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The map label for this gene is trmI [H]

Identifier: 108800102

GI number: 108800102

Start: 3328179

End: 3329033

Strand: Reverse

Name: trmI [H]

Synonym: Mmcs_3136

Alternate gene names: 108800102

Gene position: 3329033-3328179 (Counterclockwise)

Preceding gene: 108800106

Following gene: 108800098

Centisome position: 58.35

GC content: 69.94

Gene sequence:

>855_bases
ATGCCCAGAACCGGTCCGTTCGCCGTCGGAGACCGCGTCCAACTCACCGACGCCAAGGGGCGGCACTACACGATGCTGCT
CACACCGGGCGGTGAATTCCACACCCACCGCGGCATGATCGCGCTCGACAGCGTCATCGGCCTGCCCGAGGGCAGCGTCG
TCAAGTCCACCAGCGGTGACCAGTTCCTGGTGCTTCGGCCACTGCTCGTGGATTACGTGATGTCGATGCCGCGCGGCGCG
CAGGTCATCTATCCCAAGGACGCCGCGCAGATCGTCCACGAGGGCGACATCTTCCCCGGCGCCCGCGTGCTCGAGGCGGG
CGCCGGCTCCGGTGCGCTCACGTGCTCGCTGCTGCGCGCGGTCGGACCCCAGGGCCGGGTGACGTCCTACGAGGTGCGCG
ACGACCACGCCGTACACGCCGCCCGCAACGTCGAGACGTTCTTCGGGGAACGGCCGGCCAACTGGGACCTCGTCATCGCC
GACCTCAACGATTACAACGGTGGTGAGGTCGACCGCGTCGTGCTCGACATGCTGGCGCCGTGGGAGGTGCTCGACACCGT
CTCACGCAACCTCGTGCCGGGCGGCGTGCTGATGATCTACGTCGCGACCGTGACCCAGCTGTCGCGGGCGGTGGAGGCGC
TTCGGCAACAGCAGTGCTGGACCGAGCCGCGCGCGTGGGAGAGCATGCAGCGCGGCTGGTACGTCGTCGGCCTGGCCGTG
CGCCCCCAGCACACCATGCGCGGCCACACCGCGTTCCTCATCAGTGCCCGCCGGCTGGCGCCGGGAGCCATCGCCCCGAT
CCCGTTGCGCCGCAAGCGGCAACTCGCCGCGCCACCCGCCGAACCCTCGGACTAA

Upstream 100 bases:

>100_bases
GGCCTGTTCGCTCATGCTCTGCAGCCTAGGACGGCCCCCCGACAGATCTGCGCAACCCCGCGGACCCGTTGCGGCGCGCC
GACTGGCAGGCTGAGCGACT

Downstream 100 bases:

>100_bases
TCGTCGTCGCTGCGCCGCAGACCGCGGCGCGCCGAGAGCAACTCCATCTCCGGGCGGGCGGCGACAAGTCGCTCGGCGGC
GTCCAGCACGTCCACCACGT

Product: tRNA (adenine-N(1)-)-methyltransferase

Products: NA

Alternate protein names: tRNA(m1A58)-methyltransferase; tRNA(m1A58)MTase [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MPRTGPFAVGDRVQLTDAKGRHYTMLLTPGGEFHTHRGMIALDSVIGLPEGSVVKSTSGDQFLVLRPLLVDYVMSMPRGA
QVIYPKDAAQIVHEGDIFPGARVLEAGAGSGALTCSLLRAVGPQGRVTSYEVRDDHAVHAARNVETFFGERPANWDLVIA
DLNDYNGGEVDRVVLDMLAPWEVLDTVSRNLVPGGVLMIYVATVTQLSRAVEALRQQQCWTEPRAWESMQRGWYVVGLAV
RPQHTMRGHTAFLISARRLAPGAIAPIPLRRKRQLAAPPAEPSD

Sequences:

