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The map label for this gene is fklB [C]

Identifier: 108801413

GI number: 108801413

Start: 4733821

End: 4734189

Strand: Reverse

Name: fklB [C]

Synonym: Mmcs_4450

Alternate gene names: 108801413

Gene position: 4734189-4733821 (Counterclockwise)

Preceding gene: 108801417

Following gene: 108801409

Centisome position: 82.98

GC content: 68.83

Gene sequence:

>369_bases
GTGAACCCAGGACAGAAACCCGAGATCGACTTCCCGGACGGCCCGGCCCCGACTGAGCTGGTCATCGAGGATCTGGTCGT
CGGTGAGGGCCCCGAGGCGGTGCCCGGCGCCAACGTCGAAGTGCACTACGTCGGCGTGGAGTACGACACCGGCGAGGAGT
TCGACAGCTCGTGGAACCGCGGCCAGTCGATCGAGTTCCCGCTGCAGGGTCTGATCCAGGGCTGGCAGGACGGCATCCCG
GGGATGCGGGTCGGCGGCCGGCGCAAGCTGACGATTCCGCCCGCACAGGCCTACGGGCCCGCCGGCGGGGGTCACCGGCT
GTCGGGCAAGACGCTGATCTTCGTCATCGACCTGCTGGCCACCCGATAA

Upstream 100 bases:

>100_bases
GGAGCTGCTGCTCCTCGGCGACGAGCTTGTTCACCTGAGCCAGGATGTCTTGGTCTGATGCCACGGCTCCAGTCTGCCCG
ACTACCGTGGGGACGTGACT

Downstream 100 bases:

>100_bases
GGTCCGCCGAACGTGAGCCCGTGAGCGAGAAAGCGCCCGCGACTCACGCACAAGCTCACGTTCGCGCAGGGTCAGCCGCG
GGGCCCGGGTAGCCGCAGCA

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 122; Mature: 122

Protein sequence:

>122_residues
MNPGQKPEIDFPDGPAPTELVIEDLVVGEGPEAVPGANVEVHYVGVEYDTGEEFDSSWNRGQSIEFPLQGLIQGWQDGIP
GMRVGGRRKLTIPPAQAYGPAGGGHRLSGKTLIFVIDLLATR

Sequences:

>Translated_122_residues
MNPGQKPEIDFPDGPAPTELVIEDLVVGEGPEAVPGANVEVHYVGVEYDTGEEFDSSWNRGQSIEFPLQGLIQGWQDGIP
GMRVGGRRKLTIPPAQAYGPAGGGHRLSGKTLIFVIDLLATR
>Mature_122_residues
MNPGQKPEIDFPDGPAPTELVIEDLVVGEGPEAVPGANVEVHYVGVEYDTGEEFDSSWNRGQSIEFPLQGLIQGWQDGIP
GMRVGGRRKLTIPPAQAYGPAGGGHRLSGKTLIFVIDLLATR

Specific function: PPIases accelerate the folding of proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm And Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI87082390, Length=110, Percent_Identity=40, Blast_Score=66, Evalue=6e-13,
Organism=Escherichia coli, GI1789745, Length=107, Percent_Identity=38.3177570093458, Blast_Score=59, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320727, Length=83, Percent_Identity=44.578313253012, Blast_Score=70, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24647110, Length=104, Percent_Identity=40.3846153846154, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281363946, Length=87, Percent_Identity=41.3793103448276, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17352457, Length=87, Percent_Identity=41.3793103448276, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 13051; Mature: 13051

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPGQKPEIDFPDGPAPTELVIEDLVVGEGPEAVPGANVEVHYVGVEYDTGEEFDSSWNR
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCC
GQSIEFPLQGLIQGWQDGIPGMRVGGRRKLTIPPAQAYGPAGGGHRLSGKTLIFVIDLLA
CCCCCCCHHHHHHHHHCCCCCCCCCCEEEEECCCHHHCCCCCCCCEECCCEEEEEEEHHH
TR
CC
>Mature Secondary Structure
MNPGQKPEIDFPDGPAPTELVIEDLVVGEGPEAVPGANVEVHYVGVEYDTGEEFDSSWNR
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCC
GQSIEFPLQGLIQGWQDGIPGMRVGGRRKLTIPPAQAYGPAGGGHRLSGKTLIFVIDLLA
CCCCCCCHHHHHHHHHCCCCCCCCCCEEEEECCCHHHCCCCCCCCEECCCEEEEEEEHHH
TR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7522844; 12948626 [H]