BacMap

Definition	Mycobacterium sp. MCS chromosome, complete genome.
Accession	NC_008146
Length	5,705,448

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The map label for this gene is ephD [H]

Identifier: 108800163

GI number: 108800163

Start: 3389029

End: 3389883

Strand: Reverse

Name: ephD [H]

Synonym: Mmcs_3197

Alternate gene names: 108800163

Gene position: 3389883-3389029 (Counterclockwise)

Preceding gene: 108800165

Following gene: 108800162

Centisome position: 59.41

GC content: 61.17

Gene sequence:

>855_bases
ATGAGATTGCTGCCCTTCGGCGGCGCACCAGGCAGAACGCACCGCGCCGATGCAGTCGTCACGGGCGCAGGAAGCGGTAT
CGGCCGCGCATTCGCCGTGGAGCTTGCGCGCCGAGGTGGACGCGTGGTGTGCGCCGACAAAGATCCCGTCACTGCAAAAG
AGTCGGCAGAGTTGGTGAGGCAGGCTGGCGGCGAGGGCTTCGACATCGAATGCGATGTCACCGATCTTGAGCAGGTCCGC
AACCTCGCTGATGTGAGCGAAGACTGGTTCGAGAAGGCTGCGAGCCTCGTCATCAACAACGCCGGAATCGGTGCGGGCGG
CAACCGCATCGGCGCGACGTCGATCGAGGACTGGAACGCGGCGATTTCTGTCAACCTCTGGGGCGTTATCTACGGCTGCG
AGACTTTTGTGCCTCGGCTCCGCAGCAATGGGCATGGCGGAGTCATCAATGTGGCGTCGGCAGCGAGCTTTGGCTCGGCC
CCTCGGATGGCGGCTTACAACGTGAGCAAGGCCGGGGTGCTCGCTCTGTCGGAGACATTGGCGGCCGAACTGAGCGGTAC
TGACATCAACGTCACAGTGCTTTGCCCCACCTTCGTGAAGACGAACATCGTCAACAATCCTCAAATCGACGAGGCGGCTG
CAAGACTCGCGGCCAACCTGATGAAATGGACCGGCATTTCGCCACAGCACGTTGCTCGAACGACGTTGAACGCGCACGAT
CGCGGACAAATTTATGTAGTACCCCAACTCGATGCCAAAGTCTTGTGGCAACTCAAGAGAGCCCTACCCGGCCCCTTTAC
TCGCACGCTGGGCCTCGTGGAGCGCATGGCCTCATGGAACGATTCAGCCGAGTAG

Upstream 100 bases:

>100_bases
ACCACCAAACTGGTGGCATGCGACACCAATGGTGGCTGGTGCCCCCAGATGAGAGTTTCCCCACAGCAGACGTCCATGTC
GCGACCCGAAAGGCAGACGG

Downstream 100 bases:

>100_bases
AGGAGCAGGGAAAATGGCTTTCGCATACAGTGACATGCTCGAGACAATCAAAAACAAGCAATGGGCTCTTGCCGATATCG
ATTGGAACGCCCCTGGCGCG

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MRLLPFGGAPGRTHRADAVVTGAGSGIGRAFAVELARRGGRVVCADKDPVTAKESAELVRQAGGEGFDIECDVTDLEQVR
NLADVSEDWFEKAASLVINNAGIGAGGNRIGATSIEDWNAAISVNLWGVIYGCETFVPRLRSNGHGGVINVASAASFGSA
PRMAAYNVSKAGVLALSETLAAELSGTDINVTVLCPTFVKTNIVNNPQIDEAAARLAANLMKWTGISPQHVARTTLNAHD
RGQIYVVPQLDAKVLWQLKRALPGPFTRTLGLVERMASWNDSAE

Sequences:

>Translated_284_residues
MRLLPFGGAPGRTHRADAVVTGAGSGIGRAFAVELARRGGRVVCADKDPVTAKESAELVRQAGGEGFDIECDVTDLEQVR
NLADVSEDWFEKAASLVINNAGIGAGGNRIGATSIEDWNAAISVNLWGVIYGCETFVPRLRSNGHGGVINVASAASFGSA
PRMAAYNVSKAGVLALSETLAAELSGTDINVTVLCPTFVKTNIVNNPQIDEAAARLAANLMKWTGISPQHVARTTLNAHD
RGQIYVVPQLDAKVLWQLKRALPGPFTRTLGLVERMASWNDSAE
>Mature_284_residues
MRLLPFGGAPGRTHRADAVVTGAGSGIGRAFAVELARRGGRVVCADKDPVTAKESAELVRQAGGEGFDIECDVTDLEQVR
NLADVSEDWFEKAASLVINNAGIGAGGNRIGATSIEDWNAAISVNLWGVIYGCETFVPRLRSNGHGGVINVASAASFGSA
PRMAAYNVSKAGVLALSETLAAELSGTDINVTVLCPTFVKTNIVNNPQIDEAAARLAANLMKWTGISPQHVARTTLNAHD
RGQIYVVPQLDAKVLWQLKRALPGPFTRTLGLVERMASWNDSAE

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI142976729, Length=192, Percent_Identity=30.2083333333333, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI15277342, Length=206, Percent_Identity=33.495145631068, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI40807363, Length=251, Percent_Identity=26.6932270916335, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI210032110, Length=265, Percent_Identity=25.6603773584906, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI31542939, Length=226, Percent_Identity=28.7610619469027, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI25282469, Length=221, Percent_Identity=28.9592760180996, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI32483357, Length=189, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI310128830, Length=282, Percent_Identity=25.531914893617, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310115468, Length=282, Percent_Identity=25.531914893617, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI40254992, Length=189, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI33667109, Length=224, Percent_Identity=27.2321428571429, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI5031737, Length=188, Percent_Identity=29.7872340425532, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI4557649, Length=192, Percent_Identity=29.1666666666667, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI19923817, Length=199, Percent_Identity=27.1356783919598, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI226371731, Length=191, Percent_Identity=26.7015706806283, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4504505, Length=198, Percent_Identity=28.2828282828283, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI126723750, Length=206, Percent_Identity=27.6699029126214, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI10190746, Length=261, Percent_Identity=28.735632183908, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI150247226, Length=224, Percent_Identity=30.8035714285714, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI126723191, Length=180, Percent_Identity=27.2222222222222, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI2367175, Length=193, Percent_Identity=34.7150259067358, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1787905, Length=226, Percent_Identity=26.9911504424779, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789208, Length=195, Percent_Identity=28.2051282051282, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787335, Length=201, Percent_Identity=29.8507462686567, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1787820, Length=229, Percent_Identity=25.764192139738, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87082100, Length=194, Percent_Identity=26.8041237113402, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786701, Length=196, Percent_Identity=27.0408163265306, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786812, Length=189, Percent_Identity=28.042328042328, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17564282, Length=209, Percent_Identity=29.1866028708134, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI193203117, Length=189, Percent_Identity=26.984126984127, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI193203115, Length=190, Percent_Identity=26.8421052631579, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17508895, Length=211, Percent_Identity=26.5402843601896, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25147288, Length=186, Percent_Identity=32.258064516129, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17567345, Length=189, Percent_Identity=28.5714285714286, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17507613, Length=198, Percent_Identity=32.3232323232323, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI32563809, Length=198, Percent_Identity=32.3232323232323, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=187, Percent_Identity=27.807486631016, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=197, Percent_Identity=28.9340101522843, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17555612, Length=293, Percent_Identity=23.8907849829352, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=190, Percent_Identity=29.4736842105263, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=201, Percent_Identity=27.8606965174129, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17555706, Length=203, Percent_Identity=29.064039408867, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=189, Percent_Identity=28.042328042328, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=186, Percent_Identity=24.7311827956989, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17538486, Length=191, Percent_Identity=29.8429319371728, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320089, Length=195, Percent_Identity=28.2051282051282, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323882, Length=198, Percent_Identity=25.2525252525253, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24649181, Length=193, Percent_Identity=28.4974093264249, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI281364892, Length=228, Percent_Identity=26.7543859649123, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI28571526, Length=194, Percent_Identity=31.9587628865979, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24639444, Length=190, Percent_Identity=29.4736842105263, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21358495, Length=277, Percent_Identity=23.1046931407942, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17737361, Length=257, Percent_Identity=28.7937743190661, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281364494, Length=199, Percent_Identity=32.6633165829146, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24640442, Length=197, Percent_Identity=28.9340101522843, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221510726, Length=261, Percent_Identity=27.9693486590038, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI18859837, Length=191, Percent_Identity=29.3193717277487, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21356301, Length=259, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24640492, Length=196, Percent_Identity=23.9795918367347, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21357041, Length=196, Percent_Identity=29.5918367346939, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24584748, Length=191, Percent_Identity=27.2251308900524, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI161076933, Length=191, Percent_Identity=27.2251308900524, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21357673, Length=202, Percent_Identity=29.2079207920792, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI23397609, Length=196, Percent_Identity=30.6122448979592, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI116007236, Length=247, Percent_Identity=27.5303643724696, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI161076371, Length=240, Percent_Identity=27.0833333333333, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00561 Abhydrolase_1; PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 29992; Mature: 29992

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLPFGGAPGRTHRADAVVTGAGSGIGRAFAVELARRGGRVVCADKDPVTAKESAELVR
CEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHH
QAGGEGFDIECDVTDLEQVRNLADVSEDWFEKAASLVINNAGIGAGGNRIGATSIEDWNA
HCCCCCCEEEECHHHHHHHHHHHHCCHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCE
AISVNLWGVIYGCETFVPRLRSNGHGGVINVASAASFGSAPRMAAYNVSKAGVLALSETL
EEEEEEEEEEHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEECCCCCHHHHHHHHH
AAELSGTDINVTVLCPTFVKTNIVNNPQIDEAAARLAANLMKWTGISPQHVARTTLNAHD
HHHCCCCEEEEEEEECHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC
RGQIYVVPQLDAKVLWQLKRALPGPFTRTLGLVERMASWNDSAE
CCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRLLPFGGAPGRTHRADAVVTGAGSGIGRAFAVELARRGGRVVCADKDPVTAKESAELVR
CEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHH
QAGGEGFDIECDVTDLEQVRNLADVSEDWFEKAASLVINNAGIGAGGNRIGATSIEDWNA
HCCCCCCEEEECHHHHHHHHHHHHCCHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCE
AISVNLWGVIYGCETFVPRLRSNGHGGVINVASAASFGSAPRMAAYNVSKAGVLALSETL
EEEEEEEEEEHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEECCCCCHHHHHHHHH
AAELSGTDINVTVLCPTFVKTNIVNNPQIDEAAARLAANLMKWTGISPQHVARTTLNAHD
HHHCCCCEEEEEEEECHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC
RGQIYVVPQLDAKVLWQLKRALPGPFTRTLGLVERMASWNDSAE
CCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]