Click here to switch to the map view.

The map label for this gene is comEA [H]

Identifier: 108800486

GI number: 108800486

Start: 3748069

End: 3748872

Strand: Reverse

Name: comEA [H]

Synonym: Mmcs_3520

Alternate gene names: 108800486

Gene position: 3748872-3748069 (Counterclockwise)

Preceding gene: 108800487

Following gene: 108800485

Centisome position: 65.71

GC content: 73.76

Gene sequence:

>804_bases
ATGCGGACCGAAGAGCCGGCCGAGCGGCTGCACCGCCGACTCGGCGCCGAAGAGGAACCCGACCACGACGGAGCACGGCC
CGATACCGCCCTGTCCCGGTGGCTGCCGGATACGGCCACGCCGACGGGGCCGGGCTGGGTGGCGGCGGTGCGGGCCGACC
CGGGCCGCGCCGGTGTCGTCGGGCTCGCCGTCGTGGGCGTCATCGCCGTGCTGGTCACGGTGTTCACGATGTGGCGTGAC
GACCCGCCCCCGGTGGTCGCGGCGAAACTGCCCGAGGTGGAGATGGTGTCGTCGGCTTCCCCGAAGCCCGCGCCCGACCA
GCCGGTGGTCGTCAGCGTGGTCGGGCTGGTCCACAAGCCGGGGCTGGTGACCCTCGAGCCGGGCGCCCGGATCGCCGACG
CGCTCGAGGCCGCCGGGGGAGCGGTCGACGGCGCGGACCTCATCGGGCTGAACATGGCACGCCGGCTCACCGACGGCGAG
CAGATCATCGTCGGGATCGCCGCCGGCCCGGGACAACCGGCCACCATGGGCAGCTCCACCACGGCGGCGGGCGACGGTGG
CGCTGCGGCACCGTCCGGTTCTGCGCCGGCCGAACGGACCGGTGCGCCCGGTGAGCCGGTGAACCTCAACACCGCCACCG
TCGAGCAGTTGGACACGTTGCCGGGCGTCGGTCCGGTCACCGCGGCGGCGATCGTTGCCTGGCGAGATGCCCACGGCGCG
TTCAGCAGTGTCGATCAGCTCGGTGACGTGGACGGCATCGGACCGGCGCGGCTGGCCAAACTGCGCGATCTGGTCCATGT
GTGA

Upstream 100 bases:

>100_bases
ACGCTGACCGTCATCCACAGCGCGGCGTTCATCCACAACCACGCCATCCCGGCCGCCGGATGCGGCTGATCCGACGGACG
GCGTCCCTACCGTCGGGCGC

Downstream 100 bases:

>100_bases
GCGACGAGGCGGCGCCGCTGGATCTGCGACTGGTGCCGGCGGCGTCGACCGGCTGGGCCGTGACCGCGGCCGCAATCCAC
TGGCACACCGCGGCCGCGGT

Product: competence protein ComEA helix-hairpin-helix region

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MRTEEPAERLHRRLGAEEEPDHDGARPDTALSRWLPDTATPTGPGWVAAVRADPGRAGVVGLAVVGVIAVLVTVFTMWRD
DPPPVVAAKLPEVEMVSSASPKPAPDQPVVVSVVGLVHKPGLVTLEPGARIADALEAAGGAVDGADLIGLNMARRLTDGE
QIIVGIAAGPGQPATMGSSTTAAGDGGAAAPSGSAPAERTGAPGEPVNLNTATVEQLDTLPGVGPVTAAAIVAWRDAHGA
FSSVDQLGDVDGIGPARLAKLRDLVHV

Sequences:

>Translated_267_residues
MRTEEPAERLHRRLGAEEEPDHDGARPDTALSRWLPDTATPTGPGWVAAVRADPGRAGVVGLAVVGVIAVLVTVFTMWRD
DPPPVVAAKLPEVEMVSSASPKPAPDQPVVVSVVGLVHKPGLVTLEPGARIADALEAAGGAVDGADLIGLNMARRLTDGE
QIIVGIAAGPGQPATMGSSTTAAGDGGAAAPSGSAPAERTGAPGEPVNLNTATVEQLDTLPGVGPVTAAAIVAWRDAHGA
FSSVDQLGDVDGIGPARLAKLRDLVHV
>Mature_267_residues
MRTEEPAERLHRRLGAEEEPDHDGARPDTALSRWLPDTATPTGPGWVAAVRADPGRAGVVGLAVVGVIAVLVTVFTMWRD
DPPPVVAAKLPEVEMVSSASPKPAPDQPVVVSVVGLVHKPGLVTLEPGARIADALEAAGGAVDGADLIGLNMARRLTDGE
QIIVGIAAGPGQPATMGSSTTAAGDGGAAAPSGSAPAERTGAPGEPVNLNTATVEQLDTLPGVGPVTAAAIVAWRDAHGA
FSSVDQLGDVDGIGPARLAKLRDLVHV

Specific function: Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect [H]

COG id: COG1555

COG function: function code L; DNA uptake protein and related DNA-binding proteins

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HhH domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004787
- InterPro:   IPR004509
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR019554 [H]

Pfam domain/function: PF00633 HHH; PF10531 SLBB [H]

EC number: NA

Molecular weight: Translated: 26926; Mature: 26926

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTEEPAERLHRRLGAEEEPDHDGARPDTALSRWLPDTATPTGPGWVAAVRADPGRAGVV
CCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHH
GLAVVGVIAVLVTVFTMWRDDPPPVVAAKLPEVEMVSSASPKPAPDQPVVVSVVGLVHKP
HHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHCCCCCCCCCCCHHHHHHHHHCCC
GLVTLEPGARIADALEAAGGAVDGADLIGLNMARRLTDGEQIIVGIAAGPGQPATMGSST
CEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCC
TAAGDGGAAAPSGSAPAERTGAPGEPVNLNTATVEQLDTLPGVGPVTAAAIVAWRDAHGA
CCCCCCCCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCHH
FSSVDQLGDVDGIGPARLAKLRDLVHV
HHHHHHHCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRTEEPAERLHRRLGAEEEPDHDGARPDTALSRWLPDTATPTGPGWVAAVRADPGRAGVV
CCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHH
GLAVVGVIAVLVTVFTMWRDDPPPVVAAKLPEVEMVSSASPKPAPDQPVVVSVVGLVHKP
HHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHCCCCCCCCCCCHHHHHHHHHCCC
GLVTLEPGARIADALEAAGGAVDGADLIGLNMARRLTDGEQIIVGIAAGPGQPATMGSST
CEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCC
TAAGDGGAAAPSGSAPAERTGAPGEPVNLNTATVEQLDTLPGVGPVTAAAIVAWRDAHGA
CCCCCCCCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCHH
FSSVDQLGDVDGIGPARLAKLRDLVHV
HHHHHHHCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377; 7768800 [H]