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The map label for this gene is panE [C]

Identifier: 108799274

GI number: 108799274

Start: 2448029

End: 2448988

Strand: Reverse

Name: panE [C]

Synonym: Mmcs_2307

Alternate gene names: 108799274

Gene position: 2448988-2448029 (Counterclockwise)

Preceding gene: 108799276

Following gene: 108799273

Centisome position: 42.92

GC content: 73.75

Gene sequence:

>960_bases
ATGGGTGGGGCGGGACAACGGCACAGTCTAGTTGGGGGCCGTGGCGCGTCCCCGGCGGTAGCTTGGGCGATCGTGACCAC
CCGCATCGCACTCGTCGGGCCCGGCGCCATCGGCGCCACCATGGCGGCCCTGCTCCACGAGGCGGGCCGGCCGGTGCTGC
TGTGCGGTCGCACCGCCCGCAGCTCGCTGGAGGTCCGGCCCGACGACCGGGAGCCGATCGTGATACCGGGTCCGGTGCAC
ACCGATCCCGCGGATGTCGACGGCCCGGTCGACGTGGTCCTGCTGGCGGTCAAGGACACCCAGAACGAGGCGGCCGCACC
CTGGCTGAGCCGGCTGTGCGGCTCGCGCACGGTGGTGTGCGCACTGCAGAACGGTGTCGAGCAGGTCGAGCGGGTCGGCC
GCTTCTGCCCGGATGCGACGGTGGTGCCCGCCGCGGTGTGGATGTCCGCCGAGACGTCCGGGCCGGGGCAGGTGCGGTTG
CGCACCGACGCCCGGGTGGTGCTGCCCGCCACCGAGGCCGCGGCGATGCTGGCCGACACGCTCGCGACACCGCATCTGAG
CGTCGCGTGCGATCCGGACTTCGCGAGCGCGGCGTGGCGCAAGCTGCTGGTCAACGCCGTGGTCGGCCTGATGGTGCTGA
CCGGCCGCAGGTCGGGGATGTTCCGCCGCGACGACATCGCCGCGCTGGGTCGCCGCTACCTGGCCGAATGCCTGGCGGTG
GCCCGGGCCGACGGGGCTGCGCTCGGCGACGAGGTGGTGGACGAGGTGATCGGGATGCTGGCCGCGGGACCGCCCGACAT
CACCACGTCGATGCTCACCGACCGGGAGGCCGGGCGCGCGCTGGAATGGGACATCCGCAACGGGGTGATCGCCCGCAAGG
GCGCCGCGTACGGCATCGCGACGCCGATCAGCGACATCGTGGTGCCACTGTTGGCCGCGGCCGGAGAGGGGCCCGGCTAG

Upstream 100 bases:

>100_bases
CCGACGAGCCACCCAACCGGCCAGCGTCACGTTCTGACCGGCGTCGGCGGGTCGCAGCGATCCGGCGGCATGACTGCGCA
GCACAAAAAACTCCTGGGGA

Downstream 100 bases:

>100_bases
ACAGCTTGGGCTACCGTGTATGGCCATGCACTCCTGCGAGCGCGTCGACCTGTCCTTCGTCGACTCTGCGCCGTACCGCT
TCGTCAGCACCGTCGATCTG

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MGGAGQRHSLVGGRGASPAVAWAIVTTRIALVGPGAIGATMAALLHEAGRPVLLCGRTARSSLEVRPDDREPIVIPGPVH
TDPADVDGPVDVVLLAVKDTQNEAAAPWLSRLCGSRTVVCALQNGVEQVERVGRFCPDATVVPAAVWMSAETSGPGQVRL
RTDARVVLPATEAAAMLADTLATPHLSVACDPDFASAAWRKLLVNAVVGLMVLTGRRSGMFRRDDIAALGRRYLAECLAV
ARADGAALGDEVVDEVIGMLAAGPPDITTSMLTDREAGRALEWDIRNGVIARKGAAYGIATPISDIVVPLLAAAGEGPG

Sequences:

>Translated_319_residues
MGGAGQRHSLVGGRGASPAVAWAIVTTRIALVGPGAIGATMAALLHEAGRPVLLCGRTARSSLEVRPDDREPIVIPGPVH
TDPADVDGPVDVVLLAVKDTQNEAAAPWLSRLCGSRTVVCALQNGVEQVERVGRFCPDATVVPAAVWMSAETSGPGQVRL
RTDARVVLPATEAAAMLADTLATPHLSVACDPDFASAAWRKLLVNAVVGLMVLTGRRSGMFRRDDIAALGRRYLAECLAV
ARADGAALGDEVVDEVIGMLAAGPPDITTSMLTDREAGRALEWDIRNGVIARKGAAYGIATPISDIVVPLLAAAGEGPG
>Mature_318_residues
GGAGQRHSLVGGRGASPAVAWAIVTTRIALVGPGAIGATMAALLHEAGRPVLLCGRTARSSLEVRPDDREPIVIPGPVHT
DPADVDGPVDVVLLAVKDTQNEAAAPWLSRLCGSRTVVCALQNGVEQVERVGRFCPDATVVPAAVWMSAETSGPGQVRLR
TDARVVLPATEAAAMLADTLATPHLSVACDPDFASAAWRKLLVNAVVGLMVLTGRRSGMFRRDDIAALGRRYLAECLAVA
RADGAALGDEVVDEVIGMLAAGPPDITTSMLTDREAGRALEWDIRNGVIARKGAAYGIATPISDIVVPLLAAAGEGPG

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 32933; Mature: 32802

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGAGQRHSLVGGRGASPAVAWAIVTTRIALVGPGAIGATMAALLHEAGRPVLLCGRTAR
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEECCCHHHHHHHHHHHHCCCCEEEECCCCC
SSLEVRPDDREPIVIPGPVHTDPADVDGPVDVVLLAVKDTQNEAAAPWLSRLCGSRTVVC
CCCEECCCCCCCEEECCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCEEEE
ALQNGVEQVERVGRFCPDATVVPAAVWMSAETSGPGQVRLRTDARVVLPATEAAAMLADT
HHHHHHHHHHHHHHHCCCCCHHHHHHEEECCCCCCCEEEEECCCEEEEECHHHHHHHHHH
LATPHLSVACDPDFASAAWRKLLVNAVVGLMVLTGRRSGMFRRDDIAALGRRYLAECLAV
HCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
ARADGAALGDEVVDEVIGMLAAGPPDITTSMLTDREAGRALEWDIRNGVIARKGAAYGIA
HHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCC
TPISDIVVPLLAAAGEGPG
CCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
GGAGQRHSLVGGRGASPAVAWAIVTTRIALVGPGAIGATMAALLHEAGRPVLLCGRTAR
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHEECCCHHHHHHHHHHHHCCCCEEEECCCCC
SSLEVRPDDREPIVIPGPVHTDPADVDGPVDVVLLAVKDTQNEAAAPWLSRLCGSRTVVC
CCCEECCCCCCCEEECCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCEEEE
ALQNGVEQVERVGRFCPDATVVPAAVWMSAETSGPGQVRLRTDARVVLPATEAAAMLADT
HHHHHHHHHHHHHHHCCCCCHHHHHHEEECCCCCCCEEEEECCCEEEEECHHHHHHHHHH
LATPHLSVACDPDFASAAWRKLLVNAVVGLMVLTGRRSGMFRRDDIAALGRRYLAECLAV
HCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
ARADGAALGDEVVDEVIGMLAAGPPDITTSMLTDREAGRALEWDIRNGVIARKGAAYGIA
HHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCC
TPISDIVVPLLAAAGEGPG
CCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]