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The map label for this gene is alsR [H]

Identifier: 108798345

GI number: 108798345

Start: 1491724

End: 1492668

Strand: Direct

Name: alsR [H]

Synonym: Mmcs_1374

Alternate gene names: 108798345

Gene position: 1491724-1492668 (Clockwise)

Preceding gene: 108798340

Following gene: 108798346

Centisome position: 26.15

GC content: 69.42

Gene sequence:

>945_bases
GTGACTTTCAGAATCGAGACACTCATGGAGCTGCGTCATCTGCGGTATTTCGCCGCCGTCGCCGACACGTGCCACTTCGG
CCGGGCCGCGGATCAGCTGCATGTGGCTCAGCCGGCGCTGTCCTACGCGATCCGGCAACTCGAGGACGAGCTGGGCGTCA
CCCTTTTCAACAGGACCACGCGGCAGGTGTCGCTGACCGCGGCGGGGGAGTTCCTGCAGGGTGAGGCGGCCCGAATACTG
ACCGGGGTCGACGATGCCGTTCGAGGGGTACGACGCATCGCGGCCGGACGCAGCGGGTTGGTCCGGTTGGGGGTCACTGG
CACCGCGGCCTTCTCGCATCTGCCGCGCATCGCGCGGGTGGTCAGGCGTGAGTTGCCCGATGTCGCCCTCCAGATCCGGG
CGGATCTTCTGACGCCCGATCAGTGCGACGGGTTGCGCAGCGGTGCAATAGATCTCGGCGTGCTTCGCCCGCCGGCGGTG
GGGCAGGGCATCGAGTTGCGCACCATCGACGTCGAACCGCTCGTGCTCGCCGTCTCGGTGGACCACCGGCTCGCCGTCGA
ACCGGTCGTCTCACTGGCGGACCTGCGCAGCGAACCGTTCATCGCCTACGCCAGCCGCCACTCGGCGGTCAACGACGCCG
TCGTCCGCAGCTGCCGGCAGGCCGGTTTCGTTCCGCACCGCGAGCACGAGGCGCCCGGTACCGCGGTCCTGCTCTCGCTC
GTCGCCGCGGGCCTCGGAGTGGCCGTCGTCCCGGGGTCGGTGCGGGCACTTCCCTTGGAAGGGCTCGTGTTCCGCGACCT
GTTGGATGCCCAGACCATCGAGTTGGCGCTGGCCTGGCGCAGCGGCGAGGACGACCCTCTGGTCGAGGCCGTGGTCGGCG
TGCTCGCCGCCGCCTTCTCCGTCCACGCGATCGCCGATTCGATGCCAACCGGAAGGCCGCTGTGA

Upstream 100 bases:

>100_bases
TGATCGCATTGATGGATCAATAGGTCGAAAACAAGTCCTTGTCCGGTATGGATCGCGGCCATACTCTGGGCCGTGGCGCC
GGTCACATCCGCCCGGAGCT

Downstream 100 bases:

>100_bases
AGATCACTCGGGTCGACGCGATCCCGTTCGCCATTCCCTACACCAAACCCCTGAAGTTCGCCTCGGGTGAGGTCACCGAC
GCCGAACACGTTCTGGTGCG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MTFRIETLMELRHLRYFAAVADTCHFGRAADQLHVAQPALSYAIRQLEDELGVTLFNRTTRQVSLTAAGEFLQGEAARIL
TGVDDAVRGVRRIAAGRSGLVRLGVTGTAAFSHLPRIARVVRRELPDVALQIRADLLTPDQCDGLRSGAIDLGVLRPPAV
GQGIELRTIDVEPLVLAVSVDHRLAVEPVVSLADLRSEPFIAYASRHSAVNDAVVRSCRQAGFVPHREHEAPGTAVLLSL
VAAGLGVAVVPGSVRALPLEGLVFRDLLDAQTIELALAWRSGEDDPLVEAVVGVLAAAFSVHAIADSMPTGRPL

Sequences:

