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The map label for this gene is echA6 [H]

Identifier: 108801394

GI number: 108801394

Start: 4712509

End: 4713243

Strand: Reverse

Name: echA6 [H]

Synonym: Mmcs_4431

Alternate gene names: 108801394

Gene position: 4713243-4712509 (Counterclockwise)

Preceding gene: 108801396

Following gene: 108801393

Centisome position: 82.61

GC content: 68.71

Gene sequence:

>735_bases
ATGATCGGTGTCACCCGCGACGGCCAGGTACTGACCCTGGAGATGCAGCGGCCCGAGCGCCGCAACGCCCTCAACAGCGA
ACTGGTCGACGGTCTGCGCGAAGCGATCGAGAAGGCCGCGACCGAGGACGTCCGCGCCATCGTGTTGACCGGGCAGGGGC
ACGTGTTCAGCTCGGGTGCGGATCTGTCCGGTGGCCAGGGCGTCGCCGACGAGTTGCCCGACAAGGCCAGGGCGCTGAAC
TTCGCCATCGACAAGGCGCCGTTCCCGGTGATCGCCGCGATCAACGGCCCGGCGATCGGCGCAGGCGTCATCCTCTCGAT
GATCTGCGATCTGCGCGTCGTCGCGCCTGAGGCGTACTTCCAATTCCCGGTCGCCAAATACGGTATCGCACTTGACAATT
GGAGTATCCGGCGGCTGACGTCGCTGGTCGGCGCCGGCCGGGCGCGGGGCATGCTACTGGCCGCCGAACGGCTCACCGCC
GAGGTCGCGCTGCAGACCGGGATGGCCAACCGGATCGGCGCACTCGCCGACGCGCAGGCCTGGGCGCAGGAGATCGCCGG
TTTCGCGCCGTTGGCGCTGCAACACGCCAAGCGGGTGCTCAACGACGACGGCGCCTACGAGGATCCGTGGCCGGCGCACC
AGGAGTTGTTCGACAGGGCGTGGGCCAGCCAGGACATCATCGAGGCACAGGTCGCGCGCATCGAGAAGCGGCCACCGAGG
TTCCAGGGGGCCTGA

Upstream 100 bases:

>100_bases
GCGCTGTCCCAGCTGCGGAACGATCCCTCGTCCAGGACGGTGTCACGCAGCTGAAGGGCACCGATCCGGCTCACAGCGCA
AGGCTATATAAGGTGGCGGC

Downstream 100 bases:

>100_bases
GAATGCTGGGTGCGGCGCTGCGGTACGGGTTCGGCACGGCCTCGGTGCTGGCCGGCGGCTGGGTGCTGCGGGCGCTGCAG
GGCACACCGGCCTCGCTGGG

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MIGVTRDGQVLTLEMQRPERRNALNSELVDGLREAIEKAATEDVRAIVLTGQGHVFSSGADLSGGQGVADELPDKARALN
FAIDKAPFPVIAAINGPAIGAGVILSMICDLRVVAPEAYFQFPVAKYGIALDNWSIRRLTSLVGAGRARGMLLAAERLTA
EVALQTGMANRIGALADAQAWAQEIAGFAPLALQHAKRVLNDDGAYEDPWPAHQELFDRAWASQDIIEAQVARIEKRPPR
FQGA

Sequences:

>Translated_244_residues
MIGVTRDGQVLTLEMQRPERRNALNSELVDGLREAIEKAATEDVRAIVLTGQGHVFSSGADLSGGQGVADELPDKARALN
FAIDKAPFPVIAAINGPAIGAGVILSMICDLRVVAPEAYFQFPVAKYGIALDNWSIRRLTSLVGAGRARGMLLAAERLTA
EVALQTGMANRIGALADAQAWAQEIAGFAPLALQHAKRVLNDDGAYEDPWPAHQELFDRAWASQDIIEAQVARIEKRPPR
FQGA
>Mature_244_residues
MIGVTRDGQVLTLEMQRPERRNALNSELVDGLREAIEKAATEDVRAIVLTGQGHVFSSGADLSGGQGVADELPDKARALN
FAIDKAPFPVIAAINGPAIGAGVILSMICDLRVVAPEAYFQFPVAKYGIALDNWSIRRLTSLVGAGRARGMLLAAERLTA
EVALQTGMANRIGALADAQAWAQEIAGFAPLALQHAKRVLNDDGAYEDPWPAHQELFDRAWASQDIIEAQVARIEKRPPR
FQGA

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=249, Percent_Identity=30.9236947791165, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI25453481, Length=249, Percent_Identity=25.7028112449799, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI51538573, Length=249, Percent_Identity=25.7028112449799, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI70995211, Length=212, Percent_Identity=31.6037735849057, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI4757968, Length=249, Percent_Identity=25.3012048192771, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI49355787, Length=249, Percent_Identity=25.3012048192771, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI4757966, Length=239, Percent_Identity=25.9414225941423, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI51538581, Length=239, Percent_Identity=25.9414225941423, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI221136756, Length=250, Percent_Identity=24.8, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI221136753, Length=250, Percent_Identity=24.8, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI221307494, Length=250, Percent_Identity=24.8, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI45643119, Length=209, Percent_Identity=27.2727272727273, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI260275230, Length=209, Percent_Identity=27.2727272727273, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI260274832, Length=209, Percent_Identity=27.2727272727273, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI116235487, Length=159, Percent_Identity=30.188679245283, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI31542718, Length=178, Percent_Identity=28.6516853932584, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI213417737, Length=241, Percent_Identity=23.6514522821577, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI157694516, Length=241, Percent_Identity=23.6514522821577, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787659, Length=249, Percent_Identity=34.5381526104418, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI221142681, Length=260, Percent_Identity=30.7692307692308, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1788597, Length=248, Percent_Identity=30.241935483871, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI87082183, Length=258, Percent_Identity=27.1317829457364, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787660, Length=249, Percent_Identity=31.3253012048193, Blast_Score=65, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17560910, Length=235, Percent_Identity=28.936170212766, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17535521, Length=216, Percent_Identity=28.7037037037037, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17554946, Length=263, Percent_Identity=29.277566539924, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17536985, Length=266, Percent_Identity=25.187969924812, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17540714, Length=212, Percent_Identity=28.3018867924528, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI25145438, Length=258, Percent_Identity=28.6821705426357, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17534483, Length=262, Percent_Identity=26.7175572519084, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17549921, Length=208, Percent_Identity=25.9615384615385, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI20129971, Length=240, Percent_Identity=28.75, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24653477, Length=240, Percent_Identity=28.75, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19920382, Length=214, Percent_Identity=29.9065420560748, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24654903, Length=224, Percent_Identity=27.6785714285714, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24650670, Length=224, Percent_Identity=28.125, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24653139, Length=246, Percent_Identity=24.7967479674797, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357171, Length=248, Percent_Identity=26.6129032258064, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 26217; Mature: 26217

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGVTRDGQVLTLEMQRPERRNALNSELVDGLREAIEKAATEDVRAIVLTGQGHVFSSGA
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEECCC
DLSGGQGVADELPDKARALNFAIDKAPFPVIAAINGPAIGAGVILSMICDLRVVAPEAYF
CCCCCCCCHHHCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCHHHH
QFPVAKYGIALDNWSIRRLTSLVGAGRARGMLLAAERLTAEVALQTGMANRIGALADAQA
HCCHHHHCEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
WAQEIAGFAPLALQHAKRVLNDDGAYEDPWPAHQELFDRAWASQDIIEAQVARIEKRPPR
HHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
FQGA
CCCC
>Mature Secondary Structure
MIGVTRDGQVLTLEMQRPERRNALNSELVDGLREAIEKAATEDVRAIVLTGQGHVFSSGA
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEECCC
DLSGGQGVADELPDKARALNFAIDKAPFPVIAAINGPAIGAGVILSMICDLRVVAPEAYF
CCCCCCCCHHHCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCHHHH
QFPVAKYGIALDNWSIRRLTSLVGAGRARGMLLAAERLTAEVALQTGMANRIGALADAQA
HCCHHHHCEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
WAQEIAGFAPLALQHAKRVLNDDGAYEDPWPAHQELFDRAWASQDIIEAQVARIEKRPPR
HHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
FQGA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]