Click here to switch to the map view.

The map label for this gene is adhA [H]

Identifier: 108798068

GI number: 108798068

Start: 1194658

End: 1195674

Strand: Direct

Name: adhA [H]

Synonym: Mmcs_1096

Alternate gene names: 108798068

Gene position: 1194658-1195674 (Clockwise)

Preceding gene: 108798067

Following gene: 108798069

Centisome position: 20.94

GC content: 71.88

Gene sequence:

>1017_bases
GTGGGTTCCCGCACCATGCACGCCTGGCGGATGCGCGTCCCGGGACCGATAGCCACCCATCCGCTCGAATCGGTCACCAC
CGAGGTGCCCGAACCCGGGCACGGTGAACTCCTGATCGCCGTGCGGGCATGCGGTGTGTGCCGCACCGATCTGCACATCG
CGGAGGGCGATCTGCCCGTCCACCGTCCGCACGTGATGCCCGGACACGAGGTCGTGGGGGAGGTCGTCGGCATCGGTCCG
GACACGGAGCCGGGTTTCGCGGTCGGGGACCGGGTGGGGGTGGCGTGGCTCAGGCACACCTGCGGACGGTGCCGCTTCTG
TGAGCGCGGACAGGAGAACCTGTGCCCGCACTCGCGGTACACGGGGTGGGACGCCGACGGTGGCTACGCCGAATTCACCA
CAGCCCCCGCGGCTTTCGTCCACCGGCTGCCGGGCGGGTACACCGACGCCGAGCTGGCCCCGCTGTTGTGTGCCGGCATC
ATCGGATACCGGTCGCTCCTGCGCGCGGACCTGCCGCCGGGCGGCCGGCTGGGCATCTACGGGTTCGGTGGCAGCGCCCA
CATCACCGCGCAGGTGGCGCTGGCCCAGGGCGCCGAGGTCCACGTCATGACCCGAGGAGAGCACGCACGGGAGCTGGCCC
GGGCGCTGGGCGCCGCGTCGGTGCAGGGTGCCGGCGACCCGCCCCCGGTCGAACTGGATGCCGCGATCCTCTTCGCCCCG
GTGGGCGATCTGGTGTTACCCGCGCTCGAGGGTCTCGACCGCGGGGGAACGCTCGCCATCGCGGGCATCCACCTCAGCGA
CATCCCGGCACTGGACTACCAACGTCACCTGTTCCAGGAGCGTCAGGTGCGGTCGGTGACCGCCAACACCCGCGCCGACG
CGCGAGCGTTCCTCGAATTCGCCGGCCGCCATCACATCGAGGTGACGACGCCGGAGTACCCGCTGGGCCGTGCGGATGAT
GCGCTCGCAGACCTGGCGGCCGGCCGAATCGCCGGCGCGGCGGTCCTGCTCGTCTGA

Upstream 100 bases:

>100_bases
CGTTCCTGTTCTTCGTCGACGCTGCCGAGGGACGTGCCTGCGTGCTCTATCACCGCTACGACGGCCACTACGGCTTGATC
ACACCGGCGGGATAGGGGCC

Downstream 100 bases:

>100_bases
CCGCGCACCGGATAGGACCACCGGCAGCACACCCGGGACCAACGGCCCTGGTGTGGGCGGCGCGCAATTCCTAACGTCGA
AGGCAGGAGCACCGCCGACA

Product: alcohol dehydrogenase GroES-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MGSRTMHAWRMRVPGPIATHPLESVTTEVPEPGHGELLIAVRACGVCRTDLHIAEGDLPVHRPHVMPGHEVVGEVVGIGP
DTEPGFAVGDRVGVAWLRHTCGRCRFCERGQENLCPHSRYTGWDADGGYAEFTTAPAAFVHRLPGGYTDAELAPLLCAGI
IGYRSLLRADLPPGGRLGIYGFGGSAHITAQVALAQGAEVHVMTRGEHARELARALGAASVQGAGDPPPVELDAAILFAP
VGDLVLPALEGLDRGGTLAIAGIHLSDIPALDYQRHLFQERQVRSVTANTRADARAFLEFAGRHHIEVTTPEYPLGRADD
ALADLAAGRIAGAAVLLV

Sequences:

>Translated_338_residues
MGSRTMHAWRMRVPGPIATHPLESVTTEVPEPGHGELLIAVRACGVCRTDLHIAEGDLPVHRPHVMPGHEVVGEVVGIGP
DTEPGFAVGDRVGVAWLRHTCGRCRFCERGQENLCPHSRYTGWDADGGYAEFTTAPAAFVHRLPGGYTDAELAPLLCAGI
IGYRSLLRADLPPGGRLGIYGFGGSAHITAQVALAQGAEVHVMTRGEHARELARALGAASVQGAGDPPPVELDAAILFAP
VGDLVLPALEGLDRGGTLAIAGIHLSDIPALDYQRHLFQERQVRSVTANTRADARAFLEFAGRHHIEVTTPEYPLGRADD
ALADLAAGRIAGAAVLLV
>Mature_337_residues
GSRTMHAWRMRVPGPIATHPLESVTTEVPEPGHGELLIAVRACGVCRTDLHIAEGDLPVHRPHVMPGHEVVGEVVGIGPD
TEPGFAVGDRVGVAWLRHTCGRCRFCERGQENLCPHSRYTGWDADGGYAEFTTAPAAFVHRLPGGYTDAELAPLLCAGII
GYRSLLRADLPPGGRLGIYGFGGSAHITAQVALAQGAEVHVMTRGEHARELARALGAASVQGAGDPPPVELDAAILFAPV
GDLVLPALEGLDRGGTLAIAGIHLSDIPALDYQRHLFQERQVRSVTANTRADARAFLEFAGRHHIEVTTPEYPLGRADDA
LADLAAGRIAGAAVLLV

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI87081918, Length=316, Percent_Identity=27.8481012658228, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI87082401, Length=315, Percent_Identity=28.8888888888889, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1786518, Length=213, Percent_Identity=37.5586854460094, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790045, Length=272, Percent_Identity=31.6176470588235, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1788073, Length=271, Percent_Identity=29.1512915129151, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI226510992, Length=169, Percent_Identity=31.9526627218935, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1787863, Length=130, Percent_Identity=33.0769230769231, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87082125, Length=183, Percent_Identity=28.9617486338798, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=318, Percent_Identity=25.1572327044025, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17562582, Length=328, Percent_Identity=28.0487804878049, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17562584, Length=330, Percent_Identity=26.0606060606061, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17562878, Length=198, Percent_Identity=31.3131313131313, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=198, Percent_Identity=30.3030303030303, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323729, Length=325, Percent_Identity=31.3846153846154, Blast_Score=142, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6319621, Length=336, Percent_Identity=33.0357142857143, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323961, Length=331, Percent_Identity=32.02416918429, Blast_Score=141, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6324486, Length=343, Percent_Identity=30.6122448979592, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323980, Length=197, Percent_Identity=35.0253807106599, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6319949, Length=199, Percent_Identity=36.1809045226131, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17137530, Length=211, Percent_Identity=29.3838862559242, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35727; Mature: 35596

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSRTMHAWRMRVPGPIATHPLESVTTEVPEPGHGELLIAVRACGVCRTDLHIAEGDLPV
CCCCCCEEEEEECCCCCCCCCHHHHHHCCCCCCCCCEEEEEECCCCEECCCEEECCCCCC
HRPHVMPGHEVVGEVVGIGPDTEPGFAVGDRVGVAWLRHTCGRCRFCERGQENLCPHSRY
CCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCHHHCCCCCCC
TGWDADGGYAEFTTAPAAFVHRLPGGYTDAELAPLLCAGIIGYRSLLRADLPPGGRLGIY
CCCCCCCCEEEHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
GFGGSAHITAQVALAQGAEVHVMTRGEHARELARALGAASVQGAGDPPPVELDAAILFAP
EECCCCEEEEEEEEECCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCEECCEEEEEC
VGDLVLPALEGLDRGGTLAIAGIHLSDIPALDYQRHLFQERQVRSVTANTRADARAFLEF
HHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AGRHHIEVTTPEYPLGRADDALADLAAGRIAGAAVLLV
HCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCEEEEEC
>Mature Secondary Structure 
GSRTMHAWRMRVPGPIATHPLESVTTEVPEPGHGELLIAVRACGVCRTDLHIAEGDLPV
CCCCCEEEEEECCCCCCCCCHHHHHHCCCCCCCCCEEEEEECCCCEECCCEEECCCCCC
HRPHVMPGHEVVGEVVGIGPDTEPGFAVGDRVGVAWLRHTCGRCRFCERGQENLCPHSRY
CCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCHHHCCCCCCC
TGWDADGGYAEFTTAPAAFVHRLPGGYTDAELAPLLCAGIIGYRSLLRADLPPGGRLGIY
CCCCCCCCEEEHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
GFGGSAHITAQVALAQGAEVHVMTRGEHARELARALGAASVQGAGDPPPVELDAAILFAP
EECCCCEEEEEEEEECCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCEECCEEEEEC
VGDLVLPALEGLDRGGTLAIAGIHLSDIPALDYQRHLFQERQVRSVTANTRADARAFLEF
HHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AGRHHIEVTTPEYPLGRADDALADLAAGRIAGAAVLLV
HCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]