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The map label for this gene is clcA [H]

Identifier: 108801164

GI number: 108801164

Start: 4462059

End: 4463378

Strand: Reverse

Name: clcA [H]

Synonym: Mmcs_4200

Alternate gene names: 108801164

Gene position: 4463378-4462059 (Counterclockwise)

Preceding gene: 108801165

Following gene: 108801163

Centisome position: 78.23

GC content: 71.14

Gene sequence:

>1320_bases
ATGACCGATCCGGCCGTCGACCGCGACCAGCCCGCTGAATCCGGGCGCCGATGGGTCTACCTCTGCGCGACCGCCGTCGT
CGCCGGTGTGGCGATCGGTTTCATCGGCGGCGCCTTCCGCTGGTGCCTTCAGGCCGCTGACCGGTTGCGAGTCGACTTCG
TCGACTGGGCACACGATCTGGCGGGCCCAGGATGGTTGGCGCCCATGGCCGCCGCGGCGCTCGGCGCGACGCTGGCCGCC
CTGATCGTGCGCTGGGTGCCCCTGGCCGCAGGCAGCGGAATCCAGCACGTCGAGGCCGTCTATCGCGGCGACGCCCGCGC
GCCGCTGCTGATCCTGCTGCCCGCGAAGTTCGTCGGCGGTGTGCTGTCCATCGGATCCGGACTGGTGCTCGGGCGCGAGG
GGCCGACGGTGCACATGGGCGCGGCGATCGGCGCCGAGGCGGCCCGCCGCGCTCGACTTCCCGACCCCGACATCCGGATG
ATGCAGACGGCCGTCGGCGGCGCCGGCCTCGCGGTCGCGTTCAACGCGCCGATCGGCGGCACCCTGTTCGCGCTCGAGGA
AGTGACCAAATCGTTCCGGCTGCCGACGGTGCTGACCACGCTCTTCGCGGCCGCCGCCGCGGTCGGCTGCATGCGGTTCA
TCCTGGGGAACGAACCGGACTTCTTCGTCACCTCGGTGGACACCCCCGCGCTGGCGTGGTTGCCCCTCTTCGTGGTCTTC
GGGCTGCTGACCGGATGCCTCGGTGCGGCGTACAACCGGCTGGTGCTGTGGTTCCTCGACCATGTCGGCGGTATGCGACG
CGTACCGGCGATCGCCAAGGCCGCGGTGATCGGCGCGATCATCGGCCTCGCGATGTTCGTCTACCCAGAGGCCGTCGGGG
GTGGCGACACACTGACACAGCTGATCCTCGGCGGCCACGAGATCGTGCTCCCGGTGGTGGTCGGATACCTGTTGGTGCGC
TTCGTCGCGGGCCCGCTGTCCTACTCGGCCGCCGTCCCGGGTGGCCTGTTCGCGCCGTTGCTGGCGGTCGGCGCGCTGTG
GGGGCTGCTCTTCGTCGGGGTGAGCGGCCCCCTGTTGCCCGGTGACGTTGCCGCGCTGAGCATTCCGATGGCGCTGGTCG
GGATGGCCGCATTCTTCGGAGCCACGGTGCGGGCACCGGTGACCGGCATCGTCGTCGTCATCGAGATGACGGCCACGACG
GCCGTCGCCATCCCGATGCTCGCCGCCACCGCCGCGGCCGTGCTGGCCGCCGAACTGACCGGATCACCGCCCATCTACGA
CTCCCTGCGGGAGCGGATGTTGCCCCGAGCGAAGCGGTGA

Upstream 100 bases:

>100_bases
CGGGCCTACGGCGTCTACGCACTCCCCGTGACGTGGGGACCCGTGAAACGCTGAGCGGACAGGCCGCCACGAGGCCCTCA
GTCTGCGAGACTGATGCGCC

Downstream 100 bases:

>100_bases
TACGGGGTACGTTGAAGACCATGCTCGACCGTCGACGTCGCCCGCCGCGCCGCGTGCTCGGCGCAGTCGCCGGTGCGTGC
GCGGTGCTGGCCCTGTCGGC

Product: Cl- channel, voltage gated

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MTDPAVDRDQPAESGRRWVYLCATAVVAGVAIGFIGGAFRWCLQAADRLRVDFVDWAHDLAGPGWLAPMAAAALGATLAA
LIVRWVPLAAGSGIQHVEAVYRGDARAPLLILLPAKFVGGVLSIGSGLVLGREGPTVHMGAAIGAEAARRARLPDPDIRM
MQTAVGGAGLAVAFNAPIGGTLFALEEVTKSFRLPTVLTTLFAAAAAVGCMRFILGNEPDFFVTSVDTPALAWLPLFVVF
GLLTGCLGAAYNRLVLWFLDHVGGMRRVPAIAKAAVIGAIIGLAMFVYPEAVGGGDTLTQLILGGHEIVLPVVVGYLLVR
FVAGPLSYSAAVPGGLFAPLLAVGALWGLLFVGVSGPLLPGDVAALSIPMALVGMAAFFGATVRAPVTGIVVVIEMTATT
AVAIPMLAATAAAVLAAELTGSPPIYDSLRERMLPRAKR

Sequences:

>Translated_439_residues
MTDPAVDRDQPAESGRRWVYLCATAVVAGVAIGFIGGAFRWCLQAADRLRVDFVDWAHDLAGPGWLAPMAAAALGATLAA
LIVRWVPLAAGSGIQHVEAVYRGDARAPLLILLPAKFVGGVLSIGSGLVLGREGPTVHMGAAIGAEAARRARLPDPDIRM
MQTAVGGAGLAVAFNAPIGGTLFALEEVTKSFRLPTVLTTLFAAAAAVGCMRFILGNEPDFFVTSVDTPALAWLPLFVVF
GLLTGCLGAAYNRLVLWFLDHVGGMRRVPAIAKAAVIGAIIGLAMFVYPEAVGGGDTLTQLILGGHEIVLPVVVGYLLVR
FVAGPLSYSAAVPGGLFAPLLAVGALWGLLFVGVSGPLLPGDVAALSIPMALVGMAAFFGATVRAPVTGIVVVIEMTATT
AVAIPMLAATAAAVLAAELTGSPPIYDSLRERMLPRAKR
>Mature_438_residues
TDPAVDRDQPAESGRRWVYLCATAVVAGVAIGFIGGAFRWCLQAADRLRVDFVDWAHDLAGPGWLAPMAAAALGATLAAL
IVRWVPLAAGSGIQHVEAVYRGDARAPLLILLPAKFVGGVLSIGSGLVLGREGPTVHMGAAIGAEAARRARLPDPDIRMM
QTAVGGAGLAVAFNAPIGGTLFALEEVTKSFRLPTVLTTLFAAAAAVGCMRFILGNEPDFFVTSVDTPALAWLPLFVVFG
LLTGCLGAAYNRLVLWFLDHVGGMRRVPAIAKAAVIGAIIGLAMFVYPEAVGGGDTLTQLILGGHEIVLPVVVGYLLVRF
VAGPLSYSAAVPGGLFAPLLAVGALWGLLFVGVSGPLLPGDVAALSIPMALVGMAAFFGATVRAPVTGIVVVIEMTATTA
VAIPMLAATAAAVLAAELTGSPPIYDSLRERMLPRAKR

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557473, Length=420, Percent_Identity=27.6190476190476, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI189217923, Length=420, Percent_Identity=28.0952380952381, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI189217921, Length=420, Percent_Identity=28.0952380952381, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI153252026, Length=432, Percent_Identity=27.0833333333333, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI55770838, Length=408, Percent_Identity=26.7156862745098, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI55770840, Length=408, Percent_Identity=26.7156862745098, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI156104869, Length=410, Percent_Identity=25.8536585365854, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI283806622, Length=410, Percent_Identity=25.8536585365854, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI283806618, Length=410, Percent_Identity=25.8536585365854, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI4502873, Length=299, Percent_Identity=29.0969899665552, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI167466160, Length=402, Percent_Identity=27.1144278606965, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI14149607, Length=414, Percent_Identity=26.5700483091787, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1786350, Length=364, Percent_Identity=32.967032967033, Blast_Score=136, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71996452, Length=448, Percent_Identity=25.6696428571429, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71996455, Length=448, Percent_Identity=25.6696428571429, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17532615, Length=418, Percent_Identity=27.9904306220096, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71980828, Length=436, Percent_Identity=24.7706422018349, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71980824, Length=436, Percent_Identity=24.7706422018349, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71980820, Length=446, Percent_Identity=24.2152466367713, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17559050, Length=398, Percent_Identity=26.8844221105528, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322500, Length=402, Percent_Identity=28.6069651741293, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24665008, Length=418, Percent_Identity=28.7081339712919, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45551566, Length=406, Percent_Identity=27.8325123152709, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19922112, Length=421, Percent_Identity=26.3657957244656, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 45228; Mature: 45097

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDPAVDRDQPAESGRRWVYLCATAVVAGVAIGFIGGAFRWCLQAADRLRVDFVDWAHDL
CCCCCCCCCCCHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGPGWLAPMAAAALGATLAALIVRWVPLAAGSGIQHVEAVYRGDARAPLLILLPAKFVGG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEECHHHHHH
VLSIGSGLVLGREGPTVHMGAAIGAEAARRARLPDPDIRMMQTAVGGAGLAVAFNAPIGG
HHHHCCCEEECCCCCEEEECHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEECCCCCH
TLFALEEVTKSFRLPTVLTTLFAAAAAVGCMRFILGNEPDFFVTSVDTPALAWLPLFVVF
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHH
GLLTGCLGAAYNRLVLWFLDHVGGMRRVPAIAKAAVIGAIIGLAMFVYPEAVGGGDTLTQ
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LILGGHEIVLPVVVGYLLVRFVAGPLSYSAAVPGGLFAPLLAVGALWGLLFVGVSGPLLP
HHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
GDVAALSIPMALVGMAAFFGATVRAPVTGIVVVIEMTATTAVAIPMLAATAAAVLAAELT
CHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHC
GSPPIYDSLRERMLPRAKR
CCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TDPAVDRDQPAESGRRWVYLCATAVVAGVAIGFIGGAFRWCLQAADRLRVDFVDWAHDL
CCCCCCCCCCHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGPGWLAPMAAAALGATLAALIVRWVPLAAGSGIQHVEAVYRGDARAPLLILLPAKFVGG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEECHHHHHH
VLSIGSGLVLGREGPTVHMGAAIGAEAARRARLPDPDIRMMQTAVGGAGLAVAFNAPIGG
HHHHCCCEEECCCCCEEEECHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEECCCCCH
TLFALEEVTKSFRLPTVLTTLFAAAAAVGCMRFILGNEPDFFVTSVDTPALAWLPLFVVF
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHH
GLLTGCLGAAYNRLVLWFLDHVGGMRRVPAIAKAAVIGAIIGLAMFVYPEAVGGGDTLTQ
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LILGGHEIVLPVVVGYLLVRFVAGPLSYSAAVPGGLFAPLLAVGALWGLLFVGVSGPLLP
HHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
GDVAALSIPMALVGMAAFFGATVRAPVTGIVVVIEMTATTAVAIPMLAATAAAVLAAELT
CHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHC
GSPPIYDSLRERMLPRAKR
CCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA