Click here to switch to the map view.

The map label for this gene is fbiC [H]

Identifier: 108800996

GI number: 108800996

Start: 4297184

End: 4299763

Strand: Reverse

Name: fbiC [H]

Synonym: Mmcs_4032

Alternate gene names: 108800996

Gene position: 4299763-4297184 (Counterclockwise)

Preceding gene: 108800997

Following gene: 108800995

Centisome position: 75.36

GC content: 69.88

Gene sequence:

>2580_bases
GTGGCCCTGAACCCCCAGCACGGCGCTGATCTTCCCAGCCCGGCGGTCCCGCCGAAGTCTGCAGTGCCCACCCCCGCCGC
GATGAGGCGCGTACTGCGCCGGGCCCGGGACGGCGTCGCCCTCAACGTCGATGAAGCCGCGATCGCGATGACCGCGCGCG
GCGAGGATCTGGCCGATCTCTGCGCCAGCGCCGCGCGGGTGCGCGATGCCGGGCTCACATCGGCGGGCCGCCGCGGACCC
GCCGGGCGGCTGCCGGTCACCTACTCCCGCAAGGTCTTCATCCCGGTCACACATCTGTGCCGCGACACCTGCCACTACTG
CACGTTCGTCACCGTGCCCGGACGCCTGCGCGCCCAGGGTGCGGGTATGTACATGGAGCCCGACGAGATCCTCGAGGTCG
CGCGTCGCGGCGCCGAATTGGGCTGCAAGGAAGCGCTTTTCACGCTCGGTGACCGCCCTGAGGCCAGGTGGGACGAGGCG
CGGCAGTGGCTGGACGAGCGTGGCTATGACTCCACACTCGACTACGTCCGCGCGATGGCCATCCGCGTGCTCGAGGAGAC
GGGGCTGCTTCCGCATCTCAACCCCGGCGTGATGAGCTGGTCGGAGCTCTCGCGGCTCAAACCCGTTGCGCCGTCGATGG
GGATGATGCTCGAGACGACGTCGCGGCGTCTGTTCGAGACCAAGGGGCTGGCGCACTACGGCAGCCCGGACAAGGATCCG
GCCGTCCGGCTGCGCACCCTCGACGACGCCGGCCGGCTCTCGATCCCGTTCACCACGGGTCTGCTCGTCGGGATCGGCGA
GACGCTCGCCGAGCGGGCCGAGACCATGCATGCGATTCGCAAGTCGCACAAGGAATTCGGTCACGTCCAGGAAGTGATCG
TGCAGAACTTCCGGGCCAAGGATCACACCGCGATGGCGTCTACACCGGACGCCGGTATCGACGACTTCCTCGCGACGGTC
GCGACCACCCGCCTCGTGCTCGGCCCGAAGGTGCGCATCCAGGCGCCCCCGAACCTGGTGTCGCGCGACGAGTGCCTGGC
CCTGATCGCCGCCGGGGTCGACGACTGGGGTGGCGTCTCACCGCTGACCCCCGATCACGTCAACCCGGAACGGCCGTGGC
CGGCCCTCGACGAGTTGGCCGACGTGACCGCCGAGGCCGGCTACGACCTGGTGCAGCGGCTCACCGCGCAACCGCAGTAC
GTACAGGCCGGTGCGGCGTGGATCGACCCGCGCGTGCGTGGCCACGTCGACGCGCTCGCCGATCCGGAGACCGGCCTCGC
CCTCGACGTCAACCCGGAGGGCCGTCCGTGGCAGGAGCCCGACGAGGCACTGCAGTCGCTGGGACGCATCGACCTGCACG
AGGCCATCGACAGCGAGGGGCGGCTCACCGAGACCCGCAGTGACCTCGGCAGCGCCTTCGGTGACTGGGAGTCGATCCGC
GAAAAGGTCCACGAACTGGCCGCACGCGCGCCGGAGCGGGTGGACACCGATGTGCTGGCGGCGCTGCGCGCCGCCGAGCG
CGACCCGGCGTCGCTGTCCGACGACGCCTACCTGGCGTTGGCCACCGCCGACGGGTCTGCTCTGGAAGCCGTTGCCGCGC
TTGCTGATTCGCTGCGCCGCGACACCGTCGGCGACGATGTGACGTTCGTGGTCAACCGCAACATCAACTTCACCAACATC
TGCTACACCGGGTGCCGGTTCTGCGCGTTCGCGCAGCGCAAGGGTGACGCCGACGCGTATTCGCTGTCCACCGACGAGGT
CGCCGACCGCGCCTGGGAGGCGCACGTCGCCGGTGCCACGGAGGTGTGCATGCAGGGCGGGATCGACCCCGAACTGCCGG
TGACCGGTTACGCCGACCTGGTGCGGGCGGTCAAGAAGCGGGTGCCGTCCATGCACGTGCACGCTTTCTCGCCGATGGAG
ATCGCCAACGGCGTGACGAAGAGCGGTCTGTCGGTGCGCGAATGGCTGACCGCGCTGCGCGAAGCCGGTCTGGACACCAT
CCCCGGCACCGCCGCGGAGATCCTCGACGACGAGGTGCGCTGGGTGCTGACCAAGGGCAAGCTGCCGACGTCGATGTGGA
TCGACGTGGTCACCACCGCCCACGAGGTCGGGCTGCGGTCGAGTTCGACGATGATGTACGGCCACGTCGACCAGCCCCGG
CACTGGGTCGGTCACCTGCGGGTGCTGCGCGAGATCCAGGACCGCACCGGTGGGTTCACCGAGTTCGTCCCGCTGCCGTT
CGTGCACCAGTCCTCACCGCTGTACCTGTCCGGCGGCGCCCGGCCGGGACCGACGCACCGCGACAACCGGGCGGTCCACG
CGCTGGCGCGGATCATGTTGCACGGCAGGATCTCTCACATCCAGACCAGCTGGGTCAAGCTCGGCGTCGAACGTACGCAG
GTGATGCTGCAGGGCGGCGCCAACGACCTCGGCGGGACGTTGATGGAGGAGACCATCTCACGGATGGCCGGTTCGGAGAA
CGGCTCGGCCAAGACGGTCGCCGAACTCGTCGCGATCGCCGAAGGGATCGGCAGGCCGGCGCGGCAACGCACCACCACGT
ACGCACCCCTGGCGGCCTGA

Upstream 100 bases:

>100_bases
CTCGTCCGGTCGCGGACTACTGTGGCCGATATGCCGGACCCAGTGCTTCCAGGATGTGAGACACGCGGATGAAAGTTGCC
ATCGCCGGGGTTACAGGGGA

Downstream 100 bases:

>100_bases
CCGTCAGGGCAGTAGGCCTGCGCGCCGAACGTGCGCTGACTGCGAATTCCGGGCCGGTGTTTCGCAGTGGACGCACGTTC
GGCGGAGCCGGTGGAATACA

Product: FO synthase

Products: NA

Alternate protein names: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase [H]

Number of amino acids: Translated: 859; Mature: 858

Protein sequence:

>859_residues
MALNPQHGADLPSPAVPPKSAVPTPAAMRRVLRRARDGVALNVDEAAIAMTARGEDLADLCASAARVRDAGLTSAGRRGP
AGRLPVTYSRKVFIPVTHLCRDTCHYCTFVTVPGRLRAQGAGMYMEPDEILEVARRGAELGCKEALFTLGDRPEARWDEA
RQWLDERGYDSTLDYVRAMAIRVLEETGLLPHLNPGVMSWSELSRLKPVAPSMGMMLETTSRRLFETKGLAHYGSPDKDP
AVRLRTLDDAGRLSIPFTTGLLVGIGETLAERAETMHAIRKSHKEFGHVQEVIVQNFRAKDHTAMASTPDAGIDDFLATV
ATTRLVLGPKVRIQAPPNLVSRDECLALIAAGVDDWGGVSPLTPDHVNPERPWPALDELADVTAEAGYDLVQRLTAQPQY
VQAGAAWIDPRVRGHVDALADPETGLALDVNPEGRPWQEPDEALQSLGRIDLHEAIDSEGRLTETRSDLGSAFGDWESIR
EKVHELAARAPERVDTDVLAALRAAERDPASLSDDAYLALATADGSALEAVAALADSLRRDTVGDDVTFVVNRNINFTNI
CYTGCRFCAFAQRKGDADAYSLSTDEVADRAWEAHVAGATEVCMQGGIDPELPVTGYADLVRAVKKRVPSMHVHAFSPME
IANGVTKSGLSVREWLTALREAGLDTIPGTAAEILDDEVRWVLTKGKLPTSMWIDVVTTAHEVGLRSSSTMMYGHVDQPR
HWVGHLRVLREIQDRTGGFTEFVPLPFVHQSSPLYLSGGARPGPTHRDNRAVHALARIMLHGRISHIQTSWVKLGVERTQ
VMLQGGANDLGGTLMEETISRMAGSENGSAKTVAELVAIAEGIGRPARQRTTTYAPLAA

Sequences:

>Translated_859_residues
MALNPQHGADLPSPAVPPKSAVPTPAAMRRVLRRARDGVALNVDEAAIAMTARGEDLADLCASAARVRDAGLTSAGRRGP
AGRLPVTYSRKVFIPVTHLCRDTCHYCTFVTVPGRLRAQGAGMYMEPDEILEVARRGAELGCKEALFTLGDRPEARWDEA
RQWLDERGYDSTLDYVRAMAIRVLEETGLLPHLNPGVMSWSELSRLKPVAPSMGMMLETTSRRLFETKGLAHYGSPDKDP
AVRLRTLDDAGRLSIPFTTGLLVGIGETLAERAETMHAIRKSHKEFGHVQEVIVQNFRAKDHTAMASTPDAGIDDFLATV
ATTRLVLGPKVRIQAPPNLVSRDECLALIAAGVDDWGGVSPLTPDHVNPERPWPALDELADVTAEAGYDLVQRLTAQPQY
VQAGAAWIDPRVRGHVDALADPETGLALDVNPEGRPWQEPDEALQSLGRIDLHEAIDSEGRLTETRSDLGSAFGDWESIR
EKVHELAARAPERVDTDVLAALRAAERDPASLSDDAYLALATADGSALEAVAALADSLRRDTVGDDVTFVVNRNINFTNI
CYTGCRFCAFAQRKGDADAYSLSTDEVADRAWEAHVAGATEVCMQGGIDPELPVTGYADLVRAVKKRVPSMHVHAFSPME
IANGVTKSGLSVREWLTALREAGLDTIPGTAAEILDDEVRWVLTKGKLPTSMWIDVVTTAHEVGLRSSSTMMYGHVDQPR
HWVGHLRVLREIQDRTGGFTEFVPLPFVHQSSPLYLSGGARPGPTHRDNRAVHALARIMLHGRISHIQTSWVKLGVERTQ
VMLQGGANDLGGTLMEETISRMAGSENGSAKTVAELVAIAEGIGRPARQRTTTYAPLAA
>Mature_858_residues
ALNPQHGADLPSPAVPPKSAVPTPAAMRRVLRRARDGVALNVDEAAIAMTARGEDLADLCASAARVRDAGLTSAGRRGPA
GRLPVTYSRKVFIPVTHLCRDTCHYCTFVTVPGRLRAQGAGMYMEPDEILEVARRGAELGCKEALFTLGDRPEARWDEAR
QWLDERGYDSTLDYVRAMAIRVLEETGLLPHLNPGVMSWSELSRLKPVAPSMGMMLETTSRRLFETKGLAHYGSPDKDPA
VRLRTLDDAGRLSIPFTTGLLVGIGETLAERAETMHAIRKSHKEFGHVQEVIVQNFRAKDHTAMASTPDAGIDDFLATVA
TTRLVLGPKVRIQAPPNLVSRDECLALIAAGVDDWGGVSPLTPDHVNPERPWPALDELADVTAEAGYDLVQRLTAQPQYV
QAGAAWIDPRVRGHVDALADPETGLALDVNPEGRPWQEPDEALQSLGRIDLHEAIDSEGRLTETRSDLGSAFGDWESIRE
KVHELAARAPERVDTDVLAALRAAERDPASLSDDAYLALATADGSALEAVAALADSLRRDTVGDDVTFVVNRNINFTNIC
YTGCRFCAFAQRKGDADAYSLSTDEVADRAWEAHVAGATEVCMQGGIDPELPVTGYADLVRAVKKRVPSMHVHAFSPMEI
ANGVTKSGLSVREWLTALREAGLDTIPGTAAEILDDEVRWVLTKGKLPTSMWIDVVTTAHEVGLRSSSTMMYGHVDQPRH
WVGHLRVLREIQDRTGGFTEFVPLPFVHQSSPLYLSGGARPGPTHRDNRAVHALARIMLHGRISHIQTSWVKLGVERTQV
MLQGGANDLGGTLMEETISRMAGSENGSAKTVAELVAIAEGIGRPARQRTTTYAPLAA

Specific function: Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (Probable) [H]

COG id: COG1060

COG function: function code HR; Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the radical SAM superfamily. CofH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR019940
- InterPro:   IPR006638
- InterPro:   IPR019939
- InterPro:   IPR020050
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 93217; Mature: 93085

