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The map label for this gene is recQ [H]

Identifier: 108801620

GI number: 108801620

Start: 4933302

End: 4935377

Strand: Reverse

Name: recQ [H]

Synonym: Mmcs_4657

Alternate gene names: 108801620

Gene position: 4935377-4933302 (Counterclockwise)

Preceding gene: 108801621

Following gene: 108801618

Centisome position: 86.5

GC content: 71.05

Gene sequence:

>2076_bases
ATGCCGACCCGTGACGACGCCCAGGCGCTGCTCGAACAACTCGCCGGCCCGCAGGCCACACTGCGCGACGATCAGTGGAC
CGCGATCGAGGCGCTGGTGGTGCACCGCCGCCAGGCCCTCGTGGTCCAGCGCACCGGCTGGGGGAAGTCGGCCGTCTACT
TCATCTCGGCCAAACTGCTGCGCGCCGCCGGCCGCGGACCCACGGTGATCGTCTCCCCGCTGTTGGCGTTGATGCGCAAC
CAGGTCGCCGCCGCCGAGCGCGCCGGCGTGCGGGCGGCCACCATCAACTCCGGCAACGTCGCCGAATGGGAGGACATCCA
CGCGCGGGTGCAGGGCGGTGACCTCGACGTCCTGCTGGTCAGTCCCGAGCGGCTCAACAACCCCGACTTCCGCGACAACG
TGCTGCCCGCACTGGCGGCCGACGCCGGTCTGGTGGTGGTGGACGAAGCGCACTGCGTGTCCGACTGGGGGCACGACTTC
CGCCCCGACTACCGCCGGATCCGCACCCTGATCGCGGAGTTGGGCCAGGACATCCCGGTGCTCGCCACCACGGCCACCGC
GAACGACCGGGTGGTCGACGATGTGGCCACCCAACTCGGGGTGGGCGGTCGCGACACACTCGTGCTGCGCGGCGGGCTCG
ACCGCGAATCGCTGCGGCTGTCGGTGGTCCACGCGGGCAACCCCGCCCAGCGGGCCGCCTGGATCGCCGCACACCTCGGC
GACTTGCCGGGTTCGGGCATCGTCTACACGCTCACCGTCGCCCAGGCCCACGACATCGCGGCACTGTTGCGCGAACACGG
GCACCCCGTCGCCGCCTACACGGGTTCCACCGATCCGACCGAGCGCGAACAACTCGAAGCCGACCTGCTGGCCAACCGGG
TCAAGGCGTTGGTCGCGACCTCGGCGCTCGGGATGGGGTTCGACAAACCCGATCTCGGCTTCGTGGTCCATCTCGGTGCG
CCGTCCTCACCGATCGCCTATTACCAACAGGTGGGCCGCGCCGGCCGCGCCACGTCGAGCGCCGAGGTGGTCCTGCTGCC
CGGTCGCGAGGACCAGGAGGTCTGGCGGTATTTCGCCTCGGTGGCCTTCCCCTCGGAAGCCATGGTGCGCAACGTGATCG
ATGCACTCGAGACGGACCGGCCGCAGTCCACCCCGGCGCTCGAACCGCTCGTCGACCTCAACCGCAGCCGCCTGGAGATG
GTGCTCAAGGTGCTCGACGTCGACGGGGCCGTGCGGCGGGTCAAGGGCGGGTGGCTGAGCACCGGTGCGCCGTGGAGCTA
CGACGAACCGCGCTACCGCAAACTCGACGAGGCGCGCCGCCGCGAACAGCAGGCGATGCTCGACTACCAGAGCACCGACG
GATGCCGGATGGCGTTCCTGCGCCGCCAACTCGACGACCCCGAACTGCGCGAAGGTGACCGGTGCGGCCGCTGCGACAAC
TGCACGGGCAACCGGCTGCCCGCGGAGGTCGACGCGACCGCGGCCGAGGACACCCGGCAGCGGCTGATGCGCCCGGGTGT
CGAGCTCAGCCCGCGCAAACAGTGGCCGTCCGGGTTGACGAAGCTCGGTCTCGACCTGAGCGGGCGCATCCACGACGGCC
CCGCGACAGGCCGGGTGATCGGCAGGCTGACCGATCTGGGTTGGGGCGCCCGGCTACGCAAGGTGCTCGACGAACCCGAC
GGTGAGGTGTCCGACGACATGGTGCGCGCCGCGACCGACGTGCTGGCCGCGTGGACCTGGCAGCAGCGTCCGGTCGCCGT
GCTGGCGATGGACTCAGAGACCCACCCGATCCTGATCCGCTCGCTGGCTCGCCGGCTCGCCGAACTCGGCAGGCTCATCG
ACCTGGGCACACTGCAGTACCGTCCGGGCCGACGGCCGGTGACGGCGGCGAACTCCGCGTACCGCGTTGCGGCGCTGAGG
GATTCGTGGGAGACGCCGGATCTCGACGTGAACGGTCCGGTGCTGCTCGTCGACGATCTCACCGACACCGGATGGACGCT
CACCATGGCGGCCCGGGTGGTCCGTTCCGCCGGCGCCCCCGAGGTGCTGCCGTTCGCGCTGGCCGCCATCAGCTGA

Upstream 100 bases:

>100_bases
CGAGTTCTTCCACGCGTTCACCGTGGCCGCGGCGGTCTGCCACTTCGCCGCCATCTGGCTCGTCATCCGGTAGTCGGACC
CGGCAGGCACGATAGGGCAC

Downstream 100 bases:

>100_bases
TCGACGACAGACAGCCGCCCTGCGTGATCGCAGGGCGGCTGCCTTTCGAAATCCGGTTACCGCGGAAGCGGGACGAACAG
ACCGTCGTTGATCCACACAC

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 691; Mature: 690

Protein sequence:

>691_residues
MPTRDDAQALLEQLAGPQATLRDDQWTAIEALVVHRRQALVVQRTGWGKSAVYFISAKLLRAAGRGPTVIVSPLLALMRN
QVAAAERAGVRAATINSGNVAEWEDIHARVQGGDLDVLLVSPERLNNPDFRDNVLPALAADAGLVVVDEAHCVSDWGHDF
RPDYRRIRTLIAELGQDIPVLATTATANDRVVDDVATQLGVGGRDTLVLRGGLDRESLRLSVVHAGNPAQRAAWIAAHLG
DLPGSGIVYTLTVAQAHDIAALLREHGHPVAAYTGSTDPTEREQLEADLLANRVKALVATSALGMGFDKPDLGFVVHLGA
PSSPIAYYQQVGRAGRATSSAEVVLLPGREDQEVWRYFASVAFPSEAMVRNVIDALETDRPQSTPALEPLVDLNRSRLEM
VLKVLDVDGAVRRVKGGWLSTGAPWSYDEPRYRKLDEARRREQQAMLDYQSTDGCRMAFLRRQLDDPELREGDRCGRCDN
CTGNRLPAEVDATAAEDTRQRLMRPGVELSPRKQWPSGLTKLGLDLSGRIHDGPATGRVIGRLTDLGWGARLRKVLDEPD
GEVSDDMVRAATDVLAAWTWQQRPVAVLAMDSETHPILIRSLARRLAELGRLIDLGTLQYRPGRRPVTAANSAYRVAALR
DSWETPDLDVNGPVLLVDDLTDTGWTLTMAARVVRSAGAPEVLPFALAAIS

Sequences:

