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The map label for this gene is fdh [H]

Identifier: 108797733

GI number: 108797733

Start: 799113

End: 800279

Strand: Direct

Name: fdh [H]

Synonym: Mmcs_0754

Alternate gene names: 108797733

Gene position: 799113-800279 (Clockwise)

Preceding gene: 108797732

Following gene: 108797735

Centisome position: 14.01

GC content: 65.72

Gene sequence:

>1167_bases
ATGCGCGCACTGTGCTGGAACGGCGTCAACAAGCTGTCCGTCGAGACGGTCGACGATCCCGAGATCCTCAACCCGCACGA
CGTCATCCTCAAGGTCACGCTGACCACCACCTGCGGATCCGATCTGCACTTCATCGACGGTTATCTGCCTGGCATGCGGG
AAGGTGACATCTTCGGGCACGAATTCATGGGTGAGATCGTCGAAACCGGCCGCGAGGTCCGCGACGTCAAGGTCGGCGAC
CGCGTCGTCGTCCCGTCGTTCATCGGGTGCGACCGGTGCTGGTACTGCGAGCACGACCTGTACTCGTGCTGTGACACCAC
CAACCCGAATGCCGAACTGCAGCAACCACTCCTGGGCTACCCGTCCGGCGGGATCTACGGATACACCCACCCGTTCGGCG
GTTACGCCGGATCGCACGCCCAGTTCGTGCGGGTGCCGTTCGGCGATACGAACTGTTTCCCGATCCCCGGCGACATCACC
GACGAACAGGCGCTGTTCCTGTCCGACGCCGTGCCGACCGGGTTCATGGGCGCGGACTTCTGCGACGTCAACGGCGGCGA
CACCGTGGCGGTCTGGGGCGCCGGGGGAGTGGGCCTGATGGCGGCCAAGAGCGCATTGCTGCTCGGCGCCGAACGCGCCA
TCGTCATCGACCGTATCCCCGAACGCCTCTCGCTGGCAGGCGAATTCGGGCTGGAGACCATCGACTACGGCGCGGCGGAC
AGCGTGCAGGAGTCGCTGCGCGAGATGACCGGCGGGCGCGGGCCGGACGCCTGCATCGATGCGGTCGGCATGGAGGGCCA
CAGCACCGGACTGCAACAGGTCTACGACCGGGCCAAGCAGCTGCTGCGGCTGGAGACCGACCGGGCGAGCGCACTGCGCC
AGGCGATCCTCGCGTGCCGCAAGGGCGGAGTGGTGTCGGTGCTCGGCGTCTACGGGTTGACCGACAAGTTCCCGATGGGC
GTGGTGACCAACAAGGGGTTGACGCTCAGATCGGCTCAACAGCACGGTCAGCGGTACATGGCGCGTCTGTTCGACTACGT
CGAGCAGGGCGACCTCGACCCGGCGAAGCTGATCACCCACGATCTACCGCTCGAACAGGGTGTGCGCGCCTACGACATGT
TCAAGAACAAGCAGGACAACTGCATCCGCGTGGCACTGCGTCCCTAG

Upstream 100 bases:

>100_bases
ACTGCTCTACCGCTGCCGCGCGTTGTTGCAGACCGGCGAGGTCCCCACCATCCGTAAGAACCCCAGCGCGCGTCCCTCCG
CGCGGTAAGGAAGGTTACTC

Downstream 100 bases:

>100_bases
GAAGCGGCGCTAGATCGTCGAGATGAGCTTCGACAGCCAGTTGTCGTCGTTGATGTCGAGCACTTCGTCGTTGACCAGGT
CGTAGACCGTCGGCGTGCCG

Product: alcohol dehydrogenase GroES-like protein

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MRALCWNGVNKLSVETVDDPEILNPHDVILKVTLTTTCGSDLHFIDGYLPGMREGDIFGHEFMGEIVETGREVRDVKVGD
RVVVPSFIGCDRCWYCEHDLYSCCDTTNPNAELQQPLLGYPSGGIYGYTHPFGGYAGSHAQFVRVPFGDTNCFPIPGDIT
DEQALFLSDAVPTGFMGADFCDVNGGDTVAVWGAGGVGLMAAKSALLLGAERAIVIDRIPERLSLAGEFGLETIDYGAAD
SVQESLREMTGGRGPDACIDAVGMEGHSTGLQQVYDRAKQLLRLETDRASALRQAILACRKGGVVSVLGVYGLTDKFPMG
VVTNKGLTLRSAQQHGQRYMARLFDYVEQGDLDPAKLITHDLPLEQGVRAYDMFKNKQDNCIRVALRP

Sequences:

>Translated_388_residues
MRALCWNGVNKLSVETVDDPEILNPHDVILKVTLTTTCGSDLHFIDGYLPGMREGDIFGHEFMGEIVETGREVRDVKVGD
RVVVPSFIGCDRCWYCEHDLYSCCDTTNPNAELQQPLLGYPSGGIYGYTHPFGGYAGSHAQFVRVPFGDTNCFPIPGDIT
DEQALFLSDAVPTGFMGADFCDVNGGDTVAVWGAGGVGLMAAKSALLLGAERAIVIDRIPERLSLAGEFGLETIDYGAAD
SVQESLREMTGGRGPDACIDAVGMEGHSTGLQQVYDRAKQLLRLETDRASALRQAILACRKGGVVSVLGVYGLTDKFPMG
VVTNKGLTLRSAQQHGQRYMARLFDYVEQGDLDPAKLITHDLPLEQGVRAYDMFKNKQDNCIRVALRP
>Mature_388_residues
MRALCWNGVNKLSVETVDDPEILNPHDVILKVTLTTTCGSDLHFIDGYLPGMREGDIFGHEFMGEIVETGREVRDVKVGD
RVVVPSFIGCDRCWYCEHDLYSCCDTTNPNAELQQPLLGYPSGGIYGYTHPFGGYAGSHAQFVRVPFGDTNCFPIPGDIT
DEQALFLSDAVPTGFMGADFCDVNGGDTVAVWGAGGVGLMAAKSALLLGAERAIVIDRIPERLSLAGEFGLETIDYGAAD
SVQESLREMTGGRGPDACIDAVGMEGHSTGLQQVYDRAKQLLRLETDRASALRQAILACRKGGVVSVLGVYGLTDKFPMG
VVTNKGLTLRSAQQHGQRYMARLFDYVEQGDLDPAKLITHDLPLEQGVRAYDMFKNKQDNCIRVALRP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=410, Percent_Identity=27.0731707317073, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI71565152, Length=398, Percent_Identity=25.8793969849246, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI4501933, Length=411, Percent_Identity=27.9805352798054, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1786825, Length=393, Percent_Identity=40.4580152671756, Blast_Score=309, Evalue=3e-85,
Organism=Escherichia coli, GI1787863, Length=392, Percent_Identity=25.5102040816327, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1788073, Length=368, Percent_Identity=23.3695652173913, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI87082125, Length=378, Percent_Identity=27.2486772486773, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790045, Length=364, Percent_Identity=25.5494505494505, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI226510992, Length=356, Percent_Identity=22.4719101123595, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788075, Length=382, Percent_Identity=23.5602094240838, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=387, Percent_Identity=22.7390180878553, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI25146526, Length=399, Percent_Identity=25.062656641604, Blast_Score=78, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6323099, Length=399, Percent_Identity=22.0551378446115, Blast_Score=96, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6320033, Length=405, Percent_Identity=26.1728395061728, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=254, Percent_Identity=26.3779527559055, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17137530, Length=395, Percent_Identity=25.8227848101266, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17737897, Length=395, Percent_Identity=25.5696202531646, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 42166; Mature: 42166

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALCWNGVNKLSVETVDDPEILNPHDVILKVTLTTTCGSDLHFIDGYLPGMREGDIFGH
CCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEEECCCCCCHHHHCCCCCCCCCCCCCH
EFMGEIVETGREVRDVKVGDRVVVPSFIGCDRCWYCEHDLYSCCDTTNPNAELQQPLLGY
HHHHHHHHCCHHHEEEECCCEEECCHHHCCCCCEEECCHHHHHHCCCCCCHHHHCCCCCC
PSGGIYGYTHPFGGYAGSHAQFVRVPFGDTNCFPIPGDITDEQALFLSDAVPTGFMGADF
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCE
CDVNGGDTVAVWGAGGVGLMAAKSALLLGAERAIVIDRIPERLSLAGEFGLETIDYGAAD
EECCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEHHCCHHHHHHHHCCCCCCCCCCHH
SVQESLREMTGGRGPDACIDAVGMEGHSTGLQQVYDRAKQLLRLETDRASALRQAILACR
HHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
KGGVVSVLGVYGLTDKFPMGVVTNKGLTLRSAQQHGQRYMARLFDYVEQGDLDPAKLITH
CCCEEEEEEHHCCCCCCCCCEEECCCCEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DLPLEQGVRAYDMFKNKQDNCIRVALRP
CCCHHHCCHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MRALCWNGVNKLSVETVDDPEILNPHDVILKVTLTTTCGSDLHFIDGYLPGMREGDIFGH
CCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEEECCCCCCHHHHCCCCCCCCCCCCCH
EFMGEIVETGREVRDVKVGDRVVVPSFIGCDRCWYCEHDLYSCCDTTNPNAELQQPLLGY
HHHHHHHHCCHHHEEEECCCEEECCHHHCCCCCEEECCHHHHHHCCCCCCHHHHCCCCCC
PSGGIYGYTHPFGGYAGSHAQFVRVPFGDTNCFPIPGDITDEQALFLSDAVPTGFMGADF
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCE
CDVNGGDTVAVWGAGGVGLMAAKSALLLGAERAIVIDRIPERLSLAGEFGLETIDYGAAD
EECCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEHHCCHHHHHHHHCCCCCCCCCCHH
SVQESLREMTGGRGPDACIDAVGMEGHSTGLQQVYDRAKQLLRLETDRASALRQAILACR
HHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
KGGVVSVLGVYGLTDKFPMGVVTNKGLTLRSAQQHGQRYMARLFDYVEQGDLDPAKLITH
CCCEEEEEEHHCCCCCCCCCEEECCCCEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DLPLEQGVRAYDMFKNKQDNCIRVALRP
CCCHHHCCHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]