>Translated_284_residues
MPRTGPFAVGDRVQLTDAKGRHYTMLLTPGGEFHTHRGMIALDSVIGLPEGSVVKSTSGDQFLVLRPLLVDYVMSMPRGA
QVIYPKDAAQIVHEGDIFPGARVLEAGAGSGALTCSLLRAVGPQGRVTSYEVRDDHAVHAARNVETFFGERPANWDLVIA
DLNDYNGGEVDRVVLDMLAPWEVLDTVSRNLVPGGVLMIYVATVTQLSRAVEALRQQQCWTEPRAWESMQRGWYVVGLAV
RPQHTMRGHTAFLISARRLAPGAIAPIPLRRKRQLAAPPAEPSD
>Mature_283_residues
PRTGPFAVGDRVQLTDAKGRHYTMLLTPGGEFHTHRGMIALDSVIGLPEGSVVKSTSGDQFLVLRPLLVDYVMSMPRGAQ
VIYPKDAAQIVHEGDIFPGARVLEAGAGSGALTCSLLRAVGPQGRVTSYEVRDDHAVHAARNVETFFGERPANWDLVIAD
LNDYNGGEVDRVVLDMLAPWEVLDTVSRNLVPGGVLMIYVATVTQLSRAVEALRQQQCWTEPRAWESMQRGWYVVGLAVR
PQHTMRGHTAFLISARRLAPGAIAPIPLRRKRQLAAPPAEPSD

Specific function: Catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in tRNA. Is required for cell growth at extreme temperatures [H]

COG id: COG2519

COG function: function code J; tRNA(1-methyladenosine) methyltransferase and related methyltransferases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TrmI family [H]

Homologues:

Organism=Homo sapiens, GI222831587, Length=250, Percent_Identity=32.8, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI123173772, Length=212, Percent_Identity=28.3018867924528, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17509459, Length=209, Percent_Identity=25.3588516746411, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24650257, Length=193, Percent_Identity=27.979274611399, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014816 [H]

Pfam domain/function: PF08704 GCD14 [H]

EC number: =2.1.1.36 [H]

Molecular weight: Translated: 31019; Mature: 30888

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRTGPFAVGDRVQLTDAKGRHYTMLLTPGGEFHTHRGMIALDSVIGLPEGSVVKSTSGD
CCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCCCCEEEEHHHHCCCCCCEEECCCCC
QFLVLRPLLVDYVMSMPRGAQVIYPKDAAQIVHEGDIFPGARVLEAGAGSGALTCSLLRA
EEEEHHHHHHHHHHCCCCCCEEEECCHHHHHHHCCCCCCCCCEEECCCCCCHHHHHHHHH
VGPQGRVTSYEVRDDHAVHAARNVETFFGERPANWDLVIADLNDYNGGEVDRVVLDMLAP
CCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCC
WEVLDTVSRNLVPGGVLMIYVATVTQLSRAVEALRQQQCWTEPRAWESMQRGWYVVGLAV
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCEEEEEEEE
RPQHTMRGHTAFLISARRLAPGAIAPIPLRRKRQLAAPPAEPSD
CCCHHHCCCEEEEEEECCCCCCCCCCCCCCCCHHCCCCCCCCCC
>Mature Secondary Structure 
PRTGPFAVGDRVQLTDAKGRHYTMLLTPGGEFHTHRGMIALDSVIGLPEGSVVKSTSGD
CCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCCCCEEEEHHHHCCCCCCEEECCCCC
QFLVLRPLLVDYVMSMPRGAQVIYPKDAAQIVHEGDIFPGARVLEAGAGSGALTCSLLRA
EEEEHHHHHHHHHHCCCCCCEEEECCHHHHHHHCCCCCCCCCEEECCCCCCHHHHHHHHH
VGPQGRVTSYEVRDDHAVHAARNVETFFGERPANWDLVIADLNDYNGGEVDRVVLDMLAP
CCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCC
WEVLDTVSRNLVPGGVLMIYVATVTQLSRAVEALRQQQCWTEPRAWESMQRGWYVVGLAV
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCEEEEEEEE
RPQHTMRGHTAFLISARRLAPGAIAPIPLRRKRQLAAPPAEPSD
CCCHHHCCCEEEEEEECCCCCCCCCCCCCCCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA