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The map label for this gene is 108801316

Identifier: 108801316

GI number: 108801316

Start: 4630552

End: 4632828

Strand: Reverse

Name: 108801316

Synonym: Mmcs_4352

Alternate gene names: NA

Gene position: 4632828-4630552 (Counterclockwise)

Preceding gene: 108801318

Following gene: 108801315

Centisome position: 81.2

GC content: 67.06

Gene sequence:

>2277_bases
GTGGTGGATCACTTCGGTCGGGTGCGCCTGACCAACCCGGACAAGGTGCTGTACCCGGCGACGGGCACCACCAAGGCCGA
GGTGTTCGAGTACTACGTCGACGTGGCCGAGGCGATGGTGCCGCACATCGCCGGCCGGGCGGTCACCCGTAAGCGCTGGC
CCAACGGCGTCGGCGAGCTGGAGTTCTTCGAGAAGCAGCTGGCCAGCTCCGCACCCGACTGGCTCGCGCGCGGCACGATC
GTGCACAAATCCGGCACCACCACCTACCCGATCATCGACACCCGCGAAGGTCTGGCGTGGATCGCGCAGCAGGCCGCGCT
GGAGGTGCACGTGCCGCAGTGGCGGTTCGTCGGATCGGGTGGCGACTTGACTCCCGGCCCGGCCACCCGCATCGTGTTCG
ACCTCGACCCCGGCGAGGGCGTCACGTTCCGTCAGCTGTGCGAGGTCGCGCACGAGGTCCGCGACCTGATCACCGACATC
GGGCTCACGGCCTATCCGCTGACCAGCGGCAGCAAGGGCCTGCACCTCTACGTCCCGCTCAAGGAGCCGATCAGCTCCCA
GGGCGCGTCGGTGCTCGCTAAACGCGTCGCCCAACAGCTCGAGAAGGCCATGCCCAAACAGGTCACCGCCACGATGACCA
AGAGCCTGCGCGAGGGCAAGGTGTTCCTCGACTGGAGCCAGAACAACGGCAACAAGACCACGATCGCGCCGTACTCCCTG
CGCGGCCGCGAGCATCCAACGGTTGCGGCGCCGCGCACCTGGGAGGAGATCGAGGACCCCGACCTGAGACATCTGCGATT
CGACGAAGTGCTCGAGCGGATCGAGGAGTTCGGGGACCTGCTGGCCGATCTCGACGAGTACGTGCCTGTCGAGGACCGGC
TCACCAAGTACCGCAGCATGCGCGACCCGTCGAGGACGCCGGAGCCCGTGCCGCCGCTACCGCCGAAGGCCGGCAACAAC
GACCGCTTCGTGATCCAGGAACACCATGCCCGGCGGCTGCACTACGACCTGCGTCTGGAACGCGACGGTGTGCTGGTCAG
CTGGGCGGTGCCGAAGAACCTGCCCGACCGGCCCTCGGAGAACCACCTCGCCGTGCACACCGAGGACCATCCGATGGAGT
ACCTCACCTTCCACGGCACCATCCCGAAGGGTGAGTACGGCGGCGGCGACATGATCGTCTGGGACACCGGCACGTATGAG
ACCGAGAAGTTCAACGACCACGCCCCGGACGGACCCGCCAAGGGCGGGGAGGTCATCATCACCCTGCACGGCAACAGGAT
CGACGGCCGTTACGCACTGATCCAGACCGACGGCAAGAACTGGCTCGCGCACCGGATGAAGGATCAGGGCAACCCGACGT
TCGAGGACTTCGCGCCTATGCTGGCCACCCACGGCTCGGTCGAGAAGTTCACGGCGAAACAGTGGGCGTTCGAAGGCAAG
TGGGACGGCTACCGGCTGCTGGTCGACGCCGACCATGGCAAGCTGTGCCTGAAGTCCCGCAGCGGCCGCGACGTCACCGC
AGAATATCCCCAATTGCGCGCGCTGGCAGCAGATCTCGCCGACCACCATGTCGTGCTCGACGGGGAGGTCGTCGCCCTCG
ATGACAAGGGCGTGCCGAGCTTCGGCCATATGCAGAACCGGGCCCGGTCCACCCGTGTCGAGTTCTGGGCGTTCGACATC
CTGCGCCTCGACGGCCGTTGGCTGCTGAAGGCGAAGTACCGAGACCGCCGAAAGCTGTTGGAGACGTTGGCCAGTGGGGG
CGGACTGATCGTGCAACCCCTACTCGACGGCGACGGCCTCGAGGCTCTCGAGGACGCCCGCAAACGCAGGTGGGAGGGTG
TGGTCGCCAAGAAATGGGATTCCACCTATCAGCCGGGGCGGCGCTCGTCGGCGTGGATCAAGGACAAACTGTGGAACACC
CAGGAGGTCGTGATCGGCGGGTGGCGCGAAGGCAACGGCGGCCGCAGCAGCGGCATCGGCGCACTGGTGCTCGGCATCCC
CGGACCCGACGGCCTGCAGTTCGTCGGCCGAGTCGGCACCGGGTTCACCGAGAAGGAACTCGGCAGTCTCAAGAAGACGT
TGGCGCCGCTGCACACCTACGAATCCCCCTTCGCGACAAGGCTTCCCACCCAGGACGCCAAGGGCGTGACGTTCGTGCGG
CCCGAACTCGTCGGCGAGGTGCGTTACAGCGAGCGTACCGGCGACGGCCGGTTGCGCCAACCGTCCTGGCGGGGGCTGCG
ACCGGACAAGACGCCGGACGACGTCGTGTGGGAGTAG

