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The map label for this gene is ilvB [H]

Identifier: 108799904

GI number: 108799904

Start: 3095395

End: 3097143

Strand: Reverse

Name: ilvB [H]

Synonym: Mmcs_2938

Alternate gene names: 108799904

Gene position: 3097143-3095395 (Counterclockwise)

Preceding gene: 108799907

Following gene: 108799903

Centisome position: 54.28

GC content: 69.35

Gene sequence:

>1749_bases
ATGAATGACAGCACGGTCGGCACAGCTTTCCGCTCACGCGTGGTGGACCACATCGTCAACTACCTGTCCGCGGGCGGCGT
CCGGTACCTCTTCGGAGTCGACGGCGCCAACATCGAGGACGTCTACGACGCCGCCCACCTCAGCGGCGACGTCACCGCGG
TCCTGGCCAAGCACGAGTTCTCGGCCGCCGCCATGGCGGACGGCTACAGCCGCAGCGGCGCCGGCCTGGGGGTGGTCATG
GCGACCTCCGGCGGCGGCTCGCTCAACCTGGTTCCGGGACTGGGGGAGTCGCTGGCCAGTCGGGTCCCCGTCCTCGCGCT
GGTCGGTCAGCCTCCGCTGGCGCTGGACGGCCGCGGGAGCTTCCAGGACACCAGCGGGTGCAACGGTTCGCTGGATGCGC
TCGCTCTGTTCTCCACGGTGTCGGTGTTCTGCGAGCGGATCACCGAACCCGCCGACATCCTCACCGCGCTTCCGCGTGCC
GTGCGGGCAGCGTTCTCGGGCGGGCCGGCAGTCCTGTTGTTGCCCAAAGACGTTCAGCAGGCCGTGCTCGACGTACGACA
CTCGACCGAGGGCCACGAACGCGCGCCGGTGACGAGGCAGATCGGTGATCCGCGCCCGATCGCGCGGGCACTCCAGAAGG
TCGACGGCCCCGTCACCATCGTCGTCGGCAGCCAGGTGATCCACGACGACGCCCGCGCAGAACTCGAACAACTGCGCGCC
GTGCTGCGCGCCCGGGTGGCCGTCACGCCCGACGCGAAGGATGCCGCGGGGACGCCGGGGATGGGCTCGTCGTCGCTGGT
CGGCGTCACCGGCGTCATGGGCCATCCCGGTACCGCCGAGGCGATCGGCGACAGCGCGTTGTGCCTGCTGGTCGGGTCGC
GTCTGCCGGTGACCGCGCGAGCAGGTCTGGACGCGGTGCTGGCCGGTACCCGCACCCTGTCGATCGGTTCGGCACCGCCC
TTCGTCCCGTGCACCCACATCCACAGCGACGATCTGCGCGCCTCACTGCCATTGCTGACCCGGGGGCTGATCGGGCGCCG
GCGGCCGCGCGGATTGCAGGTGGCCGACACGATCCCGCGGAAAGAGTTGTCGCCACCGATCTTCGACGGAGAAGGAGTGC
GCTTCCGCGACGCGATGAAGGCCCTCGACCGGCTGCTGCCGGCCGACGTCGACATCGTCGTGGACGCCGGGAACACCGGC
GCGTCAGCGGTGCACTACCTACCCGTGCGCCGGCGAGGCAGGTTCCTCGTCGCGCTGGGCATGGGCGGGATGGGGTACAG
CTTCGGGGCCGGGATCGGCGTTGCCTTCGGCCGGCGCAGACGGACCGTGGTGATCGCCGGTGACGGATCGTTCTTCATGC
ACGGCCTCGAGTTGCACACGGCCATACAGCACCGTCTTCCGGTCACCTTCGTGCTGTTCAACAACAACGCCCACGGGATG
TGTGTGACGCGCGAACAGCTCTACTACGACGGCACGTACAGCTACAACAGGTTCGCGCCCAGCCATCTCGGCGCGGGACT
CAACGCCATGTTCCCCGGCATGCCGTCGGTCGATGTCGCCGATGTCACCGAACTTGCCGGCGCGGTCACCTCGGCGCTGG
ACGCACACGGTCCCTCGGTCGTCTCGGTCGAATGCTCGGCCGACGAAATCCCGCCTTTCGCACCATTTTTGGCGGCCGGC
CCACCGGCCGCCCCCGACCCGGCCACCGTTCACGAGGAGGAATCGATCGATGTCCCTGCCAGCGCTTGA

Upstream 100 bases:

>100_bases
CCCATTCGGCGGTAACGTATCGCAGCCAGAGAGGTTGACTACCTCGCATTATTTCGGGGCCTATTTCGCGGTGGGAGTGC
GCAGAATCGGGGTGTTCTCC

Downstream 100 bases:

>100_bases
CGATATCGCCACCCACACCGGTAGTACCAATCCGATCGACGGCGTCATCCGGATCGAGACGTCGCCGCGGGAGAAGGCGA
CCCCGATCATCATGGACATG

Product: thiamine pyrophosphate enzyme-like TPP-binding protein

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]

Number of amino acids: Translated: 582; Mature: 582

Protein sequence:

>582_residues
MNDSTVGTAFRSRVVDHIVNYLSAGGVRYLFGVDGANIEDVYDAAHLSGDVTAVLAKHEFSAAAMADGYSRSGAGLGVVM
ATSGGGSLNLVPGLGESLASRVPVLALVGQPPLALDGRGSFQDTSGCNGSLDALALFSTVSVFCERITEPADILTALPRA
VRAAFSGGPAVLLLPKDVQQAVLDVRHSTEGHERAPVTRQIGDPRPIARALQKVDGPVTIVVGSQVIHDDARAELEQLRA
VLRARVAVTPDAKDAAGTPGMGSSSLVGVTGVMGHPGTAEAIGDSALCLLVGSRLPVTARAGLDAVLAGTRTLSIGSAPP
FVPCTHIHSDDLRASLPLLTRGLIGRRRPRGLQVADTIPRKELSPPIFDGEGVRFRDAMKALDRLLPADVDIVVDAGNTG
ASAVHYLPVRRRGRFLVALGMGGMGYSFGAGIGVAFGRRRRTVVIAGDGSFFMHGLELHTAIQHRLPVTFVLFNNNAHGM
CVTREQLYYDGTYSYNRFAPSHLGAGLNAMFPGMPSVDVADVTELAGAVTSALDAHGPSVVSVECSADEIPPFAPFLAAG
PPAAPDPATVHEEESIDVPASA

Sequences:

>Translated_582_residues
MNDSTVGTAFRSRVVDHIVNYLSAGGVRYLFGVDGANIEDVYDAAHLSGDVTAVLAKHEFSAAAMADGYSRSGAGLGVVM
ATSGGGSLNLVPGLGESLASRVPVLALVGQPPLALDGRGSFQDTSGCNGSLDALALFSTVSVFCERITEPADILTALPRA
VRAAFSGGPAVLLLPKDVQQAVLDVRHSTEGHERAPVTRQIGDPRPIARALQKVDGPVTIVVGSQVIHDDARAELEQLRA
VLRARVAVTPDAKDAAGTPGMGSSSLVGVTGVMGHPGTAEAIGDSALCLLVGSRLPVTARAGLDAVLAGTRTLSIGSAPP
FVPCTHIHSDDLRASLPLLTRGLIGRRRPRGLQVADTIPRKELSPPIFDGEGVRFRDAMKALDRLLPADVDIVVDAGNTG
ASAVHYLPVRRRGRFLVALGMGGMGYSFGAGIGVAFGRRRRTVVIAGDGSFFMHGLELHTAIQHRLPVTFVLFNNNAHGM
CVTREQLYYDGTYSYNRFAPSHLGAGLNAMFPGMPSVDVADVTELAGAVTSALDAHGPSVVSVECSADEIPPFAPFLAAG
PPAAPDPATVHEEESIDVPASA
>Mature_582_residues
MNDSTVGTAFRSRVVDHIVNYLSAGGVRYLFGVDGANIEDVYDAAHLSGDVTAVLAKHEFSAAAMADGYSRSGAGLGVVM
ATSGGGSLNLVPGLGESLASRVPVLALVGQPPLALDGRGSFQDTSGCNGSLDALALFSTVSVFCERITEPADILTALPRA
VRAAFSGGPAVLLLPKDVQQAVLDVRHSTEGHERAPVTRQIGDPRPIARALQKVDGPVTIVVGSQVIHDDARAELEQLRA
VLRARVAVTPDAKDAAGTPGMGSSSLVGVTGVMGHPGTAEAIGDSALCLLVGSRLPVTARAGLDAVLAGTRTLSIGSAPP
FVPCTHIHSDDLRASLPLLTRGLIGRRRPRGLQVADTIPRKELSPPIFDGEGVRFRDAMKALDRLLPADVDIVVDAGNTG
ASAVHYLPVRRRGRFLVALGMGGMGYSFGAGIGVAFGRRRRTVVIAGDGSFFMHGLELHTAIQHRLPVTFVLFNNNAHGM
CVTREQLYYDGTYSYNRFAPSHLGAGLNAMFPGMPSVDVADVTELAGAVTSALDAHGPSVVSVECSADEIPPFAPFLAAG
PPAAPDPATVHEEESIDVPASA

