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The map label for this gene is mazG [H]

Identifier: 108801208

GI number: 108801208

Start: 4506809

End: 4507771

Strand: Reverse

Name: mazG [H]

Synonym: Mmcs_4244

Alternate gene names: 108801208

Gene position: 4507771-4506809 (Counterclockwise)

Preceding gene: 108801209

Following gene: 108801205

Centisome position: 79.01

GC content: 70.09

Gene sequence:

>963_bases
ATGACGGTTGTCCTGGTCGATCCCCGCCGCCCCTCACTCGTCCCGGTCGAGGCGATCGGACTGCTCGCCGGCGACCTGCA
ATACACCGAGGAGATGCCGATCAAGGTGCCGTGGTCGCTGCCTGCGGCGCGGCCATGCTTCGCGGGTGACCCCGAAGACA
ACAGGGCGCCGGTGCTGCTGTCGTCGGATCCGGACCACCCCGCGGTCAGGTCCCGGCTGGCGGCCGGTGACCGGCTGATC
TCGGCACCCGATCCGCAGCCCGGCGAACGCCTCGTCGACGCGGTCGCGATGATGGACAAGCTGCGCACCTCGGGGCCGTG
GGAGAGCGAGCAGACCCACGCGTCGCTGCGCCGCTACCTGCTCGAGGAGACCTACGAACTCTTCGACGCGGTGCGCAGCG
GCGACGCGGACGAACTGCGGGCCGAACTCGGCGATGTGCTGCTGCAGGTGCTGTTCCACGCCCGCATCGCCGAAGACGCC
TCCCAGCATGCGTTCACCATCGACGACGTGGCCGAATCCCTGATCCGCAAACTCGGCAACCGCGTGCCGGCGGTGCTTGC
GGGAGAATCGGTTTCGCTCGACGAGCAGTTGGCGCAGTGGGAGGAGCGCAAGGCCCTCGAGAAGACGCGTGCGTCGTGTA
TGGACGACGTGCCGACCGCCCAGCCGGCGTTGGCGCTGGCGCAGAAGGTGTTGGCGCGCGTGACCGCCGCGGGGCTGCCC
GAAGACCTGATCCCCGCCACGCTCACCACGGTGCAGGTGTCGGGGGATCACGACGCCGAGAACGCGCTGCGCGCAGACGT
TCTCGAGTTCATGGACACGGTGCGCGGTGTCGAGCGCGCGGTCGCGGCCGCCCGTCGCGGTGAGGACGTCGCCGACGAAC
TCGACAGCACACCGCCCACCCGGATCACCGAGGAGGAGTGGCGGGCGCACTGGCCGACAAGGTCCGCCGAAGACCCGCGC
TAG

Upstream 100 bases:

>100_bases
GGGACGCCGAACTGGTCGCGATGGTGGCCGGTTTGGTTCTCGCGCTCAATGGAAAACCGCAGGCGCAGATCGATACGGCG
AAGTTCGGGGGGTCACGAGC

Downstream 100 bases:

>100_bases
CGTCGCATCCGGCGGGTATGTGTGAGTCCCGAATGCGATATCGCCGGTGCTAGCTGATAGCGCGGGCGATATCGAATCTC
GAAGGGACACACCACCTGGA

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MTVVLVDPRRPSLVPVEAIGLLAGDLQYTEEMPIKVPWSLPAARPCFAGDPEDNRAPVLLSSDPDHPAVRSRLAAGDRLI
SAPDPQPGERLVDAVAMMDKLRTSGPWESEQTHASLRRYLLEETYELFDAVRSGDADELRAELGDVLLQVLFHARIAEDA
SQHAFTIDDVAESLIRKLGNRVPAVLAGESVSLDEQLAQWEERKALEKTRASCMDDVPTAQPALALAQKVLARVTAAGLP
EDLIPATLTTVQVSGDHDAENALRADVLEFMDTVRGVERAVAAARRGEDVADELDSTPPTRITEEEWRAHWPTRSAEDPR

