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The map label for this gene is hisG [H]

Identifier: 108800111

GI number: 108800111

Start: 3334951

End: 3335802

Strand: Reverse

Name: hisG [H]

Synonym: Mmcs_3145

Alternate gene names: 108800111

Gene position: 3335802-3334951 (Counterclockwise)

Preceding gene: 108800112

Following gene: 108800109

Centisome position: 58.47

GC content: 69.84

Gene sequence:

>852_bases
ATGCTGAGGGTCGCCGTGCCCAACAAGGGCACGCTGAGCGAACCGGCCGCCGAGATCCTGTCGGAGGCCGGCTACCGGCG
CCGCACGGACACCAAGGACCTCACGGTCGTCGATCCGGCCAACAACGTCGAGTTCTTCTTCCTGCGCCCCAAGGACATCG
CGATCTATGTCGGATCGGGTCAGCTCGATCTCGGGATCACCGGGCGGGACCTGGCCGCCGAATCGGATGCACCGGTGCGC
GAACGGCTGGCGCTGGGATTCGGATCGTCGACCTTCCGTTACGCCGCACCGGCCGGCCGGGACTGGGCGCCGGAGGATCT
GGCCGGTCGGCGGATCGCCACGGCGTTTCCGAACCTGGTGCGAAAAGACCTCGCGGGCAGGGGAATCGAGGCGACGGTGA
TCCGGCTCGACGGGGCGGTGGAGATCTCGGTCGCGCTCGGCGTCGCCGATGCGATCGCCGACGTGGTCGGTTCGGGCCGC
ACGCTGGGGCTGCACAACCTGGTCGCCTTCGGTGACTCGCTGTGCGATTCGGAGGCGGTGCTGATCGAGCGTGACGGCGC
CGGCGACGAGAATGCCGCGGCGCGTGACCAACTGGCCGCCCGCGTGCAGGGCGTGGTGTTCGGCCAGCAGTACCTGATGC
TGGACTACGACTGCCCGCGCCACGTCCTCGACCGGGCCACCGAGGTGACGCCGGGGCTGGAATCGCCCACCATCGCACCG
CTGGCCGACCAGGACTGGGTGGCGGTGCGGGCGCTGGTGCCGCGCCGCGACGTCAACTCGATCATGGACGAGCTCGCCGC
GATCGGCGCCAAGGCGATCCTGGCGTCGGACATCCGGTTCTGCCGCTTCTGA

Upstream 100 bases:

>100_bases
CGCTCGCCGAGGAGATCAGCCAGTTGCTGTACTGGACGCAGGTGCTGATGATCGCCCGCGGCCTGTCACCCGACGACGTC
TACCGCAAGCTGTGAACGGC

Downstream 100 bases:

>100_bases
CCACCGCTCAGACGCGCGGACGGCGCCGGCTGAGATGCACGTTGAGTCCCACGGCGGCGAGCGCCAACGCGCCCAGTGTC
CCGGCGAGTCCGATCAGGAA

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MLRVAVPNKGTLSEPAAEILSEAGYRRRTDTKDLTVVDPANNVEFFFLRPKDIAIYVGSGQLDLGITGRDLAAESDAPVR
ERLALGFGSSTFRYAAPAGRDWAPEDLAGRRIATAFPNLVRKDLAGRGIEATVIRLDGAVEISVALGVADAIADVVGSGR
TLGLHNLVAFGDSLCDSEAVLIERDGAGDENAAARDQLAARVQGVVFGQQYLMLDYDCPRHVLDRATEVTPGLESPTIAP
LADQDWVAVRALVPRRDVNSIMDELAAIGAKAILASDIRFCRF

Sequences:

>Translated_283_residues
MLRVAVPNKGTLSEPAAEILSEAGYRRRTDTKDLTVVDPANNVEFFFLRPKDIAIYVGSGQLDLGITGRDLAAESDAPVR
ERLALGFGSSTFRYAAPAGRDWAPEDLAGRRIATAFPNLVRKDLAGRGIEATVIRLDGAVEISVALGVADAIADVVGSGR
TLGLHNLVAFGDSLCDSEAVLIERDGAGDENAAARDQLAARVQGVVFGQQYLMLDYDCPRHVLDRATEVTPGLESPTIAP
LADQDWVAVRALVPRRDVNSIMDELAAIGAKAILASDIRFCRF
>Mature_283_residues
MLRVAVPNKGTLSEPAAEILSEAGYRRRTDTKDLTVVDPANNVEFFFLRPKDIAIYVGSGQLDLGITGRDLAAESDAPVR
ERLALGFGSSTFRYAAPAGRDWAPEDLAGRRIATAFPNLVRKDLAGRGIEATVIRLDGAVEISVALGVADAIADVVGSGR
TLGLHNLVAFGDSLCDSEAVLIERDGAGDENAAARDQLAARVQGVVFGQQYLMLDYDCPRHVLDRATEVTPGLESPTIAP
LADQDWVAVRALVPRRDVNSIMDELAAIGAKAILASDIRFCRF

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=285, Percent_Identity=32.6315789473684, Blast_Score=129, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320896, Length=288, Percent_Identity=32.9861111111111, Blast_Score=148, Evalue=8e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 30274; Mature: 30274

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRVAVPNKGTLSEPAAEILSEAGYRRRTDTKDLTVVDPANNVEFFFLRPKDIAIYVGSG
CEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEEEECCCEEEEEEECC
QLDLGITGRDLAAESDAPVRERLALGFGSSTFRYAAPAGRDWAPEDLAGRRIATAFPNLV
EEEEEECCCCCCCCCCCCHHHHHHHCCCCCCEEECCCCCCCCCCHHHCCCCHHHHHHHHH
RKDLAGRGIEATVIRLDGAVEISVALGVADAIADVVGSGRTLGLHNLVAFGDSLCDSEAV
HHHHCCCCCEEEEEEECCCEEEEEEHHHHHHHHHHHCCCCEECHHHHHHHHHHHCCCCEE
LIERDGAGDENAAARDQLAARVQGVVFGQQYLMLDYDCPRHVLDRATEVTPGLESPTIAP
EEEECCCCCCCHHHHHHHHHHHHHEEECCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCC
LADQDWVAVRALVPRRDVNSIMDELAAIGAKAILASDIRFCRF
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLRVAVPNKGTLSEPAAEILSEAGYRRRTDTKDLTVVDPANNVEFFFLRPKDIAIYVGSG
CEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEEEECCCEEEEEEECC
QLDLGITGRDLAAESDAPVRERLALGFGSSTFRYAAPAGRDWAPEDLAGRRIATAFPNLV
EEEEEECCCCCCCCCCCCHHHHHHHCCCCCCEEECCCCCCCCCCHHHCCCCHHHHHHHHH
RKDLAGRGIEATVIRLDGAVEISVALGVADAIADVVGSGRTLGLHNLVAFGDSLCDSEAV
HHHHCCCCCEEEEEEECCCEEEEEEHHHHHHHHHHHCCCCEECHHHHHHHHHHHCCCCEE
LIERDGAGDENAAARDQLAARVQGVVFGQQYLMLDYDCPRHVLDRATEVTPGLESPTIAP
EEEECCCCCCCHHHHHHHHHHHHHEEECCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCC
LADQDWVAVRALVPRRDVNSIMDELAAIGAKAILASDIRFCRF
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA