Click here to switch to the map view.

The map label for this gene is yqeF [C]

Identifier: 108800828

GI number: 108800828

Start: 4111723

End: 4112904

Strand: Reverse

Name: yqeF [C]

Synonym: Mmcs_3864

Alternate gene names: 108800828

Gene position: 4112904-4111723 (Counterclockwise)

Preceding gene: 108800830

Following gene: 108800827

Centisome position: 72.09

GC content: 69.04

Gene sequence:

>1182_bases
ATGACGACGTCGGTGATCGTTGCTGGGGCCCGCACGCCGGTAGGCAAGTTGATGGGTTCGCTGAAGGACTTCTCGGGCAG
TGATCTGGGCGGGATCGCGATCAAGGCCGCGTTGGAGAAGGCGGGTGTGGCACCGTCGGCCGTCGATTACGTGATCATGG
GCCAGGTGCTCACCGCCGGCGCCGGGCAGATGCCCGCCCGCCAGGCCGCCGTGGCCGCCGGCATCCCGTGGGACGTGCCT
GCGCTGACCATCAACAAGATGTGCCTCTCGGGCATCGACGCGATCGCGCTGGCCGACCAGCTGATCCGCGCGGGTGAGTT
CGACGTCGTGGTCGCCGGTGGTCAGGAGTCGATGACCCAGGCCCCGCACCTGCTCGTCAACAGCCGCTCGGGATACAAGT
ACGGCGACGTGACCGCGCTCGACCACATGGCCTACGACGGCCTGCACGACGTGTTCACCGACCAGCCGATGGGTGCGCTC
ACCGAACAGCGCAACGACGTCGACCAGTTCACCCGCGCCCAGCAGGACGAGTTCGCTGCCACCTCGCATCAGAAGGCCGC
CGCGGCGTGGAAGGACGGCGTATACGCCGACGAGGTGGTGCCGGTGTCGATCCCGCAGCGCAAGGGTGACCCCATCGAGT
TCTCGGAGGACGAGGGCATCCGGGCCAACACCACGGCCGAGTCGCTGGCCGGGCTCAAGCCGGCGTTCCGCAAGGACGGC
ACCATCACCGCCGGTTCGGCGTCGCAGATTTCGGACGGCGCCTGCGCAGTGGTGGTGATGAACAAGGCCAAGGCCGAGGA
ACTGGGCCTGACCTGGCTCGCGGAGATCGGCGCGCACGGCGTGGTCGCCGGCCCCGACTCCACCCTGCAGAGCCAGCCGG
CCAACGCGATCAAGAAGGCGATCGCCCGTGAGGGCATCTCGACCGATCAGCTCGACGTGATCGAGATCAACGAGGCGTTC
TCGGCGGTCGCGTTGGCGTCCACCAAGGAACTCGGCGTGGATCCGGAGCGGGTCAACGTCAACGGCGGCGCCATCGCGAT
CGGCCACCCGATCGGGATGTCCGGTGCCCGGATCACGCTGCACGCGGCCCTCGAGCTGGCCCGCCGCGGCTCCGGTTACG
CGGTGGCCGCGCTCTGCGGTGCGGGCGGTCAGGGCGATGCGCTGATCCTGCGTCGCCCCTGA

Upstream 100 bases:

>100_bases
CAGTCATATCGCAAAGGTAACCTAACGGCATCGGTTCCGAACACTTCAGGTCACCTGTATAGCCTCATCGGAACCGCCCG
AAACCCGCTTGGAGGTATTG

Downstream 100 bases:

>100_bases
CGCGTCGGCCCGGCCTCTACGACGGCTTGTAGTAATCGCGGCCGGCTTCCGGCACAATGGCGGCCATGTCTGGTGCTTTC
GATCTGCGTAACCCCGTCGG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTTSVIVAGARTPVGKLMGSLKDFSGSDLGGIAIKAALEKAGVAPSAVDYVIMGQVLTAGAGQMPARQAAVAAGIPWDVP
ALTINKMCLSGIDAIALADQLIRAGEFDVVVAGGQESMTQAPHLLVNSRSGYKYGDVTALDHMAYDGLHDVFTDQPMGAL
TEQRNDVDQFTRAQQDEFAATSHQKAAAAWKDGVYADEVVPVSIPQRKGDPIEFSEDEGIRANTTAESLAGLKPAFRKDG
TITAGSASQISDGACAVVVMNKAKAEELGLTWLAEIGAHGVVAGPDSTLQSQPANAIKKAIAREGISTDQLDVIEINEAF
SAVALASTKELGVDPERVNVNGGAIAIGHPIGMSGARITLHAALELARRGSGYAVAALCGAGGQGDALILRRP

Sequences:

>Translated_393_residues
MTTSVIVAGARTPVGKLMGSLKDFSGSDLGGIAIKAALEKAGVAPSAVDYVIMGQVLTAGAGQMPARQAAVAAGIPWDVP
ALTINKMCLSGIDAIALADQLIRAGEFDVVVAGGQESMTQAPHLLVNSRSGYKYGDVTALDHMAYDGLHDVFTDQPMGAL
TEQRNDVDQFTRAQQDEFAATSHQKAAAAWKDGVYADEVVPVSIPQRKGDPIEFSEDEGIRANTTAESLAGLKPAFRKDG
TITAGSASQISDGACAVVVMNKAKAEELGLTWLAEIGAHGVVAGPDSTLQSQPANAIKKAIAREGISTDQLDVIEINEAF
SAVALASTKELGVDPERVNVNGGAIAIGHPIGMSGARITLHAALELARRGSGYAVAALCGAGGQGDALILRRP
>Mature_392_residues
TTSVIVAGARTPVGKLMGSLKDFSGSDLGGIAIKAALEKAGVAPSAVDYVIMGQVLTAGAGQMPARQAAVAAGIPWDVPA
LTINKMCLSGIDAIALADQLIRAGEFDVVVAGGQESMTQAPHLLVNSRSGYKYGDVTALDHMAYDGLHDVFTDQPMGALT
EQRNDVDQFTRAQQDEFAATSHQKAAAAWKDGVYADEVVPVSIPQRKGDPIEFSEDEGIRANTTAESLAGLKPAFRKDGT
ITAGSASQISDGACAVVVMNKAKAEELGLTWLAEIGAHGVVAGPDSTLQSQPANAIKKAIAREGISTDQLDVIEINEAFS
AVALASTKELGVDPERVNVNGGAIAIGHPIGMSGARITLHAALELARRGSGYAVAALCGAGGQGDALILRRP

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=390, Percent_Identity=44.8717948717949, Blast_Score=295, Evalue=3e-80,
Organism=Homo sapiens, GI167614485, Length=387, Percent_Identity=41.0852713178295, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI4557237, Length=390, Percent_Identity=40, Blast_Score=272, Evalue=3e-73,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=37.9746835443038, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI4504327, Length=421, Percent_Identity=31.8289786223278, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=26.3427109974425, Blast_Score=119, Evalue=4e-27,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=45.6632653061224, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=45.8015267175573, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1787663, Length=400, Percent_Identity=38.5, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=34.0852130325814, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI1788683, Length=413, Percent_Identity=30.9927360774818, Blast_Score=167, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI25147385, Length=389, Percent_Identity=40.8740359897172, Blast_Score=277, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI133906874, Length=388, Percent_Identity=40.979381443299, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI17535921, Length=389, Percent_Identity=37.7892030848329, Blast_Score=249, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=34.9489795918367, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=32.2352941176471, Blast_Score=174, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6325229, Length=392, Percent_Identity=40.3061224489796, Blast_Score=264, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6322031, Length=399, Percent_Identity=35.8395989974937, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24640423, Length=389, Percent_Identity=42.4164524421594, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=42.0918367346939, Blast_Score=292, Evalue=2e-79,
Organism=Drosophila melanogaster, GI17648125, Length=388, Percent_Identity=37.6288659793814, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI17137578, Length=423, Percent_Identity=31.6784869976359, Blast_Score=170, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40479; Mature: 40348

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSVIVAGARTPVGKLMGSLKDFSGSDLGGIAIKAALEKAGVAPSAVDYVIMGQVLTAG
CCCEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
AGQMPARQAAVAAGIPWDVPALTINKMCLSGIDAIALADQLIRAGEFDVVVAGGQESMTQ
CCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCHHHHH
APHLLVNSRSGYKYGDVTALDHMAYDGLHDVFTDQPMGALTEQRNDVDQFTRAQQDEFAA
CCEEEEECCCCCCCCCCHHHHHHHHCCHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHH
TSHQKAAAAWKDGVYADEVVPVSIPQRKGDPIEFSEDEGIRANTTAESLAGLKPAFRKDG
HCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHCCCC
TITAGSASQISDGACAVVVMNKAKAEELGLTWLAEIGAHGVVAGPDSTLQSQPANAIKKA
CEECCCCCCCCCCCEEEEEECCCCHHHHCHHHHHHHCCCCEEECCCCHHHCCCHHHHHHH
IAREGISTDQLDVIEINEAFSAVALASTKELGVDPERVNVNGGAIAIGHPIGMSGARITL
HHHCCCCCCCEEEEEECHHHHHHHHHCHHHHCCCCCEEECCCCEEEECCCCCCCCCEEEH
HAALELARRGSGYAVAALCGAGGQGDALILRRP
HHHHHHHHCCCCEEEEEEECCCCCCCEEEEECC
>Mature Secondary Structure 
TTSVIVAGARTPVGKLMGSLKDFSGSDLGGIAIKAALEKAGVAPSAVDYVIMGQVLTAG
CCEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
AGQMPARQAAVAAGIPWDVPALTINKMCLSGIDAIALADQLIRAGEFDVVVAGGQESMTQ
CCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCHHHHH
APHLLVNSRSGYKYGDVTALDHMAYDGLHDVFTDQPMGALTEQRNDVDQFTRAQQDEFAA
CCEEEEECCCCCCCCCCHHHHHHHHCCHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHH
TSHQKAAAAWKDGVYADEVVPVSIPQRKGDPIEFSEDEGIRANTTAESLAGLKPAFRKDG
HCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHCCCC
TITAGSASQISDGACAVVVMNKAKAEELGLTWLAEIGAHGVVAGPDSTLQSQPANAIKKA
CEECCCCCCCCCCCEEEEEECCCCHHHHCHHHHHHHCCCCEEECCCCHHHCCCHHHHHHH
IAREGISTDQLDVIEINEAFSAVALASTKELGVDPERVNVNGGAIAIGHPIGMSGARITL
HHHCCCCCCCEEEEEECHHHHHHHHHCHHHHCCCCCEEECCCCEEEECCCCCCCCCEEEH
HAALELARRGSGYAVAALCGAGGQGDALILRRP
HHHHHHHHCCCCEEEEEEECCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA