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The map label for this gene is vgb [H]

Identifier: 108800822

GI number: 108800822

Start: 4102375

End: 4103217

Strand: Reverse

Name: vgb [H]

Synonym: Mmcs_3858

Alternate gene names: 108800822

Gene position: 4103217-4102375 (Counterclockwise)

Preceding gene: 108800823

Following gene: 108800821

Centisome position: 71.92

GC content: 72.48

Gene sequence:

>843_bases
GTGAGCCTGATCCGCGAGATCGCGGGCGGCCCCTACGCCCTGGCGGCCGGACCCGACGGGGCGATGTGGGTGACGCTCGT
GCACGACGGTGCGATCGCCCGGGTGGGGGCCGACGGAGCGGTCGACCGCTTCCCGGTTGCCGACGGCTCCCGCCCGTCGC
TGATCTCGGCCGGACCCGACGGGGCGCTGTGGTTCACCCGCAACGGCGACGACCGGATCGGGCGCCTCACCACCGCAGGG
GAACTCACCGAGTTCCCGCTCAGCGAGGGCAGCGCGCCGTTCGGCATCTGCGCAGGCGCCGACGGCGCCCTGTGGTTCAC
CGAGATGGGGTCGGGCGGTATCGGACGCATCACCGTCGACGGCCAGACCAGCGGGTGGGCGTCGGTCGGCGGAACCCCGT
CGATGATCACCCGCGGACCCGACGACGCGGTGTGGTTCACCCTCAACCAGGGCAACGCAATCGGTCGACTGCATCCCCGC
GACGGGGTGACGATGCGCGAACTGCCCACCCGCGGGGCCGGCCCGGTAGGCATCACCGCCACCCACGACGACGCGATCTG
GTTCACCGAGATCCTCGCCGACAAACTCGGCCGAATCCCACTCGACGGGGCGCTGCAGGAGATCGACCTGCCCGGCAAGC
CGCACGCCGTGGTCGCCGACCCTTCCGGCGGCGTGTGGGTGAGCCTGTGGGGCGCCGATCGACTGGCCCGGGTCAGCGCC
GACGGCGACATCGAGACCTTCGACCTGCCGCCCGGCAGTGAACCGCACGGTCTGGCGTTCGGCCCCGACGGCGGCCTGTG
GGTTGCGCTGGAGTCCGGCTTCGTCCTGCGGATGCCCGACTGA

Upstream 100 bases:

>100_bases
CGCCGCTGCCGGTGGCCGGGCCGGTGGGCTACACCGTTCGCGTGCTGCCGCACCATCGGCTGCTGGCCGCCGACAACGAA
CTCGGCCTGGTCGCGCTGGC

Downstream 100 bases:

>100_bases
CCGGGACGCACGTCGAACCTCCACTCACCGCCATGTAGGTTCCTCGGTTAGTGCGTCTAGTCAGCTAGGGGGCTACAACG
GTGTGGCAACGCGGCTTCAC

Product: hydrolase

Products: NA

Alternate protein names: Streptogramin B lyase [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MSLIREIAGGPYALAAGPDGAMWVTLVHDGAIARVGADGAVDRFPVADGSRPSLISAGPDGALWFTRNGDDRIGRLTTAG
ELTEFPLSEGSAPFGICAGADGALWFTEMGSGGIGRITVDGQTSGWASVGGTPSMITRGPDDAVWFTLNQGNAIGRLHPR
DGVTMRELPTRGAGPVGITATHDDAIWFTEILADKLGRIPLDGALQEIDLPGKPHAVVADPSGGVWVSLWGADRLARVSA
DGDIETFDLPPGSEPHGLAFGPDGGLWVALESGFVLRMPD

Sequences:

>Translated_280_residues
MSLIREIAGGPYALAAGPDGAMWVTLVHDGAIARVGADGAVDRFPVADGSRPSLISAGPDGALWFTRNGDDRIGRLTTAG
ELTEFPLSEGSAPFGICAGADGALWFTEMGSGGIGRITVDGQTSGWASVGGTPSMITRGPDDAVWFTLNQGNAIGRLHPR
DGVTMRELPTRGAGPVGITATHDDAIWFTEILADKLGRIPLDGALQEIDLPGKPHAVVADPSGGVWVSLWGADRLARVSA
DGDIETFDLPPGSEPHGLAFGPDGGLWVALESGFVLRMPD
>Mature_279_residues
SLIREIAGGPYALAAGPDGAMWVTLVHDGAIARVGADGAVDRFPVADGSRPSLISAGPDGALWFTRNGDDRIGRLTTAGE
LTEFPLSEGSAPFGICAGADGALWFTEMGSGGIGRITVDGQTSGWASVGGTPSMITRGPDDAVWFTLNQGNAIGRLHPRD
GVTMRELPTRGAGPVGITATHDDAIWFTEILADKLGRIPLDGALQEIDLPGKPHAVVADPSGGVWVSLWGADRLARVSAD
GDIETFDLPPGSEPHGLAFGPDGGLWVALESGFVLRMPD

Specific function: Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid [H]

COG id: COG4257

COG function: function code V; Streptogramin lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the vgb family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 28959; Mature: 28828

Theoretical pI: Translated: 4.27; Mature: 4.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLIREIAGGPYALAAGPDGAMWVTLVHDGAIARVGADGAVDRFPVADGSRPSLISAGPD
CCHHHHHCCCCEEEEECCCCEEEEEEEECCEEEEECCCCCCCCCCCCCCCCCCEEECCCC
GALWFTRNGDDRIGRLTTAGELTEFPLSEGSAPFGICAGADGALWFTEMGSGGIGRITVD
CEEEEEECCCCCEEEEEECCCCEECCCCCCCCCEEEEECCCCEEEEEECCCCCEEEEEEC
GQTSGWASVGGTPSMITRGPDDAVWFTLNQGNAIGRLHPRDGVTMRELPTRGAGPVGITA
CCCCCCEECCCCHHHEECCCCCEEEEEEECCCEEEEECCCCCCCHHHCCCCCCCCEEEEE
THDDAIWFTEILADKLGRIPLDGALQEIDLPGKPHAVVADPSGGVWVSLWGADRLARVSA
ECCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCEEEECCCCCEEEEEECCCEEEEEEC
DGDIETFDLPPGSEPHGLAFGPDGGLWVALESGFVLRMPD
CCCEEEEECCCCCCCCCEEECCCCCEEEEEECCEEEECCC
>Mature Secondary Structure 
SLIREIAGGPYALAAGPDGAMWVTLVHDGAIARVGADGAVDRFPVADGSRPSLISAGPD
CHHHHHCCCCEEEEECCCCEEEEEEEECCEEEEECCCCCCCCCCCCCCCCCCEEECCCC
GALWFTRNGDDRIGRLTTAGELTEFPLSEGSAPFGICAGADGALWFTEMGSGGIGRITVD
CEEEEEECCCCCEEEEEECCCCEECCCCCCCCCEEEEECCCCEEEEEECCCCCEEEEEEC
GQTSGWASVGGTPSMITRGPDDAVWFTLNQGNAIGRLHPRDGVTMRELPTRGAGPVGITA
CCCCCCEECCCCHHHEECCCCCEEEEEEECCCEEEEECCCCCCCHHHCCCCCCCCEEEEE
THDDAIWFTEILADKLGRIPLDGALQEIDLPGKPHAVVADPSGGVWVSLWGADRLARVSA
ECCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCEEEECCCCCEEEEEECCCEEEEEEC
DGDIETFDLPPGSEPHGLAFGPDGGLWVALESGFVLRMPD
CCCEEEEECCCCCCCCCEEECCCCCEEEEEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA