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The map label for this gene is tesB [H]

Identifier: 108799960

GI number: 108799960

Start: 3162350

End: 3163216

Strand: Reverse

Name: tesB [H]

Synonym: Mmcs_2994

Alternate gene names: 108799960

Gene position: 3163216-3162350 (Counterclockwise)

Preceding gene: 108799962

Following gene: 108799958

Centisome position: 55.44

GC content: 69.43

Gene sequence:

>867_bases
ATGATGCCCCGGGTGGTAGCGCGGACACTCTCGGACATCCTGACGACCCTGGACGTCGAACAGATCGCGGATGACGAGTT
CCTCGCGACGCAGATGGACAACGCGGCGCACCACATCGTCGGCGGGCACATCGCTGCCCAGGCGCTCATGTCGGCGAGCC
GGACCGTCAGCGCCGACCGCACCCCGCACAGCATGCACGTCTACCTGTTGCGGGCCGGCGACGCGCGCCGACCGGTGCAC
TTCGAGATCACCCGTCTGCGCGACGGCGGCGTGCTGTCCTCGCGGCGGGTGCTGGCGCGCCAGGACGACCAGGTGCTGCT
CGAAGCGCTCGTATCGTTCACCGCACCGCTGGACAGCTTCGAACACCAGCAGCCGATCCCCGACGTCCCGGGCCCGGAGT
CGCTGCCGTCGGTGCAGGAACAGTTGAGCCCGTACGCGGATGAGCACGACGGGCACTGGGTGCGCCCGCAGCCGCTGGAT
CTGCGATACGTCGACCCGCCGGCACGGCTGGCGCTCGATCGGCCCGACCCGTCGCCGCGCATCAGGCTGTGGTGGCGTCC
CGCCGAACCGATGCCCGACGACCCCATCCTCAACAGCTGCCTGTTGACGTACGTATCGGGCACCGCGCTGCTGGAGACGG
CGATGGTGGTGCGCCGGACGACGCCGCTGACGTCCTTCTCGGCACTGATCGACCACGCGGTGTGGTTCCATCGGCCTGCC
GACTTCTCGGACTGGGTGCTCTCGGATGCCGTCGCTCCCAGCGGTGTCCACGGTCGCGCCCTGGCCACCGCCACGATGTA
CAACCGCACCGTAGCGCTCGTCTGCACCGCCACCCAGGAGATCTACTTCGGCCGCGACCGCCGTTGA

Upstream 100 bases:

>100_bases
GGGCTGGCCGCACGACGCCCGGCGGGCGCGGAGATGTCGCAGCGCTGTCCACGACGCTCATCTTGCCTGACCGGTGCGGC
GGGACGCCGCGGCGTCCGGC

Downstream 100 bases:

>100_bases
CGTCGGTCGCCGCGCATCAACCGGGCGACGACGCGTAGATCCTCGACGAGTGCGTCGAACGCCTGCTGTCGGTTCTCGGC
CGGTCCCCGCAGCACCGACG

Product: acyl-CoA thioesterase

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MMPRVVARTLSDILTTLDVEQIADDEFLATQMDNAAHHIVGGHIAAQALMSASRTVSADRTPHSMHVYLLRAGDARRPVH
FEITRLRDGGVLSSRRVLARQDDQVLLEALVSFTAPLDSFEHQQPIPDVPGPESLPSVQEQLSPYADEHDGHWVRPQPLD
LRYVDPPARLALDRPDPSPRIRLWWRPAEPMPDDPILNSCLLTYVSGTALLETAMVVRRTTPLTSFSALIDHAVWFHRPA
DFSDWVLSDAVAPSGVHGRALATATMYNRTVALVCTATQEIYFGRDRR

Sequences:

>Translated_288_residues
MMPRVVARTLSDILTTLDVEQIADDEFLATQMDNAAHHIVGGHIAAQALMSASRTVSADRTPHSMHVYLLRAGDARRPVH
FEITRLRDGGVLSSRRVLARQDDQVLLEALVSFTAPLDSFEHQQPIPDVPGPESLPSVQEQLSPYADEHDGHWVRPQPLD
LRYVDPPARLALDRPDPSPRIRLWWRPAEPMPDDPILNSCLLTYVSGTALLETAMVVRRTTPLTSFSALIDHAVWFHRPA
DFSDWVLSDAVAPSGVHGRALATATMYNRTVALVCTATQEIYFGRDRR
>Mature_288_residues
MMPRVVARTLSDILTTLDVEQIADDEFLATQMDNAAHHIVGGHIAAQALMSASRTVSADRTPHSMHVYLLRAGDARRPVH
FEITRLRDGGVLSSRRVLARQDDQVLLEALVSFTAPLDSFEHQQPIPDVPGPESLPSVQEQLSPYADEHDGHWVRPQPLD
LRYVDPPARLALDRPDPSPRIRLWWRPAEPMPDDPILNSCLLTYVSGTALLETAMVVRRTTPLTSFSALIDHAVWFHRPA
DFSDWVLSDAVAPSGVHGRALATATMYNRTVALVCTATQEIYFGRDRR

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=281, Percent_Identity=28.1138790035587, Blast_Score=116, Evalue=2e-26,
Organism=Escherichia coli, GI1786657, Length=271, Percent_Identity=30.9963099630996, Blast_Score=135, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17558508, Length=298, Percent_Identity=28.1879194630872, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI71988741, Length=291, Percent_Identity=27.1477663230241, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17531889, Length=293, Percent_Identity=29.0102389078498, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI115532456, Length=293, Percent_Identity=29.0102389078498, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17531885, Length=293, Percent_Identity=29.0102389078498, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71982224, Length=282, Percent_Identity=28.0141843971631, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI212645202, Length=259, Percent_Identity=25.4826254826255, Blast_Score=77, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 32117; Mature: 32117

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMPRVVARTLSDILTTLDVEQIADDEFLATQMDNAAHHIVGGHIAAQALMSASRTVSADR
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
TPHSMHVYLLRAGDARRPVHFEITRLRDGGVLSSRRVLARQDDQVLLEALVSFTAPLDSF
CCCEEEEEEEECCCCCCCEEEEEEEECCCCCCCCCHHHHCCCHHHHHHHHHHHHCCHHHH
EHQQPIPDVPGPESLPSVQEQLSPYADEHDGHWVRPQPLDLRYVDPPARLALDRPDPSPR
HCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCHHHEEECCCCCCCC
IRLWWRPAEPMPDDPILNSCLLTYVSGTALLETAMVVRRTTPLTSFSALIDHAVWFHRPA
EEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
DFSDWVLSDAVAPSGVHGRALATATMYNRTVALVCTATQEIYFGRDRR
CCHHHHHHHCCCCCCCCCHHHHHHHHHCCEEEEEEEEHHHHCCCCCCC
>Mature Secondary Structure
MMPRVVARTLSDILTTLDVEQIADDEFLATQMDNAAHHIVGGHIAAQALMSASRTVSADR
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
TPHSMHVYLLRAGDARRPVHFEITRLRDGGVLSSRRVLARQDDQVLLEALVSFTAPLDSF
CCCEEEEEEEECCCCCCCEEEEEEEECCCCCCCCCHHHHCCCHHHHHHHHHHHHCCHHHH
EHQQPIPDVPGPESLPSVQEQLSPYADEHDGHWVRPQPLDLRYVDPPARLALDRPDPSPR
HCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCHHHEEECCCCCCCC
IRLWWRPAEPMPDDPILNSCLLTYVSGTALLETAMVVRRTTPLTSFSALIDHAVWFHRPA
EEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
DFSDWVLSDAVAPSGVHGRALATATMYNRTVALVCTATQEIYFGRDRR
CCHHHHHHHCCCCCCCCCHHHHHHHHHCCEEEEEEEEHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]