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The map label for this gene is mcl1 [H]

Identifier: 108800950

GI number: 108800950

Start: 4251849

End: 4252859

Strand: Reverse

Name: mcl1 [H]

Synonym: Mmcs_3986

Alternate gene names: 108800950

Gene position: 4252859-4251849 (Counterclockwise)

Preceding gene: 108800955

Following gene: 108800948

Centisome position: 74.54

GC content: 68.55

Gene sequence:

>1011_bases
ATGACTCAAAGGGTAGAGAGTAGAGCCGTGAACCACGCGCTTCGACCCCGCGAACTCGACGATTCCGCCCGGCCGCGCCG
GACCTGTCTGTCGGTGCCCGGCAGCAGTGCCAAGATGATCGCCAAGGCCAAGGGGTTGCCTGCCGACGAGGTGTTCCTCG
ATCTGGAGGACGCCGTCGCGCCGGAGGCCAAGGCCGAGGCCCGCACCCGGGTCGCGTTGGCGTTGGCCGAATCCGGTTGG
GGCGGACAGTTACGCGGTGTTCGTGTCAACGACTGGACCACGCCGTGGACCTACGCCGACGTCATCGAGGTGGTGTCGAC
CGCCGGTGCGCACCTGGACCTCATCGTGTTGCCGAAGGTCACCGACGTCAGCCACATCCACGCGCTGGACCTGTTGCTCA
CCCAGCTGGAGACGACGCACGGACTGCCCGTCGGGCGCATCGCCGTCGAGGCGCAGATCGAGAACGCCGTCGGCCTGACC
AACGTCGACGCGATCGCCGCGGGCCCGCGGGTGCAGGCACTGGTGCTCGGCCCCGCCGATCTGATGGCCAGCCTCAACAT
GCGCACGCTGGTCGTCGGCGAACAACCCGAGGGATACGACGTCGGCGACGCCTACCACCACATCTTCATGCGCATCCTGA
TCGCCGCCCGCACACACGGGATCCACGCCATCGACGGACCGTTCCTCAAGGTGCGCGACGTCGAGGCGTTCCGCCGGGTG
GCGGGGCGTTCGGCGGCGCTCGGCTTCGACGGCAAGTGGGTGCTGCATCCCGATCAGATCACTGCTGGCAACGAGATCTT
CAGCCCGCGCCAACAGGACTACGACCATGCCGAATTGATCCTCGAGGCCTACGAATGGCACACCTCGCGGGCCGGCGGCG
CCCGCGGCGCGGTGATGCTGGGCGACGAGATGATCGACGAGGCCAGCCGCAAGATGGCACGGGTGGTCGCAGGCAAGGGC
CGGGCCGCCGGGATGACGCGGCAGGGCGAACCGTTCCGGCCGCCCGCCTGA

Upstream 100 bases:

>100_bases
GCTGATCACGACATCGCGCACACGGCCGATCGACTCACCGTCGGGACCCAGCACGACCATTCCCGCCAGTCGTGCCGCGT
AGACCCTGTTCACCGCCGCC

Downstream 100 bases:

>100_bases
ACGTCAGGCGCCCATGAGGACGACGGCCATGACGAGACCGGCCAGCAGCGAGACCGCGCCGACGGCGATCCCGGCGATGG
CCAGACCCTGACCCTCTTCC

Product: Citryl-CoA lyase

Products: NA

Alternate protein names: (3S)-malyl-CoA/beta-methylmalyl-CoA lyase; L-malyl-CoA/beta-methylmalyl-CoA lyase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MTQRVESRAVNHALRPRELDDSARPRRTCLSVPGSSAKMIAKAKGLPADEVFLDLEDAVAPEAKAEARTRVALALAESGW
GGQLRGVRVNDWTTPWTYADVIEVVSTAGAHLDLIVLPKVTDVSHIHALDLLLTQLETTHGLPVGRIAVEAQIENAVGLT
NVDAIAAGPRVQALVLGPADLMASLNMRTLVVGEQPEGYDVGDAYHHIFMRILIAARTHGIHAIDGPFLKVRDVEAFRRV
AGRSAALGFDGKWVLHPDQITAGNEIFSPRQQDYDHAELILEAYEWHTSRAGGARGAVMLGDEMIDEASRKMARVVAGKG
RAAGMTRQGEPFRPPA

Sequences:

>Translated_336_residues
MTQRVESRAVNHALRPRELDDSARPRRTCLSVPGSSAKMIAKAKGLPADEVFLDLEDAVAPEAKAEARTRVALALAESGW
GGQLRGVRVNDWTTPWTYADVIEVVSTAGAHLDLIVLPKVTDVSHIHALDLLLTQLETTHGLPVGRIAVEAQIENAVGLT
NVDAIAAGPRVQALVLGPADLMASLNMRTLVVGEQPEGYDVGDAYHHIFMRILIAARTHGIHAIDGPFLKVRDVEAFRRV
AGRSAALGFDGKWVLHPDQITAGNEIFSPRQQDYDHAELILEAYEWHTSRAGGARGAVMLGDEMIDEASRKMARVVAGKG
RAAGMTRQGEPFRPPA
>Mature_335_residues
TQRVESRAVNHALRPRELDDSARPRRTCLSVPGSSAKMIAKAKGLPADEVFLDLEDAVAPEAKAEARTRVALALAESGWG
GQLRGVRVNDWTTPWTYADVIEVVSTAGAHLDLIVLPKVTDVSHIHALDLLLTQLETTHGLPVGRIAVEAQIENAVGLTN
VDAIAAGPRVQALVLGPADLMASLNMRTLVVGEQPEGYDVGDAYHHIFMRILIAARTHGIHAIDGPFLKVRDVEAFRRVA
GRSAALGFDGKWVLHPDQITAGNEIFSPRQQDYDHAELILEAYEWHTSRAGGARGAVMLGDEMIDEASRKMARVVAGKGR
AAGMTRQGEPFRPPA

Specific function: Catalyzes the reversible condensation of glyoxylate and acetyl-CoA to L-malyl-CoA and the reversible condensation of glyoxylate and propionyl-CoA to beta-methylmalyl-CoA [H]

COG id: COG2301

COG function: function code G; Citrate lyase beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

Organism=Homo sapiens, GI45545437, Length=305, Percent_Identity=30.8196721311475, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI87081764, Length=305, Percent_Identity=31.4754098360656, Blast_Score=109, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17557458, Length=292, Percent_Identity=27.3972602739726, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR011206
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: =4.1.3.24 [H]

Molecular weight: Translated: 36322; Mature: 36191

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQRVESRAVNHALRPRELDDSARPRRTCLSVPGSSAKMIAKAKGLPADEVFLDLEDAVA
CCCCHHHHHHHHCCCCCCCCCCCCCCHHEECCCCCCHHHHHHHCCCCHHHEEEEHHHHCC
PEAKAEARTRVALALAESGWGGQLRGVRVNDWTTPWTYADVIEVVSTAGAHLDLIVLPKV
CCHHHHHHHEEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEECCC
TDVSHIHALDLLLTQLETTHGLPVGRIAVEAQIENAVGLTNVDAIAAGPRVQALVLGPAD
CCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHCCCCCEEEEEECHHH
LMASLNMRTLVVGEQPEGYDVGDAYHHIFMRILIAARTHGIHAIDGPFLKVRDVEAFRRV
HHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCEECCCCEEEEECHHHHHHH
AGRSAALGFDGKWVLHPDQITAGNEIFSPRQQDYDHAELILEAYEWHTSRAGGARGAVML
HCCCEEECCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEE
GDEMIDEASRKMARVVAGKGRAAGMTRQGEPFRPPA
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TQRVESRAVNHALRPRELDDSARPRRTCLSVPGSSAKMIAKAKGLPADEVFLDLEDAVA
CCCHHHHHHHHCCCCCCCCCCCCCCHHEECCCCCCHHHHHHHCCCCHHHEEEEHHHHCC
PEAKAEARTRVALALAESGWGGQLRGVRVNDWTTPWTYADVIEVVSTAGAHLDLIVLPKV
CCHHHHHHHEEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEECCC
TDVSHIHALDLLLTQLETTHGLPVGRIAVEAQIENAVGLTNVDAIAAGPRVQALVLGPAD
CCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHCCCCCEEEEEECHHH
LMASLNMRTLVVGEQPEGYDVGDAYHHIFMRILIAARTHGIHAIDGPFLKVRDVEAFRRV
HHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCEECCCCEEEEECHHHHHHH
AGRSAALGFDGKWVLHPDQITAGNEIFSPRQQDYDHAELILEAYEWHTSRAGGARGAVML
HCCCEEECCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEE
GDEMIDEASRKMARVVAGKGRAAGMTRQGEPFRPPA
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA