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The map label for this gene is yjcE [H]

Identifier: 108800563

GI number: 108800563

Start: 3835892

End: 3837574

Strand: Reverse

Name: yjcE [H]

Synonym: Mmcs_3597

Alternate gene names: 108800563

Gene position: 3837574-3835892 (Counterclockwise)

Preceding gene: 108800564

Following gene: 108800560

Centisome position: 67.26

GC content: 69.88

Gene sequence:

>1683_bases
GTGGAACTCATCCTCGTCGTCGTCGGCGCCATCGTGGTCACCGCCATCGCCCACCGCCGCGGGCTGGAACCCGCACTCGT
CCTCGTCGTCGTCGGGTTCGCGGTGTCCTTCGCGCCCGACTTCAACGGCATCGAACTGGAATCCGATGTGCTGCTGTCGG
TGGTGCTGCCACCGCTGCTCTACTCGGCGGCGCTGAGCTTCTCGTTCCCGACGTTCCTGCGCAACATCCGGCCGATCCTC
GGCCTCGGTGTGGGGCTGGTGGTGATCACCACCTTCGCCGTGGCCGGGCTGGCGTCGTGGCTGGTGCCGTCGCTGACATT
CGGGACCGCCCTGATTCTCGGCGCGGTGGTGGCGCCACCCGATGCGGTGACCGCCGTCGCGGTGGGCCGCCGGCTCGGAC
TGCCGAAGAAGGTGATGGCGATCCTCACCGGCGAGAGCCTGGTCAACGACGCCGCCGCGCTGTCGCTGTTCTCGATCGCG
GTGGCCCAGGTGGCCGGCACCCGCGCGTTCATCGAGAACCCGGTGCTGTTGTTCGGCTACAGCGCGCTGCTCGGCCCCGT
CGTCGGCGCCGCGCTGGGCTTCATCACGCTGTGGATCCGCCGCCGCCTGGCCAATCCGGGACTGGAGACGATCCAGGGAT
TGGTGGTGCCGTTCGCGGCGTTCATCTCCGCCGAGCACCTGCACGCCTCCGGCGTGCTGGCCGTCGTGGTCGCCGGATTC
GTCGTCGGCCACGGTTCACTCGACGCCGGTTACCAGACCCGGCTGCAGGAGCGCTACGTGTGGAACTCCGTCGACGTCAT
GCTCGAGGCGTTCGTGTTCGCCTACATCGGATTACAGCTGCGCTTCGTGCTCGAGGACCTCAACGAGGCGCACGAGTCAC
TGGCCGAAGTCGCGGTGGCGTCCGCCGTCGTGCTGCTGGTGGTGCTGCTGATCCGGCCGGTGTGCGTGTTCGCGATGTTC
GGCCGCGGCGTGCTCTCCCGCAAGGTCGAGTCGAAGTTGAGCGTGCCGAAACCCGAACAGGGCGGCCGGGGCGCGCTGGG
GGTGCGCCGCCGGGGTGGGGCGGGCCGGCTGTCGGGGTTGGTCGACCGCCGGATGCTGACGTGGCAGGAGAACGTCGTGG
TGTCGTGGACCGGGATGCGCGGGGTGGTGACGCTCGCGGCCGCCTCGGGCATCCCGATGATGACGATCGACGGCGAGCCG
TTCCCCGAGCGCGCCACCATCCAGGCGATCGCGTTCGTCGTCAGTGTCGGCACCCTGCTGCTGCAGGGATGGACGCTGCC
GCCGCTGATCCGTTGGCTGCAACCGTCATTCGAGCACGACCGCCAGTCCGACGAGACCGAGACCCGCAAGGCCGAACAGG
TGGTGCACGCCGCCGCCGACGACGTGCTGAACCGGTTCGCCGACGCACCGCCGCCCGGACTCGACGACGCGACGCTGGCC
AACATCCGGCAGACCATCGCCCGGCACGCCCAGGACGCCGACGAGATGCCCGACCCGGAATCGCATACGCCCCGCGCCGA
GGTCTTCTCCAAGCTCTACCGGGATGTGTTGTGCGCGCAGCGCAATGCGCTGATCGCCGAACGCGACGCCGGCCGCATCG
AGGACGAGGCGGTGCGCGCCATGCTGGAGCGGCTCGACCTGCAGGAGGCCGGGGTGTCGGCGCGGCTGGAGAGCCGGATC
TGA

Upstream 100 bases:

>100_bases
AACACCGCCGTCCTGGAGGGCCGCAACCTGTTCTGGTGCCCGACCTGCCAGAGGTGAGGCGAAGCCCGCATACGCGCGGG
TTTGCGGCGACAATCGCCCG

Downstream 100 bases:

>100_bases
CCGACCGGCTCAGAAGCCGCCGAAGTCGCCCCCGCCGAAGTCCCCACCACCGAAATCGCCCCAGCCGCCACCGGAGTCGC
CGCCGTCCCAGCCGCCGTCG

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 560; Mature: 560

Protein sequence:

>560_residues
MELILVVVGAIVVTAIAHRRGLEPALVLVVVGFAVSFAPDFNGIELESDVLLSVVLPPLLYSAALSFSFPTFLRNIRPIL
GLGVGLVVITTFAVAGLASWLVPSLTFGTALILGAVVAPPDAVTAVAVGRRLGLPKKVMAILTGESLVNDAAALSLFSIA
VAQVAGTRAFIENPVLLFGYSALLGPVVGAALGFITLWIRRRLANPGLETIQGLVVPFAAFISAEHLHASGVLAVVVAGF
VVGHGSLDAGYQTRLQERYVWNSVDVMLEAFVFAYIGLQLRFVLEDLNEAHESLAEVAVASAVVLLVVLLIRPVCVFAMF
GRGVLSRKVESKLSVPKPEQGGRGALGVRRRGGAGRLSGLVDRRMLTWQENVVVSWTGMRGVVTLAAASGIPMMTIDGEP
FPERATIQAIAFVVSVGTLLLQGWTLPPLIRWLQPSFEHDRQSDETETRKAEQVVHAAADDVLNRFADAPPPGLDDATLA
NIRQTIARHAQDADEMPDPESHTPRAEVFSKLYRDVLCAQRNALIAERDAGRIEDEAVRAMLERLDLQEAGVSARLESRI

Sequences:

>Translated_560_residues
MELILVVVGAIVVTAIAHRRGLEPALVLVVVGFAVSFAPDFNGIELESDVLLSVVLPPLLYSAALSFSFPTFLRNIRPIL
GLGVGLVVITTFAVAGLASWLVPSLTFGTALILGAVVAPPDAVTAVAVGRRLGLPKKVMAILTGESLVNDAAALSLFSIA
VAQVAGTRAFIENPVLLFGYSALLGPVVGAALGFITLWIRRRLANPGLETIQGLVVPFAAFISAEHLHASGVLAVVVAGF
VVGHGSLDAGYQTRLQERYVWNSVDVMLEAFVFAYIGLQLRFVLEDLNEAHESLAEVAVASAVVLLVVLLIRPVCVFAMF
GRGVLSRKVESKLSVPKPEQGGRGALGVRRRGGAGRLSGLVDRRMLTWQENVVVSWTGMRGVVTLAAASGIPMMTIDGEP
FPERATIQAIAFVVSVGTLLLQGWTLPPLIRWLQPSFEHDRQSDETETRKAEQVVHAAADDVLNRFADAPPPGLDDATLA
NIRQTIARHAQDADEMPDPESHTPRAEVFSKLYRDVLCAQRNALIAERDAGRIEDEAVRAMLERLDLQEAGVSARLESRI
>Mature_560_residues
MELILVVVGAIVVTAIAHRRGLEPALVLVVVGFAVSFAPDFNGIELESDVLLSVVLPPLLYSAALSFSFPTFLRNIRPIL
GLGVGLVVITTFAVAGLASWLVPSLTFGTALILGAVVAPPDAVTAVAVGRRLGLPKKVMAILTGESLVNDAAALSLFSIA
VAQVAGTRAFIENPVLLFGYSALLGPVVGAALGFITLWIRRRLANPGLETIQGLVVPFAAFISAEHLHASGVLAVVVAGF
VVGHGSLDAGYQTRLQERYVWNSVDVMLEAFVFAYIGLQLRFVLEDLNEAHESLAEVAVASAVVLLVVLLIRPVCVFAMF
GRGVLSRKVESKLSVPKPEQGGRGALGVRRRGGAGRLSGLVDRRMLTWQENVVVSWTGMRGVVTLAAASGIPMMTIDGEP
FPERATIQAIAFVVSVGTLLLQGWTLPPLIRWLQPSFEHDRQSDETETRKAEQVVHAAADDVLNRFADAPPPGLDDATLA
NIRQTIARHAQDADEMPDPESHTPRAEVFSKLYRDVLCAQRNALIAERDAGRIEDEAVRAMLERLDLQEAGVSARLESRI

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI5454070, Length=325, Percent_Identity=25.5384615384615, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI110227626, Length=325, Percent_Identity=25.5384615384615, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI294997330, Length=259, Percent_Identity=26.2548262548263, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI14211919, Length=456, Percent_Identity=21.4912280701754, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI41872703, Length=440, Percent_Identity=21.3636363636364, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI27734935, Length=259, Percent_Identity=23.1660231660232, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1790501, Length=527, Percent_Identity=26.5654648956357, Blast_Score=146, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI71992107, Length=257, Percent_Identity=24.124513618677, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71992101, Length=257, Percent_Identity=24.124513618677, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71993590, Length=259, Percent_Identity=26.2548262548263, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71993582, Length=259, Percent_Identity=26.2548262548263, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25147678, Length=304, Percent_Identity=21.7105263157895, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=385, Percent_Identity=23.3766233766234, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI281364513, Length=266, Percent_Identity=26.6917293233083, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI221473212, Length=266, Percent_Identity=26.6917293233083, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI221473215, Length=266, Percent_Identity=26.6917293233083, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221473222, Length=266, Percent_Identity=26.6917293233083, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281360447, Length=401, Percent_Identity=20.1995012468828, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 59944; Mature: 59944

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCCHHHHHCCC
>Mature Secondary Structure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HHHHHHHHHCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]