=202, Percent_Identity=29.2079207920792, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17555612, Length=220, Percent_Identity=30, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=212, Percent_Identity=31.1320754716981, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=211, Percent_Identity=27.4881516587678, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=266, Percent_Identity=26.6917293233083, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17544670, Length=200, Percent_Identity=26.5, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=295, Percent_Identity=26.1016949152542, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=227, Percent_Identity=30.3964757709251, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=260, Percent_Identity=24.6153846153846, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=203, Percent_Identity=30.5418719211823, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193203117, Length=184, Percent_Identity=27.1739130434783, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193203115, Length=172, Percent_Identity=27.906976744186, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17538486, Length=209, Percent_Identity=28.2296650717703, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=250, Percent_Identity=46.4, Blast_Score=198, Evalue=7e-52,
Organism=Saccharomyces cerevisiae, GI6324126, Length=274, Percent_Identity=26.6423357664234, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI18859837, Length=285, Percent_Identity=41.0526315789474, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24639444, Length=265, Percent_Identity=34.3396226415094, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21357673, Length=252, Percent_Identity=29.7619047619048, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI23397609, Length=270, Percent_Identity=29.2592592592593, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17737361, Length=205, Percent_Identity=31.7073170731707, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24644339, Length=265, Percent_Identity=29.0566037735849, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21357041, Length=269, Percent_Identity=26.7657992565056, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28571526, Length=268, Percent_Identity=27.6119402985075, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24649181, Length=218, Percent_Identity=28.4403669724771, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 30616; Mature: 30484

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLLDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGVGLDGSPAGGGSAAQSVVDEI
CCCCCCEEEEEECCCCCCCHHHHHEEECCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHH
TAAGGEAVTSGANVADWAQAEGLIQTAVDSFGGLDVLVNNAGIVRDRMFANTSEEEFDAV
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEHHHHCCCCHHHCCEE
IAVHLKGHFATMKHAAAYWRAQSKAGKTVDARIVNTSSGAGLQGSVGQANYSAAKAGIAA
EEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHH
MTLVAAAEMGRYGVTVNAIAPSARTRMTETVFAEMMSTQGNDFDAMAPENVSPLVVWLGS
HHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECC
TESRDITGQVFEVEGGKIRVAEGWAHGPQVDKGARWDPAELGPVVADLLAKARPPVPVYG
CCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
A
C
>Mature Secondary Structure 
GLLDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGVGLDGSPAGGGSAAQSVVDEI
CCCCCEEEEEECCCCCCCHHHHHEEECCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHH
TAAGGEAVTSGANVADWAQAEGLIQTAVDSFGGLDVLVNNAGIVRDRMFANTSEEEFDAV
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEHHHHCCCCHHHCCEE
IAVHLKGHFATMKHAAAYWRAQSKAGKTVDARIVNTSSGAGLQGSVGQANYSAAKAGIAA
EEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHH
MTLVAAAEMGRYGVTVNAIAPSARTRMTETVFAEMMSTQGNDFDAMAPENVSPLVVWLGS
HHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECC
TESRDITGQVFEVEGGKIRVAEGWAHGPQVDKGARWDPAELGPVVADLLAKARPPVPVYG
CCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]