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The map label for this gene is pbp [H]

Identifier: 108801392

GI number: 108801392

Start: 4709777

End: 4711378

Strand: Reverse

Name: pbp [H]

Synonym: Mmcs_4429

Alternate gene names: 108801392

Gene position: 4711378-4709777 (Counterclockwise)

Preceding gene: 108801393

Following gene: 108801391

Centisome position: 82.58

GC content: 68.16

Gene sequence:

>1602_bases
GTGCAGGCTGTGAAACGCCGACTCCTGCCGCTGGTCGCCCTCGCCGCGACACTCGCCCTCGTCGCGGGATGTGACTCCGC
GCCGACCGAGGAGGCGCAGTCGACACAGCCGCCACCGGCCACACCTCAGTCCGACGTCCCGCCGCCGCTCGTGGCGGCGG
TGCCGCTGCCGGACAACGCCGTGGACAAGGCCGTCGGACAACTCGACGGCATGGTCGAGGAGCTACTGGCCAAGAGCGGA
ATCCCCGGTATGGCCGTCGCCGTCGTGCACGGTGGGAAAACGGTGTACGCCAAGGGTTTCGGTGTCACTGATGTCAAGAC
CGGCGCGAAAGTGGATCCGGACACGGTGTTTCAGCTCGCATCGATGTCCAAACCGCTCGGAGCCACCGTCGTCGCCCATC
AGGTCGGCCGGGGCGCGATCGGCTGGGACACCCCGATCGTGTCGAAGCTGCCGTGGTTCGCGTTGTCGGACCCCGCGGTC
ACCCAGATGGTGACCGTCGGCGACCTGTACTCACACCGCTCCGGACTGCCCGATCACGCCGGTGATCTGCTCGAAGACCT
CGGCTACGACCGCCGCGCCATCCTCGAGCGGTTGCGTGCACTTCCGCTGGCGCCGTTCCGGGATTCCTACGCCTACACCA
ACTTCGGGCTCACCGCAGCCGCTGAGGCGGTGGCCACGAGTGCGGGTAAACCGTGGGAGACACTCAGCGAGGAGGTGTTG
TACCGGCCGTTGGGGATGAACTCGACCAGCTCACGCTTCGCCGACTACGAGAAGCGGCCCGACCGCGCCGTCGGCCACAT
CCACGTCGACGGCCGCTACGAACCGCTCTATGTCCGCAATGCCGACGCGGAAGGCCCGGCGGGCGGGGCGAGTTCGTCGG
TCAACGACCTCACCAAGTGGCTCGCCATGGTTCTCGCCGACGGCAAGGCCGGCGGTCAGCAGCTCGTCGAACCCGACGCG
CTGCTGCCTGCGGTCACACCGCAGAGCGTGTCGAGTCCGGCCAGTGAACCGGCGATGCGCACCGGGTTCTACGGATTCGG
CTTCAACGTCGGCACCTCCTCGGCGGCGCGGGTGGAGCTCAGCCACTCGGGGGCCTTCGAACTGGGCTCCGGCACGAACT
TCGTCATCCTGCCGTCCGCGGACGTGGCGATCGTCGCCCTCACCAACGCGACCCCGGCCGGAGTGCCCGAAACGCTGACC
GCCCAGTTCGCCGACCTCGTGCAGTTCGGCGAGGTGCGAGAGGACTGGTACGGCCTCTACCACCAGGCGTTCGCCGACAT
GGAGAAGCCGCTCGGCTCGCTCGTCGGCAAGCAGCCGCCGGCGAATCCCGCTCCGCCCGCACCGCTTCCGTCGTACGCGG
GGGTCTACAACAACGATTTCTGGGGGCCTGCCGAGGTCACCGAAGCCGGCGGCACACTCGGCCTGCGGGTCGGGCCGCGC
GGCGAGGTCTGGCCGCTGAAGCACTGGGACGGCAATGTCTTCACGTTCAGCTTCGTCTCGGAGAACTCGCCGCCGGGGTC
GGTCTCGGAAGCCACCTTCGACGGGAACCGGCTGACGCTGGAGTACTTCGACGAGGAACACAACGGGGTGTTCTTCCGAT
GA

Upstream 100 bases:

>100_bases
TCCGGCCGGGGTGAGCGTCGTGGTGCCCAAGCCGGGCCAGCGTGTGGAGCGTGGCGCGTCACCGGCGATAGAGCCGTGGT
GGCAGCTCTGAGGGGCTAGC

Downstream 100 bases:

>100_bases
GCGCTTGCGCGAAGAGCCGAGGCCCCCGATGAGCGCTTGCGCGAAGAGCCGAGGCCCCCGATGAGCGCTTGCGCGAAGAG
CCGAGGCCCCCGATGAGCGC

Product: beta-lactamase

Products: NA

Alternate protein names: PBP-4 [H]

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MQAVKRRLLPLVALAATLALVAGCDSAPTEEAQSTQPPPATPQSDVPPPLVAAVPLPDNAVDKAVGQLDGMVEELLAKSG
IPGMAVAVVHGGKTVYAKGFGVTDVKTGAKVDPDTVFQLASMSKPLGATVVAHQVGRGAIGWDTPIVSKLPWFALSDPAV
TQMVTVGDLYSHRSGLPDHAGDLLEDLGYDRRAILERLRALPLAPFRDSYAYTNFGLTAAAEAVATSAGKPWETLSEEVL
YRPLGMNSTSSRFADYEKRPDRAVGHIHVDGRYEPLYVRNADAEGPAGGASSSVNDLTKWLAMVLADGKAGGQQLVEPDA
LLPAVTPQSVSSPASEPAMRTGFYGFGFNVGTSSAARVELSHSGAFELGSGTNFVILPSADVAIVALTNATPAGVPETLT
AQFADLVQFGEVREDWYGLYHQAFADMEKPLGSLVGKQPPANPAPPAPLPSYAGVYNNDFWGPAEVTEAGGTLGLRVGPR
GEVWPLKHWDGNVFTFSFVSENSPPGSVSEATFDGNRLTLEYFDEEHNGVFFR

Sequences:

>Translated_533_residues
MQAVKRRLLPLVALAATLALVAGCDSAPTEEAQSTQPPPATPQSDVPPPLVAAVPLPDNAVDKAVGQLDGMVEELLAKSG
IPGMAVAVVHGGKTVYAKGFGVTDVKTGAKVDPDTVFQLASMSKPLGATVVAHQVGRGAIGWDTPIVSKLPWFALSDPAV
TQMVTVGDLYSHRSGLPDHAGDLLEDLGYDRRAILERLRALPLAPFRDSYAYTNFGLTAAAEAVATSAGKPWETLSEEVL
YRPLGMNSTSSRFADYEKRPDRAVGHIHVDGRYEPLYVRNADAEGPAGGASSSVNDLTKWLAMVLADGKAGGQQLVEPDA
LLPAVTPQSVSSPASEPAMRTGFYGFGFNVGTSSAARVELSHSGAFELGSGTNFVILPSADVAIVALTNATPAGVPETLT
AQFADLVQFGEVREDWYGLYHQAFADMEKPLGSLVGKQPPANPAPPAPLPSYAGVYNNDFWGPAEVTEAGGTLGLRVGPR
GEVWPLKHWDGNVFTFSFVSENSPPGSVSEATFDGNRLTLEYFDEEHNGVFFR
>Mature_533_residues
MQAVKRRLLPLVALAATLALVAGCDSAPTEEAQSTQPPPATPQSDVPPPLVAAVPLPDNAVDKAVGQLDGMVEELLAKSG
IPGMAVAVVHGGKTVYAKGFGVTDVKTGAKVDPDTVFQLASMSKPLGATVVAHQVGRGAIGWDTPIVSKLPWFALSDPAV
TQMVTVGDLYSHRSGLPDHAGDLLEDLGYDRRAILERLRALPLAPFRDSYAYTNFGLTAAAEAVATSAGKPWETLSEEVL
YRPLGMNSTSSRFADYEKRPDRAVGHIHVDGRYEPLYVRNADAEGPAGGASSSVNDLTKWLAMVLADGKAGGQQLVEPDA
LLPAVTPQSVSSPASEPAMRTGFYGFGFNVGTSSAARVELSHSGAFELGSGTNFVILPSADVAIVALTNATPAGVPETLT
AQFADLVQFGEVREDWYGLYHQAFADMEKPLGSLVGKQPPANPAPPAPLPSYAGVYNNDFWGPAEVTEAGGTLGLRVGPR
GEVWPLKHWDGNVFTFSFVSENSPPGSVSEATFDGNRLTLEYFDEEHNGVFFR

Specific function: Involved in cell wall biosynthesis and may also act as a sensor of external penicillins [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-lactamase family [H]

Homologues:

Organism=Escherichia coli, GI1786574, Length=249, Percent_Identity=24.4979919678715, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115533026, Length=201, Percent_Identity=31.3432835820896, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17550934, Length=296, Percent_Identity=23.3108108108108, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: NA

Molecular weight: Translated: 56253; Mature: 56253

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAVKRRLLPLVALAATLALVAGCDSAPTEEAQSTQPPPATPQSDVPPPLVAAVPLPDNA
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCEEEEECCCCHH
VDKAVGQLDGMVEELLAKSGIPGMAVAVVHGGKTVYAKGFGVTDVKTGAKVDPDTVFQLA
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEEEECCCCCCCCCCCCCCCHHHHHHHH
SMSKPLGATVVAHQVGRGAIGWDTPIVSKLPWFALSDPAVTQMVTVGDLYSHRSGLPDHA
HCCCCCCHHHHHHHHCCCCCCCCCCHHHHCCCEEECCCHHHHHHHHHHHHHHCCCCCHHH
GDLLEDLGYDRRAILERLRALPLAPFRDSYAYTNFGLTAAAEAVATSAGKPWETLSEEVL
HHHHHHCCCCHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHCCCCCHHHHHHHHH
YRPLGMNSTSSRFADYEKRPDRAVGHIHVDGRYEPLYVRNADAEGPAGGASSSVNDLTKW
HCCCCCCCCHHHHHHHHCCCCCCEEEEEECCEECEEEEECCCCCCCCCCCCCCHHHHHHH
LAMVLADGKAGGQQLVEPDALLPAVTPQSVSSPASEPAMRTGFYGFGFNVGTSSAARVEL
HHHHHHCCCCCCCHHCCCCHHCCCCCCHHCCCCCCCCHHHHCCEEECCCCCCCCCEEEEE
SHSGAFELGSGTNFVILPSADVAIVALTNATPAGVPETLTAQFADLVQFGEVREDWYGLY
CCCCCEEECCCCCEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HQAFADMEKPLGSLVGKQPPANPAPPAPLPSYAGVYNNDFWGPAEVTEAGGTLGLRVGPR
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEEECCC
GEVWPLKHWDGNVFTFSFVSENSPPGSVSEATFDGNRLTLEYFDEEHNGVFFR
CCCCEEEECCCCEEEEEEECCCCCCCCCCCEEECCCEEEEEEECCCCCCEECC
>Mature Secondary Structure
MQAVKRRLLPLVALAATLALVAGCDSAPTEEAQSTQPPPATPQSDVPPPLVAAVPLPDNA
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCEEEEECCCCHH
VDKAVGQLDGMVEELLAKSGIPGMAVAVVHGGKTVYAKGFGVTDVKTGAKVDPDTVFQLA
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEEEECCCCCCCCCCCCCCCHHHHHHHH
SMSKPLGATVVAHQVGRGAIGWDTPIVSKLPWFALSDPAVTQMVTVGDLYSHRSGLPDHA
HCCCCCCHHHHHHHHCCCCCCCCCCHHHHCCCEEECCCHHHHHHHHHHHHHHCCCCCHHH
GDLLEDLGYDRRAILERLRALPLAPFRDSYAYTNFGLTAAAEAVATSAGKPWETLSEEVL
HHHHHHCCCCHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHCCCCCHHHHHHHHH
YRPLGMNSTSSRFADYEKRPDRAVGHIHVDGRYEPLYVRNADAEGPAGGASSSVNDLTKW
HCCCCCCCCHHHHHHHHCCCCCCEEEEEECCEECEEEEECCCCCCCCCCCCCCHHHHHHH
LAMVLADGKAGGQQLVEPDALLPAVTPQSVSSPASEPAMRTGFYGFGFNVGTSSAARVEL
HHHHHHCCCCCCCHHCCCCHHCCCCCCHHCCCCCCCCHHHHCCEEECCCCCCCCCEEEEE
SHSGAFELGSGTNFVILPSADVAIVALTNATPAGVPETLTAQFADLVQFGEVREDWYGLY
CCCCCEEECCCCCEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HQAFADMEKPLGSLVGKQPPANPAPPAPLPSYAGVYNNDFWGPAEVTEAGGTLGLRVGPR
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEEECCC
GEVWPLKHWDGNVFTFSFVSENSPPGSVSEATFDGNRLTLEYFDEEHNGVFFR
CCCCEEEECCCCEEEEEEECCCCCCCCCCCEEECCCEEEEEEECCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8440253 [H]