Upstream 100 bases:

>100_bases
AACGGCGAGTTCTACACCAGGGTCGTGCCGCGGCGCCGACAACGACCCTCACGTAGAACTCGGCGACGAGCCAAACGCAT
CGAACGGGTAATACCGTGAC

Downstream 100 bases:

>100_bases
GTGCGGTCGATGTCGCATCGAGCGGTGTGGATTTGTCGGTGGTCGAATGTATGTTCGAGGTATGTCAGGGCACGACCTCC
AGGCCGCGGTGACCGCGCTG

Product: ATP-dependent DNA ligase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 758; Mature: 758

Protein sequence:

>758_residues
MVDHFGRVRLTNPDKVLYPATGTTKAEVFEYYVDVAEAMVPHIAGRAVTRKRWPNGVGELEFFEKQLASSAPDWLARGTI
VHKSGTTTYPIIDTREGLAWIAQQAALEVHVPQWRFVGSGGDLTPGPATRIVFDLDPGEGVTFRQLCEVAHEVRDLITDI
GLTAYPLTSGSKGLHLYVPLKEPISSQGASVLAKRVAQQLEKAMPKQVTATMTKSLREGKVFLDWSQNNGNKTTIAPYSL
RGREHPTVAAPRTWEEIEDPDLRHLRFDEVLERIEEFGDLLADLDEYVPVEDRLTKYRSMRDPSRTPEPVPPLPPKAGNN
DRFVIQEHHARRLHYDLRLERDGVLVSWAVPKNLPDRPSENHLAVHTEDHPMEYLTFHGTIPKGEYGGGDMIVWDTGTYE
TEKFNDHAPDGPAKGGEVIITLHGNRIDGRYALIQTDGKNWLAHRMKDQGNPTFEDFAPMLATHGSVEKFTAKQWAFEGK
WDGYRLLVDADHGKLCLKSRSGRDVTAEYPQLRALAADLADHHVVLDGEVVALDDKGVPSFGHMQNRARSTRVEFWAFDI
LRLDGRWLLKAKYRDRRKLLETLASGGGLIVQPLLDGDGLEALEDARKRRWEGVVAKKWDSTYQPGRRSSAWIKDKLWNT
QEVVIGGWREGNGGRSSGIGALVLGIPGPDGLQFVGRVGTGFTEKELGSLKKTLAPLHTYESPFATRLPTQDAKGVTFVR
PELVGEVRYSERTGDGRLRQPSWRGLRPDKTPDDVVWE

Sequences:

>Translated_758_residues
MVDHFGRVRLTNPDKVLYPATGTTKAEVFEYYVDVAEAMVPHIAGRAVTRKRWPNGVGELEFFEKQLASSAPDWLARGTI
VHKSGTTTYPIIDTREGLAWIAQQAALEVHVPQWRFVGSGGDLTPGPATRIVFDLDPGEGVTFRQLCEVAHEVRDLITDI
GLTAYPLTSGSKGLHLYVPLKEPISSQGASVLAKRVAQQLEKAMPKQVTATMTKSLREGKVFLDWSQNNGNKTTIAPYSL
RGREHPTVAAPRTWEEIEDPDLRHLRFDEVLERIEEFGDLLADLDEYVPVEDRLTKYRSMRDPSRTPEPVPPLPPKAGNN
DRFVIQEHHARRLHYDLRLERDGVLVSWAVPKNLPDRPSENHLAVHTEDHPMEYLTFHGTIPKGEYGGGDMIVWDTGTYE
TEKFNDHAPDGPAKGGEVIITLHGNRIDGRYALIQTDGKNWLAHRMKDQGNPTFEDFAPMLATHGSVEKFTAKQWAFEGK
WDGYRLLVDADHGKLCLKSRSGRDVTAEYPQLRALAADLADHHVVLDGEVVALDDKGVPSFGHMQNRARSTRVEFWAFDI
LRLDGRWLLKAKYRDRRKLLETLASGGGLIVQPLLDGDGLEALEDARKRRWEGVVAKKWDSTYQPGRRSSAWIKDKLWNT
QEVVIGGWREGNGGRSSGIGALVLGIPGPDGLQFVGRVGTGFTEKELGSLKKTLAPLHTYESPFATRLPTQDAKGVTFVR
PELVGEVRYSERTGDGRLRQPSWRGLRPDKTPDDVVWE
>Mature_758_residues
MVDHFGRVRLTNPDKVLYPATGTTKAEVFEYYVDVAEAMVPHIAGRAVTRKRWPNGVGELEFFEKQLASSAPDWLARGTI
VHKSGTTTYPIIDTREGLAWIAQQAALEVHVPQWRFVGSGGDLTPGPATRIVFDLDPGEGVTFRQLCEVAHEVRDLITDI
GLTAYPLTSGSKGLHLYVPLKEPISSQGASVLAKRVAQQLEKAMPKQVTATMTKSLREGKVFLDWSQNNGNKTTIAPYSL
RGREHPTVAAPRTWEEIEDPDLRHLRFDEVLERIEEFGDLLADLDEYVPVEDRLTKYRSMRDPSRTPEPVPPLPPKAGNN
DRFVIQEHHARRLHYDLRLERDGVLVSWAVPKNLPDRPSENHLAVHTEDHPMEYLTFHGTIPKGEYGGGDMIVWDTGTYE
TEKFNDHAPDGPAKGGEVIITLHGNRIDGRYALIQTDGKNWLAHRMKDQGNPTFEDFAPMLATHGSVEKFTAKQWAFEGK
WDGYRLLVDADHGKLCLKSRSGRDVTAEYPQLRALAADLADHHVVLDGEVVALDDKGVPSFGHMQNRARSTRVEFWAFDI
LRLDGRWLLKAKYRDRRKLLETLASGGGLIVQPLLDGDGLEALEDARKRRWEGVVAKKWDSTYQPGRRSSAWIKDKLWNT
QEVVIGGWREGNGGRSSGIGALVLGIPGPDGLQFVGRVGTGFTEKELGSLKKTLAPLHTYESPFATRLPTQDAKGVTFVR
PELVGEVRYSERTGDGRLRQPSWRGLRPDKTPDDVVWE

Specific function: Unknown

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=276, Percent_Identity=28.9855072463768, Blast_Score=84, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71985269, Length=346, Percent_Identity=27.7456647398844, Blast_Score=94, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320038, Length=269, Percent_Identity=26.3940520446097, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24762424, Length=267, Percent_Identity=29.5880149812734, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR014146
- InterPro:   IPR002755
- InterPro:   IPR014144
- InterPro:   IPR014145
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF01896 DNA_primase_S [H]

EC number: NA

Molecular weight: Translated: 84909; Mature: 84909

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDHFGRVRLTNPDKVLYPATGTTKAEVFEYYVDVAEAMVPHIAGRAVTRKRWPNGVGEL
CCCCCCCEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHH
EFFEKQLASSAPDWLARGTIVHKSGTTTYPIIDTREGLAWIAQQAALEVHVPQWRFVGSG
HHHHHHHHCCCCCHHHCCEEEECCCCEEECEEECCCHHHHHHHHHEEEEECCCEEEECCC
GDLTPGPATRIVFDLDPGEGVTFRQLCEVAHEVRDLITDIGLTAYPLTSGSKGLHLYVPL
CCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEC
KEPISSQGASVLAKRVAQQLEKAMPKQVTATMTKSLREGKVFLDWSQNNGNKTTIAPYSL
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEEEE
RGREHPTVAAPRTWEEIEDPDLRHLRFDEVLERIEEFGDLLADLDEYVPVEDRLTKYRSM
CCCCCCCCCCCCCHHHCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
RDPSRTPEPVPPLPPKAGNNDRFVIQEHHARRLHYDLRLERDGVLVSWAVPKNLPDRPSE
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEEECCCEEEEEECCCCCCCCCCC
NHLAVHTEDHPMEYLTFHGTIPKGEYGGGDMIVWDTGTYETEKFNDHAPDGPAKGGEVII
CEEEEECCCCCEEEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEE
TLHGNRIDGRYALIQTDGKNWLAHRMKDQGNPTFEDFAPMLATHGSVEKFTAKQWAFEGK
EEECCEECCEEEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCC
WDGYRLLVDADHGKLCLKSRSGRDVTAEYPQLRALAADLADHHVVLDGEVVALDDKGVPS
CCCEEEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEECCEEEEECCCCCCC
FGHMQNRARSTRVEFWAFDILRLDGRWLLKAKYRDRRKLLETLASGGGLIVQPLLDGDGL
HHHHHHHHHHCEEEEEEEEEEEECCCEEEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCH
EALEDARKRRWEGVVAKKWDSTYQPGRRSSAWIKDKLWNTQEVVIGGWREGNGGRSSGIG
HHHHHHHHHHHCCCCEECCCCCCCCCCCCCCHHHHHCCCCCEEEEEEEECCCCCCCCCCE
ALVLGIPGPDGLQFVGRVGTGFTEKELGSLKKTLAPLHTYESPFATRLPTQDAKGVTFVR
EEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCEEEEC
PELVGEVRYSERTGDGRLRQPSWRGLRPDKTPDDVVWE
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVDHFGRVRLTNPDKVLYPATGTTKAEVFEYYVDVAEAMVPHIAGRAVTRKRWPNGVGEL
CCCCCCCEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHH
EFFEKQLASSAPDWLARGTIVHKSGTTTYPIIDTREGLAWIAQQAALEVHVPQWRFVGSG
HHHHHHHHCCCCCHHHCCEEEECCCCEEECEEECCCHHHHHHHHHEEEEECCCEEEECCC
GDLTPGPATRIVFDLDPGEGVTFRQLCEVAHEVRDLITDIGLTAYPLTSGSKGLHLYVPL
CCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEC
KEPISSQGASVLAKRVAQQLEKAMPKQVTATMTKSLREGKVFLDWSQNNGNKTTIAPYSL
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEEEE
RGREHPTVAAPRTWEEIEDPDLRHLRFDEVLERIEEFGDLLADLDEYVPVEDRLTKYRSM
CCCCCCCCCCCCCHHHCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
RDPSRTPEPVPPLPPKAGNNDRFVIQEHHARRLHYDLRLERDGVLVSWAVPKNLPDRPSE
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEEECCCEEEEEECCCCCCCCCCC
NHLAVHTEDHPMEYLTFHGTIPKGEYGGGDMIVWDTGTYETEKFNDHAPDGPAKGGEVII
CEEEEECCCCCEEEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEE
TLHGNRIDGRYALIQTDGKNWLAHRMKDQGNPTFEDFAPMLATHGSVEKFTAKQWAFEGK
EEECCEECCEEEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCC
WDGYRLLVDADHGKLCLKSRSGRDVTAEYPQLRALAADLADHHVVLDGEVVALDDKGVPS
CCCEEEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEECCEEEEECCCCCCC
FGHMQNRARSTRVEFWAFDILRLDGRWLLKAKYRDRRKLLETLASGGGLIVQPLLDGDGL
HHHHHHHHHHCEEEEEEEEEEEECCCEEEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCH
EALEDARKRRWEGVVAKKWDSTYQPGRRSSAWIKDKLWNTQEVVIGGWREGNGGRSSGIG
HHHHHHHHHHHCCCCEECCCCCCCCCCCCCCHHHHHCCCCCEEEEEEEECCCCCCCCCCE
ALVLGIPGPDGLQFVGRVGTGFTEKELGSLKKTLAPLHTYESPFATRLPTQDAKGVTFVR
EEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCEEEEC
PELVGEVRYSERTGDGRLRQPSWRGLRPDKTPDDVVWE
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]