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The map label for this gene is uppS [H]

Identifier: 108800415

GI number: 108800415

Start: 3659947

End: 3660843

Strand: Reverse

Name: uppS [H]

Synonym: Mmcs_3449

Alternate gene names: 108800415

Gene position: 3660843-3659947 (Counterclockwise)

Preceding gene: 108800416

Following gene: 108800414

Centisome position: 64.16

GC content: 67.78

Gene sequence:

>897_bases
GTGACCAGCTCGCGGCGGGGAGCTGAGCGCAAGAAGTCGCAGTTCCCGCAGCTCGACCCACCTGCCGACGACTATCCGAC
CTTCCCCGACAAGTCGACGTGGCCGGTGGTGTTCCCCGAGCTGCCGCCCAACACCAACGGCAGATTCGCCCGCCCGCCGC
AGCACACCAGCAAGGCCGCCGCGCCCAAGATCCCCGCCGACCAGGTGCCCCAGCACGTCGCGGTGGTCATGGACGGCAAC
GGCCGGTGGGCCACCCAACGCGGGCTCGGCCGTACCGAGGGCCACAAGATGGGCGAGGCGGTGCTGATCGACATCACGTG
CGGGGCCATCGAGATCGGCATCAAACACCTGACGGTGTACGCGTTCTCCACCGAGAACTGGAAGCGCAGCACCGAAGAGG
TGCGTTTCCTGATGGGGTTCAACCGCGAGGTGGTCCGCCGCCGCCGGGAGAACCTCAACGACATGGGCGTGCGGATGCGC
TGGGTCGGGTCGCGGCCGCGGATGTGGCGCAGCGTGAGCAAGGAATTCGACATCGCCGAGGAGATGACGGTCGACAACGA
CGTCATCACCATCAACTACTGCGTGAACTACGGCGGGCGCACCGAGATCGTCGAGGCGGCGCGCCAGCTCGCGCAGGAGG
CCGTCGACGGCAAGGTGAACCCGAGCCGGATCACCGAGGCGGCGTTCGCCAGACATCTGCACCGGCCCGACATCCCCGAT
GTCGACCTGTTCATCCGCACGTCGGGGGAGCAGCGGGCCAGCAACTTCCTGCTGTGGCAGTCCGCGTACGCCGAGTACGT
CTTCCAGGACAAACTGTGGCCGGACTACGACCGCCGCGACCTGTGGGCGGCGTGCGAGGAGTACGTCAGCCGCAACCGGC
GCTTCGGTAGGGCCTGA

Upstream 100 bases:

>100_bases
ACATTGCCGCTGGTGGAGCGCGTCTACCGGGTCGATCATGCGGTCGCTGATCACCGGATTTCGCTGTTGCGGCAGGATGT
GCACCGTGGTGACGAACCGG

Downstream 100 bases:

>100_bases
TGGACCTGCAGCCGCGGTTGGCCGCCGTGCTCGACGGGTTCGTCGACGCGGTGACCCGCGAATCCGACGGTGCGCTCACG
GTGCGTCACGACGGCACGAT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MTSSRRGAERKKSQFPQLDPPADDYPTFPDKSTWPVVFPELPPNTNGRFARPPQHTSKAAAPKIPADQVPQHVAVVMDGN
GRWATQRGLGRTEGHKMGEAVLIDITCGAIEIGIKHLTVYAFSTENWKRSTEEVRFLMGFNREVVRRRRENLNDMGVRMR
WVGSRPRMWRSVSKEFDIAEEMTVDNDVITINYCVNYGGRTEIVEAARQLAQEAVDGKVNPSRITEAAFARHLHRPDIPD
VDLFIRTSGEQRASNFLLWQSAYAEYVFQDKLWPDYDRRDLWAACEEYVSRNRRFGRA

Sequences:

