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The map label for this gene is dapE [H]

Identifier: 108800611

GI number: 108800611

Start: 3894010

End: 3895371

Strand: Reverse

Name: dapE [H]

Synonym: Mmcs_3645

Alternate gene names: 108800611

Gene position: 3895371-3894010 (Counterclockwise)

Preceding gene: 108800612

Following gene: 108800609

Centisome position: 68.27

GC content: 71.15

Gene sequence:

>1362_bases
GTGAAGCGGAGACCCACTACGCTCGTGCCCATGAGCGACGTGGTGGCCCGGGTGCAGGAAGTCCTACCGTCGGTCCGGTC
CGACCTCGAGGATCTGGTCCGCATCGAGTCGGTGTGGGCCGATCCGGCGCGCCGTGACGAGGTGCAGCGCAGCGCGCGGG
CGGTGGCAGATCTCCTCGGGGCGGCCGGTTTCGACGACGTCAGCATCGTCGCCGAGGGCGGCGCGCCTGCGGTGATCGCC
CGGCACCCGGCGCCGCCCGGTGCACCGACGGTGCTGCTCTACGCCCATCACGACGTACAGCCGGAGGGTGACCCCGGCCA
GTGGTCGTCGCCCCCGTTCGAACCCACCGAGCGCGACGGACGGCTGTACGGCCGCGGCACCGCCGACGACAAGGCCGGCA
TCGCCACCCACCTGGCGGCGTTCCGCGCCTTCGACGGCAAGCCACCGGTCGGGGTGACGGTGTTCGTCGAGGGCGAGGAG
GAGTCGGGTTCCCCGTCGCTGGCGAATCTGCTTGCCGCGCACAAGGAGTCGCTGGCTGCCGATGTCATCGTGATCGCCGA
CTCCGACAACTGGAGCACCGACCGGCCCGCGCTGACCGTCTCGCTGCGCGGTCTTGCCGACTGCGTCGTCGAGGTCGCCA
CCCTCGATCACGGTCTGCACTCGGGCCTGTGGGGCGGTGTGGTGCCCGACGCCCTGACCGTGCTGGTGCGGTTGTTGGCG
AGCCTGCACGACGACGACGGGAATGTGGCGGTTGCCGGCCTACACGAGGGCTCTGCTGCGGATGTCGACCGCGGTCCGGA
CTGGGTGCGCGAAGAGTCCGGACTGCTACCCGGTGTGTCCGAGATCGGTTCGGGCTCAGTGGTGCAACGGCTGTGGGCCA
AGCCGGCGATCACCGTCATCGGCATCGACACCACGCCGATCGACAAGTCGTCGAACACGCTGATCCCGCGGGCGCGGGCC
AAGATCAGCATGCGGGTGGCGCCGGGCGGTGACGCGAAGGCACACCTCGACGCGCTGACCCGCCACCTCGAAGCGCACGT
CCCCTGGGGTGCTCGGCTCACCGTGACGCCGGGGGACACCGGCCAGCCGTACGCGATCGACGCGGCCGGCCCGGTCTACG
ACGCCGCCCGTGCGGCGTTCACCCAGGCGTGGGGCGCCACACCGGTGGACATGGGCATGGGCGGGTCGATCCCGTTCATC
GCCGAGTTCGCCGCCGCGTTCCCGCAGGCGACGATCCTGGTGACCGGTGTCGAGGATCCGGGAACCCAGGCGCACAGCGT
GAACGAGAGCCTGCACCTCGGTGTGCTCGAGCGGGCGGCCACCGCCGAGGCGCTGCTGCTGGAGAAACTCGGCGCCAGTT
AG

Upstream 100 bases:

>100_bases
GGGACGCGGAGACCGACTGAGCTGAGCCCGGCCTTTCCCGCGAGCAGACGCAAATGTCCGTCGCGCCGGGGACTTCCGGG
CACATTTGCGTCTGCTCGCG

Downstream 100 bases:

>100_bases
ACCGACAGATCGCGGCGCAGTTTGGCGACGTGACCGGTGGCGCGCACGTTGTACTGCGCCTCGGCGATCTTGCCGTCCTC
GTCGACGAGGAACGTCGAGC

Product: hypothetical protein

Products: NA

Alternate protein names: SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MKRRPTTLVPMSDVVARVQEVLPSVRSDLEDLVRIESVWADPARRDEVQRSARAVADLLGAAGFDDVSIVAEGGAPAVIA
RHPAPPGAPTVLLYAHHDVQPEGDPGQWSSPPFEPTERDGRLYGRGTADDKAGIATHLAAFRAFDGKPPVGVTVFVEGEE
ESGSPSLANLLAAHKESLAADVIVIADSDNWSTDRPALTVSLRGLADCVVEVATLDHGLHSGLWGGVVPDALTVLVRLLA
SLHDDDGNVAVAGLHEGSAADVDRGPDWVREESGLLPGVSEIGSGSVVQRLWAKPAITVIGIDTTPIDKSSNTLIPRARA
KISMRVAPGGDAKAHLDALTRHLEAHVPWGARLTVTPGDTGQPYAIDAAGPVYDAARAAFTQAWGATPVDMGMGGSIPFI
AEFAAAFPQATILVTGVEDPGTQAHSVNESLHLGVLERAATAEALLLEKLGAS

Sequences:

>Translated_453_residues
MKRRPTTLVPMSDVVARVQEVLPSVRSDLEDLVRIESVWADPARRDEVQRSARAVADLLGAAGFDDVSIVAEGGAPAVIA
RHPAPPGAPTVLLYAHHDVQPEGDPGQWSSPPFEPTERDGRLYGRGTADDKAGIATHLAAFRAFDGKPPVGVTVFVEGEE
ESGSPSLANLLAAHKESLAADVIVIADSDNWSTDRPALTVSLRGLADCVVEVATLDHGLHSGLWGGVVPDALTVLVRLLA
SLHDDDGNVAVAGLHEGSAADVDRGPDWVREESGLLPGVSEIGSGSVVQRLWAKPAITVIGIDTTPIDKSSNTLIPRARA
KISMRVAPGGDAKAHLDALTRHLEAHVPWGARLTVTPGDTGQPYAIDAAGPVYDAARAAFTQAWGATPVDMGMGGSIPFI
AEFAAAFPQATILVTGVEDPGTQAHSVNESLHLGVLERAATAEALLLEKLGAS
>Mature_453_residues
MKRRPTTLVPMSDVVARVQEVLPSVRSDLEDLVRIESVWADPARRDEVQRSARAVADLLGAAGFDDVSIVAEGGAPAVIA
RHPAPPGAPTVLLYAHHDVQPEGDPGQWSSPPFEPTERDGRLYGRGTADDKAGIATHLAAFRAFDGKPPVGVTVFVEGEE
ESGSPSLANLLAAHKESLAADVIVIADSDNWSTDRPALTVSLRGLADCVVEVATLDHGLHSGLWGGVVPDALTVLVRLLA
SLHDDDGNVAVAGLHEGSAADVDRGPDWVREESGLLPGVSEIGSGSVVQRLWAKPAITVIGIDTTPIDKSSNTLIPRARA
KISMRVAPGGDAKAHLDALTRHLEAHVPWGARLTVTPGDTGQPYAIDAAGPVYDAARAAFTQAWGATPVDMGMGGSIPFI
AEFAAAFPQATILVTGVEDPGTQAHSVNESLHLGVLERAATAEALLLEKLGAS

Specific function: Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bact

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. DapE subfamily [H]

Homologues:

Organism=Homo sapiens, GI271398239, Length=472, Percent_Identity=30.9322033898305, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI21071039, Length=457, Percent_Identity=29.3216630196937, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI271398277, Length=318, Percent_Identity=30.8176100628931, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17563146, Length=474, Percent_Identity=28.4810126582279, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI193211059, Length=457, Percent_Identity=27.7899343544858, Blast_Score=153, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6321159, Length=463, Percent_Identity=27.645788336933, Blast_Score=153, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6319758, Length=448, Percent_Identity=24.7767857142857, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24585880, Length=462, Percent_Identity=31.8181818181818, Blast_Score=182, Evalue=5e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005941
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.18 [H]

Molecular weight: Translated: 47268; Mature: 47268

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRRPTTLVPMSDVVARVQEVLPSVRSDLEDLVRIESVWADPARRDEVQRSARAVADLLG
CCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
AAGFDDVSIVAEGGAPAVIARHPAPPGAPTVLLYAHHDVQPEGDPGQWSSPPFEPTERDG
CCCCCCEEEEECCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
RLYGRGTADDKAGIATHLAAFRAFDGKPPVGVTVFVEGEEESGSPSLANLLAAHKESLAA
EEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCE
DVIVIADSDNWSTDRPALTVSLRGLADCVVEVATLDHGLHSGLWGGVVPDALTVLVRLLA
EEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
SLHDDDGNVAVAGLHEGSAADVDRGPDWVREESGLLPGVSEIGSGSVVQRLWAKPAITVI
HHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCCCCHHHHCCCHHHHHHHCCCCEEEE
GIDTTPIDKSSNTLIPRARAKISMRVAPGGDAKAHLDALTRHLEAHVPWGARLTVTPGDT
ECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCC
GQPYAIDAAGPVYDAARAAFTQAWGATPVDMGMGGSIPFIAEFAAAFPQATILVTGVEDP
CCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCC
GTQAHSVNESLHLGVLERAATAEALLLEKLGAS
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKRRPTTLVPMSDVVARVQEVLPSVRSDLEDLVRIESVWADPARRDEVQRSARAVADLLG
CCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
AAGFDDVSIVAEGGAPAVIARHPAPPGAPTVLLYAHHDVQPEGDPGQWSSPPFEPTERDG
CCCCCCEEEEECCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
RLYGRGTADDKAGIATHLAAFRAFDGKPPVGVTVFVEGEEESGSPSLANLLAAHKESLAA
EEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCE
DVIVIADSDNWSTDRPALTVSLRGLADCVVEVATLDHGLHSGLWGGVVPDALTVLVRLLA
EEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
SLHDDDGNVAVAGLHEGSAADVDRGPDWVREESGLLPGVSEIGSGSVVQRLWAKPAITVI
HHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCCCCHHHHCCCHHHHHHHCCCCEEEE
GIDTTPIDKSSNTLIPRARAKISMRVAPGGDAKAHLDALTRHLEAHVPWGARLTVTPGDT
ECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCC
GQPYAIDAAGPVYDAARAAFTQAWGATPVDMGMGGSIPFIAEFAAAFPQATILVTGVEDP
CCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCC
GTQAHSVNESLHLGVLERAATAEALLLEKLGAS
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA