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The map label for this gene is uppS [C]

Identifier: 108801101

GI number: 108801101

Start: 4403917

End: 4404657

Strand: Reverse

Name: uppS [C]

Synonym: Mmcs_4137

Alternate gene names: 108801101

Gene position: 4404657-4403917 (Counterclockwise)

Preceding gene: 108801103

Following gene: 108801100

Centisome position: 77.2

GC content: 66.94

Gene sequence:

>741_bases
ATGCGGTTGCGTCAGGAGCTGATGCGGTCCAAATCACAACTGCCGCGCCACATTGCGGTGTTGTGTGACGGCAACCGCCG
GTGGGCGCGTGACGCCGGTCACGACGACGTCAGTTACGGCTATCGCGTGGGTGCGGCGAAGATCGCCGAGATGCTTCGCT
GGTGTCAGGCCGCGGGTATCGAGATGGCCACCGTCTATCTGCTGTCGACAGAGAACCTGCAACGGGACGCCGACGAACTC
GCCGAGCTCATCGAGATCATCACCGGTGTCGTGGAGGAGATCTGCGCACCGGCCAACCGCTGGAGCGTGCGCACCGTCGG
CGACCTTTCGCTGCTCGGCGACGAACCGGCGCGGCGACTGCGCGACGCGGTGGAATCCACGACGGGCAACGGCACTGCCT
TTCATGTCAACGTCGCCGTCGCCTACGGCGGCAGGCAGGAGATCGTCGACGCGGTGCGCGCGCTGCTCAGCAAGAAGCTC
GCCGACGGGGTCACGGGGGAGCAGTTGGTCGAGGCGGTCACCGCCGAGGCGATCTCCGAGAACCTCTACACCTCCGGTCA
GCCCGATCCGGACCTGGTGATCCGGACCTCCGGTGAGCAGCGGCTGTCGGGGTTCCTGCTGTGGCAGAGCGCCTATTCGG
AGATGTGGTTCACCGAGGCGTACTGGCCGGCGTTCCGGCGGGTCGACTTCCTGCGCGCACTGCGCGACTACACCCGCCGG
GATCGCCGCTACGGCACCTGA

Upstream 100 bases:

>100_bases
TCCGTCAACTCGGTTGGGGCACTCGGCCGCCACAGTAGTCTGAATACTCATGGACATCATTCCCCGCGGTCTCAAGGAGC
CTGCATACCGGCTCTATGAG

Downstream 100 bases:

>100_bases
GACGCGTGCCACACTTGTGCCATGGCTGCGCTGTCCGCCGTGGTCTTCGCGCTGAGCTGGTGGCTGGGGCTGTACCTGCT
CGCGCGCAACCCGCGTAAGC

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: (2Z,6E)-farnesyl diphosphate synthase; Z-FPP synthase; Z-isoprenyl diphosphate synthase [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MRLRQELMRSKSQLPRHIAVLCDGNRRWARDAGHDDVSYGYRVGAAKIAEMLRWCQAAGIEMATVYLLSTENLQRDADEL
AELIEIITGVVEEICAPANRWSVRTVGDLSLLGDEPARRLRDAVESTTGNGTAFHVNVAVAYGGRQEIVDAVRALLSKKL
ADGVTGEQLVEAVTAEAISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAYWPAFRRVDFLRALRDYTRR
DRRYGT

Sequences:

>Translated_246_residues
MRLRQELMRSKSQLPRHIAVLCDGNRRWARDAGHDDVSYGYRVGAAKIAEMLRWCQAAGIEMATVYLLSTENLQRDADEL
AELIEIITGVVEEICAPANRWSVRTVGDLSLLGDEPARRLRDAVESTTGNGTAFHVNVAVAYGGRQEIVDAVRALLSKKL
ADGVTGEQLVEAVTAEAISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAYWPAFRRVDFLRALRDYTRR
DRRYGT
>Mature_246_residues
MRLRQELMRSKSQLPRHIAVLCDGNRRWARDAGHDDVSYGYRVGAAKIAEMLRWCQAAGIEMATVYLLSTENLQRDADEL
AELIEIITGVVEEICAPANRWSVRTVGDLSLLGDEPARRLRDAVESTTGNGTAFHVNVAVAYGGRQEIVDAVRALLSKKL
ADGVTGEQLVEAVTAEAISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAYWPAFRRVDFLRALRDYTRR
DRRYGT

Specific function: Generates Z-farnesyl diphosphate (Z-FPP) from isopentenyl pyrophosphate (IPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family. Z-FPP synthase subfamily [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=230, Percent_Identity=34.7826086956522, Blast_Score=130, Evalue=8e-31,
Organism=Homo sapiens, GI45580742, Length=230, Percent_Identity=34.7826086956522, Blast_Score=130, Evalue=8e-31,
Organism=Escherichia coli, GI1786371, Length=232, Percent_Identity=36.2068965517241, Blast_Score=147, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI71993029, Length=230, Percent_Identity=31.304347826087, Blast_Score=123, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6319474, Length=227, Percent_Identity=33.920704845815, Blast_Score=113, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323748, Length=221, Percent_Identity=26.6968325791855, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI18857969, Length=246, Percent_Identity=34.1463414634146, Blast_Score=135, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.68 [H]

Molecular weight: Translated: 27658; Mature: 27658

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLRQELMRSKSQLPRHIAVLCDGNRRWARDAGHDDVSYGYRVGAAKIAEMLRWCQAAGI
CCHHHHHHHHHHCCCCEEEEEECCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
EMATVYLLSTENLQRDADELAELIEIITGVVEEICAPANRWSVRTVGDLSLLGDEPARRL
CEEEEEEEECCHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHCCCHHHHH
RDAVESTTGNGTAFHVNVAVAYGGRQEIVDAVRALLSKKLADGVTGEQLVEAVTAEAISE
HHHHHHCCCCCEEEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
NLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAYWPAFRRVDFLRALRDYTRR
HCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRRYGT
HCCCCC
>Mature Secondary Structure
MRLRQELMRSKSQLPRHIAVLCDGNRRWARDAGHDDVSYGYRVGAAKIAEMLRWCQAAGI
CCHHHHHHHHHHCCCCEEEEEECCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
EMATVYLLSTENLQRDADELAELIEIITGVVEEICAPANRWSVRTVGDLSLLGDEPARRL
CEEEEEEEECCHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHCCCHHHHH
RDAVESTTGNGTAFHVNVAVAYGGRQEIVDAVRALLSKKLADGVTGEQLVEAVTAEAISE
HHHHHHCCCCCEEEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
NLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAYWPAFRRVDFLRALRDYTRR
HCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRRYGT
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]