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The map label for this gene is fabG [C]

Identifier: 108801458

GI number: 108801458

Start: 4774818

End: 4775531

Strand: Reverse

Name: fabG [C]

Synonym: Mmcs_4495

Alternate gene names: 108801458

Gene position: 4775531-4774818 (Counterclockwise)

Preceding gene: 108801461

Following gene: 108801457

Centisome position: 83.7

GC content: 69.61

Gene sequence:

>714_bases
ATGGAACTGCATGGCGCCACCGCCGTGGTCACCGGCGCGAATCGCGGTATCGGTCATTACTTCGCCGTCCAGCTGCTCCA
GCGAGGTGCCAAGGTCTACGCGACCGCACGGCGCCCCGAACTCGTCGACGTGCCCGGCGCCGAGGTGCTTCGGCTCGACA
TCACCGACCAGGCGTCGGTCGAAGAGGTCGCCGAACGCGCCGGCGATGTCGACCTGCTGATCAACAATGCCGCCGACACC
GCGGGCGGGAACCTGGTCACCGGGGATCTGCGTGCGATCCGTTCGACGATGGACTCGAACTACTACGGCACGCTGGCGAT
GATTCGGGCGTTCGCACCGATCCTCGCCCGCAACGGCGGCGGCGCCATCCTCAACGTGCTGTCCGCGGCGGCGTGGAACA
CCGTGGCGGGCAACACCGCGTACGCCGCGGCGAAATCGGCGGAATGGGGTCTGACCAACGGCGTCCGCATCGAACTCGCC
GGCCAGGGAACACTCGTCGCCGCGCTGGTGCCCGGACTTGTCGGCACCCGGACACTGCTCGATTTCGCCGAACGCAACGG
GATCCGGCTTCCCGAGGACGCCGTGCTCGACCCCGCCGAAGTGGTCCGCCTGGCGCTCGACGGGCTGGCGGCCGGTGACG
TCGAGATCCTGGACCCGATGGCGGTCGAGGCGAAGGCCTCGCTGGCCGGCCCGCCGCGCGCGTTCACCCTGTGA

Upstream 100 bases:

>100_bases
GGCTACCAAGTTGACCGGTCGGTCATCTTGTGGCAACCTTCGAAGAGCAAGGTGACCACAGGGTCATTTTCTTTGAGGCG
TGAAAACGATTGGGACACAC

Downstream 100 bases:

>100_bases
GGGAATGAATCCGGGGCGTACGGCGTCGTGACCCCACGTGGCTTTCACATTCGATGACGACGCGACCCTGCTGACCCCGC
TGCAGATGGGCGAGACGTTC

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MELHGATAVVTGANRGIGHYFAVQLLQRGAKVYATARRPELVDVPGAEVLRLDITDQASVEEVAERAGDVDLLINNAADT
AGGNLVTGDLRAIRSTMDSNYYGTLAMIRAFAPILARNGGGAILNVLSAAAWNTVAGNTAYAAAKSAEWGLTNGVRIELA
GQGTLVAALVPGLVGTRTLLDFAERNGIRLPEDAVLDPAEVVRLALDGLAAGDVEILDPMAVEAKASLAGPPRAFTL

Sequences:

>Translated_237_residues
MELHGATAVVTGANRGIGHYFAVQLLQRGAKVYATARRPELVDVPGAEVLRLDITDQASVEEVAERAGDVDLLINNAADT
AGGNLVTGDLRAIRSTMDSNYYGTLAMIRAFAPILARNGGGAILNVLSAAAWNTVAGNTAYAAAKSAEWGLTNGVRIELA
GQGTLVAALVPGLVGTRTLLDFAERNGIRLPEDAVLDPAEVVRLALDGLAAGDVEILDPMAVEAKASLAGPPRAFTL
>Mature_237_residues
MELHGATAVVTGANRGIGHYFAVQLLQRGAKVYATARRPELVDVPGAEVLRLDITDQASVEEVAERAGDVDLLINNAADT
AGGNLVTGDLRAIRSTMDSNYYGTLAMIRAFAPILARNGGGAILNVLSAAAWNTVAGNTAYAAAKSAEWGLTNGVRIELA
GQGTLVAALVPGLVGTRTLLDFAERNGIRLPEDAVLDPAEVVRLALDGLAAGDVEILDPMAVEAKASLAGPPRAFTL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7706318, Length=193, Percent_Identity=31.0880829015544, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI7657478, Length=184, Percent_Identity=29.8913043478261, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI223718074, Length=185, Percent_Identity=32.972972972973, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI32483357, Length=188, Percent_Identity=30.8510638297872, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI20149619, Length=193, Percent_Identity=25.9067357512953, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI66933014, Length=173, Percent_Identity=28.9017341040462, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI32455239, Length=195, Percent_Identity=29.7435897435897, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI5031765, Length=195, Percent_Identity=29.7435897435897, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787335, Length=201, Percent_Identity=32.8358208955224, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1787820, Length=179, Percent_Identity=30.7262569832402, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI87082100, Length=233, Percent_Identity=30.4721030042918, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI87082160, Length=192, Percent_Identity=27.0833333333333, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1786812, Length=198, Percent_Identity=31.8181818181818, Blast_Score=61, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17567345, Length=175, Percent_Identity=28, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17555612, Length=228, Percent_Identity=31.5789473684211, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71997099, Length=229, Percent_Identity=29.2576419213974, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17563726, Length=198, Percent_Identity=28.7878787878788, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=196, Percent_Identity=29.5918367346939, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21358495, Length=197, Percent_Identity=26.9035532994924, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI23397609, Length=185, Percent_Identity=30.2702702702703, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI116007236, Length=204, Percent_Identity=29.9019607843137, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21355319, Length=189, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI116007238, Length=190, Percent_Identity=28.9473684210526, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 24525; Mature: 24525

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELHGATAVVTGANRGIGHYFAVQLLQRGAKVYATARRPELVDVPGAEVLRLDITDQASV
CCCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEECCCCCEEECCCCEEEEEECCCCCCH
EEVAERAGDVDLLINNAADTAGGNLVTGDLRAIRSTMDSNYYGTLAMIRAFAPILARNGG
HHHHHHCCCEEEEEECCCCCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
GAILNVLSAAAWNTVAGNTAYAAAKSAEWGLTNGVRIELAGQGTLVAALVPGLVGTRTLL
HHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCEEEEECCCCEEHHHHHCCHHHHHHHH
DFAERNGIRLPEDAVLDPAEVVRLALDGLAAGDVEILDPMAVEAKASLAGPPRAFTL
HHHHCCCCCCCHHHCCCHHHHHHHHHHCCCCCCEECCCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MELHGATAVVTGANRGIGHYFAVQLLQRGAKVYATARRPELVDVPGAEVLRLDITDQASV
CCCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEECCCCCEEECCCCEEEEEECCCCCCH
EEVAERAGDVDLLINNAADTAGGNLVTGDLRAIRSTMDSNYYGTLAMIRAFAPILARNGG
HHHHHHCCCEEEEEECCCCCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
GAILNVLSAAAWNTVAGNTAYAAAKSAEWGLTNGVRIELAGQGTLVAALVPGLVGTRTLL
HHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCEEEEECCCCEEHHHHHCCHHHHHHHH
DFAERNGIRLPEDAVLDPAEVVRLALDGLAAGDVEILDPMAVEAKASLAGPPRAFTL
HHHHCCCCCCCHHHCCCHHHHHHHHHHCCCCCCEECCCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA