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The map label for this gene is ppe68 [H]

Identifier: 108801634

GI number: 108801634

Start: 4952044

End: 4953192

Strand: Reverse

Name: ppe68 [H]

Synonym: Mmcs_4671

Alternate gene names: 108801634

Gene position: 4953192-4952044 (Counterclockwise)

Preceding gene: 108801635

Following gene: 108801633

Centisome position: 86.82

GC content: 71.11

Gene sequence:

>1149_bases
GTGGGAATCATGCCGGACACCAGCCCGTACGGCTCACAGACCGTGACCGGGCCCGGGTGGCCGAACGTCGACGAGGAGAC
CCTCGCCGCCGCCGCAGCCTCGTACGAGGCGCTCGCGGCGAAGCTCAGCGGTTCCGTCGTACCGCAGCAGCAGGGCCAGT
TGATGAAGCTCTCCGACGCCTGGGAGGGCGGCGGCGCGGTCGCCGCGGCCGGGGAGGCCAGCACGATCATCGGCGGGCAC
GAGGCGAACGCCGCGCATGCCGCCGCGATAGCGGCCAAACTGCGCGAGATGGAAGTCGCCGTCGTCCGGACCAAGACGAT
GGTGAACACGATGGCGCAGGAGACGCAGCACGAGTGCGAGGCGATCCAGGCGCTGCCGTTCAGCAACACCCAGCAGCTGG
TCCAGGCCCGCGTCAAAATGGGACTTTCGCAGAACATCGCGCAGGTCACGGCCAGCTCGACCGAACTGGCCAACTCGTTC
GGGGTGCCGCCGAGCATCCCCACCCCCGGTGTCCCGCCGACGGTTCCCGGTCAGCAGGCCGCCCAGGGCGCCGCGAAGGA
AGCCGGCCAGGCGGGCGGACAAGGGTCCCAGCAGGGCATGCAGCAGATGATGCAGATGGCGTCGATGGCCGGCCAGCTGC
CACAGCAGATCGGCCAGATGGTGAGCCAGGTGCCGCAGCAGATGATGCAGCCGCTGCAGCAGCTCTCCCAACCTCTGCAG
CAACTGACGTCGATGTTCGGTCAGGGCGGGAAGGCCGATTCCCTCGGTGCGGCGGGCCTGCCGTTCTCGTCGTTCTCCAA
CCATCCGCTGGCCGGCGGGTCGGGCGCAGGCGGGGGCGGCGGCATGATGCGGGCGGCGTCGTTGCCCGGTTCAGGCGGGG
TCTCCGCGCAGACCCCGTTGATGGCGGGTCTGGTGGGCACCAACGCGGTCTCCGTCGCGCCCGCGGAACCCGTCGTCGCC
GGTTCGGCGACGGTCGGGGGAGTCGCACCGGTTGCCGCGGGGGCCATGGGCGGTATGGGTGGTATGGGCGCGCCGATGGG
CATGATGGGCGGCCGCGGTTCGGGCGGCGGTGGCGGCACGAGGGCCGGGCTCGCTGCGCCGGAGCCGCTGGAGTACGACG
TCGGTGAGGACGTCGACGATGAGTGGTGA

Upstream 100 bases:

>100_bases
GGCTGATCCTCGGCTGAATTCCCGCGGGTACTCCCGCCAGCTACGCGGTAAAGTTTGCTGACGAAGAAGTCGTGACCGCG
GATACAGGGGGCCCGTGCTC

Downstream 100 bases:

>100_bases
CACATCCATGAGAGGAGCCGTCCGCTGATGGACCCGCTGAAGAAACCCGAGGGCATCTCATGGGATGCGGCGACGGTGGA
GCTGCCTGAGATGCCGATGG

Product: PPE family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MGIMPDTSPYGSQTVTGPGWPNVDEETLAAAAASYEALAAKLSGSVVPQQQGQLMKLSDAWEGGGAVAAAGEASTIIGGH
EANAAHAAAIAAKLREMEVAVVRTKTMVNTMAQETQHECEAIQALPFSNTQQLVQARVKMGLSQNIAQVTASSTELANSF
GVPPSIPTPGVPPTVPGQQAAQGAAKEAGQAGGQGSQQGMQQMMQMASMAGQLPQQIGQMVSQVPQQMMQPLQQLSQPLQ
QLTSMFGQGGKADSLGAAGLPFSSFSNHPLAGGSGAGGGGGMMRAASLPGSGGVSAQTPLMAGLVGTNAVSVAPAEPVVA
GSATVGGVAPVAAGAMGGMGGMGAPMGMMGGRGSGGGGGTRAGLAAPEPLEYDVGEDVDDEW

Sequences:

>Translated_382_residues
MGIMPDTSPYGSQTVTGPGWPNVDEETLAAAAASYEALAAKLSGSVVPQQQGQLMKLSDAWEGGGAVAAAGEASTIIGGH
EANAAHAAAIAAKLREMEVAVVRTKTMVNTMAQETQHECEAIQALPFSNTQQLVQARVKMGLSQNIAQVTASSTELANSF
GVPPSIPTPGVPPTVPGQQAAQGAAKEAGQAGGQGSQQGMQQMMQMASMAGQLPQQIGQMVSQVPQQMMQPLQQLSQPLQ
QLTSMFGQGGKADSLGAAGLPFSSFSNHPLAGGSGAGGGGGMMRAASLPGSGGVSAQTPLMAGLVGTNAVSVAPAEPVVA
GSATVGGVAPVAAGAMGGMGGMGAPMGMMGGRGSGGGGGTRAGLAAPEPLEYDVGEDVDDEW
>Mature_381_residues
GIMPDTSPYGSQTVTGPGWPNVDEETLAAAAASYEALAAKLSGSVVPQQQGQLMKLSDAWEGGGAVAAAGEASTIIGGHE
ANAAHAAAIAAKLREMEVAVVRTKTMVNTMAQETQHECEAIQALPFSNTQQLVQARVKMGLSQNIAQVTASSTELANSFG
VPPSIPTPGVPPTVPGQQAAQGAAKEAGQAGGQGSQQGMQQMMQMASMAGQLPQQIGQMVSQVPQQMMQPLQQLSQPLQQ
LTSMFGQGGKADSLGAAGLPFSSFSNHPLAGGSGAGGGGGMMRAASLPGSGGVSAQTPLMAGLVGTNAVSVAPAEPVVAG
SATVGGVAPVAAGAMGGMGGMGAPMGMMGGRGSGGGGGTRAGLAAPEPLEYDVGEDVDDEW

Specific function: Stimulates high levels of gamma interferon secretion in peripheral blood mononuclear cells isolated from tuberculosis patients, as well as from healthy tuberculin purified protein derivative-positive donors. Does not interfere with the secretion and prese

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted, cell wall. Cell membrane. Note=Detected predominantly in the membrane and cell wall fractions [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mycobacterial PPE family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000030 [H]

Pfam domain/function: PF00823 PPE [H]

EC number: NA

Molecular weight: Translated: 37749; Mature: 37618

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
6.5 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
6.3 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIMPDTSPYGSQTVTGPGWPNVDEETLAAAAASYEALAAKLSGSVVPQQQGQLMKLSDA
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHCCCEEEECCC
WEGGGAVAAAGEASTIIGGHEANAAHAAAIAAKLREMEVAVVRTKTMVNTMAQETQHECE
CCCCCEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIQALPFSNTQQLVQARVKMGLSQNIAQVTASSTELANSFGVPPSIPTPGVPPTVPGQQA
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHH
AQGAAKEAGQAGGQGSQQGMQQMMQMASMAGQLPQQIGQMVSQVPQQMMQPLQQLSQPLQ
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLTSMFGQGGKADSLGAAGLPFSSFSNHPLAGGSGAGGGGGMMRAASLPGSGGVSAQTPL
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEECCCCCCCCCCCCCHH
MAGLVGTNAVSVAPAEPVVAGSATVGGVAPVAAGAMGGMGGMGAPMGMMGGRGSGGGGGT
HHHHHCCCCEEECCCCCCEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
RAGLAAPEPLEYDVGEDVDDEW
CCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GIMPDTSPYGSQTVTGPGWPNVDEETLAAAAASYEALAAKLSGSVVPQQQGQLMKLSDA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHCCCEEEECCC
WEGGGAVAAAGEASTIIGGHEANAAHAAAIAAKLREMEVAVVRTKTMVNTMAQETQHECE
CCCCCEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIQALPFSNTQQLVQARVKMGLSQNIAQVTASSTELANSFGVPPSIPTPGVPPTVPGQQA
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHH
AQGAAKEAGQAGGQGSQQGMQQMMQMASMAGQLPQQIGQMVSQVPQQMMQPLQQLSQPLQ
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLTSMFGQGGKADSLGAAGLPFSSFSNHPLAGGSGAGGGGGMMRAASLPGSGGVSAQTPL
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEECCCCCCCCCCCCCHH
MAGLVGTNAVSVAPAEPVVAGSATVGGVAPVAAGAMGGMGGMGAPMGMMGGRGSGGGGGT
HHHHHCCCCEEECCCCCCEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
RAGLAAPEPLEYDVGEDVDDEW
CCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]