Sequences:

>Translated_320_residues
MTVVLVDPRRPSLVPVEAIGLLAGDLQYTEEMPIKVPWSLPAARPCFAGDPEDNRAPVLLSSDPDHPAVRSRLAAGDRLI
SAPDPQPGERLVDAVAMMDKLRTSGPWESEQTHASLRRYLLEETYELFDAVRSGDADELRAELGDVLLQVLFHARIAEDA
SQHAFTIDDVAESLIRKLGNRVPAVLAGESVSLDEQLAQWEERKALEKTRASCMDDVPTAQPALALAQKVLARVTAAGLP
EDLIPATLTTVQVSGDHDAENALRADVLEFMDTVRGVERAVAAARRGEDVADELDSTPPTRITEEEWRAHWPTRSAEDPR
>Mature_319_residues
TVVLVDPRRPSLVPVEAIGLLAGDLQYTEEMPIKVPWSLPAARPCFAGDPEDNRAPVLLSSDPDHPAVRSRLAAGDRLIS
APDPQPGERLVDAVAMMDKLRTSGPWESEQTHASLRRYLLEETYELFDAVRSGDADELRAELGDVLLQVLFHARIAEDAS
QHAFTIDDVAESLIRKLGNRVPAVLAGESVSLDEQLAQWEERKALEKTRASCMDDVPTAQPALALAQKVLARVTAAGLPE
DLIPATLTTVQVSGDHDAENALRADVLEFMDTVRGVERAVAAARRGEDVADELDSTPPTRITEEEWRAHWPTRSAEDPR

Specific function: Required to maintain the full capacity of the mycobacteria to respond to oxidative stress via the degradation of the oxidation-induced damaged nucleotides. It hydrolyzes all canonical (d)NTPs, as well as the mutagenic dUTP and 8-oxo-7,8- dihydro-2'-deoxyg

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=152, Percent_Identity=40.1315789473684, Blast_Score=104, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 35038; Mature: 34906

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVVLVDPRRPSLVPVEAIGLLAGDLQYTEEMPIKVPWSLPAARPCFAGDPEDNRAPVLL
CEEEEECCCCCCCCHHHHHHHHHHCHHHHCCCCEECCCCCCCCCCCCCCCCCCCCCCEEE
SSDPDHPAVRSRLAAGDRLISAPDPQPGERLVDAVAMMDKLRTSGPWESEQTHASLRRYL
CCCCCCHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LEETYELFDAVRSGDADELRAELGDVLLQVLFHARIAEDASQHAFTIDDVAESLIRKLGN
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHC
RVPAVLAGESVSLDEQLAQWEERKALEKTRASCMDDVPTAQPALALAQKVLARVTAAGLP
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
EDLIPATLTTVQVSGDHDAENALRADVLEFMDTVRGVERAVAAARRGEDVADELDSTPPT
HHHHCHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCC
RITEEEWRAHWPTRSAEDPR
CCCHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TVVLVDPRRPSLVPVEAIGLLAGDLQYTEEMPIKVPWSLPAARPCFAGDPEDNRAPVLL
EEEEECCCCCCCCHHHHHHHHHHCHHHHCCCCEECCCCCCCCCCCCCCCCCCCCCCEEE
SSDPDHPAVRSRLAAGDRLISAPDPQPGERLVDAVAMMDKLRTSGPWESEQTHASLRRYL
CCCCCCHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LEETYELFDAVRSGDADELRAELGDVLLQVLFHARIAEDASQHAFTIDDVAESLIRKLGN
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHC
RVPAVLAGESVSLDEQLAQWEERKALEKTRASCMDDVPTAQPALALAQKVLARVTAAGLP
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
EDLIPATLTTVQVSGDHDAENALRADVLEFMDTVRGVERAVAAARRGEDVADELDSTPPT
HHHHCHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCC
RITEEEWRAHWPTRSAEDPR
CCCHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA