Click here to switch to the map view.

The map label for this gene is obgE

Identifier: 108800514

GI number: 108800514

Start: 3775510

End: 3776967

Strand: Reverse

Name: obgE

Synonym: Mmcs_3548

Alternate gene names: 108800514

Gene position: 3776967-3775510 (Counterclockwise)

Preceding gene: 108800515

Following gene: 108800513

Centisome position: 66.2

GC content: 70.85

Gene sequence:

>1458_bases
ATGCCCCGCTTCGTCGACCGTGTCGTGATCCACGCGCGGGCCGGCAACGGCGGCAACGGCTGCGCGTCGGTGCACCGCGA
GAAGTTCAAACCACTCGGCGGTCCCGACGGCGGTAACGGCGGTCGCGGCGGCAGCATCGTGCTGGTCGTCGATCCGCAAG
TACACACACTGCTCGACTTCCACTTCCACCCGCATGTCGTGGCGCCGTCCGGCAAGCAGGGCGCAGGCAGCAATCGTGAC
GGCGCGGCCGGTGCCGACCTCGAGGTCAGGGTGCCCGACGGCACCGTCGTCCTCGACGAAGAAGGTCGAGTGCTGGCCGA
CCTCGTCGGCGCGGGCACCCGGTTCGAAGCCGCGGCGGGTGGTCGCGGCGGCCTCGGCAACGCCGCGCTGGCCTCCCGCT
CCCGCAGGGCCCCCGGCTTCGCGCTGCTCGGCGAGAAGGGGCAGGTCCGCGAGCTCACCCTCGAGCTGAAGACGGTCGCC
GACGTCGGGCTGATCGGGTTCCCGTCGGCGGGCAAATCCTCACTGGTGTCCACGATCTCGGCGGCCAAACCGAAGATCGC
CGACTACCCCTTCACCACGCTGGTGCCCAACCTCGGGGTCGTCTCGGCCGGTGACCACACCTTCACGGTCGCCGACGTGC
CCGGATTGATCCCCGGCGCTTCCGAAGGGCGCGGGTTGGGCCTGGAATTCCTCCGCCACATCGAACGCTGCGCCGTGCTG
GTGCACGTCGTCGACTGCGCGACGATGGAACCCGGCCGCGACCCGATCTCCGACATCGAGGCGCTCGAAGCCGAACTGGC
CGCCTATCGCCCGACACTGCAGGGTGATTCGACGCTCGGCGACCTCGCCGAACGCCCGCGCGCGGTGGTACTCAACAAGA
TCGACGTGCCCGACGCCCGCGAACTGGCCGACTTCGTCCGCGACGAGGTGGCCGAGCGGTTCGGCTGGCCGGTGTTCGAG
GTCTCCACGGTGGCGCGAGAAGGTCTGCGGCCGTTCATCTTCGCGCTGTGGGACATGGTCCGCACCTACCGCGAGGCCCA
ACCGCCCGTCGTCCCGCGCCGCCCGATCATCCGGCCCATCGCCGTCGACGAGACCGGGTTCTCCGTGCACCCCGACGGAC
AGGGCGGGTTCGTGGTGCGCGGCACGCGGCCCGAACGCTGGATCAACCAAACCGATTTCGACAACGACGAGGCCGTCGGC
TACCTCGGTGACCGGTTGGCCCGCCTCGGCGTCGAAGAGGAGCTGCTGCGGCTCGGCGCGCGTCCCGGCTGTGCGGTGAC
CATCGGGGACATGACGTTCGACTGGGAGCCCCAGACGCCCGCCGGGGTGGACGTGCAGATGTCCGGCCGCGGCACCGACA
CCCGCCTCGAGCAGACCGACCGCGTCTCGGCGGCCGAGCGCAAGATCGCCCGGCGGGAGCGTCGGCAGTCCACCGACGAG
CCCGGCGGTGAGGAATGA

Upstream 100 bases:

>100_bases
CCCGACCGGAGGCCTGATCCCGGCGCCGAGATCGACGTTTGTGCGCCGGCTTCTCGCAAGTTAGCGCCCATCTGTTCATT
CGGCGAAGGAGTGATCGACT

Downstream 100 bases:

>100_bases
CCGAGGCCGCCACCCGTCCGTCCGTGCACCGCGAGGCCGTCCGCACCGCGCGCAGTGTCGTCGTCAAGATCGGCACCACT
GCGCTGACCACGCCGACCGG

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MPRFVDRVVIHARAGNGGNGCASVHREKFKPLGGPDGGNGGRGGSIVLVVDPQVHTLLDFHFHPHVVAPSGKQGAGSNRD
GAAGADLEVRVPDGTVVLDEEGRVLADLVGAGTRFEAAAGGRGGLGNAALASRSRRAPGFALLGEKGQVRELTLELKTVA
DVGLIGFPSAGKSSLVSTISAAKPKIADYPFTTLVPNLGVVSAGDHTFTVADVPGLIPGASEGRGLGLEFLRHIERCAVL
VHVVDCATMEPGRDPISDIEALEAELAAYRPTLQGDSTLGDLAERPRAVVLNKIDVPDARELADFVRDEVAERFGWPVFE
VSTVAREGLRPFIFALWDMVRTYREAQPPVVPRRPIIRPIAVDETGFSVHPDGQGGFVVRGTRPERWINQTDFDNDEAVG
YLGDRLARLGVEEELLRLGARPGCAVTIGDMTFDWEPQTPAGVDVQMSGRGTDTRLEQTDRVSAAERKIARRERRQSTDE
PGGEE

Sequences:

>Translated_485_residues
MPRFVDRVVIHARAGNGGNGCASVHREKFKPLGGPDGGNGGRGGSIVLVVDPQVHTLLDFHFHPHVVAPSGKQGAGSNRD
GAAGADLEVRVPDGTVVLDEEGRVLADLVGAGTRFEAAAGGRGGLGNAALASRSRRAPGFALLGEKGQVRELTLELKTVA
DVGLIGFPSAGKSSLVSTISAAKPKIADYPFTTLVPNLGVVSAGDHTFTVADVPGLIPGASEGRGLGLEFLRHIERCAVL
VHVVDCATMEPGRDPISDIEALEAELAAYRPTLQGDSTLGDLAERPRAVVLNKIDVPDARELADFVRDEVAERFGWPVFE
VSTVAREGLRPFIFALWDMVRTYREAQPPVVPRRPIIRPIAVDETGFSVHPDGQGGFVVRGTRPERWINQTDFDNDEAVG
YLGDRLARLGVEEELLRLGARPGCAVTIGDMTFDWEPQTPAGVDVQMSGRGTDTRLEQTDRVSAAERKIARRERRQSTDE
PGGEE
>Mature_484_residues
PRFVDRVVIHARAGNGGNGCASVHREKFKPLGGPDGGNGGRGGSIVLVVDPQVHTLLDFHFHPHVVAPSGKQGAGSNRDG
AAGADLEVRVPDGTVVLDEEGRVLADLVGAGTRFEAAAGGRGGLGNAALASRSRRAPGFALLGEKGQVRELTLELKTVAD
VGLIGFPSAGKSSLVSTISAAKPKIADYPFTTLVPNLGVVSAGDHTFTVADVPGLIPGASEGRGLGLEFLRHIERCAVLV
HVVDCATMEPGRDPISDIEALEAELAAYRPTLQGDSTLGDLAERPRAVVLNKIDVPDARELADFVRDEVAERFGWPVFEV
STVAREGLRPFIFALWDMVRTYREAQPPVVPRRPIIRPIAVDETGFSVHPDGQGGFVVRGTRPERWINQTDFDNDEAVGY
LGDRLARLGVEEELLRLGARPGCAVTIGDMTFDWEPQTPAGVDVQMSGRGTDTRLEQTDRVSAAERKIARRERRQSTDEP
GGEE

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=345, Percent_Identity=43.1884057971014, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI111955139, Length=307, Percent_Identity=37.4592833876222, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI111955063, Length=193, Percent_Identity=37.3056994818653, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI58761500, Length=157, Percent_Identity=28.0254777070064, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1789574, Length=365, Percent_Identity=41.9178082191781, Blast_Score=229, Evalue=4e-61,
Organism=Escherichia coli, GI1787454, Length=129, Percent_Identity=34.1085271317829, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508313, Length=338, Percent_Identity=39.0532544378698, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17552324, Length=318, Percent_Identity=30.5031446540881, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17509631, Length=136, Percent_Identity=32.3529411764706, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17555344, Length=110, Percent_Identity=31.8181818181818, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321962, Length=191, Percent_Identity=39.7905759162304, Blast_Score=132, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6319281, Length=108, Percent_Identity=36.1111111111111, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6321649, Length=141, Percent_Identity=31.2056737588652, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321612, Length=115, Percent_Identity=34.7826086956522, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI20129375, Length=320, Percent_Identity=38.4375, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24585318, Length=317, Percent_Identity=34.384858044164, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24640873, Length=128, Percent_Identity=30.46875, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24640877, Length=128, Percent_Identity=30.46875, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24640875, Length=128, Percent_Identity=30.46875, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17981711, Length=110, Percent_Identity=33.6363636363636, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_MYCSJ (A3Q2F3)

Other databases:

- EMBL:   CP000580
- RefSeq:   YP_001071821.1
- ProteinModelPortal:   A3Q2F3
- SMR:   A3Q2F3
- STRING:   A3Q2F3
- EnsemblBacteria:   EBMYCT00000049810
- GeneID:   4879264
- GenomeReviews:   CP000580_GR
- KEGG:   mjl:Mjls_3553
- eggNOG:   COG0536
- GeneTree:   EBGT00050000015858
- HOGENOM:   HBG716038
- OMA:   LIDYRFN
- ProtClustDB:   PRK12296
- BioCyc:   MSP164757:MJLS_3553-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR015349
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR03595

Pfam domain/function: PF09269 DUF1967; PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF102741 GTP-bd_prot_GTP1/OBG_C; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 51792; Mature: 51661

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRFVDRVVIHARAGNGGNGCASVHREKFKPLGGPDGGNGGRGGSIVLVVDPQVHTLLDF
CCCHHEEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCEEEHEEE
HFHPHVVAPSGKQGAGSNRDGAAGADLEVRVPDGTVVLDEEGRVLADLVGAGTRFEAAAG
CCCCEEECCCCCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCCHHHHHCCCCEEEECCC
GRGGLGNAALASRSRRAPGFALLGEKGQVRELTLELKTVADVGLIGFPSAGKSSLVSTIS
CCCCCCCHHHHHCCCCCCCEEEECCCCCEEEEEEEHHHHHCCCEEECCCCCHHHHHHHHH
AAKPKIADYPFTTLVPNLGVVSAGDHTFTVADVPGLIPGASEGRGLGLEFLRHIERCAVL
HCCCCCCCCCHHHHCCCCCEEECCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
VHVVDCATMEPGRDPISDIEALEAELAAYRPTLQGDSTLGDLAERPRAVVLNKIDVPDAR
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEEECCCCCCHH
ELADFVRDEVAERFGWPVFEVSTVAREGLRPFIFALWDMVRTYREAQPPVVPRRPIIRPI
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
AVDETGFSVHPDGQGGFVVRGTRPERWINQTDFDNDEAVGYLGDRLARLGVEEELLRLGA
EECCCCCEECCCCCCCEEEECCCCHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCC
RPGCAVTIGDMTFDWEPQTPAGVDVQMSGRGTDTRLEQTDRVSAAERKIARRERRQSTDE
CCCCEEEECCEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
PGGEE
CCCCC
>Mature Secondary Structure 
PRFVDRVVIHARAGNGGNGCASVHREKFKPLGGPDGGNGGRGGSIVLVVDPQVHTLLDF
CCHHEEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCEEEHEEE
HFHPHVVAPSGKQGAGSNRDGAAGADLEVRVPDGTVVLDEEGRVLADLVGAGTRFEAAAG
CCCCEEECCCCCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCCHHHHHCCCCEEEECCC
GRGGLGNAALASRSRRAPGFALLGEKGQVRELTLELKTVADVGLIGFPSAGKSSLVSTIS
CCCCCCCHHHHHCCCCCCCEEEECCCCCEEEEEEEHHHHHCCCEEECCCCCHHHHHHHHH
AAKPKIADYPFTTLVPNLGVVSAGDHTFTVADVPGLIPGASEGRGLGLEFLRHIERCAVL
HCCCCCCCCCHHHHCCCCCEEECCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
VHVVDCATMEPGRDPISDIEALEAELAAYRPTLQGDSTLGDLAERPRAVVLNKIDVPDAR
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEEECCCCCCHH
ELADFVRDEVAERFGWPVFEVSTVAREGLRPFIFALWDMVRTYREAQPPVVPRRPIIRPI
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
AVDETGFSVHPDGQGGFVVRGTRPERWINQTDFDNDEAVGYLGDRLARLGVEEELLRLGA
EECCCCCEECCCCCCCEEEECCCCHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCC
RPGCAVTIGDMTFDWEPQTPAGVDVQMSGRGTDTRLEQTDRVSAAERKIARRERRQSTDE
CCCCEEEECCEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
PGGEE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA