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The map label for this gene is hisN [H]

Identifier: 108798575

GI number: 108798575

Start: 1740535

End: 1741563

Strand: Reverse

Name: hisN [H]

Synonym: Mmcs_1605

Alternate gene names: 108798575

Gene position: 1741563-1740535 (Counterclockwise)

Preceding gene: 108798576

Following gene: 108798574

Centisome position: 30.52

GC content: 68.71

Gene sequence:

>1029_bases
GTGCTCGTCGACCGTCGGGCCGTTGATCACCCCGGAGATCGTGACGAACTGCTCCCCCGTCACGTCATCCGGACGGGGGC
TGACGCCGGTCACCAGCAGAGTCCCCTGAGCGAGTTCGCCTCGCGGACCCCGGCTCCGCATGATCCACGGCGCGGCCAGC
ACGGCGATCGCCCCGATCAACAACAGGAGCACAGCGAATTCCCACACACGGCCATGGTAGGACTTGCAGACATGAGCACC
GGTTCCTCCAGCGTGGCCGACGATCTGGCGTTGGCGTTGCGGCTCGCCGACCATGCCGACGCCGTCACCGTCGACCGGTT
CCGCGCACTGGACCTCCACGTCGAGACCAAACCCGATCTCACGCCCGTGACCGACGCCGACCGTTCCGTGGAGAACGATC
TGCGGCGCGCACTCGCCGGGGAGCGCGGCGACGACTCGGTCCTCGGTGAAGAGTTCGGTGGCACAGCTGTTTTCAGCGGC
CGGCAGTGGGTGATCGACCCGATCGACGGGACGAAGAACTTCGTGCGGGGTGTCCCGATCTGGGCGACGCTGATCTCGCT
GCTGAACGACGGGGTGCCGGTGGTCGGCGTGGTCAGTGCGCCAGCCCTGCACCGTCGCTGGTGGGCGGCCGATGGGCTGG
GCGCCTTCGTCACGGTCTCCGGCGAGTCGCCGCGGCGGCTGTCGGTGTCGAAGGTGGCCGAACTGGATTCGGCCAGCCTG
TCGTTCTCCAGCCTGTCCGGGTGGGCCAAGCGCGGTCTGCGAGACCGATTCATCGACCTCACGGACGCCGTCTGGCGCGT
CCGAGGGTTCGGCGACTTCTTCTCCTACTGCCTGTTGGCCGAGGGGGCGGTGGACATCGCGGCCGAACCCGAGGTGTCGC
TGTGGGATCTGGCCGCGATCGACATTCTCGTGCGCGAGGCCGGTGGGACGTTCACGAATCTCGACGGCGCGGCGGGTCCG
CACGGAGGCAGCGTGGTCGCCTCCAACGGCCTGCTCCACGACGCGGCGCTGGGCCACCTCTCGCGTTAA

Upstream 100 bases:

>100_bases
AGTTCCAGTTGTCCGGGTTCTTCGGCGAGTACACGACGGGGAACAACGCGCCCATCGTCGGCCAGTTGTTCACGTCGACG
GCCATGCGCTGATAAACGAC

Downstream 100 bases:

>100_bases
GGGGACTTTCTCTCGCGTTAAGGGGACTTTCCGGGGCCCTCGGCCACTGCATCCACAGCACTCTGCCCTTCGGTGAACAG
GTGTGAACTAACTAACACGC

Product: histidinol-phosphate phosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MLVDRRAVDHPGDRDELLPRHVIRTGADAGHQQSPLSEFASRTPAPHDPRRGQHGDRPDQQQEHSEFPHTAMVGLADMST
GSSSVADDLALALRLADHADAVTVDRFRALDLHVETKPDLTPVTDADRSVENDLRRALAGERGDDSVLGEEFGGTAVFSG
RQWVIDPIDGTKNFVRGVPIWATLISLLNDGVPVVGVVSAPALHRRWWAADGLGAFVTVSGESPRRLSVSKVAELDSASL
SFSSLSGWAKRGLRDRFIDLTDAVWRVRGFGDFFSYCLLAEGAVDIAAEPEVSLWDLAAIDILVREAGGTFTNLDGAAGP
HGGSVVASNGLLHDAALGHLSR

Sequences:

>Translated_342_residues
MLVDRRAVDHPGDRDELLPRHVIRTGADAGHQQSPLSEFASRTPAPHDPRRGQHGDRPDQQQEHSEFPHTAMVGLADMST
GSSSVADDLALALRLADHADAVTVDRFRALDLHVETKPDLTPVTDADRSVENDLRRALAGERGDDSVLGEEFGGTAVFSG
RQWVIDPIDGTKNFVRGVPIWATLISLLNDGVPVVGVVSAPALHRRWWAADGLGAFVTVSGESPRRLSVSKVAELDSASL
SFSSLSGWAKRGLRDRFIDLTDAVWRVRGFGDFFSYCLLAEGAVDIAAEPEVSLWDLAAIDILVREAGGTFTNLDGAAGP
HGGSVVASNGLLHDAALGHLSR
>Mature_342_residues
MLVDRRAVDHPGDRDELLPRHVIRTGADAGHQQSPLSEFASRTPAPHDPRRGQHGDRPDQQQEHSEFPHTAMVGLADMST
GSSSVADDLALALRLADHADAVTVDRFRALDLHVETKPDLTPVTDADRSVENDLRRALAGERGDDSVLGEEFGGTAVFSG
RQWVIDPIDGTKNFVRGVPIWATLISLLNDGVPVVGVVSAPALHRRWWAADGLGAFVTVSGESPRRLSVSKVAELDSASL
SFSSLSGWAKRGLRDRFIDLTDAVWRVRGFGDFFSYCLLAEGAVDIAAEPEVSLWDLAAIDILVREAGGTFTNLDGAAGP
HGGSVVASNGLLHDAALGHLSR

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Escherichia coli, GI1788882, Length=271, Percent_Identity=27.3062730627306, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193202570, Length=241, Percent_Identity=30.2904564315353, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI193202572, Length=238, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320493, Length=204, Percent_Identity=30.8823529411765, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24664922, Length=253, Percent_Identity=26.4822134387352, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357329, Length=210, Percent_Identity=30.952380952381, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24664918, Length=212, Percent_Identity=28.7735849056604, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21357957, Length=243, Percent_Identity=27.5720164609054, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24664926, Length=205, Percent_Identity=27.8048780487805, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 36649; Mature: 36649

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVDRRAVDHPGDRDELLPRHVIRTGADAGHQQSPLSEFASRTPAPHDPRRGQHGDRPDQ
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCH
QQEHSEFPHTAMVGLADMSTGSSSVADDLALALRLADHADAVTVDRFRALDLHVETKPDL
HHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEHHHEEEEEEEEECCCCC
TPVTDADRSVENDLRRALAGERGDDSVLGEEFGGTAVFSGRQWVIDPIDGTKNFVRGVPI
CCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEECCCEEEEECCCCCHHHHCCCCH
WATLISLLNDGVPVVGVVSAPALHRRWWAADGLGAFVTVSGESPRRLSVSKVAELDSASL
HHHHHHHHHCCCCEEEECCCCHHHHHHHCCCCCCEEEEECCCCCCEEHHHHHHHHCCCCC
SFSSLSGWAKRGLRDRFIDLTDAVWRVRGFGDFFSYCLLAEGAVDIAAEPEVSLWDLAAI
CHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHH
DILVREAGGTFTNLDGAAGPHGGSVVASNGLLHDAALGHLSR
HHHHHHCCCCEECCCCCCCCCCCCEEECCCCHHHHHHHHCCC
>Mature Secondary Structure
MLVDRRAVDHPGDRDELLPRHVIRTGADAGHQQSPLSEFASRTPAPHDPRRGQHGDRPDQ
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCH
QQEHSEFPHTAMVGLADMSTGSSSVADDLALALRLADHADAVTVDRFRALDLHVETKPDL
HHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEHHHEEEEEEEEECCCCC
TPVTDADRSVENDLRRALAGERGDDSVLGEEFGGTAVFSGRQWVIDPIDGTKNFVRGVPI
CCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEECCCEEEEECCCCCHHHHCCCCH
WATLISLLNDGVPVVGVVSAPALHRRWWAADGLGAFVTVSGESPRRLSVSKVAELDSASL
HHHHHHHHHCCCCEEEECCCCHHHHHHHCCCCCCEEEEECCCCCCEEHHHHHHHHCCCCC
SFSSLSGWAKRGLRDRFIDLTDAVWRVRGFGDFFSYCLLAEGAVDIAAEPEVSLWDLAAI
CHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHH
DILVREAGGTFTNLDGAAGPHGGSVVASNGLLHDAALGHLSR
HHHHHHCCCCEECCCCCCCCCCCCEEECCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]