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The map label for this gene is 108800525

Identifier: 108800525

GI number: 108800525

Start: 3788823

End: 3790082

Strand: Reverse

Name: 108800525

Synonym: Mmcs_3559

Alternate gene names: NA

Gene position: 3790082-3788823 (Counterclockwise)

Preceding gene: 108800526

Following gene: 108800524

Centisome position: 66.43

GC content: 71.27

Gene sequence:

>1260_bases
ATGAGTCCCGCACAGCAGCGTGAGTTCGACATCGTCGTCTACGGAGCCACCGGATTCGTCGGGAAACTGACCGCCGAATA
CCTGGCCGACCACGGTGCCGGGGCCCGCATCGCGCTGGCCGGCCGCTCGCAGGACAAACTGCTCGAGGTCCGCGAGTCGC
TGGGGCCGAAGGCCACCGACTGGGAGCTCATCACCGCCGACGCCTCGCAGCCGTCGACGCTCAACGCGATGGCCGCCCGC
GCCCGCGTCGTCATCACCACCGTCGGGCCCTACACCAAGTACGGGCTGCCCCTGGTCGCCGCGTGCGCGGCCGCCGGCAC
CGACTACGCCGACCTGACCGGCGAGACGATGTTCGTCCGCGACAGCATCGACCACTACCACAAACAGGCGGTCGACACCG
GCGCCCGGATCGTGCACGCCTGCGGATTCGACTCCATCCCTTCGGATCTCACCGTCTACGCATTGCACCGCAAGGTGGCC
GCGGACGGGGAGGGCGAGCTCGGCGACACCAGCATGGTGGTGCGCACCCTCGCCGGCGGGGCGTCCGGGGGCACGATCGC
GTCGATCTTGGAAGTCCTGAACACCGCCTCGACCGACCCCGAGGCCCGCCGGGAGATGACCGACCCCTACACGCTGTCGC
CGGACCGCAGCGCCGAACCCGAACTCGGCGCCCAGCCCGACATGCGCTGGCGGCGCGGTGCGGAGATCGCGCCCGAACTG
TCCGGCTACTGGACCGCGGCGTTCGCGATGGCCGGGCCGAACACCCGCATCGTCCGGCGCAGCAACGCGCTGTTGGGCTA
CGCCTACGGACGCAGACTCGAATACTCCGAGGTGATGAGCACCGGGCGCACACCGGTCGCACCCGCCCTCGCCGCGTTGA
CCACCGCGGGCAGCGCCGCCGTCATGGGTCTCGGTTCGCGCTACTTCAACCGGCTGCCGCGCAAACTCGTCGACCGGGTG
CTGCCCGCGCCGGGCACCGGCCCCAGCGAGCAGACCCGCGAACGCGGGCACTACACCGTCGAGACCTACACCACGACCAC
CACCGGGGCGCGCTACCTCGCCCGGATGTCGCAGCGGGGTGACCCCGGTTACAAGGCCACGTCGGTGTTGCTCGGGGAGT
GCGGTCTGGCGCTGGCGCTCGACCGCGACAAGCTGTCCGACCTGCGCGGGGTGCTCACGCCGGCGGCGGCGATGGGTGAC
GCGCTGTTGGCGCGGTTCCCGGGTGCCGGTGTGTCGCTGGAGACGTCCCGGTTGGCGTGA

Upstream 100 bases:

>100_bases
CATGCGAAGCTCTGGTACCAGGTCGTCTTCGCATTCCTGGCCCGGCACGTGCTCGGGCGGGACGTCGAGCTGCCCGAACT
GCTCGGGTAGCGTCGAAACC

Downstream 100 bases:

>100_bases
GCAGGGGTGGGACCCGGGCGGTAGGCGGTCGCGCCGCTCCCTAGAATTGACGGGTGACCGCCACCCCTGACGCACACGCC
GAATCCCTGCCCAAGTCGTG

Product: saccharopine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MSPAQQREFDIVVYGATGFVGKLTAEYLADHGAGARIALAGRSQDKLLEVRESLGPKATDWELITADASQPSTLNAMAAR
ARVVITTVGPYTKYGLPLVAACAAAGTDYADLTGETMFVRDSIDHYHKQAVDTGARIVHACGFDSIPSDLTVYALHRKVA
ADGEGELGDTSMVVRTLAGGASGGTIASILEVLNTASTDPEARREMTDPYTLSPDRSAEPELGAQPDMRWRRGAEIAPEL
SGYWTAAFAMAGPNTRIVRRSNALLGYAYGRRLEYSEVMSTGRTPVAPALAALTTAGSAAVMGLGSRYFNRLPRKLVDRV
LPAPGTGPSEQTRERGHYTVETYTTTTTGARYLARMSQRGDPGYKATSVLLGECGLALALDRDKLSDLRGVLTPAAAMGD
ALLARFPGAGVSLETSRLA

Sequences:

>Translated_419_residues
MSPAQQREFDIVVYGATGFVGKLTAEYLADHGAGARIALAGRSQDKLLEVRESLGPKATDWELITADASQPSTLNAMAAR
ARVVITTVGPYTKYGLPLVAACAAAGTDYADLTGETMFVRDSIDHYHKQAVDTGARIVHACGFDSIPSDLTVYALHRKVA
ADGEGELGDTSMVVRTLAGGASGGTIASILEVLNTASTDPEARREMTDPYTLSPDRSAEPELGAQPDMRWRRGAEIAPEL
SGYWTAAFAMAGPNTRIVRRSNALLGYAYGRRLEYSEVMSTGRTPVAPALAALTTAGSAAVMGLGSRYFNRLPRKLVDRV
LPAPGTGPSEQTRERGHYTVETYTTTTTGARYLARMSQRGDPGYKATSVLLGECGLALALDRDKLSDLRGVLTPAAAMGD
ALLARFPGAGVSLETSRLA
>Mature_418_residues
SPAQQREFDIVVYGATGFVGKLTAEYLADHGAGARIALAGRSQDKLLEVRESLGPKATDWELITADASQPSTLNAMAARA
RVVITTVGPYTKYGLPLVAACAAAGTDYADLTGETMFVRDSIDHYHKQAVDTGARIVHACGFDSIPSDLTVYALHRKVAA
DGEGELGDTSMVVRTLAGGASGGTIASILEVLNTASTDPEARREMTDPYTLSPDRSAEPELGAQPDMRWRRGAEIAPELS
GYWTAAFAMAGPNTRIVRRSNALLGYAYGRRLEYSEVMSTGRTPVAPALAALTTAGSAAVMGLGSRYFNRLPRKLVDRVL
PAPGTGPSEQTRERGHYTVETYTTTTTGARYLARMSQRGDPGYKATSVLLGECGLALALDRDKLSDLRGVLTPAAAMGDA
LLARFPGAGVSLETSRLA

Specific function: Unknown

COG id: COG3268

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the saccharopine dehydrogenase family. Enoyl reductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI55770836, Length=442, Percent_Identity=27.8280542986425, Blast_Score=122, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17560066, Length=432, Percent_Identity=28.0092592592593, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI32567112, Length=201, Percent_Identity=36.81592039801, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71991033, Length=156, Percent_Identity=35.2564102564103, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24646278, Length=429, Percent_Identity=26.1072261072261, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24644140, Length=424, Percent_Identity=27.122641509434, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24644142, Length=424, Percent_Identity=27.122641509434, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21356081, Length=424, Percent_Identity=27.122641509434, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR005097 [H]

Pfam domain/function: PF03435 Saccharop_dh [H]

EC number: NA

Molecular weight: Translated: 44396; Mature: 44264

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPAQQREFDIVVYGATGFVGKLTAEYLADHGAGARIALAGRSQDKLLEVRESLGPKATD
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCCCC
WELITADASQPSTLNAMAARARVVITTVGPYTKYGLPLVAACAAAGTDYADLTGETMFVR
CEEEEECCCCCCHHHHHHHCEEEEEEECCCCHHHCCHHHHHHHHCCCCHHHCCCCEEEEE
DSIDHYHKQAVDTGARIVHACGFDSIPSDLTVYALHRKVAADGEGELGDTSMVVRTLAGG
HHHHHHHHHHHHHHHHEEEECCCCCCCCCCEEHHHHHHHHCCCCCCCCCHHHHHHHHHCC
ASGGTIASILEVLNTASTDPEARREMTDPYTLSPDRSAEPELGAQPDMRWRRGAEIAPEL
CCCCHHHHHHHHHHCCCCCHHHHHHCCCCEEECCCCCCCCCCCCCCCCHHHCCCCCCCCC
SGYWTAAFAMAGPNTRIVRRSNALLGYAYGRRLEYSEVMSTGRTPVAPALAALTTAGSAA
CCCEEEEEEECCCCCEEEEECCCEEEEHHCCCCCHHHHHHCCCCCHHHHHHHHHCCCCHH
VMGLGSRYFNRLPRKLVDRVLPAPGTGPSEQTRERGHYTVETYTTTTTGARYLARMSQRG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCEEEEEEEECCHHHHHHHHHHHCC
DPGYKATSVLLGECGLALALDRDKLSDLRGVLTPAAAMGDALLARFPGAGVSLETSRLA
CCCCHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCC
>Mature Secondary Structure 
SPAQQREFDIVVYGATGFVGKLTAEYLADHGAGARIALAGRSQDKLLEVRESLGPKATD
CCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCCCC
WELITADASQPSTLNAMAARARVVITTVGPYTKYGLPLVAACAAAGTDYADLTGETMFVR
CEEEEECCCCCCHHHHHHHCEEEEEEECCCCHHHCCHHHHHHHHCCCCHHHCCCCEEEEE
DSIDHYHKQAVDTGARIVHACGFDSIPSDLTVYALHRKVAADGEGELGDTSMVVRTLAGG
HHHHHHHHHHHHHHHHEEEECCCCCCCCCCEEHHHHHHHHCCCCCCCCCHHHHHHHHHCC
ASGGTIASILEVLNTASTDPEARREMTDPYTLSPDRSAEPELGAQPDMRWRRGAEIAPEL
CCCCHHHHHHHHHHCCCCCHHHHHHCCCCEEECCCCCCCCCCCCCCCCHHHCCCCCCCCC
SGYWTAAFAMAGPNTRIVRRSNALLGYAYGRRLEYSEVMSTGRTPVAPALAALTTAGSAA
CCCEEEEEEECCCCCEEEEECCCEEEEHHCCCCCHHHHHHCCCCCHHHHHHHHHCCCCHH
VMGLGSRYFNRLPRKLVDRVLPAPGTGPSEQTRERGHYTVETYTTTTTGARYLARMSQRG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCEEEEEEEECCHHHHHHHHHHHCC
DPGYKATSVLLGECGLALALDRDKLSDLRGVLTPAAAMGDALLARFPGAGVSLETSRLA
CCCCHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]