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The map label for this gene is maeB [C]

Identifier: 108800941

GI number: 108800941

Start: 4243238

End: 4244413

Strand: Reverse

Name: maeB [C]

Synonym: Mmcs_3977

Alternate gene names: 108800941

Gene position: 4244413-4243238 (Counterclockwise)

Preceding gene: 108800943

Following gene: 108800940

Centisome position: 74.39

GC content: 70.41

Gene sequence:

>1176_bases
GTGGCTGAAACTGTTGTTGGTTCCTCACAGGTCGTCATCAGTGACGACGAGATCTTCGCCGCTCACGAGGGCGGCAAGCT
CGCGGTGCAACTGAACGAACCGCTGGACACGCAGCGCGCCCTGTCGATCGCCTACACCCCGGGTGTCGCCCAGGTCAGCC
GCGCCATCGCCAAAGACCCGGCCCTGGCCGCCAGGTACACGTGGGCCAACCGGCTCGTCGCGGTGGTCAGCGACGGCAGT
GCGGTGCTCGGGCTCGGCGATATCGGCGCGGCCGCGTCGCTGCCGGTGATGGAGGGTAAGAGCGCGCTGTTCAAGACATT
CGGCGGCCTCGACTCGATCCCGATCGTGCTCGACACCAAGGACCCCGACGAGATCGTCGAGACGCTGGTGCGGCTGCGCC
CGACGTTCGGGGCGGTCAACCTCGAGGACATCTCGGCGCCGCGCTGCTTCGAGATCGAACGCCGCGTCATCGAGGCCCTC
GACTGCCCGGTCATGCACGACGATCAGCACGGCACCGCGATCGTCGTACTCGCCGCGCTGATGGGTGCGGCCCGGGTCCT
CGGCCGGGACGCGGCCACGCTGCGGGTCGTGATCTCCGGTGCGGGCGCGGCGGGCGTCGCGTGTGCCAACATCCTGCTGG
CCGCCGGCATCAGCGACGTCACCGTGCTCGACAGCAAGGGCATCGTCCACAGCGGCCGTGACGACCTCAACTCCTTCAAG
GCCGAACTCGCCGAACGCACCAACCCGGCCGGCCGCACCGGCGGTGTGGCCGAGGCCCTCGACGGCGCCGACATGTTCCT
CGGACTCTCGGCCGGTGTCGTCGCGGAGGAGTTGATCGCGACGATGGCGCCGGGCGGCATCGTGTTCGCGCTGTCCAACC
CCGATCCGGAGATCCACCCGGACCTCGCGCGTAAGTACGCCGCCGTCGTGGCGACCGGGCGCAGCGACTTCCCGAACCAG
ATCAACAACGTGCTGGCGTTCCCCGGCGTGTTCCGCGGTGCGCTCGACGCCGGGGCGCGCCGGATCACCGAGCGGATGAA
GGTGGCCGCGGCCGAGGCGATCTTCTCGGTGGTCGGCGACGACCTGGCCGTCGACCACATCGTGCCGAGCGCGCTCGATC
CGCGGGTGGCCCCTGCGGTCGCCGCCGCGGTCGGTGCGGCCTCGCAGGTCGGCTGA

Upstream 100 bases:

>100_bases
AGGACGGCATCCGGAAATGGTACGCGTCCGGCCCGGCCACCGGACCTCACCGAGGGGTGAGCCCGGTCGGTGAGAACGCG
GGGTCCGATAGTGTTCACTC

Downstream 100 bases:

>100_bases
GCCGCCGAGTCGCTGTGCGCCGCCTGCTGATCGCGTTGTGCGCAGTGGCGCTGACCGCGTGCGGTGCTCCGCAGGCCGGA
CCGTCCCTGACGATCGGCTC

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MAETVVGSSQVVISDDEIFAAHEGGKLAVQLNEPLDTQRALSIAYTPGVAQVSRAIAKDPALAARYTWANRLVAVVSDGS
AVLGLGDIGAAASLPVMEGKSALFKTFGGLDSIPIVLDTKDPDEIVETLVRLRPTFGAVNLEDISAPRCFEIERRVIEAL
DCPVMHDDQHGTAIVVLAALMGAARVLGRDAATLRVVISGAGAAGVACANILLAAGISDVTVLDSKGIVHSGRDDLNSFK
AELAERTNPAGRTGGVAEALDGADMFLGLSAGVVAEELIATMAPGGIVFALSNPDPEIHPDLARKYAAVVATGRSDFPNQ
INNVLAFPGVFRGALDAGARRITERMKVAAAEAIFSVVGDDLAVDHIVPSALDPRVAPAVAAAVGAASQVG

Sequences:

>Translated_391_residues
MAETVVGSSQVVISDDEIFAAHEGGKLAVQLNEPLDTQRALSIAYTPGVAQVSRAIAKDPALAARYTWANRLVAVVSDGS
AVLGLGDIGAAASLPVMEGKSALFKTFGGLDSIPIVLDTKDPDEIVETLVRLRPTFGAVNLEDISAPRCFEIERRVIEAL
DCPVMHDDQHGTAIVVLAALMGAARVLGRDAATLRVVISGAGAAGVACANILLAAGISDVTVLDSKGIVHSGRDDLNSFK
AELAERTNPAGRTGGVAEALDGADMFLGLSAGVVAEELIATMAPGGIVFALSNPDPEIHPDLARKYAAVVATGRSDFPNQ
INNVLAFPGVFRGALDAGARRITERMKVAAAEAIFSVVGDDLAVDHIVPSALDPRVAPAVAAAVGAASQVG
>Mature_390_residues
AETVVGSSQVVISDDEIFAAHEGGKLAVQLNEPLDTQRALSIAYTPGVAQVSRAIAKDPALAARYTWANRLVAVVSDGSA
VLGLGDIGAAASLPVMEGKSALFKTFGGLDSIPIVLDTKDPDEIVETLVRLRPTFGAVNLEDISAPRCFEIERRVIEALD
CPVMHDDQHGTAIVVLAALMGAARVLGRDAATLRVVISGAGAAGVACANILLAAGISDVTVLDSKGIVHSGRDDLNSFKA
ELAERTNPAGRTGGVAEALDGADMFLGLSAGVVAEELIATMAPGGIVFALSNPDPEIHPDLARKYAAVVATGRSDFPNQI
NNVLAFPGVFRGALDAGARRITERMKVAAAEAIFSVVGDDLAVDHIVPSALDPRVAPAVAAAVGAASQVG

Specific function: In addition to the NAD-dependent oxidative decarboxylation of L-malate, the enzyme catalyzes the decarboxylation of oxaloacetate [H]

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=404, Percent_Identity=25.4950495049505, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI62420882, Length=362, Percent_Identity=25.414364640884, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI62420880, Length=362, Percent_Identity=25.414364640884, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI239049447, Length=362, Percent_Identity=25.414364640884, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI1788806, Length=384, Percent_Identity=47.1354166666667, Blast_Score=330, Evalue=1e-91,
Organism=Escherichia coli, GI87081919, Length=394, Percent_Identity=25.8883248730964, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17537199, Length=442, Percent_Identity=23.5294117647059, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281362672, Length=348, Percent_Identity=26.4367816091954, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356279, Length=348, Percent_Identity=26.4367816091954, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281362674, Length=348, Percent_Identity=26.4367816091954, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646388, Length=361, Percent_Identity=27.7008310249307, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24646386, Length=361, Percent_Identity=27.7008310249307, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI281363503, Length=435, Percent_Identity=24.8275862068966, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI78707232, Length=435, Percent_Identity=24.8275862068966, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281363505, Length=435, Percent_Identity=24.8275862068966, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI78707236, Length=435, Percent_Identity=24.8275862068966, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI78707242, Length=381, Percent_Identity=25.1968503937008, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI78707238, Length=381, Percent_Identity=25.1968503937008, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI78707240, Length=381, Percent_Identity=25.1968503937008, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 40120; Mature: 39989

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAETVVGSSQVVISDDEIFAAHEGGKLAVQLNEPLDTQRALSIAYTPGVAQVSRAIAKDP
CCCCEECCCEEEEECCCEEEEECCCEEEEEECCCCCCHHHEEEEECCCHHHHHHHHHCCC
ALAARYTWANRLVAVVSDGSAVLGLGDIGAAASLPVMEGKSALFKTFGGLDSIPIVLDTK
CHHHHHHHHHCEEEEEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEECC
DPDEIVETLVRLRPTFGAVNLEDISAPRCFEIERRVIEALDCPVMHDDQHGTAIVVLAAL
CHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHH
MGAARVLGRDAATLRVVISGAGAAGVACANILLAAGISDVTVLDSKGIVHSGRDDLNSFK
HHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHH
AELAERTNPAGRTGGVAEALDGADMFLGLSAGVVAEELIATMAPGGIVFALSNPDPEIHP
HHHHHCCCCCCCCCCHHHHHCCCHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCH
DLARKYAAVVATGRSDFPNQINNVLAFPGVFRGALDAGARRITERMKVAAAEAIFSVVGD
HHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DLAVDHIVPSALDPRVAPAVAAAVGAASQVG
CHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AETVVGSSQVVISDDEIFAAHEGGKLAVQLNEPLDTQRALSIAYTPGVAQVSRAIAKDP
CCCEECCCEEEEECCCEEEEECCCEEEEEECCCCCCHHHEEEEECCCHHHHHHHHHCCC
ALAARYTWANRLVAVVSDGSAVLGLGDIGAAASLPVMEGKSALFKTFGGLDSIPIVLDTK
CHHHHHHHHHCEEEEEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEECC
DPDEIVETLVRLRPTFGAVNLEDISAPRCFEIERRVIEALDCPVMHDDQHGTAIVVLAAL
CHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHH
MGAARVLGRDAATLRVVISGAGAAGVACANILLAAGISDVTVLDSKGIVHSGRDDLNSFK
HHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHH
AELAERTNPAGRTGGVAEALDGADMFLGLSAGVVAEELIATMAPGGIVFALSNPDPEIHP
HHHHHCCCCCCCCCCHHHHHCCCHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCH
DLARKYAAVVATGRSDFPNQINNVLAFPGVFRGALDAGARRITERMKVAAAEAIFSVVGD
HHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DLAVDHIVPSALDPRVAPAVAAAVGAASQVG
CHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2644282 [H]