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21361361, Length=165, Percent_Identity=31.5151515151515, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI87081685, Length=510, Percent_Identity=27.843137254902, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1790104, Length=587, Percent_Identity=25.2129471890971, Blast_Score=128, Evalue=9e-31,
Organism=Escherichia coli, GI1786717, Length=508, Percent_Identity=27.755905511811, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1787096, Length=584, Percent_Identity=25, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1788716, Length=569, Percent_Identity=22.8471001757469, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6323755, Length=167, Percent_Identity=35.9281437125749, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 60405; Mature: 60405

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDSTVGTAFRSRVVDHIVNYLSAGGVRYLFGVDGANIEDVYDAAHLSGDVTAVLAKHEF
CCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCC
SAAAMADGYSRSGAGLGVVMATSGGGSLNLVPGLGESLASRVPVLALVGQPPLALDGRGS
CHHHHHCCCCCCCCCEEEEEEECCCCCEEECCCCCHHHHHCCCEEEEECCCCEEECCCCC
FQDTSGCNGSLDALALFSTVSVFCERITEPADILTALPRAVRAAFSGGPAVLLLPKDVQQ
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECHHHHH
AVLDVRHSTEGHERAPVTRQIGDPRPIARALQKVDGPVTIVVGSQVIHDDARAELEQLRA
HHHHHHCCCCCCCCCCCHHCCCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHH
VLRARVAVTPDAKDAAGTPGMGSSSLVGVTGVMGHPGTAEAIGDSALCLLVGSRLPVTAR
HHHHHEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHCCCEEEEEECCCCCEEHH
AGLDAVLAGTRTLSIGSAPPFVPCTHIHSDDLRASLPLLTRGLIGRRRPRGLQVADTIPR
CCCCEEEECCEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHCCCH
KELSPPIFDGEGVRFRDAMKALDRLLPADVDIVVDAGNTGASAVHYLPVRRRGRFLVALG
HHCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEECCCCCEEEEEE
MGGMGYSFGAGIGVAFGRRRRTVVIAGDGSFFMHGLELHTAIQHRLPVTFVLFNNNAHGM
CCCCCCHHCCCHHHHCCCCCEEEEEEECCCEEEEHHHHHHHHHHCCCEEEEEECCCCCCE
CVTREQLYYDGTYSYNRFAPSHLGAGLNAMFPGMPSVDVADVTELAGAVTSALDAHGPSV
EEEHHHEEECCCCCCCCCCHHHHCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCE
VSVECSADEIPPFAPFLAAGPPAAPDPATVHEEESIDVPASA
EEEECCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNDSTVGTAFRSRVVDHIVNYLSAGGVRYLFGVDGANIEDVYDAAHLSGDVTAVLAKHEF
CCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCC
SAAAMADGYSRSGAGLGVVMATSGGGSLNLVPGLGESLASRVPVLALVGQPPLALDGRGS
CHHHHHCCCCCCCCCEEEEEEECCCCCEEECCCCCHHHHHCCCEEEEECCCCEEECCCCC
FQDTSGCNGSLDALALFSTVSVFCERITEPADILTALPRAVRAAFSGGPAVLLLPKDVQQ
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECHHHHH
AVLDVRHSTEGHERAPVTRQIGDPRPIARALQKVDGPVTIVVGSQVIHDDARAELEQLRA
HHHHHHCCCCCCCCCCCHHCCCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHH
VLRARVAVTPDAKDAAGTPGMGSSSLVGVTGVMGHPGTAEAIGDSALCLLVGSRLPVTAR
HHHHHEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHCCCEEEEEECCCCCEEHH
AGLDAVLAGTRTLSIGSAPPFVPCTHIHSDDLRASLPLLTRGLIGRRRPRGLQVADTIPR
CCCCEEEECCEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHCCCH
KELSPPIFDGEGVRFRDAMKALDRLLPADVDIVVDAGNTGASAVHYLPVRRRGRFLVALG
HHCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEECCCCCEEEEEE
MGGMGYSFGAGIGVAFGRRRRTVVIAGDGSFFMHGLELHTAIQHRLPVTFVLFNNNAHGM
CCCCCCHHCCCHHHHCCCCCEEEEEEECCCEEEEHHHHHHHHHHCCCEEEEEECCCCCCE
CVTREQLYYDGTYSYNRFAPSHLGAGLNAMFPGMPSVDVADVTELAGAVTSALDAHGPSV
EEEHHHEEECCCCCCCCCCHHHHCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCE
VSVECSADEIPPFAPFLAAGPPAAPDPATVHEEESIDVPASA
EEEECCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]