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The map label for this gene is gutB [H]

Identifier: 108799752

GI number: 108799752

Start: 2932201

End: 2933226

Strand: Reverse

Name: gutB [H]

Synonym: Mmcs_2786

Alternate gene names: 108799752

Gene position: 2933226-2932201 (Counterclockwise)

Preceding gene: 108799753

Following gene: 108799751

Centisome position: 51.41

GC content: 68.52

Gene sequence:

>1026_bases
ATGACAGAGACCGTTGACGGCACCATGCGTGCCAGCGTGATGACCGGGGTCGGCACGCTGCGGATCGAGGAGCGGCCGGT
GCCGTCTCCCGGACCGCACGAGGTGCTCGTCGAGGTGGCCGCGGTCGGGGTGTGCGGTTCGGATGTGCACTACTACCGTC
ACGGCCGGATCGGCGATTTCGTCGTCGAGGAGCCGATGATCCTCGGCCACGAACTGTCCGGGCGGATCGCCGCCGTCGGT
GAGGGCGTCGATCCCGGACGAGTGGGTGAGCGCGTCGCCGTCGAACCACAGCATCCCTGCCGTCGCTGCAGGCAGTGCAA
GTCCGGCCGGTACAACCTGTGCCCCGAGATGAAGTTCTACGCCACCCCGCCGATCGACGGCGCGTTCTGCCGTTACGTCG
TCATCGACGACGACTTCGCCCATCCGGTGCCCGAGTCCATGTCCGATGACGCCGCCGCGCTGCTCGAACCGCTCTCGGTG
GCGATCGCCACGATGCGGAAAGCGGGAGTGGTCCCCGGATCCTCCATCCTGATCGCCGGCGCCGGTCCCATCGGCGTCAT
CTGCGCGCAGGCCGCCCGAGCCTTCGGCGCCGCCCGCATCGTCGTCACCGACCTGGTTCCGTCACGCCGGGAGATGGCGC
TGAAGTTCGGCGCCACGGAAGTGCTGGATCCGGCCGCCGTGGACGTCTCGGCCATCGAACCCGTCGACGCGTTCGTCGAC
GCCACCGGCGTACCCGCGGCGGTGGTCAGCGGTATCAAGGCCGTCGGTCCGGCGGGCAGGGTGGTGCTGGTCGGGATGGG
TGCCGATGAGTACGCGCTCCCGGTCAGCCACATCGCGAACCTCGAGATCACCGTCACCGGCGTGTTCCGGTACACCGACA
CCTGGTCCGCCGCAATACATCTCGTGAACTCCGGCGCGGTGGATCTCGACGCGATGGTGACGGGCCGCTACGACCTCGAA
CACGTGGCCGACGCCCTCGACAGCGACACCGACCCTGCCAGCCTCAAGTCGATTGTGAACCCCTGA

Upstream 100 bases:

>100_bases
ACCGAAGACGTTGCGCCGCTGTGTGTCACGGCCGGCGCCGAAGCGATGGTGGTCGGACGGGCGTTGCTCGCCGGCACCGC
GTACCGAGAGGAAGCATGAG

Downstream 100 bases:

>100_bases
TGACGCAGAAGAACCCCTTTGACCTGACCGGCCGCACCGCACTGGTGACCGGCGGCAACCAGGGCCTCGGCCGGGCCTTC
GCCTTCGGGCTGGCCCAGGC

Product: alcohol dehydrogenase GroES-like protein

Products: NA

Alternate protein names: Glucitol dehydrogenase; L-iditol 2-dehydrogenase [H]

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MTETVDGTMRASVMTGVGTLRIEERPVPSPGPHEVLVEVAAVGVCGSDVHYYRHGRIGDFVVEEPMILGHELSGRIAAVG
EGVDPGRVGERVAVEPQHPCRRCRQCKSGRYNLCPEMKFYATPPIDGAFCRYVVIDDDFAHPVPESMSDDAAALLEPLSV
AIATMRKAGVVPGSSILIAGAGPIGVICAQAARAFGAARIVVTDLVPSRREMALKFGATEVLDPAAVDVSAIEPVDAFVD
ATGVPAAVVSGIKAVGPAGRVVLVGMGADEYALPVSHIANLEITVTGVFRYTDTWSAAIHLVNSGAVDLDAMVTGRYDLE
HVADALDSDTDPASLKSIVNP

