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The map label for this gene is 108799646

Identifier: 108799646

GI number: 108799646

Start: 2831365

End: 2832876

Strand: Reverse

Name: 108799646

Synonym: Mmcs_2679

Alternate gene names: NA

Gene position: 2832876-2831365 (Counterclockwise)

Preceding gene: 108799647

Following gene: 108799645

Centisome position: 49.65

GC content: 72.09

Gene sequence:

>1512_bases
TTGTTGCGCCGCCGCGCGCTGACCGAGGACGCCGCACGCCCGGAGGCGGTCGCGCGCCGGCACGAAGCCGGTGGGCGCAC
GGCGCGCGAGAACATCGCCGATCTGGTCGACGAGGGATCGTTCGTCGAGTACGGCCGGTTCGCGATCGCCGCCCAGCGGG
CGCGTCGCGACCTCGACGACCTGATCGCCCGCACCCCCGCAGACGGGCTGATCGCCGGGACGGCACGGATCGGCGGCGCC
GCCTGCGCGGTCCTGTCGTACGACTACACCGTGCTGGCCGGCACTCAGGGTGCTCTGGGGCACCGTAAGAAGGATCGGCT
GTTCGACCTGATCGAGCGGATGCGCCTGCCCACGGTGTTCTTCGCCGAAGGTGGCGGCGGACGCCCGGGGGACACCGACT
TCCCGGTGGCGTCCTCGCTCGACGTCCGCGCGTTCAAGCTGTGGGCCGGGCTCTCGGGCCTCGCCCCCCGGATCGCGGTG
GTCAAGGGTCGGTGTTTCGCGGGCAACGCTGTCATCGCGGGCTGCGCCGATCTCATCGTCGCGACGTCGGACACGTCCAT
CGGCATGGGTGGTCCGGCCATGATCGCCGGCGGCGGCCTCGGTGACGTACCGCCCGACGCGGTCGGACCCATCACTACGC
AGGAACCCAACGGGGTGGTCGACATCGTGGTGGATGACGAGGCGCAGGCCGTCGCGGTCGCCAGGACACTCATCGGCTAC
TTCGGTGGGCCGGCCGCACCCGGCGAGGCCCCGGACCAGAGTGCTTTGCGCACAGCGGTTCCCGAGCGCGCGCGACGCGC
CTACGATGTCGCGCCGATCATCCGGACTCTGGCCGACGACGGTTCCGCGACGTTCCTGCGCGAGCGCTTCGCCAGGGAGA
TGGTGACCGCGCTCATCCGCATCGAGGGCCGGCCCGTCGGTGTGCTGGCCAACGACACCCGCTTCATGGCCGGCGCCATC
ACCGCGGCGGCCTCGGACAAGGCGGCGCGCTTCCTGCAACTCTGCGACGCGTTCGACATCCCGGTGCTGTCGCTGGTCGA
CTGCCCGGGTTACATGGTGGGACCGGCCGCGGAGGCAGAAGCTCTGGTGCGCAGGGGATCTCGGCTCCTCGTCGCGGGTG
CGGCATTGCAGGTGCCGTTGATCGCGGTGGTGTTGCGCCGAGGATACGGCCTGGGTGCGCAGGCGATGACCGGCGGCGGA
CTGCACGAACCGCTGCTGACGGTCGCCTGGCCGGGCGCGCATCTGGGTCCGATGGGGCTCGAAGGCGCTGTGCGGCTCGG
CCTGCGCAAGGAACTCGAGGCGATCGCCGACGACGCCGAACGCGAGGAGGCGGTGCGGCGGGCCACCGCCGCGGCGGAGG
ACAACGCGAAGGCGCTCAACGCCGCCGCCGTCTTCGAGATCGACGACGTGATCGACCCGGCGGAGACCCGCAGCCTCGTC
GCCGCCACCCTGGCCGCGGCCTCGGCCGCCCCACGCGAACGGCACCCGCACCGGTTCGTCGACACCTGGTGA

Upstream 100 bases:

>100_bases
GCCCGCGCGGTCAAGGGCGACATCGAGCGGTCGATCAGCCGTTTCGAGGAGCTCTACGTCTGAGGGTCCGTCCGCGGCGC
CGCGGACGGACTACGCCGAA

Downstream 100 bases:

>100_bases
CCGGTCGCGGTTGACCGCCGAAGCGCCGGGTGACACCCAGCCCGTGCCACAGAACACGGACTGATCGTCGCCGACCCGCG
GTCGAAGTGATGGGCGCCGG

Product: propionyl-CoA carboxylase

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MLRRRALTEDAARPEAVARRHEAGGRTARENIADLVDEGSFVEYGRFAIAAQRARRDLDDLIARTPADGLIAGTARIGGA
ACAVLSYDYTVLAGTQGALGHRKKDRLFDLIERMRLPTVFFAEGGGGRPGDTDFPVASSLDVRAFKLWAGLSGLAPRIAV
VKGRCFAGNAVIAGCADLIVATSDTSIGMGGPAMIAGGGLGDVPPDAVGPITTQEPNGVVDIVVDDEAQAVAVARTLIGY
FGGPAAPGEAPDQSALRTAVPERARRAYDVAPIIRTLADDGSATFLRERFAREMVTALIRIEGRPVGVLANDTRFMAGAI
TAAASDKAARFLQLCDAFDIPVLSLVDCPGYMVGPAAEAEALVRRGSRLLVAGAALQVPLIAVVLRRGYGLGAQAMTGGG
LHEPLLTVAWPGAHLGPMGLEGAVRLGLRKELEAIADDAEREEAVRRATAAAEDNAKALNAAAVFEIDDVIDPAETRSLV
AATLAAASAAPRERHPHRFVDTW

Sequences:

>Translated_503_residues
MLRRRALTEDAARPEAVARRHEAGGRTARENIADLVDEGSFVEYGRFAIAAQRARRDLDDLIARTPADGLIAGTARIGGA
ACAVLSYDYTVLAGTQGALGHRKKDRLFDLIERMRLPTVFFAEGGGGRPGDTDFPVASSLDVRAFKLWAGLSGLAPRIAV
VKGRCFAGNAVIAGCADLIVATSDTSIGMGGPAMIAGGGLGDVPPDAVGPITTQEPNGVVDIVVDDEAQAVAVARTLIGY
FGGPAAPGEAPDQSALRTAVPERARRAYDVAPIIRTLADDGSATFLRERFAREMVTALIRIEGRPVGVLANDTRFMAGAI
TAAASDKAARFLQLCDAFDIPVLSLVDCPGYMVGPAAEAEALVRRGSRLLVAGAALQVPLIAVVLRRGYGLGAQAMTGGG
LHEPLLTVAWPGAHLGPMGLEGAVRLGLRKELEAIADDAEREEAVRRATAAAEDNAKALNAAAVFEIDDVIDPAETRSLV
AATLAAASAAPRERHPHRFVDTW
>Mature_503_residues
MLRRRALTEDAARPEAVARRHEAGGRTARENIADLVDEGSFVEYGRFAIAAQRARRDLDDLIARTPADGLIAGTARIGGA
ACAVLSYDYTVLAGTQGALGHRKKDRLFDLIERMRLPTVFFAEGGGGRPGDTDFPVASSLDVRAFKLWAGLSGLAPRIAV
VKGRCFAGNAVIAGCADLIVATSDTSIGMGGPAMIAGGGLGDVPPDAVGPITTQEPNGVVDIVVDDEAQAVAVARTLIGY
FGGPAAPGEAPDQSALRTAVPERARRAYDVAPIIRTLADDGSATFLRERFAREMVTALIRIEGRPVGVLANDTRFMAGAI
TAAASDKAARFLQLCDAFDIPVLSLVDCPGYMVGPAAEAEALVRRGSRLLVAGAALQVPLIAVVLRRGYGLGAQAMTGGG
LHEPLLTVAWPGAHLGPMGLEGAVRLGLRKELEAIADDAEREEAVRRATAAAEDNAKALNAAAVFEIDDVIDPAETRSLV
AATLAAASAAPRERHPHRFVDTW

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=486, Percent_Identity=28.1893004115226, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI295821216, Length=506, Percent_Identity=27.0750988142292, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI11545863, Length=491, Percent_Identity=28.1059063136456, Blast_Score=148, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI25147359, Length=491, Percent_Identity=28.5132382892057, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI25147362, Length=491, Percent_Identity=28.5132382892057, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17552936, Length=502, Percent_Identity=26.6932270916335, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24586065, Length=518, Percent_Identity=25.8687258687259, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 52573; Mature: 52573

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRRRALTEDAARPEAVARRHEAGGRTARENIADLVDEGSFVEYGRFAIAAQRARRDLDD
CCCCHHCCHHHCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHH
LIARTPADGLIAGTARIGGAACAVLSYDYTVLAGTQGALGHRKKDRLFDLIERMRLPTVF
HHHCCCCCCEEECHHHHCCCEEEEEECCEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEE
FAEGGGGRPGDTDFPVASSLDVRAFKLWAGLSGLAPRIAVVKGRCFAGNAVIAGCADLIV
EECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCEEECCHHHHCHHHEEE
ATSDTSIGMGGPAMIAGGGLGDVPPDAVGPITTQEPNGVVDIVVDDEAQAVAVARTLIGY
EECCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
FGGPAAPGEAPDQSALRTAVPERARRAYDVAPIIRTLADDGSATFLRERFAREMVTALIR
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
IEGRPVGVLANDTRFMAGAITAAASDKAARFLQLCDAFDIPVLSLVDCPGYMVGPAAEAE
CCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHCCCCCCEECCCHHHH
ALVRRGSRLLVAGAALQVPLIAVVLRRGYGLGAQAMTGGGLHEPLLTVAWPGAHLGPMGL
HHHHCCCEEEEECHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCEEEECCCCCCCCCCC
EGAVRLGLRKELEAIADDAEREEAVRRATAAAEDNAKALNAAAVFEIDDVIDPAETRSLV
CHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHCCEEEEEHHHCCCCHHHHHHH
AATLAAASAAPRERHPHRFVDTW
HHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLRRRALTEDAARPEAVARRHEAGGRTARENIADLVDEGSFVEYGRFAIAAQRARRDLDD
CCCCHHCCHHHCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHH
LIARTPADGLIAGTARIGGAACAVLSYDYTVLAGTQGALGHRKKDRLFDLIERMRLPTVF
HHHCCCCCCEEECHHHHCCCEEEEEECCEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEE
FAEGGGGRPGDTDFPVASSLDVRAFKLWAGLSGLAPRIAVVKGRCFAGNAVIAGCADLIV
EECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCEEECCHHHHCHHHEEE
ATSDTSIGMGGPAMIAGGGLGDVPPDAVGPITTQEPNGVVDIVVDDEAQAVAVARTLIGY
EECCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
FGGPAAPGEAPDQSALRTAVPERARRAYDVAPIIRTLADDGSATFLRERFAREMVTALIR
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
IEGRPVGVLANDTRFMAGAITAAASDKAARFLQLCDAFDIPVLSLVDCPGYMVGPAAEAE
CCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHCCCCCCEECCCHHHH
ALVRRGSRLLVAGAALQVPLIAVVLRRGYGLGAQAMTGGGLHEPLLTVAWPGAHLGPMGL
HHHHCCCEEEEECHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCEEEECCCCCCCCCCC
EGAVRLGLRKELEAIADDAEREEAVRRATAAAEDNAKALNAAAVFEIDDVIDPAETRSLV
CHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHCCEEEEEHHHCCCCHHHHHHH
AATLAAASAAPRERHPHRFVDTW
HHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]