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The map label for this gene is uvrB [H]

Identifier: 108799967

GI number: 108799967

Start: 3171286

End: 3173445

Strand: Reverse

Name: uvrB [H]

Synonym: Mmcs_3001

Alternate gene names: 108799967

Gene position: 3173445-3171286 (Counterclockwise)

Preceding gene: 108799970

Following gene: 108799966

Centisome position: 55.62

GC content: 65.65

Gene sequence:

>2160_bases
ATGGCTTTCGCGACCGAACACCCAGTGCTCGCACACTCCGAGTACCGCCCTGTCGAGGCGATGGTGCGGACCGGCAACCG
GTTCGAGGTGGTCAGCCCCTACCAGCCCGCCGGTGATCAGCCCGCGGCGATCGACGAGCTGGAGCGGCGCATCAGGGCGG
GGGAGCGTGACGTCGTGCTCCTCGGCGCGACCGGCACCGGCAAGTCGGCGACCACCGCGTGGTTGATCGAACGGCTCCAA
CGGCCGACGTTGTTGATGGCGCCGAACAAGACGCTCGCCGCCCAGCTCGCGAACGAACTGCGAGAGATGTTGCCGCACAA
CGCCGTCGAGTACTTCGTGTCGTACTACGACTACTACCAGCCCGAGGCGTACATCGCCCAGACGGACACCTACATCGAAA
AGGACAGCTCCATCAACGACGATGTGGAGCGGTTACGGCACTCCGCGACGTCGAGTCTGCTCTCGCGGCGTGACGTGGTC
GTTGTGGCGTCGGTGTCGTGCATCTACGGTCTGGGCACGCCGCAGTCCTACATGGACCGGTCGGTGGAGCTGAAGGTGGG
CGACGAGGTGCCCCGGGACGCGCTGCTGCGACTGCTGGTAGACGTGCAGTACGCCCGCAACGACATGGCGTTCACCCGCG
GGACGTTCCGCGTACGCGGCGACACAGTAGAGATCATCCCCTCCTACGAGGAACTCGCGGTGCGCATCGAGTACTTCGGC
GACGAGGTCGAGGCGTTGTACTACATGCACCCGTTGACCGGTGATGTCGTCCGCCGGGTCGACTCTCTGCGGGTTTTCCC
GGCGACGCATTACGTCGCCGGGCCGGAGCGGATGGCGCAGGCGATCTCCAGCATCGAGAAGGAACTCGAGGACCGGTTGG
CCGAGCTCGAAGGCCAGGGCAAGCTGCTGGAGGCTCAGCGGCTGCGGATGCGCACCAATTACGACATCGAGATGATGCGG
CAGGTCGGGTTCTGCTCCGGCATCGAGAACTATTCGCGTCATATCGACGGACGCGGTCCCGGCACCGCCCCCGCGACGCT
CATCGACTACTTCCCGGAGGACTTCCTGCTGGTCATCGACGAGTCCCATGTGACCGTGCCGCAGATCGGCGGTATGTACG
AAGGGGACATGTCGAGGAAGCGCAATCTGGTCGACTTCGGTTTCCGGTTGCCGTCGGCAGTCGACAACCGCCCGCTGACG
TGGGAGGAGTTCGCGTCACGGATCGGGCAGACCGTGTACCTGTCGGCGACGCCGGGCCCATACGAGATGAGCCAGTCCGG
CGGCGAGTTCGTCGAACAGGTCATCCGCCCGACGGGGCTGGTCGATCCGCAGGTGATCGTCAAACCCACCAAGGGGCAGA
TCGACGATCTGATCGGGGAGATCCGCAAGCGCACGGAACTCGACGAGCGGGTGCTGGTCACCACGTTGACCAAGAAGATG
GCCGAGGATCTCACCGACTACCTGCTCGAGTTGGGCATCCGGGTGCGCTACCTGCACTCCGAAGTCGACACGCTGCGCCG
CGTCGAGTTGCTGCGCCAGCTCCGGCTCGGCGAGTACGACGTGCTGGTGGGTATCAACCTGCTGCGCGAAGGTCTGGACC
TGCCGGAGGTGTCGCTGGTGGCGATCCTCGACGCCGACAAGGAGGGGTTCCTGCGGTCGACGCGCAGCCTCATCCAGACC
ATCGGCCGTGCCGCCCGCAACGTATCCGGTGAGGTTCACATGTACGCGGACAAGATCACCGACTCGATGCGTGAGGCGAT
CGACGAGACCGAACGCCGCCGCGCCAAGCAGATCGCTTACAACGAGGAGCGGGGCATCGACCCCAAACCCCTGCGCAAGA
AGATCGCCGACATCCTCGACCAGGTCTACCGCGAGGCCGACGACAGCGAGACCGTCGAGGTGGGCGGTTCGGGCCGCAAC
GCGTCCCGCGGCCGGCGCGCCCAGGGCGAGCCGGGCCGTGCGGTCAGCGCAGGCATCGTCGAGGGGCGCGACACCGCCAA
CATGCCGCGTGCCGAACTGGCGGATCTGATCAAGGATCTGACCGAGCAGATGATGACCGCCGCCCGCGACCTGCAATTCG
AACTGGCCGCCCGCATCCGCGACGAGATTCAGGACCTCAAGAAGGAACTGCGCGGTATGGACGCCGCGGGCCTGAAGTGA

Upstream 100 bases:

>100_bases
TGCAGGCGAGCAGGTCGAACGTCTCGTGTTTGGGTGGGTGGATACCTCAGCATAGAACCGGGAACAAGAACCTGTCGGTG
GCTGGTTCTACCCTGGTGAA

Downstream 100 bases:

>100_bases
CACGTGGTTGACCTCAACCGCTGTTGAGCTCATAGCGTGGCGGTGTGACTGACACCTCGCGCGTCTCGGTGGGCACCTGG
CGCGACCTGCTGGGCCCGGC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 719; Mature: 718

Protein sequence:

>719_residues
MAFATEHPVLAHSEYRPVEAMVRTGNRFEVVSPYQPAGDQPAAIDELERRIRAGERDVVLLGATGTGKSATTAWLIERLQ
RPTLLMAPNKTLAAQLANELREMLPHNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDDVERLRHSATSSLLSRRDVV
VVASVSCIYGLGTPQSYMDRSVELKVGDEVPRDALLRLLVDVQYARNDMAFTRGTFRVRGDTVEIIPSYEELAVRIEYFG
DEVEALYYMHPLTGDVVRRVDSLRVFPATHYVAGPERMAQAISSIEKELEDRLAELEGQGKLLEAQRLRMRTNYDIEMMR
QVGFCSGIENYSRHIDGRGPGTAPATLIDYFPEDFLLVIDESHVTVPQIGGMYEGDMSRKRNLVDFGFRLPSAVDNRPLT
WEEFASRIGQTVYLSATPGPYEMSQSGGEFVEQVIRPTGLVDPQVIVKPTKGQIDDLIGEIRKRTELDERVLVTTLTKKM
AEDLTDYLLELGIRVRYLHSEVDTLRRVELLRQLRLGEYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSTRSLIQT
IGRAARNVSGEVHMYADKITDSMREAIDETERRRAKQIAYNEERGIDPKPLRKKIADILDQVYREADDSETVEVGGSGRN
ASRGRRAQGEPGRAVSAGIVEGRDTANMPRAELADLIKDLTEQMMTAARDLQFELAARIRDEIQDLKKELRGMDAAGLK

Sequences:

>Translated_719_residues
MAFATEHPVLAHSEYRPVEAMVRTGNRFEVVSPYQPAGDQPAAIDELERRIRAGERDVVLLGATGTGKSATTAWLIERLQ
RPTLLMAPNKTLAAQLANELREMLPHNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDDVERLRHSATSSLLSRRDVV
VVASVSCIYGLGTPQSYMDRSVELKVGDEVPRDALLRLLVDVQYARNDMAFTRGTFRVRGDTVEIIPSYEELAVRIEYFG
DEVEALYYMHPLTGDVVRRVDSLRVFPATHYVAGPERMAQAISSIEKELEDRLAELEGQGKLLEAQRLRMRTNYDIEMMR
QVGFCSGIENYSRHIDGRGPGTAPATLIDYFPEDFLLVIDESHVTVPQIGGMYEGDMSRKRNLVDFGFRLPSAVDNRPLT
WEEFASRIGQTVYLSATPGPYEMSQSGGEFVEQVIRPTGLVDPQVIVKPTKGQIDDLIGEIRKRTELDERVLVTTLTKKM
AEDLTDYLLELGIRVRYLHSEVDTLRRVELLRQLRLGEYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSTRSLIQT
IGRAARNVSGEVHMYADKITDSMREAIDETERRRAKQIAYNEERGIDPKPLRKKIADILDQVYREADDSETVEVGGSGRN
ASRGRRAQGEPGRAVSAGIVEGRDTANMPRAELADLIKDLTEQMMTAARDLQFELAARIRDEIQDLKKELRGMDAAGLK
>Mature_718_residues
AFATEHPVLAHSEYRPVEAMVRTGNRFEVVSPYQPAGDQPAAIDELERRIRAGERDVVLLGATGTGKSATTAWLIERLQR
PTLLMAPNKTLAAQLANELREMLPHNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDDVERLRHSATSSLLSRRDVVV
VASVSCIYGLGTPQSYMDRSVELKVGDEVPRDALLRLLVDVQYARNDMAFTRGTFRVRGDTVEIIPSYEELAVRIEYFGD
EVEALYYMHPLTGDVVRRVDSLRVFPATHYVAGPERMAQAISSIEKELEDRLAELEGQGKLLEAQRLRMRTNYDIEMMRQ
VGFCSGIENYSRHIDGRGPGTAPATLIDYFPEDFLLVIDESHVTVPQIGGMYEGDMSRKRNLVDFGFRLPSAVDNRPLTW
EEFASRIGQTVYLSATPGPYEMSQSGGEFVEQVIRPTGLVDPQVIVKPTKGQIDDLIGEIRKRTELDERVLVTTLTKKMA
EDLTDYLLELGIRVRYLHSEVDTLRRVELLRQLRLGEYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSTRSLIQTI
GRAARNVSGEVHMYADKITDSMREAIDETERRRAKQIAYNEERGIDPKPLRKKIADILDQVYREADDSETVEVGGSGRNA
SRGRRAQGEPGRAVSAGIVEGRDTANMPRAELADLIKDLTEQMMTAARDLQFELAARIRDEIQDLKKELRGMDAAGLK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=683, Percent_Identity=56.5153733528551, Blast_Score=742, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 80990; Mature: 80859

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFATEHPVLAHSEYRPVEAMVRTGNRFEVVSPYQPAGDQPAAIDELERRIRAGERDVVL
CCCCCCCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEE
LGATGTGKSATTAWLIERLQRPTLLMAPNKTLAAQLANELREMLPHNAVEYFVSYYDYYQ
EECCCCCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC
PEAYIAQTDTYIEKDSSINDDVERLRHSATSSLLSRRDVVVVASVSCIYGLGTPQSYMDR
CCEEEECCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHCC
SVELKVGDEVPRDALLRLLVDVQYARNDMAFTRGTFRVRGDTVEIIPSYEELAVRIEYFG
CEEEEECCCCCHHHHHHHHHHHHHHHCCHHEECCEEEECCCEEEECCCHHHHHEEHHHHC
DEVEALYYMHPLTGDVVRRVDSLRVFPATHYVAGPERMAQAISSIEKELEDRLAELEGQG
CCCEEEEEECCCCHHHHHHHHHCEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
KLLEAQRLRMRTNYDIEMMRQVGFCSGIENYSRHIDGRGPGTAPATLIDYFPEDFLLVID
CHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEEE
ESHVTVPQIGGMYEGDMSRKRNLVDFGFRLPSAVDNRPLTWEEFASRIGQTVYLSATPGP
CCCCCCCCCCCCCCCCHHHHCCHHHHCCCCCCCCCCCCCCHHHHHHHCCCEEEEECCCCC
YEMSQSGGEFVEQVIRPTGLVDPQVIVKPTKGQIDDLIGEIRKRTELDERVLVTTLTKKM
CHHHCCHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEDLTDYLLELGIRVRYLHSEVDTLRRVELLRQLRLGEYDVLVGINLLREGLDLPEVSLV
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEE
AILDADKEGFLRSTRSLIQTIGRAARNVSGEVHMYADKITDSMREAIDETERRRAKQIAY
EEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHC
NEERGIDPKPLRKKIADILDQVYREADDSETVEVGGSGRNASRGRRAQGEPGRAVSAGIV
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEECCCC
EGRDTANMPRAELADLIKDLTEQMMTAARDLQFELAARIRDEIQDLKKELRGMDAAGLK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AFATEHPVLAHSEYRPVEAMVRTGNRFEVVSPYQPAGDQPAAIDELERRIRAGERDVVL
CCCCCCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEE
LGATGTGKSATTAWLIERLQRPTLLMAPNKTLAAQLANELREMLPHNAVEYFVSYYDYYQ
EECCCCCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC
PEAYIAQTDTYIEKDSSINDDVERLRHSATSSLLSRRDVVVVASVSCIYGLGTPQSYMDR
CCEEEECCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHCC
SVELKVGDEVPRDALLRLLVDVQYARNDMAFTRGTFRVRGDTVEIIPSYEELAVRIEYFG
CEEEEECCCCCHHHHHHHHHHHHHHHCCHHEECCEEEECCCEEEECCCHHHHHEEHHHHC
DEVEALYYMHPLTGDVVRRVDSLRVFPATHYVAGPERMAQAISSIEKELEDRLAELEGQG
CCCEEEEEECCCCHHHHHHHHHCEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
KLLEAQRLRMRTNYDIEMMRQVGFCSGIENYSRHIDGRGPGTAPATLIDYFPEDFLLVID
CHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEEE
ESHVTVPQIGGMYEGDMSRKRNLVDFGFRLPSAVDNRPLTWEEFASRIGQTVYLSATPGP
CCCCCCCCCCCCCCCCHHHHCCHHHHCCCCCCCCCCCCCCHHHHHHHCCCEEEEECCCCC
YEMSQSGGEFVEQVIRPTGLVDPQVIVKPTKGQIDDLIGEIRKRTELDERVLVTTLTKKM
CHHHCCHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEDLTDYLLELGIRVRYLHSEVDTLRRVELLRQLRLGEYDVLVGINLLREGLDLPEVSLV
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEE
AILDADKEGFLRSTRSLIQTIGRAARNVSGEVHMYADKITDSMREAIDETERRRAKQIAY
EEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHC
NEERGIDPKPLRKKIADILDQVYREADDSETVEVGGSGRNASRGRRAQGEPGRAVSAGIV
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEECCCC
EGRDTANMPRAELADLIKDLTEQMMTAARDLQFELAARIRDEIQDLKKELRGMDAAGLK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA