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The map label for this gene is fadD [C]

Identifier: 108800568

GI number: 108800568

Start: 3840388

End: 3842196

Strand: Reverse

Name: fadD [C]

Synonym: Mmcs_3602

Alternate gene names: 108800568

Gene position: 3842196-3840388 (Counterclockwise)

Preceding gene: 108800569

Following gene: 108800567

Centisome position: 67.34

GC content: 66.61

Gene sequence:

>1809_bases
ATGTCCATCGACAGCCAGAAGCGGCCCGGAACCACCTCCGCGAACGTCGCCCGGATGTTCTTCGACCGTGTCGAGAAATC
CGCGCAGTCCGAAGCCTTCCGCAAACTCGACGACGGCAAGTGGACGTCGCTGACGTGGCAGGACGCCGCCGGTCAGGTCG
AGGCGCTGGCCGCCGGCCTGCTCGCGTTGGGCATCGAACCCGAACAGCGGGTGGGCATCGCGTCGAGCACCCGCTACGAC
TGGATCCTGGCCGACCTGGCGATCATGTGTGCCGGCGGTGCCACCACCACGGTGTACCCGACGACGAATGCCGCCGACAC
GGCCTACATCCTCGCCGACTCCGGGTCGCGCTTCGTGTTCGCCGAAGACGACGCGCAGCTCGCGAAGCTGCGGGACAAAC
GCGACGAACTGCCGAACCTCGAGAAGGTGGTGCTGTTCGACGGCACCGGCGACGGCGACTGGGTGCTGAACCTGGCCGAC
GTCGTCGACCTGGGCCGCAAACACCTCGAGGAGCAGCCGTCGGCCGTGCGTGACCGCTCCGCGGCGATCACCTCCGATCA
GCTGGCCACGCTGATCTACACCTCGGGCACCACCGGCAAACCCAAGGGCGTCCGGCTCGCCCACCGGGCGTGGGTGTACG
AGGGGGAGACGGTCGCCGGTTTCGACATCCTGCACGAGGACGATCTGCAGCTTCTGTGGCTGCCGCTGGCCCACGCGTTC
GGCAAGGTGCTGATCTCGGCGCAGCTGGCCTGCGGGTTCGCCAGCGCCATCGACGGTCGGGTGGACAAGATCGTCGAGAA
CATGGGGACGGTGAAGCCGACCTTCATGGGGGCGGCGCCGCGCATCTTCGAGAAGGCCCACGCCAAGGTCGTCATGCAGC
AGCACGGCGTCAAGGAGAAGCTGTTCAACGCCGCGTTCGCGGTGGGCCGTCAGGTCAGCCGCCTGCGGCGTGAGGGCAAG
TCCGTGCCGCCGCATCTGGCGCTGGCGCACACCCTGTTCGACCGTCTCGTCTTCAGCAAGGTGCGTGCGGTGTTCGGCGG
CCGGATCCGGTTCATGATCTCCGGCTCCGCACCGCTCAACCGCGACATCGCCGAGTGGTTCCACGCGGCCGGCCTGCTGA
TCCTCGAGGGTTACGGGCTCACCGAGACCGCCGCCGGTGCGTTCATCAACCGGCTGGAGAACTACCGGCTCGGCACGGTC
GGGCAGGTCTTCGACGGCAGCGAGGTGCGCATCAGCGACGACGGCGAGGTCCAGATCAAGGGGCCGTGTGTGATGGACGG
CTACCACAACTTGCCGGACAAGACCGCCGAGACGCTGACCGACGACGGATGGCTGCGCACCGGTGACCGTGGTCAACTCG
ACGACGACGGCTTCCTCACCATCACCGGCCGGATCAAGGAGCTGTTCAAGACCTCCGGCGGGAAATACGTTGCGCCACCG
GCCATCGAGGGCAGGTTCATGGCGCTGTGCCCGTACGCGGGGCACATGCTGGTGTTCGGCGAGTCCCGGAACTTCTGCGT
CGCGCTGGTGACGCTGGACCCCGACGCCATCTCCGGCTGGGCCGCAGAACACGGCATGGGGGACAAGTCGTACCCCGACC
TGGTGAAGTCCGATGCGGTGCGCGAGCTGATCGGCGGCTACATCGAGCGGTTGAACTCGGAGCTCAACAGGTGGGAGACC
ATCAAGAAGTGGGCGATCCTCGACCACGACCTGTCCATCGAGAACAACGAGCTGACACCGTCGTTGAAGGTCAAGCGGGG
GGTTGTCGAGGAGAAGCAGAAGGACCTGCTGGACTCGTTCTACACGTGA

Upstream 100 bases:

>100_bases
GCTGCGTCGAAACGGCGTGGACCGGGTATGAGTGTGCAACCATCGATGACCACCCCGTGAGGGGCGGCGTCGCACCCAGC
CCCGAGTCCCGGAGACAACG

Downstream 100 bases:

>100_bases
GGGCCTTCGTCGCGCCGTAACCGCCGCCGGGTGCTAGTTTCTGGGCTGTGCCGAGCCCACCCCGCCCCGTGACCAGCGTC
GCCGACATGCTCGACGTCGC

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 602; Mature: 601

Protein sequence:

>602_residues
MSIDSQKRPGTTSANVARMFFDRVEKSAQSEAFRKLDDGKWTSLTWQDAAGQVEALAAGLLALGIEPEQRVGIASSTRYD
WILADLAIMCAGGATTTVYPTTNAADTAYILADSGSRFVFAEDDAQLAKLRDKRDELPNLEKVVLFDGTGDGDWVLNLAD
VVDLGRKHLEEQPSAVRDRSAAITSDQLATLIYTSGTTGKPKGVRLAHRAWVYEGETVAGFDILHEDDLQLLWLPLAHAF
GKVLISAQLACGFASAIDGRVDKIVENMGTVKPTFMGAAPRIFEKAHAKVVMQQHGVKEKLFNAAFAVGRQVSRLRREGK
SVPPHLALAHTLFDRLVFSKVRAVFGGRIRFMISGSAPLNRDIAEWFHAAGLLILEGYGLTETAAGAFINRLENYRLGTV
GQVFDGSEVRISDDGEVQIKGPCVMDGYHNLPDKTAETLTDDGWLRTGDRGQLDDDGFLTITGRIKELFKTSGGKYVAPP
AIEGRFMALCPYAGHMLVFGESRNFCVALVTLDPDAISGWAAEHGMGDKSYPDLVKSDAVRELIGGYIERLNSELNRWET
IKKWAILDHDLSIENNELTPSLKVKRGVVEEKQKDLLDSFYT

Sequences:

>Translated_602_residues
MSIDSQKRPGTTSANVARMFFDRVEKSAQSEAFRKLDDGKWTSLTWQDAAGQVEALAAGLLALGIEPEQRVGIASSTRYD
WILADLAIMCAGGATTTVYPTTNAADTAYILADSGSRFVFAEDDAQLAKLRDKRDELPNLEKVVLFDGTGDGDWVLNLAD
VVDLGRKHLEEQPSAVRDRSAAITSDQLATLIYTSGTTGKPKGVRLAHRAWVYEGETVAGFDILHEDDLQLLWLPLAHAF
GKVLISAQLACGFASAIDGRVDKIVENMGTVKPTFMGAAPRIFEKAHAKVVMQQHGVKEKLFNAAFAVGRQVSRLRREGK
SVPPHLALAHTLFDRLVFSKVRAVFGGRIRFMISGSAPLNRDIAEWFHAAGLLILEGYGLTETAAGAFINRLENYRLGTV
GQVFDGSEVRISDDGEVQIKGPCVMDGYHNLPDKTAETLTDDGWLRTGDRGQLDDDGFLTITGRIKELFKTSGGKYVAPP
AIEGRFMALCPYAGHMLVFGESRNFCVALVTLDPDAISGWAAEHGMGDKSYPDLVKSDAVRELIGGYIERLNSELNRWET
IKKWAILDHDLSIENNELTPSLKVKRGVVEEKQKDLLDSFYT
>Mature_601_residues
SIDSQKRPGTTSANVARMFFDRVEKSAQSEAFRKLDDGKWTSLTWQDAAGQVEALAAGLLALGIEPEQRVGIASSTRYDW
ILADLAIMCAGGATTTVYPTTNAADTAYILADSGSRFVFAEDDAQLAKLRDKRDELPNLEKVVLFDGTGDGDWVLNLADV
VDLGRKHLEEQPSAVRDRSAAITSDQLATLIYTSGTTGKPKGVRLAHRAWVYEGETVAGFDILHEDDLQLLWLPLAHAFG
KVLISAQLACGFASAIDGRVDKIVENMGTVKPTFMGAAPRIFEKAHAKVVMQQHGVKEKLFNAAFAVGRQVSRLRREGKS
VPPHLALAHTLFDRLVFSKVRAVFGGRIRFMISGSAPLNRDIAEWFHAAGLLILEGYGLTETAAGAFINRLENYRLGTVG
QVFDGSEVRISDDGEVQIKGPCVMDGYHNLPDKTAETLTDDGWLRTGDRGQLDDDGFLTITGRIKELFKTSGGKYVAPPA
IEGRFMALCPYAGHMLVFGESRNFCVALVTLDPDAISGWAAEHGMGDKSYPDLVKSDAVRELIGGYIERLNSELNRWETI
KKWAILDHDLSIENNELTPSLKVKRGVVEEKQKDLLDSFYT

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI27477105, Length=629, Percent_Identity=30.6836248012719, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI83745141, Length=633, Percent_Identity=30.0157977883096, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI42794756, Length=605, Percent_Identity=29.4214876033058, Blast_Score=238, Evalue=2e-62,
Organism=Homo sapiens, GI42794760, Length=605, Percent_Identity=29.4214876033058, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI42794758, Length=605, Percent_Identity=29.4214876033058, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI40807491, Length=602, Percent_Identity=29.0697674418605, Blast_Score=229, Evalue=6e-60,
Organism=Homo sapiens, GI57165412, Length=610, Percent_Identity=28.8524590163934, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI57165410, Length=610, Percent_Identity=28.6885245901639, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI42794754, Length=611, Percent_Identity=26.1865793780687, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI42794752, Length=611, Percent_Identity=26.1865793780687, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI12669909, Length=611, Percent_Identity=24.3862520458265, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI4758332, Length=611, Percent_Identity=24.3862520458265, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI156151445, Length=517, Percent_Identity=25.1450676982592, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1788107, Length=506, Percent_Identity=27.8656126482213, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI145693145, Length=468, Percent_Identity=22.6495726495727, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789201, Length=220, Percent_Identity=30.4545454545455, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17556552, Length=610, Percent_Identity=26.8852459016393, Blast_Score=224, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17510401, Length=566, Percent_Identity=29.5053003533569, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17541856, Length=608, Percent_Identity=27.9605263157895, Blast_Score=203, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI25147511, Length=615, Percent_Identity=26.0162601626016, Blast_Score=191, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI17553312, Length=624, Percent_Identity=27.2435897435897, Blast_Score=189, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI193204819, Length=634, Percent_Identity=28.391167192429, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17564090, Length=621, Percent_Identity=24.1545893719807, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17558820, Length=461, Percent_Identity=29.0672451193059, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17538037, Length=492, Percent_Identity=26.219512195122, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI32563687, Length=216, Percent_Identity=37.5, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17559526, Length=519, Percent_Identity=24.6628131021195, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17557194, Length=492, Percent_Identity=24.7967479674797, Blast_Score=105, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI133901848, Length=225, Percent_Identity=29.3333333333333, Blast_Score=89, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6320852, Length=614, Percent_Identity=26.0586319218241, Blast_Score=197, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6324893, Length=621, Percent_Identity=24.4766505636071, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6322182, Length=544, Percent_Identity=26.2867647058824, Blast_Score=140, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6323903, Length=542, Percent_Identity=23.6162361623616, Blast_Score=131, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6319699, Length=170, Percent_Identity=35.8823529411765, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24666501, Length=600, Percent_Identity=30.8333333333333, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24666497, Length=600, Percent_Identity=30.8333333333333, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI281366413, Length=599, Percent_Identity=30.550918196995, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI19921316, Length=632, Percent_Identity=27.0569620253165, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI17933690, Length=610, Percent_Identity=27.5409836065574, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI62471679, Length=621, Percent_Identity=26.8921095008052, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI62471683, Length=621, Percent_Identity=26.8921095008052, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI62471685, Length=621, Percent_Identity=26.8921095008052, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24586636, Length=621, Percent_Identity=26.8921095008052, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI62471681, Length=621, Percent_Identity=26.8921095008052, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI62471687, Length=621, Percent_Identity=26.8921095008052, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24586634, Length=621, Percent_Identity=26.8921095008052, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI22026970, Length=621, Percent_Identity=26.8921095008052, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI62471689, Length=621, Percent_Identity=26.8921095008052, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24581924, Length=509, Percent_Identity=25.3438113948919, Blast_Score=113, Evalue=4e-25,
Organism=Drosophila melanogaster, GI21355181, Length=445, Percent_Identity=25.3932584269663, Blast_Score=92, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 66000; Mature: 65868

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIDSQKRPGTTSANVARMFFDRVEKSAQSEAFRKLDDGKWTSLTWQDAAGQVEALAAGL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHH
LALGIEPEQRVGIASSTRYDWILADLAIMCAGGATTTVYPTTNAADTAYILADSGSRFVF
HHCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCCEEEE
AEDDAQLAKLRDKRDELPNLEKVVLFDGTGDGDWVLNLADVVDLGRKHLEEQPSAVRDRS
ECCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEHHHHHHHHHHHHHCCCHHHHHHH
AAITSDQLATLIYTSGTTGKPKGVRLAHRAWVYEGETVAGFDILHEDDLQLLWLPLAHAF
HHCCCCCEEEEEEECCCCCCCCCCEEEHHEEEECCCEEECEEEEECCCCCEEHHHHHHHH
GKVLISAQLACGFASAIDGRVDKIVENMGTVKPTFMGAAPRIFEKAHAKVVMQQHGVKEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHHHHHHCCHHHH
LFNAAFAVGRQVSRLRREGKSVPPHLALAHTLFDRLVFSKVRAVFGGRIRFMISGSAPLN
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCC
RDIAEWFHAAGLLILEGYGLTETAAGAFINRLENYRLGTVGQVFDGSEVRISDDGEVQIK
HHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCEEEE
GPCVMDGYHNLPDKTAETLTDDGWLRTGDRGQLDDDGFLTITGRIKELFKTSGGKYVAPP
CCEEECCCCCCCCHHHHHCCCCCCEECCCCCCCCCCCEEEEEHHHHHHHHCCCCCEECCC
AIEGRFMALCPYAGHMLVFGESRNFCVALVTLDPDAISGWAAEHGMGDKSYPDLVKSDAV
CCCCCEEEECCCCCEEEEEECCCCEEEEEEEECCCHHCCHHHHCCCCCCCCHHHHHHHHH
RELIGGYIERLNSELNRWETIKKWAILDHDLSIENNELTPSLKVKRGVVEEKQKDLLDSF
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
YT
CC
>Mature Secondary Structure 
SIDSQKRPGTTSANVARMFFDRVEKSAQSEAFRKLDDGKWTSLTWQDAAGQVEALAAGL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHH
LALGIEPEQRVGIASSTRYDWILADLAIMCAGGATTTVYPTTNAADTAYILADSGSRFVF
HHCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCCEEEE
AEDDAQLAKLRDKRDELPNLEKVVLFDGTGDGDWVLNLADVVDLGRKHLEEQPSAVRDRS
ECCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEHHHHHHHHHHHHHCCCHHHHHHH
AAITSDQLATLIYTSGTTGKPKGVRLAHRAWVYEGETVAGFDILHEDDLQLLWLPLAHAF
HHCCCCCEEEEEEECCCCCCCCCCEEEHHEEEECCCEEECEEEEECCCCCEEHHHHHHHH
GKVLISAQLACGFASAIDGRVDKIVENMGTVKPTFMGAAPRIFEKAHAKVVMQQHGVKEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHHHHHHCCHHHH
LFNAAFAVGRQVSRLRREGKSVPPHLALAHTLFDRLVFSKVRAVFGGRIRFMISGSAPLN
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCC
RDIAEWFHAAGLLILEGYGLTETAAGAFINRLENYRLGTVGQVFDGSEVRISDDGEVQIK
HHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCEEEE
GPCVMDGYHNLPDKTAETLTDDGWLRTGDRGQLDDDGFLTITGRIKELFKTSGGKYVAPP
CCEEECCCCCCCCHHHHHCCCCCCEECCCCCCCCCCCEEEEEHHHHHHHHCCCCCEECCC
AIEGRFMALCPYAGHMLVFGESRNFCVALVTLDPDAISGWAAEHGMGDKSYPDLVKSDAV
CCCCCEEEECCCCCEEEEEECCCCEEEEEEEECCCHHCCHHHHCCCCCCCCHHHHHHHHH
RELIGGYIERLNSELNRWETIKKWAILDHDLSIENNELTPSLKVKRGVVEEKQKDLLDSF
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
YT
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]