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALNPQHGADLPSPAVPPKSAVPTPAAMRRVLRRARDGVALNVDEAAIAMTARGEDLADL
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECHHEEEEECCCCHHHHH
CASAARVRDAGLTSAGRRGPAGRLPVTYSRKVFIPVTHLCRDTCHYCTFVTVPGRLRAQG
HHHHHHHHHCCCCCCCCCCCCCCCCEEECCEEEEEHHHHHHHHHHHEEEEECCCCCEECC
AGMYMEPDEILEVARRGAELGCKEALFTLGDRPEARWDEARQWLDERGYDSTLDYVRAMA
CCCCCCHHHHHHHHHCCHHCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
IRVLEETGLLPHLNPGVMSWSELSRLKPVAPSMGMMLETTSRRLFETKGLAHYGSPDKDP
HHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
AVRLRTLDDAGRLSIPFTTGLLVGIGETLAERAETMHAIRKSHKEFGHVQEVIVQNFRAK
CEEEEEECCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DHTAMASTPDAGIDDFLATVATTRLVLGPKVRIQAPPNLVSRDECLALIAAGVDDWGGVS
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCC
PLTPDHVNPERPWPALDELADVTAEAGYDLVQRLTAQPQYVQAGAAWIDPRVRGHVDALA
CCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCHHHHCCCHHCCCHHHCCHHHCC
DPETGLALDVNPEGRPWQEPDEALQSLGRIDLHEAIDSEGRLTETRSDLGSAFGDWESIR
CCCCCEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHCCHHHHH
EKVHELAARAPERVDTDVLAALRAAERDPASLSDDAYLALATADGSALEAVAALADSLRR
HHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
DTVGDDVTFVVNRNINFTNICYTGCRFCAFAQRKGDADAYSLSTDEVADRAWEAHVAGAT
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHCCHH
EVCMQGGIDPELPVTGYADLVRAVKKRVPSMHVHAFSPMEIANGVTKSGLSVREWLTALR
HHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCHHHHCCCCCCCCCHHHHHHHHH
EAGLDTIPGTAAEILDDEVRWVLTKGKLPTSMWIDVVTTAHEVGLRSSSTMMYGHVDQPR
HCCCCCCCCCHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHH
HWVGHLRVLREIQDRTGGFTEFVPLPFVHQSSPLYLSGGARPGPTHRDNRAVHALARIML
HHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHH
HGRISHIQTSWVKLGVERTQVMLQGGANDLGGTLMEETISRMAGSENGSAKTVAELVAIA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
EGIGRPARQRTTTYAPLAA
HHCCCCHHHCCCCCCCCCC
>Mature Secondary Structure 
ALNPQHGADLPSPAVPPKSAVPTPAAMRRVLRRARDGVALNVDEAAIAMTARGEDLADL
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECHHEEEEECCCCHHHHH
CASAARVRDAGLTSAGRRGPAGRLPVTYSRKVFIPVTHLCRDTCHYCTFVTVPGRLRAQG
HHHHHHHHHCCCCCCCCCCCCCCCCEEECCEEEEEHHHHHHHHHHHEEEEECCCCCEECC
AGMYMEPDEILEVARRGAELGCKEALFTLGDRPEARWDEARQWLDERGYDSTLDYVRAMA
CCCCCCHHHHHHHHHCCHHCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
IRVLEETGLLPHLNPGVMSWSELSRLKPVAPSMGMMLETTSRRLFETKGLAHYGSPDKDP
HHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
AVRLRTLDDAGRLSIPFTTGLLVGIGETLAERAETMHAIRKSHKEFGHVQEVIVQNFRAK
CEEEEEECCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DHTAMASTPDAGIDDFLATVATTRLVLGPKVRIQAPPNLVSRDECLALIAAGVDDWGGVS
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCC
PLTPDHVNPERPWPALDELADVTAEAGYDLVQRLTAQPQYVQAGAAWIDPRVRGHVDALA
CCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCHHHHCCCHHCCCHHHCCHHHCC
DPETGLALDVNPEGRPWQEPDEALQSLGRIDLHEAIDSEGRLTETRSDLGSAFGDWESIR
CCCCCEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHCCHHHHH
EKVHELAARAPERVDTDVLAALRAAERDPASLSDDAYLALATADGSALEAVAALADSLRR
HHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
DTVGDDVTFVVNRNINFTNICYTGCRFCAFAQRKGDADAYSLSTDEVADRAWEAHVAGAT
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHCCHH
EVCMQGGIDPELPVTGYADLVRAVKKRVPSMHVHAFSPMEIANGVTKSGLSVREWLTALR
HHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCHHHHCCCCCCCCCHHHHHHHHH
EAGLDTIPGTAAEILDDEVRWVLTKGKLPTSMWIDVVTTAHEVGLRSSSTMMYGHVDQPR
HCCCCCCCCCHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHH
HWVGHLRVLREIQDRTGGFTEFVPLPFVHQSSPLYLSGGARPGPTHRDNRAVHALARIML
HHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHH
HGRISHIQTSWVKLGVERTQVMLQGGANDLGGTLMEETISRMAGSENGSAKTVAELVAIA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
EGIGRPARQRTTTYAPLAA
HHCCCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11948155; 12788972 [H]