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The map label for this gene is nrdZ [H]

Identifier: 108798058

GI number: 108798058

Start: 1184070

End: 1186151

Strand: Direct

Name: nrdZ [H]

Synonym: Mmcs_1085

Alternate gene names: 108798058

Gene position: 1184070-1186151 (Clockwise)

Preceding gene: 108798057

Following gene: 108798060

Centisome position: 20.75

GC content: 69.79

Gene sequence:

>2082_bases
GTGACGGCATCGCGGTGGCCCACCAGGGTCCGGCGGCGCGACGGGACGTTGGTGCCCTTCGATGCCGGCCGGATCGAGGC
CGCCGTGCTGCGCGCCGCACGCGAAGTCGCCTGTGACGACCCGGACATGCCGGGTGCGGTGGCACGAACCGTGGCCGACA
CCCTGGGGCCGGGAACAGCCGATGTCGAGACCATCCAGGATTTCGTCGAGGCGCGGCTGGGGGAGGCCGGCCTCGACGAT
GTCGCCCGCGCCTACATCGTCTATCGCCGCGACCGCGCGGACCTGCGGGCGGCCAAGGCGCTGCTCGGGGTGCGCGACGA
GCTCAAGCTGAGCCTGGCCGCGGTCACGGTGCTGCGGGAGCGCTACCTGCTGCGGGATCAGCGCGGCCGGCCGGTCGAAT
CGACGGGCGAGATGATGGACCGCGCGGCGCGTTGTGTCGCCGCTGCCGAAGACGCGTACGAACCCGGCTCGTCGGCCGAG
TGGACCGATCGGTTCTCCCGCGGCCTGCGCGACCTGGAGTTCCTGCCGAACTCCCCGACACTGATGAACGCGGGCACCGA
TCTCGGGCTTCTCTCCGGGTGTTTCGTCCTGCCGGTCGAGGATTCGCTTCGCTCGATCTTCGCGACGTTGGCCAAGGCCG
CCGAGATCCAGCGCGCCGGCGGGGGAACGGGGTTCTCCTTCAGCCGCATCCGCCCCGACGGTGACCCCATCACCACGACG
ACCGGGTCGGCCTGTGGCCCCGTGCCGTTTGTCGGCCTCTTCGACGCTGCCGCACAAGTGGTTTCGCTGGGCGGGCGCCG
CCGGGGTGCGTGTATGGCGGTGCTCGACGTGTCGCATCCGGACATCTACGACTTCATCGCGAGCAAGAGCGGGTCCACCG
CGAAGCTGCCGCATTTCAACCTCTCGATCGGCGTCGGCGACGCCTTCATGCGTGCGGTGGAAAGCGGCGGGATGCATCGG
CTGGTCAATCCGCGAACCGGCAAGACGGCCGCACGGGTGCGCGCCGACGAGTTGTTCGCCGCGATCTGCGAGGCCGCGAA
CCACGGTGGCGACCCCGGCCTGGTCTTCCTGGACACGATCAACCGGGCCAACCCGGTGCCGCAACGGGGCCGGATCGAGG
CCACGAATCCCTGTGGTGAGGTCCCGCTGCTGCCGTATGAGTCGTGCAACCTCGGCTCGGTCAACCTCACCCGGATGCTC
ACCGGCGACGAGGTCGACTGGACACGGCTCACCGCGGTCACCGAGATGGCGGTCCGCTTCTTCGACGACGTCATCGACGT
CAGCCGGTATCCGTTCGCCGAGCTGGGCGAGGCGACCCGAGCCACCCGCAAGATCGGTCTGGGTGTCATGGGGTTGGCCG
AGATGCTGGCGCGACTGGGAATTCCCTACGACAGTGAGGAGGCGCTGCGGCTGACCGATCGGGTGATGCGCCACATCCAG
CGAGCGGCGCACCGTGCCTCGCGCCGGCTGGCCGAAGACCGGGGGTCCTTCCCCGCCTTCCCGGACAGTCGGCTCGTGCG
GTCCGGGCCGCGCCGCAACGCACAGGTCACGTCCGTGGCGCCCACGGGCACCATCTCGCTGATCGCAGGCACCACCGCCG
GGATCGAGCCGATGTTCGCCATCGCCTACACGCGCGCGATCCTGGGACGCCATTTGCTCGAGGTGAACCCGACGTTCGAC
CGGTTGGCCCGCGACCGCGGTTTCTACCGCGATGAACTGATCACCGAGATCGCGGAGCGTGGGGGCGTGCGGCGGTGCCC
GTCGCTTCCGGCCGAGGTGCGGTCCGCCTTCCCGACCGCCACCGAGATCTCTCCCGACTGGCATCTACGCATGCAGGCGG
TCGTCCAGCGACACGTCGACGCGGCAGTGTCGAAGACGGTCAACCTGCCGTCCACGGCCACACCGGCCGACGTCCGCGAC
ATCTACCTCAAGGCGTGGAAAGCGAAGGTCAAGGGCGTCACGGTGTACCGGTACGGCAGCCGGGAAGATCAGGTGCTGAC
CTTCGCCGCGCCGCCCGGGATGCCGGTCCAGGCGCCGGCCGACTTCAGCGGCGGCTGTGCGCAGCGCTCCTGTGAGTTCT
GA

Upstream 100 bases:

>100_bases
CGCCGCCGACGAACGGGCAAGCCGCCGTTTCGGGGCCGTGCAGTCGGAAATCCTCCACGGCGACGCGAATTAGTCGGCGT
CCGGCCGGGGTGCAACGGCG

Downstream 100 bases:

>100_bases
ACTCAGTCTTCTTCTGTTTCTTCGTCCTCGTCGATGACGTGGACCGCCGCCTCCTCCGCGGAGGCCGCGCCCCCGTCGAT
GCCGACGTCCTCGGCGACCA

Product: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 693; Mature: 692

Protein sequence:

>693_residues
MTASRWPTRVRRRDGTLVPFDAGRIEAAVLRAAREVACDDPDMPGAVARTVADTLGPGTADVETIQDFVEARLGEAGLDD
VARAYIVYRRDRADLRAAKALLGVRDELKLSLAAVTVLRERYLLRDQRGRPVESTGEMMDRAARCVAAAEDAYEPGSSAE
WTDRFSRGLRDLEFLPNSPTLMNAGTDLGLLSGCFVLPVEDSLRSIFATLAKAAEIQRAGGGTGFSFSRIRPDGDPITTT
TGSACGPVPFVGLFDAAAQVVSLGGRRRGACMAVLDVSHPDIYDFIASKSGSTAKLPHFNLSIGVGDAFMRAVESGGMHR
LVNPRTGKTAARVRADELFAAICEAANHGGDPGLVFLDTINRANPVPQRGRIEATNPCGEVPLLPYESCNLGSVNLTRML
TGDEVDWTRLTAVTEMAVRFFDDVIDVSRYPFAELGEATRATRKIGLGVMGLAEMLARLGIPYDSEEALRLTDRVMRHIQ
RAAHRASRRLAEDRGSFPAFPDSRLVRSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAIAYTRAILGRHLLEVNPTFD
RLARDRGFYRDELITEIAERGGVRRCPSLPAEVRSAFPTATEISPDWHLRMQAVVQRHVDAAVSKTVNLPSTATPADVRD
IYLKAWKAKVKGVTVYRYGSREDQVLTFAAPPGMPVQAPADFSGGCAQRSCEF

Sequences:

>Translated_693_residues
MTASRWPTRVRRRDGTLVPFDAGRIEAAVLRAAREVACDDPDMPGAVARTVADTLGPGTADVETIQDFVEARLGEAGLDD
VARAYIVYRRDRADLRAAKALLGVRDELKLSLAAVTVLRERYLLRDQRGRPVESTGEMMDRAARCVAAAEDAYEPGSSAE
WTDRFSRGLRDLEFLPNSPTLMNAGTDLGLLSGCFVLPVEDSLRSIFATLAKAAEIQRAGGGTGFSFSRIRPDGDPITTT
TGSACGPVPFVGLFDAAAQVVSLGGRRRGACMAVLDVSHPDIYDFIASKSGSTAKLPHFNLSIGVGDAFMRAVESGGMHR
LVNPRTGKTAARVRADELFAAICEAANHGGDPGLVFLDTINRANPVPQRGRIEATNPCGEVPLLPYESCNLGSVNLTRML
TGDEVDWTRLTAVTEMAVRFFDDVIDVSRYPFAELGEATRATRKIGLGVMGLAEMLARLGIPYDSEEALRLTDRVMRHIQ
RAAHRASRRLAEDRGSFPAFPDSRLVRSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAIAYTRAILGRHLLEVNPTFD
RLARDRGFYRDELITEIAERGGVRRCPSLPAEVRSAFPTATEISPDWHLRMQAVVQRHVDAAVSKTVNLPSTATPADVRD
IYLKAWKAKVKGVTVYRYGSREDQVLTFAAPPGMPVQAPADFSGGCAQRSCEF
>Mature_692_residues
TASRWPTRVRRRDGTLVPFDAGRIEAAVLRAAREVACDDPDMPGAVARTVADTLGPGTADVETIQDFVEARLGEAGLDDV
ARAYIVYRRDRADLRAAKALLGVRDELKLSLAAVTVLRERYLLRDQRGRPVESTGEMMDRAARCVAAAEDAYEPGSSAEW
TDRFSRGLRDLEFLPNSPTLMNAGTDLGLLSGCFVLPVEDSLRSIFATLAKAAEIQRAGGGTGFSFSRIRPDGDPITTTT
GSACGPVPFVGLFDAAAQVVSLGGRRRGACMAVLDVSHPDIYDFIASKSGSTAKLPHFNLSIGVGDAFMRAVESGGMHRL
VNPRTGKTAARVRADELFAAICEAANHGGDPGLVFLDTINRANPVPQRGRIEATNPCGEVPLLPYESCNLGSVNLTRMLT
GDEVDWTRLTAVTEMAVRFFDDVIDVSRYPFAELGEATRATRKIGLGVMGLAEMLARLGIPYDSEEALRLTDRVMRHIQR
AAHRASRRLAEDRGSFPAFPDSRLVRSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAIAYTRAILGRHLLEVNPTFDR
LARDRGFYRDELITEIAERGGVRRCPSLPAEVRSAFPTATEISPDWHLRMQAVVQRHVDAAVSKTVNLPSTATPADVRDI
YLKAWKAKVKGVTVYRYGSREDQVLTFAAPPGMPVQAPADFSGGCAQRSCEF

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=545, Percent_Identity=27.3394495412844, Blast_Score=210, Evalue=4e-54,
Organism=Escherichia coli, GI1789030, Length=581, Percent_Identity=28.5714285714286, Blast_Score=164, Evalue=2e-41,
Organism=Escherichia coli, GI1790686, Length=193, Percent_Identity=30.0518134715026, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17555242, Length=541, Percent_Identity=26.9870609981516, Blast_Score=196, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6320914, Length=698, Percent_Identity=27.3638968481375, Blast_Score=199, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6322123, Length=690, Percent_Identity=25.7971014492754, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI17352481, Length=693, Percent_Identity=25.3968253968254, Blast_Score=197, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 75091; Mature: 74960

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: PS51161 ATP_CONE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASRWPTRVRRRDGTLVPFDAGRIEAAVLRAAREVACDDPDMPGAVARTVADTLGPGTA
CCCCCCCHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCC
DVETIQDFVEARLGEAGLDDVARAYIVYRRDRADLRAAKALLGVRDELKLSLAAVTVLRE
CHHHHHHHHHHHCCCCCHHHHHHHHHHEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
RYLLRDQRGRPVESTGEMMDRAARCVAAAEDAYEPGSSAEWTDRFSRGLRDLEFLPNSPT
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHCCCCCCC
LMNAGTDLGLLSGCFVLPVEDSLRSIFATLAKAAEIQRAGGGTGFSFSRIRPDGDPITTT
EEECCCCHHHHHCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
TGSACGPVPFVGLFDAAAQVVSLGGRRRGACMAVLDVSHPDIYDFIASKSGSTAKLPHFN
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHCCCCCCEECCCEE
LSIGVGDAFMRAVESGGMHRLVNPRTGKTAARVRADELFAAICEAANHGGDPGLVFLDTI
EEECCCHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
NRANPVPQRGRIEATNPCGEVPLLPYESCNLGSVNLTRMLTGDEVDWTRLTAVTEMAVRF
CCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
FDDVIDVSRYPFAELGEATRATRKIGLGVMGLAEMLARLGIPYDSEEALRLTDRVMRHIQ
HHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
RAAHRASRRLAEDRGSFPAFPDSRLVRSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFA
HHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCEEEEECCCCEEEEEECCCCCCCHHHH
IAYTRAILGRHLLEVNPTFDRLARDRGFYRDELITEIAERGGVRRCPSLPAEVRSAFPTA
HHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCC
TEISPDWHLRMQAVVQRHVDAAVSKTVNLPSTATPADVRDIYLKAWKAKVKGVTVYRYGS
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEECC
REDQVLTFAAPPGMPVQAPADFSGGCAQRSCEF
CCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TASRWPTRVRRRDGTLVPFDAGRIEAAVLRAAREVACDDPDMPGAVARTVADTLGPGTA
CCCCCCHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCC
DVETIQDFVEARLGEAGLDDVARAYIVYRRDRADLRAAKALLGVRDELKLSLAAVTVLRE
CHHHHHHHHHHHCCCCCHHHHHHHHHHEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
RYLLRDQRGRPVESTGEMMDRAARCVAAAEDAYEPGSSAEWTDRFSRGLRDLEFLPNSPT
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHCCCCCCC
LMNAGTDLGLLSGCFVLPVEDSLRSIFATLAKAAEIQRAGGGTGFSFSRIRPDGDPITTT
EEECCCCHHHHHCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
TGSACGPVPFVGLFDAAAQVVSLGGRRRGACMAVLDVSHPDIYDFIASKSGSTAKLPHFN
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHCCCCCCEECCCEE
LSIGVGDAFMRAVESGGMHRLVNPRTGKTAARVRADELFAAICEAANHGGDPGLVFLDTI
EEECCCHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
NRANPVPQRGRIEATNPCGEVPLLPYESCNLGSVNLTRMLTGDEVDWTRLTAVTEMAVRF
CCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
FDDVIDVSRYPFAELGEATRATRKIGLGVMGLAEMLARLGIPYDSEEALRLTDRVMRHIQ
HHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
RAAHRASRRLAEDRGSFPAFPDSRLVRSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFA
HHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCEEEEECCCCEEEEEECCCCCCCHHHH
IAYTRAILGRHLLEVNPTFDRLARDRGFYRDELITEIAERGGVRRCPSLPAEVRSAFPTA
HHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCC
TEISPDWHLRMQAVVQRHVDAAVSKTVNLPSTATPADVRDIYLKAWKAKVKGVTVYRYGS
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEECC
REDQVLTFAAPPGMPVQAPADFSGGCAQRSCEF
CCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]