Sequences:

>Translated_341_residues
MTETVDGTMRASVMTGVGTLRIEERPVPSPGPHEVLVEVAAVGVCGSDVHYYRHGRIGDFVVEEPMILGHELSGRIAAVG
EGVDPGRVGERVAVEPQHPCRRCRQCKSGRYNLCPEMKFYATPPIDGAFCRYVVIDDDFAHPVPESMSDDAAALLEPLSV
AIATMRKAGVVPGSSILIAGAGPIGVICAQAARAFGAARIVVTDLVPSRREMALKFGATEVLDPAAVDVSAIEPVDAFVD
ATGVPAAVVSGIKAVGPAGRVVLVGMGADEYALPVSHIANLEITVTGVFRYTDTWSAAIHLVNSGAVDLDAMVTGRYDLE
HVADALDSDTDPASLKSIVNP
>Mature_340_residues
TETVDGTMRASVMTGVGTLRIEERPVPSPGPHEVLVEVAAVGVCGSDVHYYRHGRIGDFVVEEPMILGHELSGRIAAVGE
GVDPGRVGERVAVEPQHPCRRCRQCKSGRYNLCPEMKFYATPPIDGAFCRYVVIDDDFAHPVPESMSDDAAALLEPLSVA
IATMRKAGVVPGSSILIAGAGPIGVICAQAARAFGAARIVVTDLVPSRREMALKFGATEVLDPAAVDVSAIEPVDAFVDA
TGVPAAVVSGIKAVGPAGRVVLVGMGADEYALPVSHIANLEITVTGVFRYTDTWSAAIHLVNSGAVDLDAMVTGRYDLEH
VADALDSDTDPASLKSIVNP

Specific function: Reduces glucitol to fructose [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=338, Percent_Identity=40.8284023668639, Blast_Score=265, Evalue=3e-71,
Organism=Homo sapiens, GI4501933, Length=363, Percent_Identity=25.3443526170799, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4501929, Length=364, Percent_Identity=26.0989010989011, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI34577061, Length=239, Percent_Identity=29.7071129707113, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4501939, Length=232, Percent_Identity=29.7413793103448, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI156523966, Length=232, Percent_Identity=29.7413793103448, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI71743840, Length=230, Percent_Identity=27.8260869565217, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI262073058, Length=230, Percent_Identity=27.8260869565217, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI71565152, Length=360, Percent_Identity=23.8888888888889, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI71565154, Length=229, Percent_Identity=28.3842794759825, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1788073, Length=326, Percent_Identity=34.9693251533742, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1790718, Length=325, Percent_Identity=28.9230769230769, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1790045, Length=343, Percent_Identity=28.2798833819242, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1787863, Length=326, Percent_Identity=29.7546012269939, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI226510992, Length=331, Percent_Identity=30.8157099697885, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1788075, Length=344, Percent_Identity=29.0697674418605, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1788407, Length=343, Percent_Identity=28.2798833819242, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI87082125, Length=358, Percent_Identity=26.2569832402235, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87081918, Length=291, Percent_Identity=27.4914089347079, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1786552, Length=357, Percent_Identity=25.4901960784314, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1786518, Length=263, Percent_Identity=28.1368821292776, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=340, Percent_Identity=41.4705882352941, Blast_Score=289, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17562878, Length=340, Percent_Identity=41.1764705882353, Blast_Score=263, Evalue=8e-71,
Organism=Caenorhabditis elegans, GI71988145, Length=272, Percent_Identity=32.3529411764706, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI25146526, Length=361, Percent_Identity=25.207756232687, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=363, Percent_Identity=25.068870523416, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=182, Percent_Identity=30.2197802197802, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562584, Length=211, Percent_Identity=29.8578199052133, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323099, Length=336, Percent_Identity=38.6904761904762, Blast_Score=243, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6322619, Length=334, Percent_Identity=35.9281437125749, Blast_Score=240, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6319955, Length=334, Percent_Identity=35.6287425149701, Blast_Score=237, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6319257, Length=385, Percent_Identity=30.1298701298701, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6319258, Length=327, Percent_Identity=29.0519877675841, Blast_Score=126, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6319621, Length=264, Percent_Identity=29.5454545454545, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323729, Length=327, Percent_Identity=26.2996941896024, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=262, Percent_Identity=26.7175572519084, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320033, Length=361, Percent_Identity=22.4376731301939, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324486, Length=262, Percent_Identity=26.7175572519084, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6319949, Length=207, Percent_Identity=34.2995169082126, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323980, Length=199, Percent_Identity=31.1557788944724, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17737897, Length=327, Percent_Identity=45.565749235474, Blast_Score=268, Evalue=3e-72,
Organism=Drosophila melanogaster, GI17137530, Length=328, Percent_Identity=43.2926829268293, Blast_Score=257, Evalue=7e-69,
Organism=Drosophila melanogaster, GI221457811, Length=326, Percent_Identity=27.3006134969325, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI45550770, Length=326, Percent_Identity=27.3006134969325, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI45551930, Length=326, Percent_Identity=27.3006134969325, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI17737895, Length=231, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.14 [H]

Molecular weight: Translated: 35705; Mature: 35574

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETVDGTMRASVMTGVGTLRIEERPVPSPGPHEVLVEVAAVGVCGSDVHYYRHGRIGDF
CCCCCCCHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCE
VVEEPMILGHELSGRIAAVGEGVDPGRVGERVAVEPQHPCRRCRQCKSGRYNLCPEMKFY
EECCCEEECCCCCCEEEEECCCCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCCCCCEEE
ATPPIDGAFCRYVVIDDDFAHPVPESMSDDAAALLEPLSVAIATMRKAGVVPGSSILIAG
ECCCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEC
AGPIGVICAQAARAFGAARIVVTDLVPSRREMALKFGATEVLDPAAVDVSAIEPVDAFVD
CCHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHCCCHHHCCCCCCCHHHCCCHHHHHC
ATGVPAAVVSGIKAVGPAGRVVLVGMGADEYALPVSHIANLEITVTGVFRYTDTWSAAIH
CCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHCCEEEEEEEEEEECCCHHHEEE
LVNSGAVDLDAMVTGRYDLEHVADALDSDTDPASLKSIVNP
EECCCCEEEEEEEECCCCHHHHHHHHCCCCCHHHHHHHCCC
>Mature Secondary Structure 
TETVDGTMRASVMTGVGTLRIEERPVPSPGPHEVLVEVAAVGVCGSDVHYYRHGRIGDF
CCCCCCHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCE
VVEEPMILGHELSGRIAAVGEGVDPGRVGERVAVEPQHPCRRCRQCKSGRYNLCPEMKFY
EECCCEEECCCCCCEEEEECCCCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCCCCCEEE
ATPPIDGAFCRYVVIDDDFAHPVPESMSDDAAALLEPLSVAIATMRKAGVVPGSSILIAG
ECCCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEC
AGPIGVICAQAARAFGAARIVVTDLVPSRREMALKFGATEVLDPAAVDVSAIEPVDAFVD
CCHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHCCCHHHCCCCCCCHHHCCCHHHHHC
ATGVPAAVVSGIKAVGPAGRVVLVGMGADEYALPVSHIANLEITVTGVFRYTDTWSAAIH
CCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHCCEEEEEEEEEEECCCHHHEEE
LVNSGAVDLDAMVTGRYDLEHVADALDSDTDPASLKSIVNP
EECCCCEEEEEEEECCCCHHHHHHHHCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1460002; 9384377; 8195086 [H]