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The map label for this gene is caiC [H]

Identifier: 108800971

GI number: 108800971

Start: 4271186

End: 4272964

Strand: Reverse

Name: caiC [H]

Synonym: Mmcs_4007

Alternate gene names: 108800971

Gene position: 4272964-4271186 (Counterclockwise)

Preceding gene: 108800972

Following gene: 108800970

Centisome position: 74.89

GC content: 66.05

Gene sequence:

>1779_bases
ATGAGCGACGAGAAATCGGGGACTCGTAGCAGCGTCGGTTTGCTGGACATCGCCGCGAGGTTGCCGGGGTTCCTCATGGA
CGTGCCGACGATCCTGGGCGGCGTCGTCACCGGGTTCGGGGCCAGGCCGTCGGCGAAGACGTCGATCGGCAAGGTCTTCC
AGGAGCGGGCCGCCAAGTACGCCGACAAGACCTTCCTCAGGTTCGAGGACCACGACATCTCCTACCGGGAGGCCAACGAG
ACGGTCAACCGCTACGCCGCCGTACTGGCCGACCGCGGAGTCGGCCGCGGTGACGTCGTGGCGATCATGCTGCGCAACTC
ACCCGAACCCGTGCTGCTCATGCTGGCGGCCGTCAAATGCGGCGCGATCTCCGGGATGCTCAACTTCCACCAGCGCGGCG
ACGTGCTCAAGCACAGCCTCGGCCTGCTCTCGGCCAAGGTCGTGATCGCCGACCCCGACTTCGTCGACCCGATCAAGGAA
TGCGGCGCCGACACCGACGGTCTGCTGACGATCGAGGAGTTCGAGGAGCTCGCGGAGGGCGCCCCGACCGACGACCCGGA
ATCGGCGTCGGCCGTCCTCGCCAAGGACAAGGCGTTCTACATCTTCACCTCGGGCACCACCGGGATGCCGAAGGCCAGCG
TGATGACGCACTACCGCTGGCTGCGCGCACTGGCCGGCTTCGGCGGGCTCGGTGTGCGGCTGAGCAGCAAGGACACCATG
TACTGCTGCCTGCCGCTGTACCACAACAACGCGCTGACGGTGGCGCTGTCGTCGGTGCTGAACTCCGGCGCGACACTCGC
GCTGGGCAAGTCGTTCTCGGCGTCGAAGTTCTGGGACGACGTCATCCGTTACGACGCCACCGCATTCGTCTACATCGGTG
AGATCTGCACCTACCTGCTCAACCAGCCGAAGAAGGACACCGACCGCAAGCACAAGGTCCGCGTCATCGCGGGCAACGGT
CTGCGCCCGGCGATCTGGGACGAGTTCACCAACCGGTTCGGCATCGACCGGGTGTGCGAGTTCTACGCCGCCAGCGAGGG
CAACACCGCCTTCGTCAACGCCCTCAACGTCGACAAGACCACCGGCATGTGCCCGACCCCGGTCGCGTTCGTCGAATACG
ACGGCGACTCGGGCGATCCGGTCCGCGACGAGAAGGGCCGGGTCAAGAAGGTCCGCACGGGTGAGCCGGGGCTGCTGTTG
AGCAAGGTCAGCAACTTCCAGCCCTTCGACGGCTACACCGACGAGAAGGAGTCCGAGAAGAAGCTCGTTCGCGACGCCTT
CAAGGACGGCGACGTGTGGTTCAACACCGGCGACCTGATGCGCTACCAGGGTCTCGGGCACGCTGCGTTCGTCGACCGCC
TGGGCGACACCTTCCGGTGGAAGGGGGAGAACGTCGCCACCACCGAGGTCGAGGCGGCGCTGTCGTTGGACCCGACGGTG
GACGAGTGCACGGTCTACGGCGTCGAGGTGGAAGGCGCAGGCGGCCGGGCGGGTATGGCGGCGATCAAGCTCAACGAGGG
CTGCGACTTCGACGGCAAGACGCTGGCGCAGACCCTCTACGACCGGCTGCCCTCGTACGCCGTGCCGCTGTTCGTCCGCG
TCGTCGGCGAACTCGAGCACACCTCGACCTTCAAGAGCCTCAAGGTCGACCTGCGCAAGGAGGGCCACGGCAGCCACATC
GAGGATCCGCTGTACGTGCTCAAGAGCCGCGACGAGGGCTACGTCGAGTACTACGACGAGTACGCCGAAGAGGTCAAGGA
AGGCAAGAAGCCGAAGTAG

Upstream 100 bases:

>100_bases
GTCGACAACATCGACGAGGCGATGGCAGCGTGCGCCCCTCGCCTCTGAGTGAGCGTGGTTAGGTGGTGCGCACGCACGAC
GATCGGAGGGGTTGCACCAC

Downstream 100 bases:

>100_bases
CGGCGATTCGGGCGTGGTTGGTCGCGCCCAGCGCGACCGAACACGCCGAAATCACCCCGCCCGTAGCCTGGCAGGGTGGA
GTCGACCTTCTGCGGACGTC

Product: long-chain-acyl-CoA synthetase

Products: D-carnitinyl-CoA; crotonobetainyl-CoA; L-carnitinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 592; Mature: 591

Protein sequence:

>592_residues
MSDEKSGTRSSVGLLDIAARLPGFLMDVPTILGGVVTGFGARPSAKTSIGKVFQERAAKYADKTFLRFEDHDISYREANE
TVNRYAAVLADRGVGRGDVVAIMLRNSPEPVLLMLAAVKCGAISGMLNFHQRGDVLKHSLGLLSAKVVIADPDFVDPIKE
CGADTDGLLTIEEFEELAEGAPTDDPESASAVLAKDKAFYIFTSGTTGMPKASVMTHYRWLRALAGFGGLGVRLSSKDTM
YCCLPLYHNNALTVALSSVLNSGATLALGKSFSASKFWDDVIRYDATAFVYIGEICTYLLNQPKKDTDRKHKVRVIAGNG
LRPAIWDEFTNRFGIDRVCEFYAASEGNTAFVNALNVDKTTGMCPTPVAFVEYDGDSGDPVRDEKGRVKKVRTGEPGLLL
SKVSNFQPFDGYTDEKESEKKLVRDAFKDGDVWFNTGDLMRYQGLGHAAFVDRLGDTFRWKGENVATTEVEAALSLDPTV
DECTVYGVEVEGAGGRAGMAAIKLNEGCDFDGKTLAQTLYDRLPSYAVPLFVRVVGELEHTSTFKSLKVDLRKEGHGSHI
EDPLYVLKSRDEGYVEYYDEYAEEVKEGKKPK

Sequences:

>Translated_592_residues
MSDEKSGTRSSVGLLDIAARLPGFLMDVPTILGGVVTGFGARPSAKTSIGKVFQERAAKYADKTFLRFEDHDISYREANE
TVNRYAAVLADRGVGRGDVVAIMLRNSPEPVLLMLAAVKCGAISGMLNFHQRGDVLKHSLGLLSAKVVIADPDFVDPIKE
CGADTDGLLTIEEFEELAEGAPTDDPESASAVLAKDKAFYIFTSGTTGMPKASVMTHYRWLRALAGFGGLGVRLSSKDTM
YCCLPLYHNNALTVALSSVLNSGATLALGKSFSASKFWDDVIRYDATAFVYIGEICTYLLNQPKKDTDRKHKVRVIAGNG
LRPAIWDEFTNRFGIDRVCEFYAASEGNTAFVNALNVDKTTGMCPTPVAFVEYDGDSGDPVRDEKGRVKKVRTGEPGLLL
SKVSNFQPFDGYTDEKESEKKLVRDAFKDGDVWFNTGDLMRYQGLGHAAFVDRLGDTFRWKGENVATTEVEAALSLDPTV
DECTVYGVEVEGAGGRAGMAAIKLNEGCDFDGKTLAQTLYDRLPSYAVPLFVRVVGELEHTSTFKSLKVDLRKEGHGSHI
EDPLYVLKSRDEGYVEYYDEYAEEVKEGKKPK
>Mature_591_residues
SDEKSGTRSSVGLLDIAARLPGFLMDVPTILGGVVTGFGARPSAKTSIGKVFQERAAKYADKTFLRFEDHDISYREANET
VNRYAAVLADRGVGRGDVVAIMLRNSPEPVLLMLAAVKCGAISGMLNFHQRGDVLKHSLGLLSAKVVIADPDFVDPIKEC
GADTDGLLTIEEFEELAEGAPTDDPESASAVLAKDKAFYIFTSGTTGMPKASVMTHYRWLRALAGFGGLGVRLSSKDTMY
CCLPLYHNNALTVALSSVLNSGATLALGKSFSASKFWDDVIRYDATAFVYIGEICTYLLNQPKKDTDRKHKVRVIAGNGL
RPAIWDEFTNRFGIDRVCEFYAASEGNTAFVNALNVDKTTGMCPTPVAFVEYDGDSGDPVRDEKGRVKKVRTGEPGLLLS
KVSNFQPFDGYTDEKESEKKLVRDAFKDGDVWFNTGDLMRYQGLGHAAFVDRLGDTFRWKGENVATTEVEAALSLDPTVD
ECTVYGVEVEGAGGRAGMAAIKLNEGCDFDGKTLAQTLYDRLPSYAVPLFVRVVGELEHTSTFKSLKVDLRKEGHGSHIE
DPLYVLKSRDEGYVEYYDEYAEEVKEGKKPK

Specific function: Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI227499619, Length=588, Percent_Identity=40.4761904761905, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI40807357, Length=576, Percent_Identity=37.8472222222222, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI62865631, Length=561, Percent_Identity=35.2941176470588, Blast_Score=343, Evalue=4e-94,
Organism=Homo sapiens, GI13325055, Length=561, Percent_Identity=35.2941176470588, Blast_Score=343, Evalue=4e-94,
Organism=Homo sapiens, GI38524616, Length=530, Percent_Identity=38.3018867924528, Blast_Score=341, Evalue=1e-93,
Organism=Homo sapiens, GI13325057, Length=512, Percent_Identity=38.671875, Blast_Score=335, Evalue=9e-92,
Organism=Homo sapiens, GI227499621, Length=569, Percent_Identity=37.4340949033392, Blast_Score=323, Evalue=3e-88,
Organism=Homo sapiens, GI13236579, Length=507, Percent_Identity=37.2781065088757, Blast_Score=312, Evalue=7e-85,
Organism=Homo sapiens, GI28416953, Length=534, Percent_Identity=25.4681647940075, Blast_Score=91, Evalue=4e-18,
Organism=Escherichia coli, GI221142682, Length=526, Percent_Identity=25.2851711026616, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1788107, Length=561, Percent_Identity=23.1729055258467, Blast_Score=93, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17551278, Length=576, Percent_Identity=33.8541666666667, Blast_Score=326, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI115534440, Length=554, Percent_Identity=35.0180505415162, Blast_Score=322, Evalue=3e-88,
Organism=Saccharomyces cerevisiae, GI6319515, Length=522, Percent_Identity=35.4406130268199, Blast_Score=281, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6319699, Length=520, Percent_Identity=22.5, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28573631, Length=581, Percent_Identity=36.3166953528399, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI20130353, Length=581, Percent_Identity=36.3166953528399, Blast_Score=350, Evalue=2e-96,
Organism=Drosophila melanogaster, GI24583465, Length=555, Percent_Identity=37.4774774774775, Blast_Score=350, Evalue=2e-96,
Organism=Drosophila melanogaster, GI24583463, Length=555, Percent_Identity=37.4774774774775, Blast_Score=350, Evalue=2e-96,
Organism=Drosophila melanogaster, GI281364798, Length=555, Percent_Identity=37.4774774774775, Blast_Score=349, Evalue=3e-96,
Organism=Drosophila melanogaster, GI45550496, Length=551, Percent_Identity=36.8421052631579, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI45552801, Length=551, Percent_Identity=36.8421052631579, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI24581924, Length=572, Percent_Identity=22.3776223776224, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI18859661, Length=513, Percent_Identity=23.5867446393762, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI21355181, Length=498, Percent_Identity=23.2931726907631, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24656500, Length=471, Percent_Identity=21.0191082802548, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.3.2.- [C]

Molecular weight: Translated: 64753; Mature: 64622

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDEKSGTRSSVGLLDIAARLPGFLMDVPTILGGVVTGFGARPSAKTSIGKVFQERAAKY
CCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
ADKTFLRFEDHDISYREANETVNRYAAVLADRGVGRGDVVAIMLRNSPEPVLLMLAAVKC
HHHEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHH
GAISGMLNFHQRGDVLKHSLGLLSAKVVIADPDFVDPIKECGADTDGLLTIEEFEELAEG
HHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHCCCCCCEEEHHHHHHHHCC
APTDDPESASAVLAKDKAFYIFTSGTTGMPKASVMTHYRWLRALAGFGGLGVRLSSKDTM
CCCCCCCCCHHEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCE
YCCLPLYHNNALTVALSSVLNSGATLALGKSFSASKFWDDVIRYDATAFVYIGEICTYLL
EEEEEEEECCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCHHEEHHHHHHHHHH
NQPKKDTDRKHKVRVIAGNGLRPAIWDEFTNRFGIDRVCEFYAASEGNTAFVNALNVDKT
CCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEECCCCC
TGMCPTPVAFVEYDGDSGDPVRDEKGRVKKVRTGEPGLLLSKVSNFQPFDGYTDEKESEK
CCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCCEEHHHHCCCCCCCCCCCCHHHHH
KLVRDAFKDGDVWFNTGDLMRYQGLGHAAFVDRLGDTFRWKGENVATTEVEAALSLDPTV
HHHHHHHCCCCEEECCCCEEEECCCCHHHHHHHCCCCEEECCCCEEEHHHHEEEECCCCC
DECTVYGVEVEGAGGRAGMAAIKLNEGCDFDGKTLAQTLYDRLPSYAVPLFVRVVGELEH
CCEEEEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
TSTFKSLKVDLRKEGHGSHIEDPLYVLKSRDEGYVEYYDEYAEEVKEGKKPK
HHHHHHHHHHHHCCCCCCCCCCCHHEEECCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SDEKSGTRSSVGLLDIAARLPGFLMDVPTILGGVVTGFGARPSAKTSIGKVFQERAAKY
CCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
ADKTFLRFEDHDISYREANETVNRYAAVLADRGVGRGDVVAIMLRNSPEPVLLMLAAVKC
HHHEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHH
GAISGMLNFHQRGDVLKHSLGLLSAKVVIADPDFVDPIKECGADTDGLLTIEEFEELAEG
HHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHCCCCCCEEEHHHHHHHHCC
APTDDPESASAVLAKDKAFYIFTSGTTGMPKASVMTHYRWLRALAGFGGLGVRLSSKDTM
CCCCCCCCCHHEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCE
YCCLPLYHNNALTVALSSVLNSGATLALGKSFSASKFWDDVIRYDATAFVYIGEICTYLL
EEEEEEEECCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCHHEEHHHHHHHHHH
NQPKKDTDRKHKVRVIAGNGLRPAIWDEFTNRFGIDRVCEFYAASEGNTAFVNALNVDKT
CCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEECCCCC
TGMCPTPVAFVEYDGDSGDPVRDEKGRVKKVRTGEPGLLLSKVSNFQPFDGYTDEKESEK
CCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCCEEHHHHCCCCCCCCCCCCHHHHH
KLVRDAFKDGDVWFNTGDLMRYQGLGHAAFVDRLGDTFRWKGENVATTEVEAALSLDPTV
HHHHHHHCCCCEEECCCCEEEECCCCHHHHHHHCCCCEEECCCCEEEHHHHEEEECCCCC
DECTVYGVEVEGAGGRAGMAAIKLNEGCDFDGKTLAQTLYDRLPSYAVPLFVRVVGELEH
CCEEEEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
TSTFKSLKVDLRKEGHGSHIEDPLYVLKSRDEGYVEYYDEYAEEVKEGKKPK
HHHHHHHHHHHHCCCCCCCCCCCHHEEECCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coenzyme A; D-carnitine; Coenzyme A; crotono-betaine; L-carnitine [C]

Specific reaction: Coenzyme A + D-carnitine = D-carnitinyl-CoA Coenzyme A + crotono-betaine = crotonobetainyl-CoA Coenzyme A + L-carnitine = L-carnitinyl-CoA [C]

General reaction: Ligases; Forming Carbon-Sulfur Bonds; Acid-Thiol Ligases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA