BacMap

Definition	Mycobacterium sp. MCS chromosome, complete genome.
Accession	NC_008146
Length	5,705,448

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The map label for this gene is yqhE [C]

Identifier: 108798907

GI number: 108798907

Start: 2085634

End: 2086257

Strand: Reverse

Name: yqhE [C]

Synonym: Mmcs_1939

Alternate gene names: 108798907

Gene position: 2086257-2085634 (Counterclockwise)

Preceding gene: 108798922

Following gene: 108798906

Centisome position: 36.57

GC content: 62.18

Gene sequence:

>624_bases
GTGTACCTGGTCACCAAGCTGTGGAACTCCGAACAGGGCTATGACGCGACGCTGGCGGCCTTCGAGGCGAGTGTGGACCG
CCTCGGGGTCGACTACCTCGACCTGTACCTCATCCACTGGCCGGTCCCCGAGAAGAACCTCTTCGTCGACACCTTCAAAG
CGTTCGCCCGGCTACGTGAGGACGGTCGCATCCGGTCCATCGGTGTGAGCAACTTCGAACCCGAACACCTGCGGGTCCTG
ATCGACTCGACCGGCATCGTGCCCGCGGTCAACCAGATCGAGTTGCATCCACTGCTGCCTCAGCGGGAACTGCGAGAGCT
GCACGCGCAGTTGGGAATCGCCACCGAGGCGTGGAGCCCGCTGGGCCAGGGGTCGCTGCTGGCGCACCCCACGGTGACCG
GTGTCGCCGAGTCGCACGGGAAAACCGCAGCACAGGCACTGATTAGGTGGCATATGCAACTCGGTAATATCGTCATCCCC
AAGTCGGTGAACCCACAACGGATTGAGAGCAACTTCGACGTGTTCGACTTCGAGTTGAGCGAGCAGGACATGGCGTCCAT
CTCGTCTCTCGAGGACGGCTCCCGCCTGGGTCCCGACCCCAAAACATTCAACTTCACAGGGTAG

Upstream 100 bases:

>100_bases
GCTCGCCGCCGGCTATCGACACGTCGATACGGCCGCAGCGTACGGCAACGAGGAGCAGACCGGCCGGGCGATCGCCCAGT
CCGGACTGGACCGTTCGCAG

Downstream 100 bases:

>100_bases
GTGACATGACGTCAACGCGCGGTGAGGCAGCCGGCATCCCCTCCGTCTCCCTCAACGACGGACACTCGATCCCGGTCCTC
GGACTCGGCGTCGGTGAGCT

Product: aldo/keto reductase

Products: 2-keto-L-gulonate; NADP [C]

Alternate protein names: NA

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MYLVTKLWNSEQGYDATLAAFEASVDRLGVDYLDLYLIHWPVPEKNLFVDTFKAFARLREDGRIRSIGVSNFEPEHLRVL
IDSTGIVPAVNQIELHPLLPQRELRELHAQLGIATEAWSPLGQGSLLAHPTVTGVAESHGKTAAQALIRWHMQLGNIVIP
KSVNPQRIESNFDVFDFELSEQDMASISSLEDGSRLGPDPKTFNFTG

Sequences:

>Translated_207_residues
MYLVTKLWNSEQGYDATLAAFEASVDRLGVDYLDLYLIHWPVPEKNLFVDTFKAFARLREDGRIRSIGVSNFEPEHLRVL
IDSTGIVPAVNQIELHPLLPQRELRELHAQLGIATEAWSPLGQGSLLAHPTVTGVAESHGKTAAQALIRWHMQLGNIVIP
KSVNPQRIESNFDVFDFELSEQDMASISSLEDGSRLGPDPKTFNFTG
>Mature_207_residues
MYLVTKLWNSEQGYDATLAAFEASVDRLGVDYLDLYLIHWPVPEKNLFVDTFKAFARLREDGRIRSIGVSNFEPEHLRVL
IDSTGIVPAVNQIELHPLLPQRELRELHAQLGIATEAWSPLGQGSLLAHPTVTGVAESHGKTAAQALIRWHMQLGNIVIP
KSVNPQRIESNFDVFDFELSEQDMASISSLEDGSRLGPDPKTFNFTG

Specific function: Reduction [C]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI223468663, Length=225, Percent_Identity=37.3333333333333, Blast_Score=144, Evalue=6e-35,
Organism=Homo sapiens, GI93277124, Length=247, Percent_Identity=34.0080971659919, Blast_Score=137, Evalue=5e-33,
Organism=Homo sapiens, GI291291012, Length=225, Percent_Identity=35.1111111111111, Blast_Score=136, Evalue=1e-32,
Organism=Homo sapiens, GI4502049, Length=226, Percent_Identity=38.4955752212389, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI24497577, Length=223, Percent_Identity=31.8385650224215, Blast_Score=128, Evalue=4e-30,
Organism=Homo sapiens, GI5174391, Length=223, Percent_Identity=31.8385650224215, Blast_Score=128, Evalue=4e-30,
Organism=Homo sapiens, GI310109922, Length=208, Percent_Identity=33.1730769230769, Blast_Score=124, Evalue=8e-29,
Organism=Homo sapiens, GI5453543, Length=226, Percent_Identity=33.1858407079646, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI45446745, Length=226, Percent_Identity=33.1858407079646, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI4503285, Length=226, Percent_Identity=33.1858407079646, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI310109920, Length=226, Percent_Identity=33.1858407079646, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI5174695, Length=227, Percent_Identity=29.9559471365639, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI24497583, Length=222, Percent_Identity=30.1801801801802, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI24497585, Length=226, Percent_Identity=30.0884955752212, Blast_Score=110, Evalue=8e-25,
Organism=Homo sapiens, GI300116273, Length=205, Percent_Identity=29.2682926829268, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI310109924, Length=152, Percent_Identity=32.8947368421053, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI300116271, Length=207, Percent_Identity=28.5024154589372, Blast_Score=85, Evalue=4e-17,
Organism=Escherichia coli, GI87082198, Length=205, Percent_Identity=46.8292682926829, Blast_Score=204, Evalue=4e-54,
Organism=Escherichia coli, GI1786400, Length=198, Percent_Identity=32.8282828282828, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1788081, Length=217, Percent_Identity=31.3364055299539, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI48994888, Length=117, Percent_Identity=36.7521367521368, Blast_Score=61, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71998625, Length=201, Percent_Identity=38.8059701492537, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17564128, Length=229, Percent_Identity=34.4978165938865, Blast_Score=138, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17537075, Length=231, Percent_Identity=34.6320346320346, Blast_Score=133, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17537077, Length=225, Percent_Identity=33.7777777777778, Blast_Score=132, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17538386, Length=203, Percent_Identity=34.9753694581281, Blast_Score=116, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17552492, Length=214, Percent_Identity=29.9065420560748, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17561298, Length=205, Percent_Identity=30.2439024390244, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17537079, Length=230, Percent_Identity=28.695652173913, Blast_Score=107, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17566692, Length=213, Percent_Identity=30.5164319248826, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17550248, Length=224, Percent_Identity=27.2321428571429, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17561300, Length=181, Percent_Identity=31.4917127071823, Blast_Score=90, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17562292, Length=208, Percent_Identity=27.4038461538462, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320576, Length=220, Percent_Identity=39.0909090909091, Blast_Score=150, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6324694, Length=220, Percent_Identity=35.9090909090909, Blast_Score=138, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6322556, Length=187, Percent_Identity=34.2245989304813, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6321896, Length=247, Percent_Identity=30.7692307692308, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319625, Length=205, Percent_Identity=33.1707317073171, Blast_Score=109, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6320079, Length=190, Percent_Identity=29.4736842105263, Blast_Score=92, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24657054, Length=224, Percent_Identity=37.5, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24662789, Length=227, Percent_Identity=37.4449339207048, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24663317, Length=225, Percent_Identity=34.2222222222222, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21356425, Length=225, Percent_Identity=33.7777777777778, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI20129731, Length=220, Percent_Identity=34.5454545454545, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24644950, Length=232, Percent_Identity=35.3448275862069, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24662785, Length=226, Percent_Identity=38.9380530973451, Blast_Score=123, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24662781, Length=226, Percent_Identity=38.9380530973451, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI45553081, Length=222, Percent_Identity=32.4324324324324, Blast_Score=120, Evalue=7e-28,
Organism=Drosophila melanogaster, GI281366140, Length=222, Percent_Identity=32.4324324324324, Blast_Score=120, Evalue=7e-28,
Organism=Drosophila melanogaster, GI221378297, Length=252, Percent_Identity=32.9365079365079, Blast_Score=117, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 23105; Mature: 23105

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLVTKLWNSEQGYDATLAAFEASVDRLGVDYLDLYLIHWPVPEKNLFVDTFKAFARLRE
CEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHC
DGRIRSIGVSNFEPEHLRVLIDSTGIVPAVNQIELHPLLPQRELRELHAQLGIATEAWSP
CCCEEEECCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCHHHCCC
LGQGSLLAHPTVTGVAESHGKTAAQALIRWHMQLGNIVIPKSVNPQRIESNFDVFDFELS
CCCCCEEECCCHHHHHHHCCHHHHHHHHHHHHHHCCEEECCCCCHHHHCCCCCEEEEEEC
EQDMASISSLEDGSRLGPDPKTFNFTG
HHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MYLVTKLWNSEQGYDATLAAFEASVDRLGVDYLDLYLIHWPVPEKNLFVDTFKAFARLRE
CEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHC
DGRIRSIGVSNFEPEHLRVLIDSTGIVPAVNQIELHPLLPQRELRELHAQLGIATEAWSP
CCCEEEECCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCHHHCCC
LGQGSLLAHPTVTGVAESHGKTAAQALIRWHMQLGNIVIPKSVNPQRIESNFDVFDFELS
CCCCCEEECCCHHHHHHHCCHHHHHHHHHHHHHHCCEEECCCCCHHHHCCCCCEEEEEEC
EQDMASISSLEDGSRLGPDPKTFNFTG
HHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2,5-diketo-D-gluconate; NADPH [C]

Specific reaction: 2,5-diketo-D-gluconate + NADPH = 2-keto-L-gulonate + NADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA