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The map label for this gene is puuP [H]

Identifier: 108801332

GI number: 108801332

Start: 4647987

End: 4649360

Strand: Reverse

Name: puuP [H]

Synonym: Mmcs_4368

Alternate gene names: 108801332

Gene position: 4649360-4647987 (Counterclockwise)

Preceding gene: 108801333

Following gene: 108801322

Centisome position: 81.49

GC content: 66.45

Gene sequence:

>1374_bases
ATGTCCTCGACCACACCCCTGAACCCGTCCGTCGGGGAGGGTGAGGGACAGCTTCGCCGCGTGCTCGGCGTGCCGTCCCT
GGTGCTGTTCGGCCTGGTCTACATGGTGCCGCTCACCGTGTTCACCACCTACGGGATCGTCACCGTGGAATCCGGTGGCC
GCGTACCGCTGGCCTACGTGGTGACGCTGGCGGCGATGATCTTCACCGCGCGGTCGTATGCGCGGATGGCGGCCGCGTAC
CCGGTCGCCGGGTCGGCGTATGCCTACACGCAGAAGACGTTCGGCGCGCCCGTCGGATTCCTCGCCGGCTGGTCGCTGCT
GCTGGACTACCTGTTCCTGCCGATGCTCAACTACCTCGTCATCGGCCTCTACCTCAACGCCGCGGTGCCCGCGATCCCGC
AGTGGCTCATCGTGGTGGTGACCATCGCCATCGTGACGGTGCTCAACATCATCGGCATCGTGTCCGTGGCGCGGGCCAAC
CTGCTCATCATCGCGATCCAGGCGATCTTCATCGTGGTGTTCATCGTCATGGCGGTTGCGGCGGTCTCGGGTTCGGGAAG
CGTCGACGTGATGGCGCCGTTCCGCGGCGACGGCACCGCGGACGGGATGGCCCCCGTCTTGGCGGGTGCGGCGATCCTGT
GCCTGTCGTTCCTCGGGTTCGACGCCGTGTCAACGCTTTCCGAGGAGGCCAGGGACGCGCGACGCGATGTGCCCAAGGCC
ATCATGCTGGCGACGATCATCTGCGGCGTGCTGTTCATCATCCTGTCCTACGTATCGCAGCTGGTGTTCCCGTCGAATGC
GTTCACCGACGTCGACTCGGGTTCGCTCGACGTCATGCAGTCCGCGGGCGGGGCGTTCCTGGCGGCGTTCTTCACCGCGG
CGTACGTCGCGGGCGCATCGGGGTCGGCGCTCACGTCGCAGGCGTCGGTGGCGCGCATTCTGTACGCGATGGGGCGCGAC
GGTGTGTTGCCCCGCAAGGTGTTCGGGCATGTCTCGGTGAAGTTCGGCACGCCGACGTGGGCGGTCCTGGTGATCTCGAT
CGTCTCGCTGCTGGCACTCGTGATCGACCTGGCGATCCTGGCCTCGGTCGTGAGCTTCGGTGCGCTGGTGGCTTTCTCGG
CGGTCAACCTGACCGTGATCAAGCACTACTTCGTCGACGCCGGCGAGAAGAACGTGGTCAACAACCTGGTCTTGCCGTTG
ATCGGCTTCGTGCTGACGGTGTGGCTGTGGACGAGCCTGTCGGCCGAGTCGCTCACGATCGGATTGATCTGGCTGGCGAT
CGGCTTCCTGTGGCTGCTCGGCGTCACCCGCGGCTTCCGTCGCCCGACACCGGTCCTCGACCTGGAGGAGCTGCCGGCTC
AGCCGGCGAAGTAG

Upstream 100 bases:

>100_bases
CGAGATCGACGCCCGCGCTGGAGATTCCGGCGATCGAGGTGCGCGGAACGTGTCTGGCGGGCAAGCTCGTAGGGCCGTCG
GCCCGCTGAAGGGAGTTCTC

Downstream 100 bases:

>100_bases
CTCACCAGGATCTTGCGGCCGCGACCAGCCCCTGCACCAGCGCCGAGGTGGCGGGGGAGAGACCGTCGTCGCCCGGCAGC
GGGCTGCGCGGGCTCAGGCC

Product: amino acid permease-associated protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MSSTTPLNPSVGEGEGQLRRVLGVPSLVLFGLVYMVPLTVFTTYGIVTVESGGRVPLAYVVTLAAMIFTARSYARMAAAY
PVAGSAYAYTQKTFGAPVGFLAGWSLLLDYLFLPMLNYLVIGLYLNAAVPAIPQWLIVVVTIAIVTVLNIIGIVSVARAN
LLIIAIQAIFIVVFIVMAVAAVSGSGSVDVMAPFRGDGTADGMAPVLAGAAILCLSFLGFDAVSTLSEEARDARRDVPKA
IMLATIICGVLFIILSYVSQLVFPSNAFTDVDSGSLDVMQSAGGAFLAAFFTAAYVAGASGSALTSQASVARILYAMGRD
GVLPRKVFGHVSVKFGTPTWAVLVISIVSLLALVIDLAILASVVSFGALVAFSAVNLTVIKHYFVDAGEKNVVNNLVLPL
IGFVLTVWLWTSLSAESLTIGLIWLAIGFLWLLGVTRGFRRPTPVLDLEELPAQPAK

Sequences:

>Translated_457_residues
MSSTTPLNPSVGEGEGQLRRVLGVPSLVLFGLVYMVPLTVFTTYGIVTVESGGRVPLAYVVTLAAMIFTARSYARMAAAY
PVAGSAYAYTQKTFGAPVGFLAGWSLLLDYLFLPMLNYLVIGLYLNAAVPAIPQWLIVVVTIAIVTVLNIIGIVSVARAN
LLIIAIQAIFIVVFIVMAVAAVSGSGSVDVMAPFRGDGTADGMAPVLAGAAILCLSFLGFDAVSTLSEEARDARRDVPKA
IMLATIICGVLFIILSYVSQLVFPSNAFTDVDSGSLDVMQSAGGAFLAAFFTAAYVAGASGSALTSQASVARILYAMGRD
GVLPRKVFGHVSVKFGTPTWAVLVISIVSLLALVIDLAILASVVSFGALVAFSAVNLTVIKHYFVDAGEKNVVNNLVLPL
IGFVLTVWLWTSLSAESLTIGLIWLAIGFLWLLGVTRGFRRPTPVLDLEELPAQPAK
>Mature_456_residues
SSTTPLNPSVGEGEGQLRRVLGVPSLVLFGLVYMVPLTVFTTYGIVTVESGGRVPLAYVVTLAAMIFTARSYARMAAAYP
VAGSAYAYTQKTFGAPVGFLAGWSLLLDYLFLPMLNYLVIGLYLNAAVPAIPQWLIVVVTIAIVTVLNIIGIVSVARANL
LIIAIQAIFIVVFIVMAVAAVSGSGSVDVMAPFRGDGTADGMAPVLAGAAILCLSFLGFDAVSTLSEEARDARRDVPKAI
MLATIICGVLFIILSYVSQLVFPSNAFTDVDSGSLDVMQSAGGAFLAAFFTAAYVAGASGSALTSQASVARILYAMGRDG
VLPRKVFGHVSVKFGTPTWAVLVISIVSLLALVIDLAILASVVSFGALVAFSAVNLTVIKHYFVDAGEKNVVNNLVLPLI
GFVLTVWLWTSLSAESLTIGLIWLAIGFLWLLGVTRGFRRPTPVLDLEELPAQPAK

Specific function: Imports putrescine [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=394, Percent_Identity=29.1878172588832, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI258645169, Length=412, Percent_Identity=27.1844660194175, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI258614005, Length=412, Percent_Identity=26.2135922330097, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI258614003, Length=412, Percent_Identity=26.2135922330097, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI110347453, Length=349, Percent_Identity=29.512893982808, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI4507047, Length=408, Percent_Identity=25.2450980392157, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI114326544, Length=213, Percent_Identity=27.6995305164319, Blast_Score=66, Evalue=9e-11,
Organism=Homo sapiens, GI114326550, Length=213, Percent_Identity=27.6995305164319, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI87081869, Length=460, Percent_Identity=41.304347826087, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI87082023, Length=442, Percent_Identity=41.6289592760181, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI1786602, Length=300, Percent_Identity=22.3333333333333, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788480, Length=405, Percent_Identity=22.7160493827161, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786302, Length=368, Percent_Identity=23.3695652173913, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081915, Length=288, Percent_Identity=21.5277777777778, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1786789, Length=342, Percent_Identity=22.5146198830409, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789017, Length=337, Percent_Identity=23.4421364985163, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87081708, Length=425, Percent_Identity=23.0588235294118, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=431, Percent_Identity=26.2180974477958, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17531343, Length=454, Percent_Identity=23.568281938326, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17533459, Length=198, Percent_Identity=28.7878787878788, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI221512776, Length=424, Percent_Identity=25.7075471698113, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24666159, Length=420, Percent_Identity=25.7142857142857, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24668806, Length=416, Percent_Identity=27.4038461538462, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21356285, Length=416, Percent_Identity=27.4038461538462, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24668802, Length=416, Percent_Identity=27.4038461538462, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI281366235, Length=418, Percent_Identity=25.8373205741627, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI116007820, Length=418, Percent_Identity=25.8373205741627, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI116007818, Length=406, Percent_Identity=26.6009852216749, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI85725152, Length=406, Percent_Identity=26.6009852216749, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24667468, Length=392, Percent_Identity=24.7448979591837, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI161077963, Length=329, Percent_Identity=23.7082066869301, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48064; Mature: 47933

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCC
>Mature Secondary Structure 
SSTTPLNPSVGEGEGQLRRVLGVPSLVLFGLVYMVPLTVFTTYGIVTVESGGRVPLAYV
CCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHH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HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]