>Translated_691_residues
MPTRDDAQALLEQLAGPQATLRDDQWTAIEALVVHRRQALVVQRTGWGKSAVYFISAKLLRAAGRGPTVIVSPLLALMRN
QVAAAERAGVRAATINSGNVAEWEDIHARVQGGDLDVLLVSPERLNNPDFRDNVLPALAADAGLVVVDEAHCVSDWGHDF
RPDYRRIRTLIAELGQDIPVLATTATANDRVVDDVATQLGVGGRDTLVLRGGLDRESLRLSVVHAGNPAQRAAWIAAHLG
DLPGSGIVYTLTVAQAHDIAALLREHGHPVAAYTGSTDPTEREQLEADLLANRVKALVATSALGMGFDKPDLGFVVHLGA
PSSPIAYYQQVGRAGRATSSAEVVLLPGREDQEVWRYFASVAFPSEAMVRNVIDALETDRPQSTPALEPLVDLNRSRLEM
VLKVLDVDGAVRRVKGGWLSTGAPWSYDEPRYRKLDEARRREQQAMLDYQSTDGCRMAFLRRQLDDPELREGDRCGRCDN
CTGNRLPAEVDATAAEDTRQRLMRPGVELSPRKQWPSGLTKLGLDLSGRIHDGPATGRVIGRLTDLGWGARLRKVLDEPD
GEVSDDMVRAATDVLAAWTWQQRPVAVLAMDSETHPILIRSLARRLAELGRLIDLGTLQYRPGRRPVTAANSAYRVAALR
DSWETPDLDVNGPVLLVDDLTDTGWTLTMAARVVRSAGAPEVLPFALAAIS
>Mature_690_residues
PTRDDAQALLEQLAGPQATLRDDQWTAIEALVVHRRQALVVQRTGWGKSAVYFISAKLLRAAGRGPTVIVSPLLALMRNQ
VAAAERAGVRAATINSGNVAEWEDIHARVQGGDLDVLLVSPERLNNPDFRDNVLPALAADAGLVVVDEAHCVSDWGHDFR
PDYRRIRTLIAELGQDIPVLATTATANDRVVDDVATQLGVGGRDTLVLRGGLDRESLRLSVVHAGNPAQRAAWIAAHLGD
LPGSGIVYTLTVAQAHDIAALLREHGHPVAAYTGSTDPTEREQLEADLLANRVKALVATSALGMGFDKPDLGFVVHLGAP
SSPIAYYQQVGRAGRATSSAEVVLLPGREDQEVWRYFASVAFPSEAMVRNVIDALETDRPQSTPALEPLVDLNRSRLEMV
LKVLDVDGAVRRVKGGWLSTGAPWSYDEPRYRKLDEARRREQQAMLDYQSTDGCRMAFLRRQLDDPELREGDRCGRCDNC
TGNRLPAEVDATAAEDTRQRLMRPGVELSPRKQWPSGLTKLGLDLSGRIHDGPATGRVIGRLTDLGWGARLRKVLDEPDG
EVSDDMVRAATDVLAAWTWQQRPVAVLAMDSETHPILIRSLARRLAELGRLIDLGTLQYRPGRRPVTAANSAYRVAALRD
SWETPDLDVNGPVLLVDDLTDTGWTLTMAARVVRSAGAPEVLPFALAAIS

Specific function: Probable DNA helicase. Required for DNA repair and intramolecular recombination; probably has overlapping function with recS (AC P50729). It probably acts to help generate ss-DNA from ds-DNA breaks [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm, nucleoid. Note=Localized throughout the nucleoid in the presence or absence of DNA double- strand breaks [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI169218196, Length=355, Percent_Identity=28.4507042253521, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI110735439, Length=355, Percent_Identity=28.4507042253521, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI4557365, Length=342, Percent_Identity=31.8713450292398, Blast_Score=149, Evalue=1e-35,
Organism=Homo sapiens, GI14591902, Length=327, Percent_Identity=29.3577981651376, Blast_Score=149, Evalue=1e-35,
Organism=Homo sapiens, GI14591904, Length=327, Percent_Identity=29.3577981651376, Blast_Score=149, Evalue=1e-35,
Organism=Homo sapiens, GI51242943, Length=342, Percent_Identity=33.9181286549708, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI51242947, Length=342, Percent_Identity=33.9181286549708, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI148612816, Length=368, Percent_Identity=32.0652173913043, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI284005309, Length=335, Percent_Identity=31.6417910447761, Blast_Score=124, Evalue=4e-28,
Organism=Escherichia coli, GI48994977, Length=349, Percent_Identity=36.676217765043, Blast_Score=181, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI32564293, Length=375, Percent_Identity=30.6666666666667, Blast_Score=171, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI71987997, Length=353, Percent_Identity=31.728045325779, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71987993, Length=353, Percent_Identity=31.728045325779, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI25145561, Length=321, Percent_Identity=32.398753894081, Blast_Score=152, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17552866, Length=357, Percent_Identity=29.9719887955182, Blast_Score=146, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6323844, Length=319, Percent_Identity=32.2884012539185, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24646066, Length=344, Percent_Identity=30.2325581395349, Blast_Score=153, Evalue=5e-37,
Organism=Drosophila melanogaster, GI62472181, Length=331, Percent_Identity=31.7220543806647, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24664226, Length=332, Percent_Identity=31.6265060240964, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24664230, Length=331, Percent_Identity=31.7220543806647, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI21358123, Length=325, Percent_Identity=28.9230769230769, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 75266; Mature: 75135

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00690 DEAH_ATP_HELICASE ; PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTRDDAQALLEQLAGPQATLRDDQWTAIEALVVHRRQALVVQRTGWGKSAVYFISAKLL
CCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHH
RAAGRGPTVIVSPLLALMRNQVAAAERAGVRAATINSGNVAEWEDIHARVQGGDLDVLLV
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHEEECCCCEEEEEE
SPERLNNPDFRDNVLPALAADAGLVVVDEAHCVSDWGHDFRPDYRRIRTLIAELGQDIPV
CHHHCCCCCCHHHCCHHHHCCCCEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCE
LATTATANDRVVDDVATQLGVGGRDTLVLRGGLDRESLRLSVVHAGNPAQRAAWIAAHLG
EEEECCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHC
DLPGSGIVYTLTVAQAHDIAALLREHGHPVAAYTGSTDPTEREQLEADLLANRVKALVAT
CCCCCCEEEEEEEHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
SALGMGFDKPDLGFVVHLGAPSSPIAYYQQVGRAGRATSSAEVVLLPGREDQEVWRYFAS
HHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHH
VAFPSEAMVRNVIDALETDRPQSTPALEPLVDLNRSRLEMVLKVLDVDGAVRRVKGGWLS
HCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHCCCHHHHHHCCCCCC
TGAPWSYDEPRYRKLDEARRREQQAMLDYQSTDGCRMAFLRRQLDDPELREGDRCGRCDN
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
CTGNRLPAEVDATAAEDTRQRLMRPGVELSPRKQWPSGLTKLGLDLSGRIHDGPATGRVI
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCEECCCCCCCHHH
GRLTDLGWGARLRKVLDEPDGEVSDDMVRAATDVLAAWTWQQRPVAVLAMDSETHPILIR
HHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHH
SLARRLAELGRLIDLGTLQYRPGRRPVTAANSAYRVAALRDSWETPDLDVNGPVLLVDDL
HHHHHHHHHHHHEECCCEEECCCCCCEECCCCCEEEEEECCCCCCCCCCCCCCEEEEECC
TDTGWTLTMAARVVRSAGAPEVLPFALAAIS
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure 
PTRDDAQALLEQLAGPQATLRDDQWTAIEALVVHRRQALVVQRTGWGKSAVYFISAKLL
CCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHH
RAAGRGPTVIVSPLLALMRNQVAAAERAGVRAATINSGNVAEWEDIHARVQGGDLDVLLV
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHEEECCCCEEEEEE
SPERLNNPDFRDNVLPALAADAGLVVVDEAHCVSDWGHDFRPDYRRIRTLIAELGQDIPV
CHHHCCCCCCHHHCCHHHHCCCCEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCE
LATTATANDRVVDDVATQLGVGGRDTLVLRGGLDRESLRLSVVHAGNPAQRAAWIAAHLG
EEEECCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHC
DLPGSGIVYTLTVAQAHDIAALLREHGHPVAAYTGSTDPTEREQLEADLLANRVKALVAT
CCCCCCEEEEEEEHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
SALGMGFDKPDLGFVVHLGAPSSPIAYYQQVGRAGRATSSAEVVLLPGREDQEVWRYFAS
HHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHH
VAFPSEAMVRNVIDALETDRPQSTPALEPLVDLNRSRLEMVLKVLDVDGAVRRVKGGWLS
HCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHCCCHHHHHHCCCCCC
TGAPWSYDEPRYRKLDEARRREQQAMLDYQSTDGCRMAFLRRQLDDPELREGDRCGRCDN
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
CTGNRLPAEVDATAAEDTRQRLMRPGVELSPRKQWPSGLTKLGLDLSGRIHDGPATGRVI
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCEECCCCCCCHHH
GRLTDLGWGARLRKVLDEPDGEVSDDMVRAATDVLAAWTWQQRPVAVLAMDSETHPILIR
HHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHH
SLARRLAELGRLIDLGTLQYRPGRRPVTAANSAYRVAALRDSWETPDLDVNGPVLLVDDL
HHHHHHHHHHHHEECCCEEECCCCCCEECCCCCEEEEEECCCCCCCCCCCCCCEEEEECC
TDTGWTLTMAARVVRSAGAPEVLPFALAAIS
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9642195 [H]