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The map label for this gene is moeA1 [H]

Identifier: 108801253

GI number: 108801253

Start: 4556730

End: 4557989

Strand: Reverse

Name: moeA1 [H]

Synonym: Mmcs_4289

Alternate gene names: 108801253

Gene position: 4557989-4556730 (Counterclockwise)

Preceding gene: 108801254

Following gene: 108801252

Centisome position: 79.89

GC content: 72.14

Gene sequence:

>1260_bases
GTGCGTTCGGTTGAGGAGCAGCAGGCTCGGATAGCGGCCGCCGCGGTGGCTCCGCGACCGGTACGGGTTGCCATCGCCGA
ATCCCAGGGCCTGATGTGCGCCGAAGAGGTGGTCACCGAGCGGCCGATGCCCGGATTCGATCAGGCCGCGATCGACGGGT
ACGCGGTGCGCAGTGTCGACGTCCTCGGCGTCGGCGGCGGTCCCGGGGCCGATGACCACGACGGCCGTGACGTCAGCCTC
CCGGTGATGGCCATGATCGAGGCCGGTGCCCGGACCCCGAGCCGGTTACAACCCCGGCAGGCCGCCCGGGTGCAGACCGG
TGCGCCGATGCCGACGTTGGCCGATGCGGTGCTGCCCCTGCGGTGGACCGATGGCGGCGCGAATCGCGTGCGGGTGCTGC
GCGGGGTGCGCTCCGGTGCGTATGTGCGCCGCGCCGGCGACGATGTACAGCCCGGTGACGTGGCGGTGCGTGCGGGCACC
ATCATCGGCCCGGCGCAGGTGGGTCTGTTGGCGGCGGTCGGGCGGGAGCGGGTGCTGGTGCATCCGCGGCCGCGGCTTTC
GGTGATGAGCGTGGGCGGTGAGCTGGTCGACATCTCCCGCACCCCGGGCAACGGCCAGGTCTACGACGTGAACTCGTACG
CCCTGGCCGCCGCGGGGCGCGATGCGGGTGCGGAGGTGAACCGGGTCGGCATCGTCGACACCGACCCCGCCCGGCTCCGG
GAGATCGTCGAGGGGCAGCTCAACCGGGCCGAGATCGTGGTGATCGCCGGTGCGGTCGGCGGCGCGGCGGCCGAGTCGGT
CCGCACGGTCCTCGCGGAGTTGGGGGAGATGGAGGTCTCCCGGATCGCGATGCATCCCGGTTCGGTGCAGGGCTTCGGTC
AGCTCGGCCGCGACCGGGTCCCGGTGTTCCTGTTGCCGGCCAATCCCGTCAGTGCGCTGGTGGTGTTCGAGGTGATGGTG
CGGCCGCTGATCCGGTTGTCGCTGGGCAAGCGGGCACCTATGCGCCGCATCGTCGAGGCCCGCGCCCTGTCGCCGATCAC
CTCGGTGGCCGGCCGCAAGGGCTACCTCCGCGGTCAGCTGATGCGCGATCAGGACACCGGCGAGTACCTCGTGCAGGCGC
TCGGCGGCGCCCCGGGCGCCTCGTCGCATCTGCTCGCCACGTTGGCCGAGGCAAACTGTCTGGTGATCGTCCCCACGGAC
GTCGACGAGGTCCGTACCGGTGAGACCGTGGACGTCGCCTTCCTGGCCCAACGCGGCTGA

Upstream 100 bases:

>100_bases
ACTACGGCCCCGAGCTGCGGCAGTGGTTGGTCGAGCGATTGGGCCTGACCGAGAACTAGATCTGCGCGACAGGCCCGACA
GAGGTGGAGAAAGGCGTGTT

Downstream 100 bases:

>100_bases
GCACCGCTGATCGAAGTCGAGGTGAACCTGCTGCGGTCGAGTTCTCTCCACCCTGGATGGCCGATGCCGGCGGGCCCGCT
GCGGGTGCCCGCCGGTGTGG

Product: MoeA-likedomain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase 1 [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MRSVEEQQARIAAAAVAPRPVRVAIAESQGLMCAEEVVTERPMPGFDQAAIDGYAVRSVDVLGVGGGPGADDHDGRDVSL
PVMAMIEAGARTPSRLQPRQAARVQTGAPMPTLADAVLPLRWTDGGANRVRVLRGVRSGAYVRRAGDDVQPGDVAVRAGT
IIGPAQVGLLAAVGRERVLVHPRPRLSVMSVGGELVDISRTPGNGQVYDVNSYALAAAGRDAGAEVNRVGIVDTDPARLR
EIVEGQLNRAEIVVIAGAVGGAAAESVRTVLAELGEMEVSRIAMHPGSVQGFGQLGRDRVPVFLLPANPVSALVVFEVMV
RPLIRLSLGKRAPMRRIVEARALSPITSVAGRKGYLRGQLMRDQDTGEYLVQALGGAPGASSHLLATLAEANCLVIVPTD
VDEVRTGETVDVAFLAQRG

Sequences:

>Translated_419_residues
MRSVEEQQARIAAAAVAPRPVRVAIAESQGLMCAEEVVTERPMPGFDQAAIDGYAVRSVDVLGVGGGPGADDHDGRDVSL
PVMAMIEAGARTPSRLQPRQAARVQTGAPMPTLADAVLPLRWTDGGANRVRVLRGVRSGAYVRRAGDDVQPGDVAVRAGT
IIGPAQVGLLAAVGRERVLVHPRPRLSVMSVGGELVDISRTPGNGQVYDVNSYALAAAGRDAGAEVNRVGIVDTDPARLR
EIVEGQLNRAEIVVIAGAVGGAAAESVRTVLAELGEMEVSRIAMHPGSVQGFGQLGRDRVPVFLLPANPVSALVVFEVMV
RPLIRLSLGKRAPMRRIVEARALSPITSVAGRKGYLRGQLMRDQDTGEYLVQALGGAPGASSHLLATLAEANCLVIVPTD
VDEVRTGETVDVAFLAQRG
>Mature_419_residues
MRSVEEQQARIAAAAVAPRPVRVAIAESQGLMCAEEVVTERPMPGFDQAAIDGYAVRSVDVLGVGGGPGADDHDGRDVSL
PVMAMIEAGARTPSRLQPRQAARVQTGAPMPTLADAVLPLRWTDGGANRVRVLRGVRSGAYVRRAGDDVQPGDVAVRAGT
IIGPAQVGLLAAVGRERVLVHPRPRLSVMSVGGELVDISRTPGNGQVYDVNSYALAAAGRDAGAEVNRVGIVDTDPARLR
EIVEGQLNRAEIVVIAGAVGGAAAESVRTVLAELGEMEVSRIAMHPGSVQGFGQLGRDRVPVFLLPANPVSALVVFEVMV
RPLIRLSLGKRAPMRRIVEARALSPITSVAGRKGYLRGQLMRDQDTGEYLVQALGGAPGASSHLLATLAEANCLVIVPTD
VDEVRTGETVDVAFLAQRG

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=401, Percent_Identity=31.1720698254364, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI66932975, Length=401, Percent_Identity=31.1720698254364, Blast_Score=145, Evalue=1e-34,
Organism=Escherichia coli, GI1787049, Length=379, Percent_Identity=32.9815303430079, Blast_Score=167, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI25147659, Length=355, Percent_Identity=28.7323943661972, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17562606, Length=335, Percent_Identity=21.4925373134328, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17136978, Length=299, Percent_Identity=26.4214046822742, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24638841, Length=299, Percent_Identity=26.4214046822742, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43893; Mature: 43893

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSVEEQQARIAAAAVAPRPVRVAIAESQGLMCAEEVVTERPMPGFDQAAIDGYAVRSVD
CCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHCCCCCCCCHHHCCCEEEEEEE
VLGVGGGPGADDHDGRDVSLPVMAMIEAGARTPSRLQPRQAARVQTGAPMPTLADAVLPL
EEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCHHHHHEEEE
RWTDGGANRVRVLRGVRSGAYVRRAGDDVQPGDVAVRAGTIIGPAQVGLLAAVGRERVLV
EECCCCCHHHHHHHHHHCCCEEEECCCCCCCCCEEEEECCEECHHHHHHHHHCCCCEEEE
HPRPRLSVMSVGGELVDISRTPGNGQVYDVNSYALAAAGRDAGAEVNRVGIVDTDPARLR
CCCCCEEEEECCCEEEEEEECCCCCEEEEECCEEEEECCCCCCCCCEEEEEEECCHHHHH
EIVEGQLNRAEIVVIAGAVGGAAAESVRTVLAELGEMEVSRIAMHPGSVQGFGQLGRDRV
HHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHEEECCCCCCHHHHCCCCCC
PVFLLPANPVSALVVFEVMVRPLIRLSLGKRAPMRRIVEARALSPITSVAGRKGYLRGQL
CEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHCCCCCEECEE
MRDQDTGEYLVQALGGAPGASSHLLATLAEANCLVIVPTDVDEVRTGETVDVAFLAQRG
ECCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEECCHHHHCCCCEEEEEEEECCC
>Mature Secondary Structure
MRSVEEQQARIAAAAVAPRPVRVAIAESQGLMCAEEVVTERPMPGFDQAAIDGYAVRSVD
CCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHCCCCCCCCHHHCCCEEEEEEE
VLGVGGGPGADDHDGRDVSLPVMAMIEAGARTPSRLQPRQAARVQTGAPMPTLADAVLPL
EEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCHHHHHEEEE
RWTDGGANRVRVLRGVRSGAYVRRAGDDVQPGDVAVRAGTIIGPAQVGLLAAVGRERVLV
EECCCCCHHHHHHHHHHCCCEEEECCCCCCCCCEEEEECCEECHHHHHHHHHCCCCEEEE
HPRPRLSVMSVGGELVDISRTPGNGQVYDVNSYALAAAGRDAGAEVNRVGIVDTDPARLR
CCCCCEEEEECCCEEEEEEECCCCCEEEEECCEEEEECCCCCCCCCEEEEEEECCHHHHH
EIVEGQLNRAEIVVIAGAVGGAAAESVRTVLAELGEMEVSRIAMHPGSVQGFGQLGRDRV
HHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHEEECCCCCCHHHHCCCCCC
PVFLLPANPVSALVVFEVMVRPLIRLSLGKRAPMRRIVEARALSPITSVAGRKGYLRGQL
CEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHCCCCCEECEE
MRDQDTGEYLVQALGGAPGASSHLLATLAEANCLVIVPTDVDEVRTGETVDVAFLAQRG
ECCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEECCHHHHCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]