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The map label for this gene is cyaB [H]

Identifier: 108798207

GI number: 108798207

Start: 1334260

End: 1335222

Strand: Direct

Name: cyaB [H]

Synonym: Mmcs_1236

Alternate gene names: 108798207

Gene position: 1334260-1335222 (Clockwise)

Preceding gene: 108798204

Following gene: 108798208

Centisome position: 23.39

GC content: 67.39

Gene sequence:

>963_bases
ATGACGGTGAGAGCGTGCCGGACGTGCGGTACCGAACTCCTCGACGCCGCGCGGTTCTGTCACGGCTGTGGATCAGAACT
CGCGAACTCGGACTCCCATGCCGAGTACAAGTGGGTGACCGTGTTGTTCGCCGATGTGGTCCGGTCCATGGCCATCGCCG
CCGCGGTCGGACCGGAACGGCTGCGGGAGATCATGGCGGAGTTGTTCTCGCGCTCGTCTGCGGTGGTGCGCCGCTACGGC
GGCACGGTCGACAAGTTCACCGGCGACGGAATCATGGCGGTGTTCGGGGCGCCATTGGCGCTCGAGGACCACGCGTTCCG
GGCATGTCTGGCCGCATCGGCCATCCAGCAGGAATCGCAGGGTCTGTCGCGAGAGGTCGAGGCTCACGACGGGGTCACCC
TGCAACTGCGCGTCGGCCTGAACTCCGGTGCTGTCATCGCCGGTGAGATCGGGTCCCAACCCCACAGCTACACCACGGTC
GGCGAGCAGGTCGGGATAGCCCAACGACTGGAATCGGTCGCGCCTCCTGGCGGCGTGCTGCTCAGCGAATCGACCGCACG
GCTGGCTCAGGACATGGTGACACTCGCTCCGCCTGTGATCCTGACCGTGAAGGGCGCGGATGCCCCGGTGGTCGCGCGGC
GCCTGCTGACCATCGAGGGGCACCGGGTCCGTGACCGAGGCGAGCCCGCGCTGGTGGGGCGTACCCGCGAACTCGCCTTC
CTCACCGCAATACTCGACGAAACCATCGGCGGGTCGGGATCTGTGGTGATCTCCCGGCTCGAACTGTTCTCGACCGATCG
GCGGCTGGTTCTCGACGAATTGGCCCTGCTTCGGCTGAATGCTCTCCTGGCCCGCGCTTGCGGTGACGCGGCGTCTTACC
GGCGGTGGCGCGACTGCTACCGGGTCAAGGCGCGGGTTCTCGGCCTCGAAGGGCAGCTTGCGTTGGCCGAGGCGATGCCG
TGA

Upstream 100 bases:

>100_bases
GGTGCAGGCCGGCGGTGCGTTCCGAAACTCGCCAAACCGCTTCGAGCACACGTCGGCGTTCCTATCGTGGGAATTGGTCG
ACAGCGGCGGGAGCCGGGTG

Downstream 100 bases:

>100_bases
CGATCGACGGCGGGTCCGACGACCAGACCCACGGCGCGTCGATCGACGAGATGCTCGACCGAGCGGTCGCGGCCATCAAC
CGCGGGGATCGGGCCACCGC

Product: adenylate/guanylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 2; Adenylyl cyclase 2; AC2 [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MTVRACRTCGTELLDAARFCHGCGSELANSDSHAEYKWVTVLFADVVRSMAIAAAVGPERLREIMAELFSRSSAVVRRYG
GTVDKFTGDGIMAVFGAPLALEDHAFRACLAASAIQQESQGLSREVEAHDGVTLQLRVGLNSGAVIAGEIGSQPHSYTTV
GEQVGIAQRLESVAPPGGVLLSESTARLAQDMVTLAPPVILTVKGADAPVVARRLLTIEGHRVRDRGEPALVGRTRELAF
LTAILDETIGGSGSVVISRLELFSTDRRLVLDELALLRLNALLARACGDAASYRRWRDCYRVKARVLGLEGQLALAEAMP

Sequences:

>Translated_320_residues
MTVRACRTCGTELLDAARFCHGCGSELANSDSHAEYKWVTVLFADVVRSMAIAAAVGPERLREIMAELFSRSSAVVRRYG
GTVDKFTGDGIMAVFGAPLALEDHAFRACLAASAIQQESQGLSREVEAHDGVTLQLRVGLNSGAVIAGEIGSQPHSYTTV
GEQVGIAQRLESVAPPGGVLLSESTARLAQDMVTLAPPVILTVKGADAPVVARRLLTIEGHRVRDRGEPALVGRTRELAF
LTAILDETIGGSGSVVISRLELFSTDRRLVLDELALLRLNALLARACGDAASYRRWRDCYRVKARVLGLEGQLALAEAMP
>Mature_319_residues
TVRACRTCGTELLDAARFCHGCGSELANSDSHAEYKWVTVLFADVVRSMAIAAAVGPERLREIMAELFSRSSAVVRRYGG
TVDKFTGDGIMAVFGAPLALEDHAFRACLAASAIQQESQGLSREVEAHDGVTLQLRVGLNSGAVIAGEIGSQPHSYTTVG
EQVGIAQRLESVAPPGGVLLSESTARLAQDMVTLAPPVILTVKGADAPVVARRLLTIEGHRVRDRGEPALVGRTRELAFL
TAILDETIGGSGSVVISRLELFSTDRRLVLDELALLRLNALLARACGDAASYRRWRDCYRVKARVLGLEGQLALAEAMP

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Homo sapiens, GI4557255, Length=171, Percent_Identity=28.0701754385965, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI24497587, Length=182, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI148536830, Length=147, Percent_Identity=31.2925170068027, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI115387102, Length=147, Percent_Identity=29.9319727891156, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI86564713, Length=156, Percent_Identity=27.5641025641026, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI193205840, Length=169, Percent_Identity=28.4023668639053, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17534657, Length=153, Percent_Identity=28.7581699346405, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71995895, Length=148, Percent_Identity=27.027027027027, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71995893, Length=151, Percent_Identity=26.4900662251656, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71989805, Length=150, Percent_Identity=26.6666666666667, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71989822, Length=150, Percent_Identity=26.6666666666667, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71995899, Length=151, Percent_Identity=26.4900662251656, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994363, Length=158, Percent_Identity=27.8481012658228, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193210669, Length=158, Percent_Identity=27.8481012658228, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17557192, Length=147, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI161078020, Length=173, Percent_Identity=30.635838150289, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24583976, Length=148, Percent_Identity=33.1081081081081, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI116008008, Length=158, Percent_Identity=30.379746835443, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI62484298, Length=158, Percent_Identity=30.379746835443, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI62484477, Length=158, Percent_Identity=30.379746835443, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24585694, Length=152, Percent_Identity=28.9473684210526, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00072 Response_reg [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 34179; Mature: 34047

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVRACRTCGTELLDAARFCHGCGSELANSDSHAEYKWVTVLFADVVRSMAIAAAVGPER
CCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHH
LREIMAELFSRSSAVVRRYGGTVDKFTGDGIMAVFGAPLALEDHAFRACLAASAIQQESQ
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCEEEHHHHHHHHHHHHHHHHHHH
GLSREVEAHDGVTLQLRVGLNSGAVIAGEIGSQPHSYTTVGEQVGIAQRLESVAPPGGVL
CCHHHHHCCCCEEEEEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEE
LSESTARLAQDMVTLAPPVILTVKGADAPVVARRLLTIEGHRVRDRGEPALVGRTRELAF
ECCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCEECCHHHHHH
LTAILDETIGGSGSVVISRLELFSTDRRLVLDELALLRLNALLARACGDAASYRRWRDCY
HHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
RVKARVLGLEGQLALAEAMP
HHHHHHCCCCCCCHHHCCCC
>Mature Secondary Structure 
TVRACRTCGTELLDAARFCHGCGSELANSDSHAEYKWVTVLFADVVRSMAIAAAVGPER
CCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHH
LREIMAELFSRSSAVVRRYGGTVDKFTGDGIMAVFGAPLALEDHAFRACLAASAIQQESQ
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCEEEHHHHHHHHHHHHHHHHHHH
GLSREVEAHDGVTLQLRVGLNSGAVIAGEIGSQPHSYTTVGEQVGIAQRLESVAPPGGVL
CCHHHHHCCCCEEEEEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEE
LSESTARLAQDMVTLAPPVILTVKGADAPVVARRLLTIEGHRVRDRGEPALVGRTRELAF
ECCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCEECCHHHHHH
LTAILDETIGGSGSVVISRLELFSTDRRLVLDELALLRLNALLARACGDAASYRRWRDCY
HHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
RVKARVLGLEGQLALAEAMP
HHHHHHCCCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]