>Translated_314_residues
MTFRIETLMELRHLRYFAAVADTCHFGRAADQLHVAQPALSYAIRQLEDELGVTLFNRTTRQVSLTAAGEFLQGEAARIL
TGVDDAVRGVRRIAAGRSGLVRLGVTGTAAFSHLPRIARVVRRELPDVALQIRADLLTPDQCDGLRSGAIDLGVLRPPAV
GQGIELRTIDVEPLVLAVSVDHRLAVEPVVSLADLRSEPFIAYASRHSAVNDAVVRSCRQAGFVPHREHEAPGTAVLLSL
VAAGLGVAVVPGSVRALPLEGLVFRDLLDAQTIELALAWRSGEDDPLVEAVVGVLAAAFSVHAIADSMPTGRPL
>Mature_313_residues
TFRIETLMELRHLRYFAAVADTCHFGRAADQLHVAQPALSYAIRQLEDELGVTLFNRTTRQVSLTAAGEFLQGEAARILT
GVDDAVRGVRRIAAGRSGLVRLGVTGTAAFSHLPRIARVVRRELPDVALQIRADLLTPDQCDGLRSGAIDLGVLRPPAVG
QGIELRTIDVEPLVLAVSVDHRLAVEPVVSLADLRSEPFIAYASRHSAVNDAVVRSCRQAGFVPHREHEAPGTAVLLSLV
AAGLGVAVVPGSVRALPLEGLVFRDLLDAQTIELALAWRSGEDDPLVEAVVGVLAAAFSVHAIADSMPTGRPL

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=282, Percent_Identity=36.5248226950355, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI1788887, Length=289, Percent_Identity=34.2560553633218, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI2367136, Length=294, Percent_Identity=32.6530612244898, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1790399, Length=245, Percent_Identity=33.0612244897959, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI157672245, Length=231, Percent_Identity=34.1991341991342, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI145693105, Length=246, Percent_Identity=30.0813008130081, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1788748, Length=253, Percent_Identity=30.4347826086957, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI87081904, Length=184, Percent_Identity=33.695652173913, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790208, Length=303, Percent_Identity=30.03300330033, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1788297, Length=249, Percent_Identity=29.3172690763052, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790262, Length=288, Percent_Identity=25.6944444444444, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1789639, Length=242, Percent_Identity=25.6198347107438, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787530, Length=262, Percent_Identity=25.9541984732824, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789204, Length=266, Percent_Identity=27.4436090225564, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786508, Length=214, Percent_Identity=23.8317757009346, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI48994962, Length=82, Percent_Identity=43.9024390243902, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786713, Length=297, Percent_Identity=26.2626262626263, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1786448, Length=127, Percent_Identity=36.2204724409449, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787806, Length=293, Percent_Identity=26.962457337884, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1786401, Length=120, Percent_Identity=34.1666666666667, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787589, Length=126, Percent_Identity=34.1269841269841, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33533; Mature: 33402

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFRIETLMELRHLRYFAAVADTCHFGRAADQLHVAQPALSYAIRQLEDELGVTLFNRTT
CCEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCC
RQVSLTAAGEFLQGEAARILTGVDDAVRGVRRIAAGRSGLVRLGVTGTAAFSHLPRIARV
CEEEEEECCHHHCCCHHHHHHCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHH
VRRELPDVALQIRADLLTPDQCDGLRSGAIDLGVLRPPAVGQGIELRTIDVEPLVLAVSV
HHHHCCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCEEEEEEC
DHRLAVEPVVSLADLRSEPFIAYASRHSAVNDAVVRSCRQAGFVPHREHEAPGTAVLLSL
CCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
VAAGLGVAVVPGSVRALPLEGLVFRDLLDAQTIELALAWRSGEDDPLVEAVVGVLAAAFS
HHHCCCEEECCCCCEEECCCHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHH
VHAIADSMPTGRPL
HHHHHHCCCCCCCC
>Mature Secondary Structure 
TFRIETLMELRHLRYFAAVADTCHFGRAADQLHVAQPALSYAIRQLEDELGVTLFNRTT
CEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCC
RQVSLTAAGEFLQGEAARILTGVDDAVRGVRRIAAGRSGLVRLGVTGTAAFSHLPRIARV
CEEEEEECCHHHCCCHHHHHHCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHH
VRRELPDVALQIRADLLTPDQCDGLRSGAIDLGVLRPPAVGQGIELRTIDVEPLVLAVSV
HHHHCCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCEEEEEEC
DHRLAVEPVVSLADLRSEPFIAYASRHSAVNDAVVRSCRQAGFVPHREHEAPGTAVLLSL
CCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
VAAGLGVAVVPGSVRALPLEGLVFRDLLDAQTIELALAWRSGEDDPLVEAVVGVLAAAFS
HHHCCCEEECCCCCEEECCCHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHH
VHAIADSMPTGRPL
HHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]