>Translated_298_residues
MTSSRRGAERKKSQFPQLDPPADDYPTFPDKSTWPVVFPELPPNTNGRFARPPQHTSKAAAPKIPADQVPQHVAVVMDGN
GRWATQRGLGRTEGHKMGEAVLIDITCGAIEIGIKHLTVYAFSTENWKRSTEEVRFLMGFNREVVRRRRENLNDMGVRMR
WVGSRPRMWRSVSKEFDIAEEMTVDNDVITINYCVNYGGRTEIVEAARQLAQEAVDGKVNPSRITEAAFARHLHRPDIPD
VDLFIRTSGEQRASNFLLWQSAYAEYVFQDKLWPDYDRRDLWAACEEYVSRNRRFGRA
>Mature_297_residues
TSSRRGAERKKSQFPQLDPPADDYPTFPDKSTWPVVFPELPPNTNGRFARPPQHTSKAAAPKIPADQVPQHVAVVMDGNG
RWATQRGLGRTEGHKMGEAVLIDITCGAIEIGIKHLTVYAFSTENWKRSTEEVRFLMGFNREVVRRRRENLNDMGVRMRW
VGSRPRMWRSVSKEFDIAEEMTVDNDVITINYCVNYGGRTEIVEAARQLAQEAVDGKVNPSRITEAAFARHLHRPDIPDV
DLFIRTSGEQRASNFLLWQSAYAEYVFQDKLWPDYDRRDLWAACEEYVSRNRRFGRA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=232, Percent_Identity=36.2068965517241, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI45580738, Length=232, Percent_Identity=36.2068965517241, Blast_Score=142, Evalue=4e-34,
Organism=Escherichia coli, GI1786371, Length=236, Percent_Identity=41.5254237288136, Blast_Score=186, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71993029, Length=230, Percent_Identity=36.5217391304348, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6319474, Length=216, Percent_Identity=35.6481481481481, Blast_Score=129, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=218, Percent_Identity=31.1926605504587, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI18857969, Length=213, Percent_Identity=34.2723004694836, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 34243; Mature: 34112

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSRRGAERKKSQFPQLDPPADDYPTFPDKSTWPVVFPELPPNTNGRFARPPQHTSKAA
CCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCC
APKIPADQVPQHVAVVMDGNGRWATQRGLGRTEGHKMGEAVLIDITCGAIEIGIKHLTVY
CCCCCHHHCCCEEEEEECCCCCEEHHCCCCCCCCCCCCCEEEEEEECCHHHCCEEEEEEE
AFSTENWKRSTEEVRFLMGFNREVVRRRRENLNDMGVRMRWVGSRPRMWRSVSKEFDIAE
EEECCCHHHHHHHHHHHHCCCHHHHHHHHHCCHHHCEEEEEECCCCHHHHHHHHHCCCHH
EMTVDNDVITINYCVNYGGRTEIVEAARQLAQEAVDGKVNPSRITEAAFARHLHRPDIPD
HHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCC
VDLFIRTSGEQRASNFLLWQSAYAEYVFQDKLWPDYDRRDLWAACEEYVSRNRRFGRA
CEEEEECCCCHHHHHEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TSSRRGAERKKSQFPQLDPPADDYPTFPDKSTWPVVFPELPPNTNGRFARPPQHTSKAA
CCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCC
APKIPADQVPQHVAVVMDGNGRWATQRGLGRTEGHKMGEAVLIDITCGAIEIGIKHLTVY
CCCCCHHHCCCEEEEEECCCCCEEHHCCCCCCCCCCCCCEEEEEEECCHHHCCEEEEEEE
AFSTENWKRSTEEVRFLMGFNREVVRRRRENLNDMGVRMRWVGSRPRMWRSVSKEFDIAE
EEECCCHHHHHHHHHHHHCCCHHHHHHHHHCCHHHCEEEEEECCCCHHHHHHHHHCCCHH
EMTVDNDVITINYCVNYGGRTEIVEAARQLAQEAVDGKVNPSRITEAAFARHLHRPDIPD
HHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCC
VDLFIRTSGEQRASNFLLWQSAYAEYVFQDKLWPDYDRRDLWAACEEYVSRNRRFGRA
CEEEEECCCCHHHHHEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA